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Ricardo T Gazzinelli DSc, DVM

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-2400
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    Federal University of Minas Gerais, Belo Horizonte, MG, BrazilDSCBiochemisty & Immunology
    Federal University of Minas Gerais, Belo Horizonte, MG, BrazilDVMVeterinary
    National Institute of Allergy and Infectious Diseases, BethesdaPost-Doctoral Fellow12/1994Immunology

    Collapse Overview 
    Collapse overview

    Research:

    My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

    Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

    Main Projects:

    Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

    Role of monocyte-derived dendritic cells in malária

    The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

    The role of IRAKs and Myddosomes in infection with T. gondii

    Development of the recombinant-A2 vaccine for visceral leishmaniasis

    Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

    My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).


    Collapse Post Docs

    Fiocruz-Minas

    Caroline Junqueira, PhD - Staff Scientist

    • Camila Brabosa, PhD student - Mapping of CD8 T cell-specifc Epitopes from Malaria Blood Stage
    • Gregorio Almeida, DVM, PhD - Immunology of Asymptomatic Malaria
    • Guilherme Maia, PhD - Innate Lymphocytes in Malaria
    • Isabella Hirako, PhD - Monocyte-Derived Dendritic Cells in Malaria
    • Júlia Castro, MSc student - Chagas Disease Vaccine
    • Larissa Pereira, MSc student - Inflammatory Caspases in Malaria
    • Kely Mateucci, PhD - Monocyte-Derived Dendritic Cells Metabolism in Malaria
    • Milton Pereira, PhD - Caspases and inflammasomes in Malaria and Chagas Disease
    • Natalia Satchiko Souza, PhD - CD8+ T cells in malaria

    UMASS

    • Danielle Durso, PhD - IRAKs and Myddosomes in host resistance to T. gondii
    • Patricia Assis, PhD - Host Clock genes and Malaria
    • Ogooluwa Ojelabi, PhD - Glucose Metabolism and Malaria


