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Oliver J Rando MD, PhD

InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology

    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBABiochemistry
    Stanford University, Palo Alto, CA, United StatesMD
    Stanford University, Palo Alto, CA, United StatesPHDGenomic Studies

    Collapse Overview 
    Collapse overview

    Oliver Rando

    Genomic approaches to chromatin structure and function, and to epigenetic inheritance.

    Public data sets:

    Organisms sharing identical genomes may nonetheless exhibit heritable variation in traits that are now called “epigenetic” traits. Information carriers for epigenetic traits include prion conformation and cytosine methylation, and it is widely believed that the packaging of eukaryotic genomes into chromatin provides another carrier of epigenetic information. Epigenetics is of great interest for researchers interested in fields ranging from systems biology to evolution to human disease.

    Our lab is broadly interested in epigenetic inheritance, but most of our research focuses on one putative carrier of epigenetic information – the nucleoprotein complex known as chromatin. We utilize “genomics” tools such as DNA microarrays and high-throughput sequencing to measure chromatin structure over entire genomes at single-nucleosome resolution, with the eventual goal of determining how chromatin states are established and maintained.

    We consider the primary sequence of chromatin to consist of three major features – the positioning of nucleosomes relative to underlying genomic sequence, the covalent modification pattern of each nucleosome, and the histone variants comprising each histone octamer. To date, we have measured these three features in actively growing yeast cultures, and have also measured the exchange rates of histone H3 in G1-arrested yeast. A number of interesting features emerge from these studies:

    Most interesting, we have identified what may be considered “motifs” in chromatin structure in yeast. For example, yeast promoters are characterized by a nucleosome-free region (NFR) of about 140 bp flanked by two well-positioned nucleosomes that lack a number of modifications such as H4K16ac, and that are rapidly replaced throughout the cell cycle. The +1 nucleosome also tends to carry Htz1 in place of H2A, while the -1 nucleosome carries Htz1 at a subset of promoters.

    Another interesting feature of yeast chromatin is that covalent modifications tend to occur in a small number of highly-correlated groups, suggesting that histone modification patterns do not encode complex “messages.” Nonetheless, the abundance of covalent modifications (over 100 have been described!!!) raises the question of why so many exist.

    By measuring histone replacement dynamics, we have found that coding regions are surprisingly “cold”, meaning the passage of RNA polymerase does not result in nucleosome replacement except at extremely high transcription rates. Heterochromatin is also cold, while promoter and tRNA genes are associated with hot nucleosomes. Chromatin boundaries – sequences whose presence prevents the lateral spread of silencing complexes from a nucleating element – are also associated with rapidly-exchanged nucleosomes, suggesting that “scrubbing” or chromatin by rapid replacement serves as the mechanism to limit this lateral spreading.

    Our lab is interested in the following questions:

    1) What are the rules by which chromatin motifs are generated? How do genomic sequences, and factors such as RNA polymerase passage, result in the common chromatin patterns seen at so many genes?

    2) What are the mechanisms resulting in replication-independent histone replacement?

    3) What are there so many histone modifications? What are the “systems” features that result from histone modification crosstalk?

    4) More generally, how does chromatin act as a signal filter in cells, given its location between upstream signaling pathways and downstream transcriptional outcomes?

    5) What happens to nucleosomes during genomic replication, and how do old nucleosomes influence the states of newly-incorporated nucleosomes? What is the machinery required to maintain a chromatin state?

    6) How does chromatin structure change over evolution, and how do chromatin regulators contribute to phenotypic divergence in closely-related species?

    7) What phenotypes are epigenetically heritable, and under what conditions is a selective advantage conferred by stochastic switching as opposed to plastic responsiveness to the environment?

    8) How is the genome packaged in sperm and embryonic stem cells, and how do histone dynamics change during differentiation?

    Collapse Rotation Projects

    Rotation projects are available to study chromatin structure and function.

    Project 1. Measure histone dynamics in yeast.

    Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions.

    Project 2. Characterize mechanisms for epigenetic inheritance in yeast.

    We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns.

    Project 3. Measure histone dynamics in embryonic stem cells.

    Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.

