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Oliver J Rando MD, PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8879
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBABiochemistry
    Stanford University, Palo Alto, CA, United StatesMD
    Stanford University, Palo Alto, CA, United StatesPHDGenomic Studies

    Collapse Overview 
    Collapse overview

    Oliver Rando


    Genomic approaches to chromatin structure and function, and to epigenetic inheritance.


    Public data sets:
    http://users.umassmed.edu/Oliver.Rando/


    Organisms sharing identical genomes may nonetheless exhibit heritable variation in traits that are now called “epigenetic” traits. Information carriers for epigenetic traits include prion conformation and cytosine methylation, and it is widely believed that the packaging of eukaryotic genomes into chromatin provides another carrier of epigenetic information. Epigenetics is of great interest for researchers interested in fields ranging from systems biology to evolution to human disease.


    Our lab is broadly interested in epigenetic inheritance, but most of our research focuses on one putative carrier of epigenetic information – the nucleoprotein complex known as chromatin. We utilize “genomics” tools such as DNA microarrays and high-throughput sequencing to measure chromatin structure over entire genomes at single-nucleosome resolution, with the eventual goal of determining how chromatin states are established and maintained.


    We consider the primary sequence of chromatin to consist of three major features – the positioning of nucleosomes relative to underlying genomic sequence, the covalent modification pattern of each nucleosome, and the histone variants comprising each histone octamer. To date, we have measured these three features in actively growing yeast cultures, and have also measured the exchange rates of histone H3 in G1-arrested yeast. A number of interesting features emerge from these studies:


    Most interesting, we have identified what may be considered “motifs” in chromatin structure in yeast. For example, yeast promoters are characterized by a nucleosome-free region (NFR) of about 140 bp flanked by two well-positioned nucleosomes that lack a number of modifications such as H4K16ac, and that are rapidly replaced throughout the cell cycle. The +1 nucleosome also tends to carry Htz1 in place of H2A, while the -1 nucleosome carries Htz1 at a subset of promoters.


    Another interesting feature of yeast chromatin is that covalent modifications tend to occur in a small number of highly-correlated groups, suggesting that histone modification patterns do not encode complex “messages.” Nonetheless, the abundance of covalent modifications (over 100 have been described!!!) raises the question of why so many exist.


    By measuring histone replacement dynamics, we have found that coding regions are surprisingly “cold”, meaning the passage of RNA polymerase does not result in nucleosome replacement except at extremely high transcription rates. Heterochromatin is also cold, while promoter and tRNA genes are associated with hot nucleosomes. Chromatin boundaries – sequences whose presence prevents the lateral spread of silencing complexes from a nucleating element – are also associated with rapidly-exchanged nucleosomes, suggesting that “scrubbing” or chromatin by rapid replacement serves as the mechanism to limit this lateral spreading.


    Our lab is interested in the following questions:


    1) What are the rules by which chromatin motifs are generated? How do genomic sequences, and factors such as RNA polymerase passage, result in the common chromatin patterns seen at so many genes?


    2) What are the mechanisms resulting in replication-independent histone replacement?


    3) What are there so many histone modifications? What are the “systems” features that result from histone modification crosstalk?


    4) More generally, how does chromatin act as a signal filter in cells, given its location between upstream signaling pathways and downstream transcriptional outcomes?


    5) What happens to nucleosomes during genomic replication, and how do old nucleosomes influence the states of newly-incorporated nucleosomes? What is the machinery required to maintain a chromatin state?


    6) How does chromatin structure change over evolution, and how do chromatin regulators contribute to phenotypic divergence in closely-related species?


    7) What phenotypes are epigenetically heritable, and under what conditions is a selective advantage conferred by stochastic switching as opposed to plastic responsiveness to the environment?


    8) How is the genome packaged in sperm and embryonic stem cells, and how do histone dynamics change during differentiation?



    Collapse Rotation Projects

    Rotation projects are available to study chromatin structure and function.

    Project 1. Measure histone dynamics in yeast.

    Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions.

    Project 2. Characterize mechanisms for epigenetic inheritance in yeast.

    We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns.