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Valiate BVS, Castro JT, Mar?al TG, Andrade LAF, Oliveira LI, Maia GBF, Faustino LP, Hojo-Souza NS, Reis MAAD, Bagno FF, Salazar N, Teixeira SR, Almeida GG, Gazzinelli RT. Evaluation of an RBD-nucleocapsid fusion protein as a booster candidate for COVID-19 vaccine. iScience. 2024 Jul 19; 27(7):110177. PMID: 38993669.
      Citations:    
    2. Marques RF, Gimenez AM, Caballero O, Simpson A, Salazar AM, Amino R, Godin S, Gazzinelli RT, Soares IS. Non-clinical toxicity and immunogenicity evaluation of a Plasmodium vivax malaria vaccine using Poly-ICLC (Hiltonol?) as adjuvant. Vaccine. 2024 Apr 02; 42(9):2394-2406. PMID: 38448321.
      Citations:    
    3. Pereira M, Ramalho T, Andrade WA, Durso DF, Souza MC, Fitzgerald KA, Golenbock DT, Silverman N, Gazzinelli RT. The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27; 43(2):113795. PMID: 38367238.
      Citations:    
    4. Ramalho T, Assis PA, Ojelabi O, Tan L, Carvalho B, Gardinassi L, Campos O, Lorenzi PL, Fitzgerald KA, Haynes C, Golenbock DT, Gazzinelli RT. Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells. Cell Metab. 2024 03 05; 36(3):484-497.e6. PMID: 38325373.
      Citations:    Fields:    
    5. Coelho FF, da Silva MA, Lopes TB, Polatto JM, de Castro NS, Andrade LAF, Louren?o KL, Sato HI, de Carvalho AF, Coelho HP, Bagno FF, Luz D, Viala VL, Cattony PQ, Melo BS, Moro AM, Quintilio W, Barbosa AP, Bomfim CG, Soares CP, Guzzo CR, Fonseca FG, Durigon EL, Gazzinelli RT, Ribeiro Teixeira SM, Piazza RMF, Fernandes AP. SARS-CoV-2 Rapid Antigen Test Based on a New Anti-Nucleocapsid Protein Monoclonal Antibody: Development and Real-Time Validation. Microorganisms. 2023 Sep 28; 11(10). PMID: 37894080.
      Citations:    
    6. Dias Assis BR, Gomes IP, de Castro JT, Rivelli GG, de Castro NS, Gomez-Mendoza DP, Bagno FF, Hojo-Souza NS, Chaves Maia AL, Lages EB, da Fonseca FG, Ribeiro Teixeira SM, Fernandes AP, Gazzinelli RT, Castro Goulart GA. Quality attributes of CTVad1, a nanoemulsified adjuvant for phase I clinical trial of SpiN COVID-19 vaccine. Nanomedicine (Lond). 2023 08; 18(18):1175-1194. PMID: 37712604.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    7. Diniz SQ, Figueiredo MM, Costa PAC, Martins-Filho OA, Teixeira-Carvalho A, Pereira DB, Shugiro Tada M, Crocco Afonso LC, Kohlhoff M, Zani CL, Gazzinelli RT, Oliveira F, Antonelli LR. Adenosine pathway regulates inflammation during Plasmodium vivax infection. Front Immunol. 2023; 14:1193256. PMID: 37545509.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Andrade AO, Santos NAC, Bastos AS, Pontual JDC, Ara?jo JE, Silva AMV, Martinez LN, Lima AA, Aguiar ACC, G Teles CB, Medeiros JF, Pereira DB, Vinetz JM, Gazzinelli RT, Ara?jo MS. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLoS Negl Trop Dis. 2023 Jun; 17(6):e0011425. PMID: 37327209.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Castro JT, Brito R, Hojo-Souza NS, Azevedo B, Salazar N, Ferreira CP, Junqueira C, Fernandes AP, Vasconcellos R, Cardoso JM, Aguiar-Soares RDO, Vieira PMA, Carneiro CM, Valiate B, Toledo C, Salazar AM, Caballero O, Lannes-Vieira J, Teixeira SR, Reis AB, Gazzinelli RT. ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas' disease. NPJ Vaccines. 2023 May 31; 8(1):81. PMID: 37258518.
      Citations:    
    10. Pereira M, Gazzinelli RT. Regulation of innate immune signaling by IRAK proteins. Front Immunol. 2023; 14:1133354. PMID: 36865541.
      Citations: 5     Fields:    Translation:HumansCells
    11. Azevedo PO, Hojo-Souza NS, Faustino LP, Fumagalli MJ, Hirako IC, Oliveira ER, Figueiredo MM, Carvalho AF, Doro D, Benevides L, Durigon E, Fonseca F, Machado AM, Fernandes AP, Teixeira SR, Silva JS, Gazzinelli RT. Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern. NPJ Vaccines. 2023 Feb 13; 8(1):15. PMID: 36781862.
      Citations:    
    12. Hirako IC, Antunes MM, Rezende RM, Hojo-Souza NS, Figueiredo MM, Dias T, Nakaya H, Menezes GB, Gazzinelli RT. Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections. Sci Rep. 2022 11 17; 12(1):19805. PMID: 36396745.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Torres K, Ferreira MU, Castro MC, Escalante AA, Conn JE, Villasis E, da Silva Araujo M, Almeida G, Rodrigues PT, Corder RM, Fernandes ARJ, Calil PR, Ladeia WA, Garcia-Castillo SS, Gomez J, do Valle Antonelli LR, Gazzinelli RT, Golenbock DT, Llanos-Cuentas A, Gamboa D, Vinetz JM. Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):168-181. PMID: 36228921.
      Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    14. Ferreira MU, Gamboa D, Torres K, Rodriguez-Ferrucci H, Soto-Calle VE, Pardo K, Fontoura PS, Tomko SS, Gazzinelli RT, Conn JE, Castro MC, Llanos-Cuentas A, Vinetz JM. Evidence-Based Malaria Control and Elimination in the Amazon: Input from the International Center of Excellence in Malaria Research Network in Peru and Brazil. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):160-167. PMID: 36228907.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    15. Castro JT, Azevedo P, Fumagalli MJ, Hojo-Souza NS, Salazar N, Almeida GG, Oliveira LI, Faustino L, Antonelli LR, Mar?al TG, Augusto M, Valiate B, Fiorini A, Rattis B, Ramos SG, Piccin M, Nonato OC, Benevides L, Magalh?es R, Cassaro B, Burle G, Doro D, Kalil J, Durigon E, Salazar A, Caballero O, Santiago H, Machado A, Silva JS, da Fonseca F, Fernandes AP, Teixeira SR, Gazzinelli RT. Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein. Nat Commun. 2022 08 17; 13(1):4831. PMID: 35977933.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    16. Bagno FF, S?rgio SAR, Figueiredo MM, Godoi LC, Andrade LAF, Salazar NC, Soares CP, Aguiar A, Almeida FJ, da Silva ED, Ferreira AGP, Durigon EL, Gazzinelli RT, Teixeira SMR, Fernandes APSM, da Fonseca FG. DEVELOPMENT AND VALIDATION OF AN ENZYME-LINKED IMMUNOASSAY KIT FOR DIAGNOSIS AND SURVEILLANCE OF COVID-19. J Clin Virol Plus. 2022 Aug 17; 100103. PMID: 35993012.