    Collapse Post Docs

    For more information about the Postdoctoral position in Dr. Rando’s lab please use the link provided.
    Post doc position

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yin Q, Yang CH, Strelkova OS, Wu J, Sun Y, Gopalan S, Yang L, Dekker J, Fazzio TG, Li XZ, Gibcus J, Rando OJ. Revisiting chromatin packaging in mouse sperm. Genome Res. 2023 Dec 21. PMID: 38129076.
      Citations: 3     Fields:    
    2. Maitin-Shepard M, Werner EF, Feig LA, Chavarro JE, Mumford SL, Wylie B, Rando OJ, Gaskins AJ, Sakkas D, Arora M, Kudesia R, Lujan ME, Braun J, Mozaffarian D. Food, nutrition, and fertility: from soil to fork. Am J Clin Nutr. 2024 Feb; 119(2):578-589. PMID: 38101699.
      Citations:    Fields:    Translation:Humans
    3. Barshad G, Lewis JJ, Chivu AG, Abuhashem A, Krietenstein N, Rice EJ, Ma Y, Wang Z, Rando OJ, Hadjantonakis AK, Danko CG. RNA polymerase II dynamics shape enhancer-promoter interactions. Nat Genet. 2023 08; 55(8):1370-1380. PMID: 37430091.
      Citations: 5     Fields:    Translation:Cells
    4. Rinaldi V, Messemer K, Desevin K, Sun F, Berry BC, Kukreja S, Tapper AR, Wagers AJ, Rando OJ. Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse. Elife. 2023 03 27; 12. PMID: 36971355.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Kaymak E, Rando OJ. Staying together after the breakup: tRNA halves in extracellular fluids. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2300300120. PMID: 36780520.
      Citations: 1     Fields:    Translation:Cells
    6. Tourzani DA, Yin Q, Jackson EA, Rando OJ, Visconti PE, Gervasi MG. Sperm Energy Restriction and Recovery (SER) Alters Epigenetic Marks during the First Cell Cycle of Development in Mice. Int J Mol Sci. 2022 Dec 30; 24(1). PMID: 36614081.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Krietenstein N, Rando OJ. Mammalian Micro-C-XL. Methods Mol Biol. 2022; 2458:321-332. PMID: 35103975.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Conine CC, Rando OJ. Soma-to-germline RNA communication. Nat Rev Genet. 2022 02; 23(2):73-88. PMID: 34545247.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    9. Akgol Oksuz B, Yang L, Abraham S, Venev SV, Krietenstein N, Parsi KM, Ozadam H, Oomen ME, Nand A, Mao H, Genga RMJ, Maehr R, Rando OJ, Mirny LA, Gibcus JH, Dekker J. Systematic evaluation of chromosome conformation capture assays. Nat Methods. 2021 09; 18(9):1046-1055. PMID: 34480151.
      Citations: 45     Fields:    Translation:HumansCells
    10. Galan C, Serra RW, Sun F, Rinaldi VD, Conine CC, Rando OJ. Stability of the cytosine methylome during post-testicular sperm maturation in mouse. PLoS Genet. 2021 03; 17(3):e1009416. PMID: 33661909.
      Citations: 7     Fields:    Translation:AnimalsCells
    11. Wang F, Gervasi MG, Bo?kovic A, Sun F, Rinaldi VD, Yu J, Wallingford MC, Tourzani DA, Mager J, Zhu LJ, Rando OJ, Visconti PE, Strittmatter L, Bach I. Deficient spermiogenesis in mice lacking Rlim. Elife. 2021 02 23; 10. PMID: 33620316.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Conine CC, Sun F, Song L, Rivera-P?rez JA, Rando OJ. Sperm Head Preparation and Genetic Background Affect Caput Sperm ICSI Embryo Viability: Cauda-Enriched miRNAs Only Essential in Specific Conditions. Dev Cell. 2020 12 21; 55(6):677-678. PMID: 33352142.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Forey R, Barthe A, Tittel-Elmer M, Wery M, Barrault MB, Ducrot C, Seeber A, Krietenstein N, Szachnowski U, Skrzypczak M, Ginalski K, Rowicka M, Cobb JA, Rando OJ, Soutourina J, Werner M, Dubrana K, Gasser SM, Morillon A, Pasero P, Lengronne A, Poli J. A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization. Mol Cell. 2021 01 07; 81(1):183-197.e6. PMID: 33278361.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Kassem S, Ferrari P, Hughes AL, Soudet J, Rando OJ, Strubin M. Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci. Sci Adv. 2020 09; 6(36). PMID: 32917590.
      Citations: 4     Fields:    Translation:Cells
    15. Ignatova VV, Kaiser S, Ho JSY, Bing X, Stolz P, Tan YX, Lee CL, Gay FPH, Lastres PR, Gerlini R, Rathkolb B, Aguilar-Pimentel A, Sanz-Moreno A, Klein-Rodewald T, Calzada-Wack J, Ibragimov E, Valenta M, Lukauskas S, Pavesi A, Marschall S, Leuchtenberger S, Fuchs H, Gailus-Durner V, de Angelis MH, Bultmann S, Rando OJ, Guccione E, Kellner SM, Schneider R. METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. Sci Adv. 2020 08; 6(35):eaaz4551. PMID: 32923617.