    Project 3. Measure histone dynamics in embryonic stem cells.

    Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.



    Collapse Post Docs

    For more information about the Postdoctoral position in Dr. Rando’s lab please use the link provided.
    Post doc position




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coehlo AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ. Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018 Oct 21. PMID: 30344184.
      View in: PubMed
    2. Boškovic A, Rando OJ. Transgenerational Epigenetic Inheritance. Annu Rev Genet. 2018 Aug 30. PMID: 30160987.
      View in: PubMed
    3. Conine CC, Sun F, Song L, Rivera-Pérez JA, Rando OJ. Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice. Dev Cell. 2018 08 20; 46(4):470-480.e3. PMID: 30057276.
      View in: PubMed
    4. Sharma U, Sun F, Conine CC, Reichholf B, Kukreja S, Herzog VA, Ameres SL, Rando OJ. Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm. Dev Cell. 2018 Jul 16. PMID: 30057273.
      View in: PubMed
    5. Chan IL, Rando OJ, Conine CC. Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization. G3 (Bethesda). 2018 May 04; 8(5):1787-1793. PMID: 29602810.
      View in: PubMed
    6. Wang F, McCannell KN, Boškovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 Dec 26; 21(13):3691-3699. PMID: 29281819.
      View in: PubMed
    7. Chou HJ, Donnard E, Gustafsson HT, Garber M, Rando OJ. Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation. Mol Cell. 2017 Dec 07; 68(5):978-992.e4. PMID: 29198561.
      View in: PubMed
    8. Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müller CW, Kelleher NL, Friedman N, Bolon DN, Rando OJ, Kaufman PD. A synthetic biology approach to probing nucleosome symmetry. Elife. 2017 09 12; 6. PMID: 28895528.
      View in: PubMed
    9. Jachowicz JW, Bing X, Pontabry J, Boškovic A, Rando OJ, Torres-Padilla ME. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo. Nat Genet. 2017 Oct; 49(10):1502-1510. PMID: 28846101.
      View in: PubMed
    10. Sharma U, Rando OJ. Metabolic Inputs into the Epigenome. Cell Metab. 2017 Mar 07; 25(3):544-558. PMID: 28273477.
      View in: PubMed
    11. Vallaster MP, Kukreja S, Bing XY, Ngolab J, Zhao-Shea R, Gardner PD, Tapper AR, Rando OJ. Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring. Elife. 2017 Feb 14; 6. PMID: 28196335.
      View in: PubMed
    12. Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG. DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells. Elife. 2016 Nov 16; 5. PMID: 27849519.
      View in: PubMed
    13. Hsieh TS, Fudenberg G, Goloborodko A, Rando OJ. Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome. Nat Methods. 2016 Dec; 13(12):1009-1011. PMID: 27723753.
      View in: PubMed
    14. Wang F, Shin J, Shea JM, Yu J, Boškovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 Sep 19; 5. PMID: 27642011.
      View in: PubMed
    15. Vasseur P, Tonazzini S, Ziane R, Camasses A, Rando OJ, Radman-Livaja M. Dynamics of Nucleosome Positioning Maturation following Genomic Replication. Cell Rep. 2016 Sep 06; 16(10):2651-65. PMID: 27568571.
      View in: PubMed
    16. Rando OJ. Intergenerational Transfer of Epigenetic Information in Sperm. Cold Spring Harb Perspect Med. 2016; 6(5). PMID: 26801897.
      View in: PubMed
    17. Sharma U, Conine CC, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Song L, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, Rando OJ. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016 Jan 22; 351(6271):391-6. PMID: 26721685.
      View in: PubMed