      Citations:    
    17. Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 08 16; 40(7):111225. PMID: 35977521.
      Citations: 6     Fields:    Translation:HumansCells
    18. Okuda K, Silva Costa Franco MM, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. iScience. 2022 Sep 16; 25(9):104909. PMID: 36060064.
      Citations:    
    19. Bagno FF, S?rgio SAR, Figueiredo MM, Godoi LC, Andrade LAF, Salazar NC, Soares CP, Aguiar A, Almeida FJ, da Silva ED, Ferreira AGP, Durigon EL, Gazzinelli RT, Teixeira SMR, Fernandes APSM, da Fonseca FG. Development and validation of an enzyme-linked immunoassay kit for diagnosis and surveillance of COVID-19. J Clin Virol Plus. 2022 Aug; 2(3):100101. PMID: 35959109.
      Citations:    
    20. Matteucci KC, Ramalho TR, Hirako IC, Gazzinelli RT. Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism. Cell Metab. 2022 08 02; 34(8):1083-1085. PMID: 35921815.
      Citations:    Fields:    Translation:HumansCells
    21. Morais MCC, Silva D, Milagre MM, de Oliveira MT, Pereira T, Silva JS, Costa LDF, Minoprio P, Junior RMC, Gazzinelli R, de Lana M, Nakaya HI. Automatic detection of the parasite Trypanosoma cruzi in blood smears using a machine learning approach applied to mobile phone images. PeerJ. 2022; 10:e13470. PMID: 35651746.
      Citations: 4     Fields:    
    22. Camargo EP, Gazzinelli RT, Morel CM, Precioso AR. Why do we still have not a vaccine against Chagas disease? Mem Inst Oswaldo Cruz. 2022; 117:e200314. PMID: 35544856.
      Citations: 6     Fields:    Translation:HumansAnimals
    23. Bagno FF, Andrade LAF, S?rgio SAR, Parise PL, Toledo-Teixeira DA, Gazzinelli RT, Fernandes APSM, Teixeira SMR, Granja F, Proen?a-M?dena JL, da Fonseca FG. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses. 2022 03 02; 14(3). PMID: 35336917.
      Citations: 5     Fields:    Translation:HumansCells
    24. Fumagalli MJ, Castro-Jorge LA, de Souza WM, de Azevedo PO, Hansen AW, Gazzinelli RT, da Fonseca BAL, Spilki FR, Figueiredo LTM. CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant. Viruses. 2022 02 01; 14(2). PMID: 35215895.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    25. Burle-Caldas GA, Dos Santos NSA, de Castro JT, Mugge FLB, Grazielle-Silva V, Oliveira AER, Pereira MCA, Reis-Cunha JL, Dos Santos AC, Gomes DA, Bartholomeu DC, Moretti NS, Schenkman S, Gazzinelli RT, Teixeira SMR. Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites. mBio. 2022 02 22; 13(1):e0347821. PMID: 35073735.
      Citations: 4     Fields:    Translation:Animals
    26. Fumagalli MJ, Castro-Jorge LA, Fraga-Silva TFC, de Azevedo PO, Capato CF, Rattis BAC, Hojo-Souza NS, Floriano VG, de Castro JT, Ramos SG, da Fonseca BAL, Bonato VLD, Gazzinelli RT, Figueiredo LTM. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses. 2021 12 04; 13(12). PMID: 34960708.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    27. Almeida GG, Costa PAC, Araujo MDS, Gomes GR, Carvalho AF, Figueiredo MM, Pereira DB, Tada MS, Medeiros JF, Soares IDS, Carvalho LH, Kano FS, Castro MC, Vinetz JM, Golenbock DT, Antonelli LRDV, Gazzinelli RT. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Negl Trop Dis. 2021 10; 15(10):e0009077. PMID: 34714821.
      Citations: 13     Fields:    Translation:HumansAnimals
    28. Miranda FJB, Rocha BC, Pereira MCA, Pereira LMN, de Souza EHM, Marino AP, Costa PAC, Vasconcelos-Santos DV, Antonelli LRV, Gazzinelli RT. Toxoplasma gondii-Induced Neutrophil Extracellular Traps Amplify the Innate and Adaptive Response. mBio. 2021 10 26; 12(5):e0130721. PMID: 34607465.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Rodrigues da Cunha GM, Azevedo MA, Nogueira DS, Cl?maco MC, Valencia Ayala E, Jimenez Chunga JA, La Valle RJY, da Cunha Galv?o LM, Chiari E, Brito CRN, Soares RP, Nogueira PM, Fujiwara RT, Gazzinelli R, Hincapie R, Chaves CS, Oliveira FMS, Finn MG, Marques AF. a-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model. PLoS Negl Trop Dis. 2021 07; 15(7):e0009613. PMID: 34314435.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Diniz SQ, Teixeira-Carvalho A, Figueiredo MM, Costa PAC, Rocha BC, Martins-Filho OA, Gon?alves R, Pereira DB, Tada MS, Oliveira F, Gazzinelli RT, Antonelli LRDV. Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes. mBio. 2021 08 31; 12(4):e0124721. PMID: 34311577.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    31. Moraschi BF, Noronha IH, Ferreira CP, Cariste LM, Monteiro CB, Denapoli P, Vrechi T, Pereira GJS, Gazzinelli RT, Lannes-Vieira J, Rodrigues MM, Bortoluci KR, Vasconcelos JRC. Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi. Front Cell Infect Microbiol. 2021; 11:676183. PMID: 34123875.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Figueiredo MM, Dos Santos ARR, Godoi LC, de Castro NS, de Andrade BC, Sergio SAR, Jer?nimo SMB, de Oliveira EJ, Valencia-Portillo RT, Bezerra LM, Goto H, Sanchez MCA, Junqueira C, Teixeira SMR, da Fonseca FG, Gazzinelli RT, Fernandes AP. Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2-Based Protein for Human Visceral Leishmaniasis Diagnosis. J Immunol Res. 2021; 2021:5568077. PMID: 34007852.