      Citations: 33     Fields:    Translation:Animals
    16. Rinaldi VD, Donnard E, Gellatly K, Rasmussen M, Kucukural A, Yukselen O, Garber M, Sharma U, Rando OJ. An atlas of cell types in the mouse epididymis and vas deferens. Elife. 2020 07 30; 9. PMID: 32729827.
      Citations: 30     Fields:    Translation:Animals
    17. Krietenstein N, Rando OJ. Mesoscale organization of the chromatin fiber. Curr Opin Genet Dev. 2020 04; 61:32-36. PMID: 32305817.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, Seisenberger C, H?lter SM, Borland K, Van De Logt E, Jansen PWTC, Baltissen MP, Valenta M, Vermeulen M, Wurst W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Rando OJ, Kellner SM, Bultmann S, Schneider R. The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev. 2020 05 01; 34(9-10):715-729. PMID: 32217665.
      Citations: 55     Fields:    Translation:AnimalsCells
    19. Krietenstein N, Abraham S, Venev SV, Abdennur N, Gibcus J, Hsieh TS, Parsi KM, Yang L, Maehr R, Mirny LA, Dekker J, Rando OJ. Ultrastructural Details of Mammalian Chromosome Architecture. Mol Cell. 2020 05 07; 78(3):554-565.e7. PMID: 32213324.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    20. Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Rando OJ, Tjian R, Darzacq X. Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding. Mol Cell. 2020 05 07; 78(3):539-553.e8. PMID: 32213323.
      Citations: 184     Fields:    Translation:AnimalsCells
    21. Boskovic A, Bing XY, Kaymak E, Rando OJ. Corrigendum: Control of noncoding RNA production and histone levels by a 5' tRNA fragment. Genes Dev. 2020 03 01; 34(5-6):462. PMID: 32122968.
      Citations: 1     Fields:    
    22. Cauceglia JW, Nelson AC, Rubinstein ND, Kukreja S, Sasso LN, Beaufort JA, Rando OJ, Potts WK. Transitions in paternal social status predict patterns of offspring growth and metabolic transcription. Mol Ecol. 2020 02; 29(3):624-638. PMID: 31885115.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Galan C, Krykbaeva M, Rando OJ. Early life lessons: The lasting effects of germline epigenetic information on organismal development. Mol Metab. 2020 08; 38:100924. PMID: 31974037.
      Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Boskovic A, Bing XY, Kaymak E, Rando OJ. Control of noncoding RNA production and histone levels by a 5' tRNA fragment. Genes Dev. 2020 01 01; 34(1-2):118-131. PMID: 31831626.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    25. Rando O. Blocking Polylysines on Homemade Microarrays. Cold Spring Harb Protoc. 2019 09 03; 2019(9). PMID: 31481489.
      Citations:    Fields:    
    26. Rando O. Hybridization to Homemade Microarrays. Cold Spring Harb Protoc. 2019 09 03; 2019(9). PMID: 31481490.
      Citations:    Fields:    Translation:Cells
    27. Rando O. Printing Microarrays. Cold Spring Harb Protoc. 2019 09 03; 2019(9). PMID: 31481488.
      Citations:    Fields:    
    28. Rando O. Nucleic Acid Platform Technologies. Cold Spring Harb Protoc. 2019 09 03; 2019(9). PMID: 31167924.
      Citations:    Fields:    Translation:Cells
    29. Rando O. Direct Cyanine-dCTP Labeling of DNA for Microarrays. Cold Spring Harb Protoc. 2019 08 01; 2019(8). PMID: 31371471.
      Citations:    Fields:    Translation:Humans
    30. Rando O. T7 Linear Amplification of DNA (TLAD) for Microarrays. Cold Spring Harb Protoc. 2019 08 01; 2019(8). PMID: 31371470.
      Citations:    Fields:    Translation:Cells
    31. Rando O. Round A/Round B Amplification of DNA for Microarrays. Cold Spring Harb Protoc. 2019 08 01; 2019(8). PMID: 31371469.
      Citations:    Fields:    
    32. Rando O. Indirect Labeling of DNA for Microarrays. Cold Spring Harb Protoc. 2019 08 01; 2019(8). PMID: 31371472.
      Citations:    Fields:    
    33. Rando O. Amplification of RNA for Microarrays. Cold Spring Harb Protoc. 2019 07 01; 2019(7). PMID: 31262957.
      Citations:    Fields:    
    34. Rando O. Indirect Aminoallyl-dUTP Labeling of RNA for Microarrays. Cold Spring Harb Protoc. 2019 07 01; 2019(7). PMID: 31262959.
      Citations:    Fields:    
    35. Conine CC, Sun F, Song L, Rivera-P?rez JA, Rando OJ. MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development. Dev Cell. 2019 07 01; 50(1):7-8. PMID: 31265813.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Rando O. Direct Cyanine-dUTP Labeling of RNA for Microarrays. Cold Spring Harb Protoc. 2019 07 01; 2019(7). PMID: 31262958.
      Citations:    Fields:    