    18. Shea JM, Serra RW, Carone BR, Shulha HP, Kucukural A, Ziller MJ, Vallaster MP, Gu H, Tapper AR, Gardner PD, Meissner A, Garber M, Rando OJ. Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome. Dev Cell. 2015 Dec 21; 35(6):750-8. PMID: 26702833.
      View in: PubMed
    19. Rege M, Subramanian V, Zhu C, Hsieh TH, Weiner A, Friedman N, Clauder-Münster S, Steinmetz LM, Rando OJ, Boyer LA, Peterson CL. Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis. Cell Rep. 2015 Nov 24; 13(8):1610-22. PMID: 26586442.
      View in: PubMed
    20. Chen PB, Chen HV, Acharya D, Rando OJ, Fazzio TG. R loops regulate promoter-proximal chromatin architecture and cellular differentiation. Nat Struct Mol Biol. 2015 Dec; 22(12):999-1007. PMID: 26551076.
      View in: PubMed
    21. Friedman N, Rando OJ. Epigenomics and the structure of the living genome. Genome Res. 2015 Oct; 25(10):1482-90. PMID: 26430158.
      View in: PubMed
    22. Hughes AL, Rando OJ. Comparative Genomics Reveals Chd1 as a Determinant of Nucleosome Spacing in Vivo. G3 (Bethesda). 2015 Jul 14; 5(9):1889-97. PMID: 26175451.
      View in: PubMed
    23. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015; 6:7625. PMID: 26133887.
      View in: PubMed
    24. Hsieh TH, Weiner A, Lajoie B, Dekker J, Friedman N, Rando OJ. Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C. Cell. 2015 Jul 2; 162(1):108-19. PMID: 26119342.
      View in: PubMed
    25. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770. PMID: 25898242.
      View in: PubMed
    26. Rando OJ, Simmons RA. I'm eating for two: parental dietary effects on offspring metabolism. Cell. 2015 Mar 26; 161(1):93-105. PMID: 25815988.
      View in: PubMed
    27. Weiner A, Hsieh TH, Appleboim A, Chen HV, Rahat A, Amit I, Rando OJ, Friedman N. High-resolution chromatin dynamics during a yeast stress response. Mol Cell. 2015 Apr 16; 58(2):371-86. PMID: 25801168.
      View in: PubMed
    28. Hainer SJ, Gu W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG. Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes Dev. 2015 Feb 15; 29(4):362-78. PMID: 25691467.
      View in: PubMed
    29. Yildirim O, Hung JH, Cedeno RJ, Weng Z, Lengner CJ, Rando OJ. A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters. PLoS Genet. 2014 Aug; 10(8):e1004515. PMID: 25102063.
      View in: PubMed
    30. Carone BR, Hung JH, Hainer SJ, Chou MT, Carone DM, Weng Z, Fazzio TG, Rando OJ. High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm. Dev Cell. 2014 Jul 14; 30(1):11-22. PMID: 24998598.
      View in: PubMed
    31. Sharma U, Rando OJ. Father-son chats: inheriting stress through sperm RNA. Cell Metab. 2014 Jun 3; 19(6):894-5. PMID: 24896534.
      View in: PubMed
    32. Soares LM, Radman-Livaja M, Lin SG, Rando OJ, Buratowski S. Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns. Cell Rep. 2014 Mar 27; 6(6):961-72. PMID: 24613354.
      View in: PubMed
    33. Hughes AL, Rando OJ. Mechanisms underlying nucleosome positioning in vivo. Annu Rev Biophys. 2014; 43:41-63. PMID: 24702039.
      View in: PubMed
    34. Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science. 2013 Apr 12; 340(6129):195-9. PMID: 23580526.
      View in: PubMed
    35. Möbius W, Osberg B, Tsankov AM, Rando OJ, Gerland U. Toward a unified physical model of nucleosome patterns flanking transcription start sites. Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14):5719-24. PMID: 23509245.
      View in: PubMed
    36. Chen HV, Rando OJ. Painting by numbers: increasing the parts list for chromatin domains. Mol Cell. 2013 Feb 21; 49(4):620-1. PMID: 23438859.
      View in: PubMed
    37. Schug TT, Erlebacher A, Leibowitz S, Ma L, Muglia LJ, Rando OJ, Rogers JM, Romero R, vom Saal FS, Wise DL. Fetal programming and environmental exposures: implications for prenatal care and preterm birth. Ann N Y Acad Sci. 2012 Dec; 1276:37-46. PMID: 23278645.