      Citations: 3     Fields:    Translation:HumansAnimals
    33. Ferreira CP, Cariste LM, Noronha IH, Durso DF, Lannes-Vieira J, Bortoluci KR, Ribeiro DA, Golenbock D, Gazzinelli RT, de Vasconcelos JRC. Correction: CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. PLoS Negl Trop Dis. 2021 Apr; 15(4):e0009326. PMID: 33826616.
      Citations:    Fields:    
    34. Muglia Amancio A, Mittereder L, Carletti A, Tosh KW, Green D, Antonelli LR, Gazzinelli RT, Sher A, Jankovic D. IFNs Reset the Differential Capacity of Human Monocyte Subsets to Produce IL-12 in Response to Microbial Stimulation. J Immunol. 2021 04 01; 206(7):1642-1652. PMID: 33627376.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Dos Santos LI, Torres TA, Diniz SQ, Gon?alves R, Caballero-Flores G, N??ez G, Gazzinelli RT, Maloy KJ, Ribeiro do V Antonelli L. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen. Cell Rep. 2021 01 12; 34(2):108613. PMID: 33440153.
      Citations: 1     Fields:    Translation:HumansAnimals
    36. Junqueira C, Polidoro RB, Castro G, Absalon S, Liang Z, Sen Santara S, Crespo ?, Pereira DB, Gazzinelli RT, Dvorin JD, Lieberman J. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357. PMID: 33432229.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    37. Pereira LMN, Assis PA, de Ara?jo NM, Durso DF, Junqueira C, Ata?de MA, Pereira DB, Lien E, Fitzgerald KA, Zamboni DS, Golenbock DT, Gazzinelli RT. Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020 Nov 03; 11(1):5673. PMID: 33144583.
      Citations: 1     Fields:    
    38. Brand?o-de-Resende C, Santos HH, Rojas Lagos AA, Lara CM, Arruda JSD, Marino APMP, do Valle Antonelli LR, Gazzinelli RT, de Almeida Vitor RW, Vasconcelos-Santos DV. Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1. Emerg Infect Dis. 2020 11; 26(12). PMID: 33219657.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    39. Pereira LMN, Assis PA, de Ara?jo NM, Durso DF, Junqueira C, Ata?de MA, Pereira DB, Lien E, Fitzgerald KA, Zamboni DS, Golenbock DT, Gazzinelli RT. Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020 09 14; 11(1):4596. PMID: 32929083.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    40. Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A, Lieberman J, Junqueira C, Gazzinelli RT. Contributions of IFN-??and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathog. 2020 09; 16(9):e1008840. PMID: 32913355.
      Citations: 11     Fields:    Translation:AnimalsCells
    41. Osier F, Ting JPY, Fraser J, Lambrecht BN, Romano M, Gazzinelli RT, Bortoluci KR, Zamboni DS, Akbar AN, Evans J, Brown DE, Patel KD, Wu Y, Perez AB, P?rez O, Kamradt T, Falk C, Barda-Saad M, Ariel A, Santoni A, Annunziato F, Cassatella MA, Kiyono H, Chereshnev V, Dieye A, Mbow M, Mbengue B, Niang MDS, Suchard M. The global response to the COVID-19 pandemic: how have immunology societies contributed? Nat Rev Immunol. 2020 10; 20(10):594-602. PMID: 32913283.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    42. Oliveira AER, Pereira MCA, Belew AT, Ferreira LRP, Pereira LMN, Neves EGA, Nunes MDCP, Burleigh BA, Dutra WO, El-Sayed NM, Gazzinelli RT, Teixeira SMR. Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi?strains unveil a role for fibroblasts in neutrophil recruitment and activation. PLoS Pathog. 2020 08; 16(8):e1008781. PMID: 32810179.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    43. Pontes Ferreira C, Moro Cariste L, Henrique Noronha I, Fernandes Durso D, Lannes-Vieira J, Ramalho Bortoluci K, Araki Ribeiro D, Golenbock D, Gazzinelli RT, Vasconcelos JRC. CXCR3 chemokine receptor contributes to specific CD8+?T cell activation by pDC during infection with intracellular pathogens. PLoS Negl Trop Dis. 2020 06; 14(6):e0008414. PMID: 32574175.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Ayala EV, Rodrigues da Cunha G, Azevedo MA, Calderon M, Jimenez J, Venuto AP, Gazzinelli R, Lavalle RJY, Riva AGV, Hincapie R, Finn MG, Marques AF. C57BL/6 a-1,3-Galactosyltransferase Knockout Mouse as an Animal Model for Experimental Chagas Disease. ACS Infect Dis. 2020 07 10; 6(7):1807-1815. PMID: 32374586.
      Citations: 4     Fields:    Translation:Animals
    45. Marino AP, Dos Santos LI, Henriques PM, Roffe E, Vasconcelos-Santos DV, Sher A, Jankovic D, Gomes MS, Amaral LR, Campi-Azevedo AC, Teixeira-Carvalho A, Martins-Filho OA, Gazzinelli RT, Antonelli LR. Circulating inflammatory mediators as biomarkers of ocular toxoplasmosis in acute and in chronic infection. J Leukoc Biol. 2020 10; 108(4):1253-1264. PMID: 32421913.
      Citations: 7     Fields:    Translation:HumansAnimals