    37. Hainer SJ, Bo?kovic A, McCannell KN, Rando OJ, Fazzio TG. Profiling of Pluripotency Factors in Single Cells and Early Embryos. Cell. 2019 05 16; 177(5):1319-1329.e11. PMID: 30955888.
      Citations: 87     Fields:    Translation:AnimalsCells
    38. Hamdani O, Dhillon N, Hsieh TS, Fujita T, Ocampo J, Kirkland JG, Lawrimore J, Kobayashi TJ, Friedman B, Fulton D, Wu KY, Chereji RV, Oki M, Bloom K, Clark DJ, Rando OJ, Kamakaka RT. tRNA Genes Affect Chromosome Structure and Function via Local Effects. Mol Cell Biol. 2019 04 15; 39(8). PMID: 30718362.
      Citations: 9     Fields:    Translation:AnimalsCells
    39. Swygert SG, Kim S, Wu X, Fu T, Hsieh TH, Rando OJ, Eisenman RN, Shendure J, McKnight JN, Tsukiyama T. Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence. Mol Cell. 2019 02 07; 73(3):533-546.e4. PMID: 30595435.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    40. Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coelho AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ. Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018 12; 67(12):2530-2540. PMID: 30344184.
      Citations: 39     Fields:    Translation:AnimalsCells
    41. Bo?kovic A, Rando OJ. Transgenerational Epigenetic Inheritance. Annu Rev Genet. 2018 11 23; 52:21-41. PMID: 30160987.
      Citations: 95     Fields:    Translation:Cells
    42. Conine CC, Sun F, Song L, Rivera-P?rez JA, Rando OJ. Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice. Dev Cell. 2018 08 20; 46(4):470-480.e3. PMID: 30057276.
      Citations: 116     Fields:    Translation:AnimalsCells
    43. Sharma U, Sun F, Conine CC, Reichholf B, Kukreja S, Herzog VA, Ameres SL, Rando OJ. Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Dev Cell. 2018 08 20; 46(4):481-494.e6. PMID: 30057273.
      Citations: 139     Fields:    Translation:AnimalsCells
    44. Chan IL, Rando OJ, Conine CC. Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization. G3 (Bethesda). 2018 05 04; 8(5):1787-1793. PMID: 29602810.
      Citations: 1     Fields:    Translation:AnimalsCells
    45. Wang F, McCannell KN, Bo?kovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 12 26; 21(13):3691-3699. PMID: 29281819.
      Citations: 11     Fields:    Translation:AnimalsCells
    46. Chou HJ, Donnard E, Gustafsson HT, Garber M, Rando OJ. Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation. Mol Cell. 2017 Dec 07; 68(5):978-992.e4. PMID: 29198561.
      Citations: 78     Fields:    Translation:AnimalsCells
    47. Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, M?ller CW, Kelleher NL, Friedman N, Bolon DN, Rando OJ, Kaufman PD. A synthetic biology approach to probing nucleosome symmetry. Elife. 2017 09 12; 6. PMID: 28895528.
      Citations: 11     Fields:    Translation:AnimalsCells
    48. Jachowicz JW, Bing X, Pontabry J, Bo?kovic A, Rando OJ, Torres-Padilla ME. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo. Nat Genet. 2017 Oct; 49(10):1502-1510. PMID: 28846101.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    49. Sharma U, Rando OJ. Metabolic Inputs into the Epigenome. Cell Metab. 2017 03 07; 25(3):544-558. PMID: 28273477.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    50. Vallaster MP, Kukreja S, Bing XY, Ngolab J, Zhao-Shea R, Gardner PD, Tapper AR, Rando OJ. Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring. Elife. 2017 02 14; 6. PMID: 28196335.
      Citations: 30     Fields:    Translation:AnimalsPHPublic Health
    51. Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG. DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells. Elife. 2016 11 16; 5. PMID: 27849519.
      Citations: 15     Fields:    Translation:AnimalsCells
    52. Hsieh TS, Fudenberg G, Goloborodko A, Rando OJ. Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome. Nat Methods. 2016 Dec; 13(12):1009-1011. PMID: 27723753.
      Citations: 80     Fields:    Translation:AnimalsCells
    53. Wang F, Shin J, Shea JM, Yu J, Bo?kovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 09 19; 5. PMID: 27642011.
      Citations: 25     Fields:    Translation:Animals
    54. Vasseur P, Tonazzini S, Ziane R, Camasses A, Rando OJ, Radman-Livaja M. Dynamics of Nucleosome Positioning Maturation following Genomic Replication. Cell Rep. 2016 09 06; 16(10):2651-2665. PMID: 27568571.
      Citations: 46     Fields:    Translation:AnimalsCells