      View in: PubMed
    38. Rando OJ. Daddy issues: paternal effects on phenotype. Cell. 2012 Nov 9; 151(4):702-8. PMID: 23141533.
      View in: PubMed
    39. Wang J, Zhuang J, Iyer S, Lin X, Whitfield TW, Greven MC, Pierce BG, Dong X, Kundaje A, Cheng Y, Rando OJ, Birney E, Myers RM, Noble WS, Snyder M, Weng Z. Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res. 2012 Sep; 22(9):1798-812. PMID: 22955990.
      View in: PubMed
    40. Hughes AL, Jin Y, Rando OJ, Struhl K. A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern. Mol Cell. 2012 Oct 12; 48(1):5-15. PMID: 22885008.
      View in: PubMed
    41. Weiner A, Chen HV, Liu CL, Rahat A, Klien A, Soares L, Gudipati M, Pfeffner J, Regev A, Buratowski S, Pleiss JA, Friedman N, Rando OJ. Systematic dissection of roles for chromatin regulators in a yeast stress response. PLoS Biol. 2012; 10(7):e1001369. PMID: 22912562.
      View in: PubMed
    42. Radman-Livaja M, Quan TK, Valenzuela L, Armstrong JA, van Welsem T, Kim T, Lee LJ, Buratowski S, van Leeuwen F, Rando OJ, Hartzog GA. A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. PLoS Genet. 2012; 8(7):e1002811. PMID: 22807688.
      View in: PubMed
    43. Carone BR, Rando OJ. Rewriting the epigenome. Cell. 2012 Jun 22; 149(7):1422-3. PMID: 22726428.
      View in: PubMed
    44. Fazzio TG, Rando OJ. NURDs are required for diversity. EMBO J. 2012 May 11; 31(14):3036-7. PMID: 22580827.
      View in: PubMed
    45. Xu J, Yanagisawa Y, Tsankov AM, Hart C, Aoki K, Kommajosyula N, Steinmann KE, Bochicchio J, Russ C, Regev A, Rando OJ, Nusbaum C, Niki H, Milos P, Weng Z, Rhind N. Genome-wide identification and characterization of replication origins by deep sequencing. Genome Biol. 2012; 13(4):R27. PMID: 22531001.
      View in: PubMed
    46. Rando OJ. Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr Opin Genet Dev. 2012 Apr; 22(2):148-55. PMID: 22440480.
      View in: PubMed
    47. Rando OJ, Winston F. Chromatin and transcription in yeast. Genetics. 2012 Feb; 190(2):351-87. PMID: 22345607.
      View in: PubMed
    48. Yildirim O, Li R, Hung JH, Chen PB, Dong X, Ee LS, Weng Z, Rando OJ, Fazzio TG. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell. 2011 Dec 23; 147(7):1498-510. PMID: 22196727.
      View in: PubMed
    49. Sikorski TW, Ficarro SB, Holik J, Kim T, Rando OJ, Marto JA, Buratowski S. Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell. 2011 Nov 4; 44(3):397-409. PMID: 22055186.
      View in: PubMed
    50. Tsankov A, Yanagisawa Y, Rhind N, Regev A, Rando OJ. Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization. Genome Res. 2011 Nov; 21(11):1851-62. PMID: 21914852.
      View in: PubMed
    51. Radman-Livaja M, Verzijlbergen KF, Weiner A, van Welsem T, Friedman N, Rando OJ, van Leeuwen F. Patterns and mechanisms of ancestral histone protein inheritance in budding yeast. PLoS Biol. 2011 Jun; 9(6):e1001075. PMID: 21666805.
      View in: PubMed
    52. Radman-Livaja M, Ruben G, Weiner A, Friedman N, Kamakaka R, Rando OJ. Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization. EMBO J. 2011 Mar 16; 30(6):1012-26. PMID: 21336256.
      View in: PubMed
    53. Papamichos-Chronakis M, Watanabe S, Rando OJ, Peterson CL. Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity. Cell. 2011 Jan 21; 144(2):200-13. PMID: 21241891.
      View in: PubMed
    54. Rando OJ. Genome-wide measurement of histone H3 replacement dynamics in yeast. Methods Mol Biol. 2011; 759:41-60. PMID: 21863480.
      View in: PubMed
    55. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell. 2010 Dec 23; 143(7):1084-96. PMID: 21183072.