    46. Gibaldi D, Vilar-Pereira G, Pereira IR, Silva AA, Barrios LC, Ramos IP, Mata Dos Santos HA, Gazzinelli R, Lannes-Vieira J. CCL3/Macrophage Inflammatory Protein-1a Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFN?-Enriched Inflammatory Milieu in Trypanosoma cruzi-Induced Chronic Cardiomyopathy. Front Immunol. 2020; 11:306. PMID: 32194558.
      Citations: 23     Fields:    Translation:AnimalsCells
    47. Prior KF, Rijo-Ferreira F, Assis PA, Hirako IC, Weaver DR, Gazzinelli RT, Reece SE. Periodic Parasites and Daily Host Rhythms. Cell Host Microbe. 2020 02 12; 27(2):176-187. PMID: 32053788.
      Citations: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Antonelli LR, Junqueira C, Vinetz JM, Golenbock DT, Ferreira MU, Gazzinelli RT. The immunology of Plasmodium vivax malaria. Immunol Rev. 2020 01; 293(1):163-189. PMID: 31642531.
      Citations: 22     Fields:    Translation:HumansAnimals
    49. Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andr? I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, B?scher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Cicin-?ain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, D?rner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, F?rster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, Gonz?lez-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Gr?tzkau A, Haftmann C, Hahn J, Hammad H, H?mmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hern?ndez DC, Herrera G, Herrmann M, Hess C, H?fer T, Hoffmann P, Hogquist K, Holland T, H?llt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, J?ck HM, Jani PK, J?vega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, K?hne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, L?pez-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Mart?nez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Mauer?der C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mj?sberg J, Moore J, Moran B, Moretta L, Mosmann TR, M?ller S, Multhoff G, Mu?oz LE, M?nz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, N??ez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis e Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalm?ller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct; 49(10):1457-1973. PMID: 31633216.
      Citations: 351     Fields:    Translation:Humans
    50. Hirako IC, Assis PA, Galv?o-Filho B, Luster AD, Antonelli LR, Gazzinelli RT. Monocyte-derived dendritic cells in malaria. Curr Opin Microbiol. 2019 12; 52:139-150. PMID: 31542508.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    51. Pontes Ferreira C, Cariste LM, Ferri Moraschi B, Ferrarini Zanetti B, Won Han S, Araki Ribeiro D, Vieira Machado A, Lannes-Vieira J, Gazzinelli RT, Vasconcelos JRC. CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge. PLoS Negl Trop Dis. 2019 07; 13(7):e0007597. PMID: 31356587.
      Citations: 6     Fields:    Translation:AnimalsCells
    52. Gazzinelli R. Seeing through the parasites' eyes. Nat Rev Immunol. 2019 03; 19(3):137. PMID: 30700863.
      Citations:    Fields:    
    53. Santos ARRD, Serufo ?V, Figueiredo MM, Godoi LC, Vit?rio JG, Marcelino AP, Avelar DM, Rodrigues FTG, Machado-Coelho GLL, Medeiros FAC, Jer?nimo SMB, Oliveira EJ, Nascimento FC, Teixeira SMR, Gazzinelli RT, Nagem RAP, Fernandes AP. Evaluation of three recombinant proteins for the development of ELISA and immunochromatographic tests for visceral leishmaniasis serodiagnosis. Mem Inst Oswaldo Cruz. 2019 Feb 04; 114:e180405. PMID: 30726344.
      Citations: 4     Fields:    Translation:HumansAnimals
    54. Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150. PMID: 30442645.
      Citations: 20     Fields:    Translation:AnimalsCells
    55. Galv?o-Filho B, de Castro JT, Figueiredo MM, Rosmaninho CG, Antonelli LRDV, Gazzinelli RT. The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4. Mucosal Immunol. 2019 03; 12(2):312-322. PMID: 30337650.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    56. Costa PAC, Figueiredo MM, Diniz SQ, Peixoto APMM, Maloy KJ, Teixeira-Carvalho A, Tada MS, Pereira DB, Gazzinelli RT, Antonelli LRV. Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria. J Infect Dis. 2018 09 08; 218(8):1314-1323. PMID: 29800313.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    57. Junqueira C, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira DB, Antonelli LR, Lieberman J, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018 09; 24(9):1330-1336. PMID: 30038217.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    58. Hirako IC, Assis PA, Hojo-Souza NS, Reed G, Nakaya H, Golenbock DT, Coimbra RS, Gazzinelli RT. Daily Rhythms of TNFa Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle. Cell Host Microbe. 2018 06 13; 23(6):796-808.e6. PMID: 29805094.
      Citations: 29     Fields:    Translation:AnimalsCells
    59. Schrum JE, Crabtree JN, Dobbs KR, Kiritsy MC, Reed GW, Gazzinelli RT, Netea MG, Kazura JW, Dent AE, Fitzgerald KA, Golenbock DT. Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity. J Immunol. 2018 02 15; 200(4):1243-1248. PMID: 29330325.
      Citations: 60     Fields:    Translation:Humans
    60. Belew AT, Junqueira C, Rodrigues-Luiz GF, Valente BM, Oliveira AER, Polidoro RB, Zuccherato LW, Bartholomeu DC, Schenkman S, Gazzinelli RT, Burleigh BA, El-Sayed NM, Teixeira SMR. Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection. PLoS Pathog. 2017 12; 13(12):e1006767. PMID: 29240831.