    55. Rando OJ. Intergenerational Transfer of Epigenetic Information in Sperm. Cold Spring Harb Perspect Med. 2016 05 02; 6(5). PMID: 26801897.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    56. Sharma U, Conine CC, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Song L, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, Rando OJ. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016 Jan 22; 351(6271):391-396. PMID: 26721685.
      Citations: 526     Fields:    Translation:AnimalsCells
    57. Shea JM, Serra RW, Carone BR, Shulha HP, Kucukural A, Ziller MJ, Vallaster MP, Gu H, Tapper AR, Gardner PD, Meissner A, Garber M, Rando OJ. Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome. Dev Cell. 2015 Dec 21; 35(6):750-8. PMID: 26702833.
      Citations: 69     Fields:    Translation:AnimalsCells
    58. Rege M, Subramanian V, Zhu C, Hsieh TH, Weiner A, Friedman N, Clauder-M?nster S, Steinmetz LM, Rando OJ, Boyer LA, Peterson CL. Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis. Cell Rep. 2015 Nov 24; 13(8):1610-22. PMID: 26586442.
      Citations: 24     Fields:    Translation:AnimalsCells
    59. Chen PB, Chen HV, Acharya D, Rando OJ, Fazzio TG. R loops regulate promoter-proximal chromatin architecture and cellular differentiation. Nat Struct Mol Biol. 2015 Dec; 22(12):999-1007. PMID: 26551076.
      Citations: 87     Fields:    Translation:AnimalsCells
    60. Friedman N, Rando OJ. Epigenomics and the structure of the living genome. Genome Res. 2015 Oct; 25(10):1482-90. PMID: 26430158.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    61. Hughes AL, Rando OJ. Comparative Genomics Reveals Chd1 as a Determinant of Nucleosome Spacing in Vivo. G3 (Bethesda). 2015 Jul 14; 5(9):1889-97. PMID: 26175451.
      Citations: 7     Fields:    Translation:AnimalsCells
    62. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Jul 02; 6:7625. PMID: 26133887.
      Citations: 2     Fields:    
    63. Hsieh TH, Weiner A, Lajoie B, Dekker J, Friedman N, Rando OJ. Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C. Cell. 2015 Jul 02; 162(1):108-19. PMID: 26119342.
      Citations: 302     Fields:    Translation:AnimalsCells
    64. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770. PMID: 25898242.
      Citations: 79     Fields:    Translation:AnimalsCells
    65. Rando OJ, Simmons RA. I'm eating for two: parental dietary effects on offspring metabolism. Cell. 2015 Mar 26; 161(1):93-105. PMID: 25815988.
      Citations: 112     Fields:    Translation:HumansAnimals
    66. Weiner A, Hsieh TH, Appleboim A, Chen HV, Rahat A, Amit I, Rando OJ, Friedman N. High-resolution chromatin dynamics during a yeast stress response. Mol Cell. 2015 Apr 16; 58(2):371-86. PMID: 25801168.
      Citations: 105     Fields:    Translation:AnimalsCells
    67. Hainer SJ, Gu W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG. Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes Dev. 2015 Feb 15; 29(4):362-78. PMID: 25691467.
      Citations: 46     Fields:    Translation:AnimalsCells
    68. Yildirim O, Hung JH, Cedeno RJ, Weng Z, Lengner CJ, Rando OJ. A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters. PLoS Genet. 2014 Aug; 10(8):e1004515. PMID: 25102063.
      Citations: 17     Fields:    Translation:AnimalsCells
    69. Carone BR, Hung JH, Hainer SJ, Chou MT, Carone DM, Weng Z, Fazzio TG, Rando OJ. High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm. Dev Cell. 2014 Jul 14; 30(1):11-22. PMID: 24998598.
      Citations: 117     Fields:    Translation:AnimalsCells
    70. Sharma U, Rando OJ. Father-son chats: inheriting stress through sperm RNA. Cell Metab. 2014 Jun 03; 19(6):894-5. PMID: 24896534.
      Citations: 8     Fields:    Translation:AnimalsCells
    71. Soares LM, Radman-Livaja M, Lin SG, Rando OJ, Buratowski S. Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns. Cell Rep. 2014 Mar 27; 6(6):961-972. PMID: 24613354.
      Citations: 31     Fields:    Translation:AnimalsCells
    72. Hughes AL, Rando OJ. Mechanisms underlying nucleosome positioning in vivo. Annu Rev Biophys. 2014; 43:41-63. PMID: 24702039.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    73. Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science. 2013 Apr 12; 340(6129):195-9. PMID: 23580526.
      Citations: 108     Fields:    Translation:AnimalsCells
    74. M?bius W, Osberg B, Tsankov AM, Rando OJ, Gerland U. Toward a unified physical model of nucleosome patterns flanking transcription start sites. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5719-24. PMID: 23509245.