      View in: PubMed
    56. Ivanovska I, Jacques PÉ, Rando OJ, Robert F, Winston F. Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Mol Cell Biol. 2011 Feb; 31(3):531-41. PMID: 21098123.
      View in: PubMed
    57. Lopes da Rosa J, Holik J, Green EM, Rando OJ, Kaufman PD. Overlapping regulation of CenH3 localization and histone H3 turnover by CAF-1 and HIR proteins in Saccharomyces cerevisiae. Genetics. 2011 Jan; 187(1):9-19. PMID: 20944015.
      View in: PubMed
    58. Kim TS, Liu CL, Yassour M, Holik J, Friedman N, Buratowski S, Rando OJ. RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast. Genome Biol. 2010; 11(7):R75. PMID: 20637075.
      View in: PubMed
    59. Tsankov AM, Thompson DA, Socha A, Regev A, Rando OJ. The role of nucleosome positioning in the evolution of gene regulation. PLoS Biol. 2010 Jul 06; 8(7):e1000414. PMID: 20625544.
      View in: PubMed
    60. Jensen JD, Rando OJ. Recent evidence for pervasive adaptation targeting gene expression attributable to population size change. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):E109-10; author reply 111. PMID: 20566840.
      View in: PubMed
    61. Kaufman PD, Rando OJ. Chromatin as a potential carrier of heritable information. Curr Opin Cell Biol. 2010 Jun; 22(3):284-90. PMID: 20299197.
      View in: PubMed
    62. Rando OJ. Genome-wide mapping of nucleosomes in yeast. Methods Enzymol. 2010; 470:105-18. PMID: 20946808.
      View in: PubMed
    63. Radman-Livaja M, Liu CL, Friedman N, Schreiber SL, Rando OJ. Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast. PLoS Genet. 2010 Feb 05; 6(2):e1000837. PMID: 20140185.
      View in: PubMed
    64. Hughes A, Rando OJ. Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC? J Biol. 2009; 8(11):96. PMID: 20067596.
      View in: PubMed
    65. Weiner A, Hughes A, Yassour M, Rando OJ, Friedman N. High-resolution nucleosome mapping reveals transcription-dependent promoter packaging. Genome Res. 2010 Jan; 20(1):90-100. PMID: 19846608.
      View in: PubMed
    66. Rowat AC, Bird JC, Agresti JJ, Rando OJ, Weitz DA. Tracking lineages of single cells in lines using a microfluidic device. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18149-54. PMID: 19826080.
      View in: PubMed
    67. Radman-Livaja M, Rando OJ. Nucleosome positioning: how is it established, and why does it matter? Dev Biol. 2010 Mar 15; 339(2):258-66. PMID: 19527704.
      View in: PubMed
    68. Rando OJ, Chang HY. Genome-wide views of chromatin structure. Annu Rev Biochem. 2009; 78:245-71. PMID: 19317649.
      View in: PubMed
    69. Rando OJ. Evolution in a test tube: the hatchet before the scalpel. Cell. 2008 Nov 28; 135(5):789-91. PMID: 19041741.
      View in: PubMed
    70. Kaplan T, Liu CL, Erkmann JA, Holik J, Grunstein M, Kaufman PD, Friedman N, Rando OJ. Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast. PLoS Genet. 2008 Nov; 4(11):e1000270. PMID: 19023413.
      View in: PubMed
    71. Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D. Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. Nat Biotechnol. 2008 Nov; 26(11):1251-9. PMID: 18953355.
      View in: PubMed
    72. Jeddeloh JA, Greally JM, Rando OJ. Reduced-representation methylation mapping. Genome Biol. 2008; 9(8):231. PMID: 18771577.
      View in: PubMed
    73. Rando O. A biologist despairs over the difficulty of demonstrating heritability of chromatin states. Nature. 2008 Jul 10; 454(7201):141. PMID: 18615034.
      View in: PubMed
    74. Au WC, Crisp MJ, DeLuca SZ, Rando OJ, Basrai MA. Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiae. Genetics. 2008 May; 179(1):263-75. PMID: 18458100.
      View in: PubMed