      Citations: 30     Fields:    Translation:HumansAnimals
    61. Ferreira CP, Cariste LM, Santos Virg?lio FD, Moraschi BF, Monteiro CB, Vieira Machado AM, Gazzinelli RT, Bruna-Romero O, Menin Ruiz PL, Ribeiro DA, Lannes-Vieira J, Lopes MF, Rodrigues MM, de Vasconcelos JRC. LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection. Front Immunol. 2017; 8:1291. PMID: 29081775.
      Citations: 9     Fields:    
    62. Moura APV, Santos LCB, Brito CRN, Valencia E, Junqueira C, Filho AAP, Sant'Anna MRV, Gontijo NF, Bartholomeu DC, Fujiwara RT, Gazzinelli RT, McKay CS, Sanhueza CA, Finn MG, Marques AF. Virus-like Particle Display of the a-Gal Carbohydrate for Vaccination against Leishmania Infection. ACS Cent Sci. 2017 Sep 27; 3(9):1026-1031. PMID: 28979944.
      Citations:    
    63. Figueiredo MM, Costa PAC, Diniz SQ, Henriques PM, Kano FS, Tada MS, Pereira DB, Soares IS, Martins-Filho OA, Jankovic D, Gazzinelli RT, Antonelli LRDV. T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection. PLoS Pathog. 2017 Jul; 13(7):e1006484. PMID: 28700710.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    64. Hirako IC, Ataide MA, Faustino L, Assis PA, Sorensen EW, Ueta H, Ara?jo NM, Menezes GB, Luster AD, Gazzinelli RT. Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria. Nat Commun. 2016 11 03; 7:13277. PMID: 27808089.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    65. Okuda K, Tong M, Dempsey B, Moore KJ, Gazzinelli RT, Silverman N. Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation. PLoS Pathog. 2016 06; 12(6):e1005669. PMID: 27280707.
      Citations: 18     Fields:    Translation:AnimalsCells
    66. Farias Luz N, Balaji S, Okuda K, Barreto AS, Bertin J, Gough PJ, Gazzinelli R, Almeida RP, Bozza MT, Borges VM, Chan FK. RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. J Immunol. 2016 06 15; 196(12):5056-63. PMID: 27183605.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    67. Ersching J, Vasconcelos JR, Ferreira CP, Caetano BC, Machado AV, Bruna-Romero O, Baron MA, Ferreira LR, Cunha-Neto E, Rock KL, Gazzinelli RT, Rodrigues MM. The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. PLoS Pathog. 2016 04; 12(4):e1005593. PMID: 27128676.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    68. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    69. Rocha BC, Marques PE, Leoratti FMS, Junqueira C, Pereira DB, Antonelli LRDV, Menezes GB, Golenbock DT, Gazzinelli RT. Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria. Cell Rep. 2015 Dec 29; 13(12):2829-2841. PMID: 26711347.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    70. Hirako IC, Gallego-Marin C, Ataide MA, Andrade WA, Gravina H, Rocha BC, de Oliveira RB, Pereira DB, Vinetz J, Diamond B, Ram S, Golenbock DT, Gazzinelli RT. DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients. mBio. 2015 Nov 17; 6(6):e01605-15. PMID: 26578679.
      Citations: 26     Fields:    Translation:HumansCells
    71. Costa PA, Leoratti FM, Figueiredo MM, Tada MS, Pereira DB, Junqueira C, Soares IS, Barber DL, Gazzinelli RT, Antonelli LR. Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production. J Infect Dis. 2015 Dec 15; 212(12):1999-2010. PMID: 26019284.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    72. Pereira IR, Vilar-Pereira G, Marques V, da Silva AA, Caetano B, Moreira OC, Machado AV, Bruna-Romero O, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J. A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy. PLoS Pathog. 2015 Jan; 11(1):e1004594. PMID: 25617628.
      Citations: 49     Fields:    Translation:AnimalsCellsPHPublic Health
    73. Dos Santos LI, Galv?o-Filho B, de Faria PC, Junqueira C, Dutra MS, Teixeira SM, Rodrigues MM, Ritter G, Bannard O, Fearon DT, Antonelli LR, Gazzinelli RT. Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother. 2015 Mar; 64(3):311-23. PMID: 25403749.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    74. Gazzinelli RT, Kalantari P, Fitzgerald KA, Golenbock DT. Innate sensing of malaria parasites. Nat Rev Immunol. 2014 Nov; 14(11):744-57. PMID: 25324127.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    75. Antonelli LR, Leoratti FM, Costa PA, Rocha BC, Diniz SQ, Tada MS, Pereira DB, Teixeira-Carvalho A, Golenbock DT, Gon?alves R, Gazzinelli RT. The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria. PLoS Pathog. 2014 Sep; 10(9):e1004393. PMID: 25233271.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    76. de Faria PC, dos Santos LI, Coelho JP, Ribeiro HB, Pimenta MA, Ladeira LO, Gomes DA, Furtado CA, Gazzinelli RT. Oxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8(+) T cell response and protection against cancer. Nano Lett. 2014 Sep 10; 14(9):5458-70. PMID: 25115645.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    77. Grimaldi G, Teva A, Porrozzi R, Pinto MA, Marchevsky RS, Rocha MG, Dutra MS, Bru?a-Romero O, Fernandes AP, Gazzinelli RT. Clinical and parasitological protection in a Leishmania infantum-macaque model vaccinated with adenovirus and the recombinant A2 antigen. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2853. PMID: 24945284.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    78. Vasconcelos JR, Dominguez MR, Neves RL, Ersching J, Ara?jo A, Santos LI, Virgilio FS, Machado AV, Bruna-Romero O, Gazzinelli RT, Rodrigues MM. Adenovirus vector-induced CD8? T effector memory cell differentiation and recirculation, but not proliferation, are important for protective immunity against experimental Trypanosoma cruzi Infection. Hum Gene Ther. 2014 Apr; 25(4):350-63. PMID: 24568548.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    79. Gazzinelli RT, Mendon?a-Neto R, Lilue J, Howard J, Sher A. Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men. Cell Host Microbe. 2014 Feb 12; 15(2):132-8. PMID: 24528860.