      Citations: 22     Fields:    Translation:AnimalsCells
    75. Chen HV, Rando OJ. Painting by numbers: increasing the parts list for chromatin domains. Mol Cell. 2013 Feb 21; 49(4):620-1. PMID: 23438859.
      Citations:    Fields:    
    76. Schug TT, Erlebacher A, Leibowitz S, Ma L, Muglia LJ, Rando OJ, Rogers JM, Romero R, vom Saal FS, Wise DL. Fetal programming and environmental exposures: implications for prenatal care and preterm birth. Ann N Y Acad Sci. 2012 Dec; 1276:37-46. PMID: 23278645.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    77. Rando OJ. Daddy issues: paternal effects on phenotype. Cell. 2012 Nov 09; 151(4):702-708. PMID: 23141533.
      Citations: 117     Fields:    Translation:HumansAnimals
    78. Wang J, Zhuang J, Iyer S, Lin X, Whitfield TW, Greven MC, Pierce BG, Dong X, Kundaje A, Cheng Y, Rando OJ, Birney E, Myers RM, Noble WS, Snyder M, Weng Z. Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res. 2012 Sep; 22(9):1798-812. PMID: 22955990.
      Citations: 493     Fields:    Translation:HumansCells
    79. Hughes AL, Jin Y, Rando OJ, Struhl K. A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern. Mol Cell. 2012 Oct 12; 48(1):5-15. PMID: 22885008.
      Citations: 81     Fields:    Translation:AnimalsCells
    80. Weiner A, Chen HV, Liu CL, Rahat A, Klien A, Soares L, Gudipati M, Pfeffner J, Regev A, Buratowski S, Pleiss JA, Friedman N, Rando OJ. Systematic dissection of roles for chromatin regulators in a yeast stress response. PLoS Biol. 2012; 10(7):e1001369. PMID: 22912562.
      Citations: 98     Fields:    Translation:AnimalsCells
    81. Radman-Livaja M, Quan TK, Valenzuela L, Armstrong JA, van Welsem T, Kim T, Lee LJ, Buratowski S, van Leeuwen F, Rando OJ, Hartzog GA. A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. PLoS Genet. 2012; 8(7):e1002811. PMID: 22807688.
      Citations: 43     Fields:    Translation:AnimalsCells
    82. Carone BR, Rando OJ. Rewriting the epigenome. Cell. 2012 Jun 22; 149(7):1422-3. PMID: 22726428.
      Citations: 4     Fields:    
    83. Fazzio TG, Rando OJ. NURDs are required for diversity. EMBO J. 2012 May 11; 31(14):3036-7. PMID: 22580827.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    84. Xu J, Yanagisawa Y, Tsankov AM, Hart C, Aoki K, Kommajosyula N, Steinmann KE, Bochicchio J, Russ C, Regev A, Rando OJ, Nusbaum C, Niki H, Milos P, Weng Z, Rhind N. Genome-wide identification and characterization of replication origins by deep sequencing. Genome Biol. 2012 Apr 24; 13(4):R27. PMID: 22531001.
      Citations: 54     Fields:    Translation:AnimalsCells
    85. Rando OJ. Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr Opin Genet Dev. 2012 Apr; 22(2):148-55. PMID: 22440480.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    86. Rando OJ, Winston F. Chromatin and transcription in yeast. Genetics. 2012 Feb; 190(2):351-87. PMID: 22345607.
      Citations: 155     Fields:    Translation:AnimalsCells
    87. Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell. 2011 Dec 23; 147(7):1498-510. PMID: 22196727.
      Citations: 265     Fields:    Translation:HumansAnimalsCells
    88. Sikorski TW, Ficarro SB, Holik J, Kim T, Rando OJ, Marto JA, Buratowski S. Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell. 2011 Nov 04; 44(3):397-409. PMID: 22055186.
      Citations: 54     Fields:    Translation:AnimalsCells
    89. Tsankov A, Yanagisawa Y, Rhind N, Regev A, Rando OJ. Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization. Genome Res. 2011 Nov; 21(11):1851-62. PMID: 21914852.
      Citations: 46     Fields:    Translation:AnimalsCells
    90. Radman-Livaja M, Verzijlbergen KF, Weiner A, van Welsem T, Friedman N, Rando OJ, van Leeuwen F. Patterns and mechanisms of ancestral histone protein inheritance in budding yeast. PLoS Biol. 2011 Jun; 9(6):e1001075. PMID: 21666805.
      Citations: 90     Fields:    Translation:AnimalsCells
    91. Radman-Livaja M, Ruben G, Weiner A, Friedman N, Kamakaka R, Rando OJ. Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization. EMBO J. 2011 Mar 16; 30(6):1012-26. PMID: 21336256.
      Citations: 32     Fields:    Translation:AnimalsCells
    92. Papamichos-Chronakis M, Watanabe S, Rando OJ, Peterson CL. Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity. Cell. 2011 Jan 21; 144(2):200-13. PMID: 21241891.
      Citations: 216     Fields:    Translation:AnimalsCells