    75. Whitehouse I, Rando OJ, Delrow J, Tsukiyama T. Chromatin remodelling at promoters suppresses antisense transcription. Nature. 2007 Dec 13; 450(7172):1031-5. PMID: 18075583.
      View in: PubMed
    76. Rando O. Oliver Rando: taking chromatin analysis to the genomic scale. Interview by Ruth Williams. J Cell Biol. 2007 Jun 18; 177(6):948-9. PMID: 17576793.
      View in: PubMed
    77. Dennis JH, Fan HY, Reynolds SM, Yuan G, Meldrim JC, Richter DJ, Peterson DG, Rando OJ, Noble WS, Kingston RE. Independent and complementary methods for large-scale structural analysis of mammalian chromatin. Genome Res. 2007 Jun; 17(6):928-39. PMID: 17568008.
      View in: PubMed
    78. Rando OJ, Ahmad K. Rules and regulation in the primary structure of chromatin. Curr Opin Cell Biol. 2007 Jun; 19(3):250-6. PMID: 17466507.
      View in: PubMed
    79. Dion MF, Kaplan T, Kim M, Buratowski S, Friedman N, Rando OJ. Dynamics of replication-independent histone turnover in budding yeast. Science. 2007 Mar 9; 315(5817):1405-8. PMID: 17347438.
      View in: PubMed
    80. Rando OJ, Verstrepen KJ. Timescales of genetic and epigenetic inheritance. Cell. 2007 Feb 23; 128(4):655-68. PMID: 17320504.
      View in: PubMed
    81. Rando OJ. Global patterns of histone modifications. Curr Opin Genet Dev. 2007 Apr; 17(2):94-9. PMID: 17317148.
      View in: PubMed
    82. Rando OJ. Chromatin structure in the genomics era. Trends Genet. 2007 Feb; 23(2):67-73. PMID: 17188397.
      View in: PubMed
    83. Kim M, Vasiljeva L, Rando OJ, Zhelkovsky A, Moore C, Buratowski S. Distinct pathways for snoRNA and mRNA termination. Mol Cell. 2006 Dec 8; 24(5):723-34. PMID: 17157255.
      View in: PubMed
    84. Rando OJ, Paulsson J. Noisy silencing of chromatin. Dev Cell. 2006 Aug; 11(2):134-6. PMID: 16890152.
      View in: PubMed
    85. Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 2005 Oct 21; 123(2):233-48. PMID: 16239142.
      View in: PubMed
    86. Liu CL, Kaplan T, Kim M, Buratowski S, Schreiber SL, Friedman N, Rando OJ. Single-nucleosome mapping of histone modifications in S. cerevisiae. PLoS Biol. 2005 Oct; 3(10):e328. PMID: 16122352.
      View in: PubMed
    87. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      View in: PubMed
    88. Casolari JM, Brown CR, Drubin DA, Rando OJ, Silver PA. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes Dev. 2005 May 15; 19(10):1188-98. PMID: 15905407.
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    89. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371.
      View in: PubMed
    90. Kim M, Krogan NJ, Vasiljeva L, Rando OJ, Nedea E, Greenblatt JF, Buratowski S. The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature. 2004 Nov 25; 432(7016):517-22. PMID: 15565157.
      View in: PubMed
    91. Rando OJ, Chi TH, Crabtree GR. Second messenger control of chromatin remodeling. Nat Struct Biol. 2003 Feb; 10(2):81-3. PMID: 12555081.
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    92. Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A. 2002 Sep 3; 99(18):11796-801. PMID: 12195013.
      View in: PubMed
    93. Rando OJ, Zhao K, Janmey P, Crabtree GR. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):2824-9. PMID: 11880634.
      View in: PubMed
    94. Rando OJ, Zhao K, Crabtree GR. Searching for a function for nuclear actin. Trends Cell Biol. 2000 Mar; 10(3):92-7. PMID: 10675902.
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    95. Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998 Nov 25; 95(5):625-36. PMID: 9845365.
      View in: PubMed
    96. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994 Sep 9; 78(5):773-85. PMID: 8087845.
      View in: PubMed
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