      Citations: 66     Fields:    Translation:HumansAnimals
    80. Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 2014 Jan; 10(1):e1003885. PMID: 24453977.
      Citations: 89     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    81. Kalantari P, DeOliveira RB, Chan J, Corbett Y, Rathinam V, Stutz A, Latz E, Gazzinelli RT, Golenbock DT, Fitzgerald KA. Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 2014 Jan 16; 6(1):196-210. PMID: 24388751.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    82. Silva GK, Costa RS, Silveira TN, Caetano BC, Horta CV, Gutierrez FR, Guedes PM, Andrade WA, De Niz M, Gazzinelli RT, Zamboni DS, Silva JS. Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1? response and host resistance to Trypanosoma cruzi infection. J Immunol. 2013 Sep 15; 191(6):3373-83. PMID: 23966627.
      Citations: 54     Fields:    Translation:Animals
    83. Cardoso MS, Junqueira C, Trigueiro RC, Shams-Eldin H, Macedo CS, Ara?jo PR, Gomes DA, Martinelli PM, Kimmel J, Stahl P, Niehus S, Schwarz RT, Previato JO, Mendon?a-Previato L, Gazzinelli RT, Teixeira SM. Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway. PLoS Negl Trop Dis. 2013; 7(8):e2369. PMID: 23951384.
      Citations: 14     Fields:    Translation:AnimalsCells
    84. Marinotti O, Cerqueira GC, de Almeida LG, Ferro MI, Loreto EL, Zaha A, Teixeira SM, Wespiser AR, Almeida E Silva A, Schlindwein AD, Pacheco AC, Silva AL, Graveley BR, Walenz BP, Lima Bde A, Ribeiro CA, Nunes-Silva CG, de Carvalho CR, Soares CM, de Menezes CB, Matiolli C, Caffrey D, Ara?jo DA, de Oliveira DM, Golenbock D, Grisard EC, Fantinatti-Garboggini F, de Carvalho FM, Barcellos FG, Prosdocimi F, May G, Azevedo Junior GM, Guimar?es GM, Goldman GH, Padilha IQ, Batista Jda S, Ferro JA, Ribeiro JM, Fietto JL, Dabbas KM, Cerdeira L, Agnez-Lima LF, Brocchi M, de Carvalho MO, Teixeira Mde M, Diniz Maia Mde M, Goldman MH, Cruz Schneider MP, Felipe MS, Hungria M, Nicol?s MF, Pereira M, Montes MA, Cant?o ME, Vincentz M, Rafael MS, Silverman N, Stoco PH, Souza RC, Vicentini R, Gazzinelli RT, Neves Rde O, Silva R, Astolfi-Filho S, Maciel TE, Urm?nyi TP, Tadei WP, Camargo EP, de Vasconcelos AT. The genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Res. 2013 Aug; 41(15):7387-400. PMID: 23761445.
      Citations: 62     Fields:    Translation:AnimalsCellsPHPublic Health
    85. Barbosa RP, Filho BG, Dos Santos LI, Junior PA, Marques PE, Pereira RV, Cara DC, Bru?a-Romero O, Rodrigues MM, Gazzinelli RT, Machado AV. Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection. PLoS One. 2013; 8(4):e61795. PMID: 23637908.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    86. Schamber-Reis BL, Petritus PM, Caetano BC, Martinez ER, Okuda K, Golenbock D, Scott P, Gazzinelli RT. UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major. J Biol Chem. 2013 Mar 08; 288(10):7127-36. PMID: 23325805.
      Citations: 21     Fields:    Translation:AnimalsCells
    87. Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT. Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe. 2013 Jan 16; 13(1):42-53. PMID: 23290966.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    88. Dutra MS, B?la SR, Peixoto-Rangel AL, Fakiola M, Cruz AG, Gazzinelli A, Quites HF, Bahia-Oliveira LM, Peixe RG, Campos WR, Higino-Rocha AC, Miller NE, Blackwell JM, Antonelli LR, Gazzinelli RT. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. J Infect Dis. 2013 Jan 01; 207(1):152-63. PMID: 23100559.
      Citations: 24     Fields:    Translation:HumansCells
    89. B?la SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT. Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infect Immun. 2012 Dec; 80(12):4298-308. PMID: 23027530.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    90. Leoratti FM, Trevelin SC, Cunha FQ, Rocha BC, Costa PA, Gravina HD, Tada MS, Pereira DB, Golenbock DT, Antonelli LR, Gazzinelli RT. Neutrophil paralysis in Plasmodium vivax malaria. PLoS Negl Trop Dis. 2012; 6(6):e1710. PMID: 22745844.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    91. Fernandes AP, Coelho EA, Machado-Coelho GL, Grimaldi G, Gazzinelli RT. Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. Curr Opin Microbiol. 2012 Aug; 15(4):476-85. PMID: 22698479.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    92. Vasconcelos JR, Bru?a-Romero O, Ara?jo AF, Dominguez MR, Ersching J, de Alencar BC, Machado AV, Gazzinelli RT, Bortoluci KR, Amarante-Mendes GP, Lopes MF, Rodrigues MM. Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine. PLoS Pathog. 2012; 8(5):e1002699. PMID: 22615561.