    93. Rando OJ. Genome-wide measurement of histone H3 replacement dynamics in yeast. Methods Mol Biol. 2011; 759:41-60. PMID: 21863480.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell. 2010 Dec 23; 143(7):1084-96. PMID: 21183072.
      Citations: 479     Fields:    Translation:HumansAnimalsCells
    95. Ivanovska I, Jacques P?, Rando OJ, Robert F, Winston F. Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Mol Cell Biol. 2011 Feb; 31(3):531-41. PMID: 21098123.
      Citations: 45     Fields:    Translation:AnimalsCells
    96. Lopes da Rosa J, Holik J, Green EM, Rando OJ, Kaufman PD. Overlapping regulation of CenH3 localization and histone H3 turnover by CAF-1 and HIR proteins in Saccharomyces cerevisiae. Genetics. 2011 Jan; 187(1):9-19. PMID: 20944015.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    97. Kim TS, Liu CL, Yassour M, Holik J, Friedman N, Buratowski S, Rando OJ. RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast. Genome Biol. 2010; 11(7):R75. PMID: 20637075.
      Citations: 36     Fields:    Translation:AnimalsCells
    98. Tsankov AM, Thompson DA, Socha A, Regev A, Rando OJ. The role of nucleosome positioning in the evolution of gene regulation. PLoS Biol. 2010 Jul 06; 8(7):e1000414. PMID: 20625544.
      Citations: 133     Fields:    Translation:AnimalsCells
    99. Jensen JD, Rando OJ. Recent evidence for pervasive adaptation targeting gene expression attributable to population size change. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):E109-10; author reply 111. PMID: 20566840.
      Citations:    Fields:    Translation:Animals
    100. Kaufman PD, Rando OJ. Chromatin as a potential carrier of heritable information. Curr Opin Cell Biol. 2010 Jun; 22(3):284-90. PMID: 20299197.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    101. Rando OJ. Genome-wide mapping of nucleosomes in yeast. Methods Enzymol. 2010; 470:105-18. PMID: 20946808.
      Citations: 23     Fields:    Translation:AnimalsCells
    102. Radman-Livaja M, Liu CL, Friedman N, Schreiber SL, Rando OJ. Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast. PLoS Genet. 2010 Feb 05; 6(2):e1000837. PMID: 20140185.
      Citations: 27     Fields:    Translation:AnimalsCells
    103. Hughes A, Rando OJ. Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC? J Biol. 2009; 8(11):96. PMID: 20067596.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    104. Weiner A, Hughes A, Yassour M, Rando OJ, Friedman N. High-resolution nucleosome mapping reveals transcription-dependent promoter packaging. Genome Res. 2010 Jan; 20(1):90-100. PMID: 19846608.
      Citations: 224     Fields:    Translation:HumansAnimalsCells
    105. Rowat AC, Bird JC, Agresti JJ, Rando OJ, Weitz DA. Tracking lineages of single cells in lines using a microfluidic device. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18149-54. PMID: 19826080.
      Citations: 44     Fields:    Translation:Animals
    106. Radman-Livaja M, Rando OJ. Nucleosome positioning: how is it established, and why does it matter? Dev Biol. 2010 Mar 15; 339(2):258-66. PMID: 19527704.
      Citations: 148     Fields:    Translation:Cells
    107. Rando OJ, Chang HY. Genome-wide views of chromatin structure. Annu Rev Biochem. 2009; 78:245-71. PMID: 19317649.
      Citations: 164     Fields:    Translation:HumansAnimalsCells
    108. Rando OJ. Evolution in a test tube: the hatchet before the scalpel. Cell. 2008 Nov 28; 135(5):789-91. PMID: 19041741.
      Citations:    Fields:    Translation:HumansAnimalsCells
    109. Kaplan T, Liu CL, Erkmann JA, Holik J, Grunstein M, Kaufman PD, Friedman N, Rando OJ. Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast. PLoS Genet. 2008 Nov; 4(11):e1000270. PMID: 19023413.
      Citations: 97     Fields:    Translation:AnimalsCells
    110. Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D. Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. Nat Biotechnol. 2008 Nov; 26(11):1251-9. PMID: 18953355.
      Citations: 79     Fields:    Translation:AnimalsCells
    111. Jeddeloh JA, Greally JM, Rando OJ. Reduced-representation methylation mapping. Genome Biol. 2008; 9(8):231. PMID: 18771577.
      Citations: 13     Fields:    Translation:AnimalsCells
    112. Rando O. A biologist despairs over the difficulty of demonstrating heritability of chromatin states. Nature. 2008 Jul 10; 454(7201):141. PMID: 18615034.
      Citations:    Fields:    Translation:HumansAnimalsCells