      Citations: 43     Fields:    Translation:AnimalsCells
    93. Junqueira C, Guerrero AT, Galv?o-Filho B, Andrade WA, Salgado AP, Cunha TM, Ropert C, Campos MA, Penido ML, Mendon?a-Previato L, Previato JO, Ritter G, Cunha FQ, Gazzinelli RT. Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. PLoS One. 2012; 7(5):e36245. PMID: 22567144.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    94. Silverio JC, Pereira IR, Cipitelli Mda C, Vinagre NF, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J. CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy. PLoS Pathog. 2012; 8(4):e1002645. PMID: 22532799.
      Citations: 65     Fields:    Translation:AnimalsCells
    95. Junqueira C, Santos LI, Galv?o-Filho B, Teixeira SM, Rodrigues FG, DaRocha WD, Chiari E, Jungbluth AA, Ritter G, Gnjatic S, Old LJ, Gazzinelli RT. Trypanosoma cruzi as an effective cancer antigen delivery vector. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19695-700. PMID: 22114198.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    96. Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity. 2011 Aug 26; 35(2):194-207. PMID: 21820332.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    97. Caetano BC, Carmo BB, Melo MB, Cerny A, dos Santos SL, Bartholomeu DC, Golenbock DT, Gazzinelli RT. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol. 2011 Aug 15; 187(4):1903-11. PMID: 21753151.
      Citations: 42     Fields:    Translation:Animals
    98. Costa MM, Andrade HM, Bartholomeu DC, Freitas LM, Pires SF, Chapeaurouge AD, Perales J, Ferreira AT, Giusta MS, Melo MN, Gazzinelli RT. Analysis of Leishmania chagasi by 2-D difference gel electrophoresis (2-D DIGE) and immunoproteomic: identification of novel candidate antigens for diagnostic tests and vaccine. J Proteome Res. 2011 May 06; 10(5):2172-84. PMID: 21355625.
      Citations: 21     Fields:    Translation:Animals
    99. Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W, Ata?de MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3689-94. PMID: 21303985.
      Citations: 57     Fields:    Translation:HumansAnimals
    100. Junqueira C, Caetano B, Bartholomeu DC, Melo MB, Ropert C, Rodrigues MM, Gazzinelli RT. The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease. Expert Rev Mol Med. 2010 Sep 15; 12:e29. PMID: 20840799.
      Citations: 89     Fields:    Translation:HumansAnimals
    101. Melo MB, Kasperkovitz P, Cerny A, K?nen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT. UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog. 2010 Aug 26; 6(8):e1001071. PMID: 20865117.
      Citations: 38     Fields:    Translation:AnimalsCells
    102. Machado AV, Caetano BC, Barbosa RP, Salgado AP, Rabelo RH, Garcia CC, Bruna-Romero O, Escriou N, Gazzinelli RT. Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity. Vaccine. 2010 Apr 19; 28(18):3247-56. PMID: 20189485.
      Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    103. de Alencar BC, Persechini PM, Haolla FA, de Oliveira G, Silverio JC, Lannes-Vieira J, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination. Infect Immun. 2009 Oct; 77(10):4383-95. PMID: 19651871.
      Citations: 54     Fields:    Translation:AnimalsCellsPHPublic Health
    104. Franklin BS, Parroche P, Ata?de MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT. Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5789-94. PMID: 19297619.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    105. Fernandes AP, Costa MM, Coelho EA, Michalick MS, de Freitas E, Melo MN, Luiz Tafuri W, Resende Dde M, Hermont V, Abrantes Cde F, Gazzinelli RT. Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein. Vaccine. 2008 Oct 29; 26(46):5888-95. PMID: 18786587.
      Citations: 72     Fields:    Translation:AnimalsCellsPHPublic Health
    106. Bartholomeu DC, Ropert C, Melo MB, Parroche P, Junqueira CF, Teixeira SM, Sirois C, Kasperkovitz P, Knetter CF, Lien E, Latz E, Golenbock DT, Gazzinelli RT. Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol. 2008 Jul 15; 181(2):1333-44. PMID: 18606688.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    107. Resende DM, Caetano BC, Dutra MS, Penido ML, Abrantes CF, Verly RM, Resende JM, Pil?-Veloso D, Rezende SA, Bruna-Romero O, Fernandes AP, Gazzinelli RT. Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN-gamma and cytolytic activity by CD8+ T cells. Vaccine. 2008 Aug 18; 26(35):4585-93. PMID: 18588933.
      Citations: 30     Fields:    Translation:AnimalsCells
    108. Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT. Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1919-24. PMID: 17261807.
      Citations: 260     Fields:    Translation:HumansAnimals
    109. Gazzinelli RT, Denkers EY. Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nat Rev Immunol. 2006 Dec; 6(12):895-906. PMID: 17110955.
      Citations: 137     Fields:    Translation:AnimalsCells
    110. Campos MA, Closel M, Valente EP, Cardoso JE, Akira S, Alvarez-Leite JI, Ropert C, Gazzinelli RT. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol. 2004 Feb 01; 172(3):1711-8. PMID: 14734753.
      Citations: 71     Fields:    Translation:AnimalsCells
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