    113. Au WC, Crisp MJ, DeLuca SZ, Rando OJ, Basrai MA. Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiae. Genetics. 2008 May; 179(1):263-75. PMID: 18458100.
      Citations: 60     Fields:    Translation:AnimalsCells
    114. Whitehouse I, Rando OJ, Delrow J, Tsukiyama T. Chromatin remodelling at promoters suppresses antisense transcription. Nature. 2007 Dec 13; 450(7172):1031-5. PMID: 18075583.
      Citations: 250     Fields:    Translation:AnimalsCells
    115. Rando O. Oliver Rando: taking chromatin analysis to the genomic scale. Interview by Ruth Williams. J Cell Biol. 2007 Jun 18; 177(6):948-9. PMID: 17576793.
      Citations:    Fields:    Translation:Cells
    116. Dennis JH, Fan HY, Reynolds SM, Yuan G, Meldrim JC, Richter DJ, Peterson DG, Rando OJ, Noble WS, Kingston RE. Independent and complementary methods for large-scale structural analysis of mammalian chromatin. Genome Res. 2007 Jun; 17(6):928-39. PMID: 17568008.
      Citations: 25     Fields:    Translation:HumansCells
    117. Rando OJ, Ahmad K. Rules and regulation in the primary structure of chromatin. Curr Opin Cell Biol. 2007 Jun; 19(3):250-6. PMID: 17466507.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    118. Dion MF, Kaplan T, Kim M, Buratowski S, Friedman N, Rando OJ. Dynamics of replication-independent histone turnover in budding yeast. Science. 2007 Mar 09; 315(5817):1405-8. PMID: 17347438.
      Citations: 346     Fields:    Translation:AnimalsCells
    119. Rando OJ, Verstrepen KJ. Timescales of genetic and epigenetic inheritance. Cell. 2007 Feb 23; 128(4):655-68. PMID: 17320504.
      Citations: 171     Fields:    Translation:HumansAnimals
    120. Rando OJ. Global patterns of histone modifications. Curr Opin Genet Dev. 2007 Apr; 17(2):94-9. PMID: 17317148.
      Citations: 50     Fields:    
    121. Rando OJ. Chromatin structure in the genomics era. Trends Genet. 2007 Feb; 23(2):67-73. PMID: 17188397.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    122. Kim M, Vasiljeva L, Rando OJ, Zhelkovsky A, Moore C, Buratowski S. Distinct pathways for snoRNA and mRNA termination. Mol Cell. 2006 Dec 08; 24(5):723-734. PMID: 17157255.
      Citations: 113     Fields:    Translation:AnimalsCells
    123. Rando OJ, Paulsson J. Noisy silencing of chromatin. Dev Cell. 2006 Aug; 11(2):134-6. PMID: 16890152.
      Citations: 3     Fields:    Translation:AnimalsCells
    124. Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 2005 Oct 21; 123(2):233-48. PMID: 16239142.
      Citations: 368     Fields:    Translation:AnimalsCells
    125. Liu CL, Kaplan T, Kim M, Buratowski S, Schreiber SL, Friedman N, Rando OJ. Single-nucleosome mapping of histone modifications in S. cerevisiae. PLoS Biol. 2005 Oct; 3(10):e328. PMID: 16122352.
      Citations: 284     Fields:    Translation:AnimalsCells
    126. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      Citations: 620     Fields:    Translation:AnimalsCells
    127. Casolari JM, Brown CR, Drubin DA, Rando OJ, Silver PA. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev. 2005 May 15; 19(10):1188-98. PMID: 15905407.
      Citations: 95     Fields:    Translation:AnimalsCells
    128. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371.
      Citations: 174     Fields:    Translation:AnimalsCells
    129. Kim M, Krogan NJ, Vasiljeva L, Rando OJ, Nedea E, Greenblatt JF, Buratowski S. The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature. 2004 Nov 25; 432(7016):517-22. PMID: 15565157.
      Citations: 274     Fields:    Translation:AnimalsCells
    130. Rando OJ, Chi TH, Crabtree GR. Second messenger control of chromatin remodeling. Nat Struct Biol. 2003 Feb; 10(2):81-3. PMID: 12555081.
      Citations: 9     Fields:    Translation:AnimalsCells
    131. Rando OJ, Zhao K, Janmey P, Crabtree GR. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2824-9. PMID: 11880634.
      Citations: 89     Fields:    Translation:HumansCells
    132. Rando OJ, Zhao K, Crabtree GR. Searching for a function for nuclear actin. Trends Cell Biol. 2000 Mar; 10(3):92-7. PMID: 10675902.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    133. Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998 Nov 25; 95(5):625-36. PMID: 9845365.
      Citations: 273     Fields:    Translation:HumansAnimalsCells
    134. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994 Sep 09; 78(5):773-85. PMID: 8087845.
      Citations: 569     Fields:    Translation:HumansAnimalsCells
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