Kadambavanasund Papavinasasundaram PhD
Title | Assistant Professor |
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Institution | UMass Chan Medical School |
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Department | Microbiology |
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Address | UMass Chan Medical School 55 Lake Avenue North Worcester MA 01655
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vCard | Download vCard |
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Institution | T.H. Chan School of Medicine |
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Department | Microbiology |
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Biography
Tamil Nadu Agricultural University, Coimbatore, TN, India | BS | | Science |
Tamil Nadu Agricultural University, Coimbatore, TN, India | MS | | Microbiology |
University of Sydney, Sydney, NSW, Australia | PHD | | Microbiology |
Overview
Focus: Mycobacterial cell wall synthesis, mycobacterial genetic manipulation
Bibliographic
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
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Oluoch PO, Koh EI, Proulx MK, Reames CJ, Papavinasasundaram KG, Murphy KC, Zimmerman MD, Dartois V, Sassetti CM. Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection. Proc Natl Acad Sci U S A. 2025 Mar 04; 122(9):e2417525122.
PMID: 39993187.
Citations:
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Jaecklein E, Papavinasasundaram K, Ostroff GR, Sassetti C, Soto ER. Targeted delivery of antitubercular drugs using glucan lipid particles. Microbiol Spectr. 2025 Mar 04; 13(3):e0274424.
PMID: 39912634.
Citations:
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Luna MJ, Oluoch PO, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, Shell SS, Ioerger TR, Fortune SM, Farhat MR, Sassetti CM. Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures. mBio. 2025 Mar 12; 16(3):e0376224.
PMID: 39873486.
Citations:
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Oluoch PO, Koh EI, Proulx MK, Reames CJ, Papavinasasundaram KG, Murphy KC, Zimmerman MD, Dartois V, Sassetti CM. Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection. bioRxiv. 2024 Sep 04.
PMID: 39282290.
Citations:
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Cuthbert BJ, Mendoza J, de Miranda R, Papavinasasundaram K, Sassetti CM, Goulding CW. The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics. 2024 03 12; 16(3).
PMID: 38425033.
Citations:
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de Miranda R, Cuthbert BJ, Klevorn T, Chao A, Mendoza J, Arbing M, Sieminski PJ, Papavinasasundaram K, Abdul-Hafiz S, Chan S, Sassetti CM, Ehrt S, Goulding CW. Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake. PLoS Pathog. 2023 09; 19(9):e1011650.
PMID: 37747938.
Citations: Fields:
Translation:
HumansCells
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Mott D, Yang J, Baer C, Papavinasasundaram K, Sassetti CM, Behar SM. High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis-Infected Macrophages to CD8 T Cells. J Immunol. 2023 05 15; 210(10):1531-1542.
PMID: 37000471.
Citations:
2 Fields:
Translation:
AnimalsCells
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Koh EI, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A, Zimmerman MD, Aslebagh R, Baker RE, Shaffer SA, Guinn KM, Fitzgerald M, Dartois V, Ehrt S, Hung DT, Ioerger TR, Rubin EJ, Rhee KY, Schnappinger D, Sassetti CM. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2201632119.
PMID: 35380903.
Citations:
10 Fields:
Translation:
HumansCells
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Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SW, Lee HN, Kiritsy MC, Bellerose MM, Olive AJ, Murphy KC, Papavinasasundaram K, Boehm FJ, Reames CJ, Meade RK, Hampton BK, Linnertz CL, Shaw GD, Hock P, Bell TA, Ehrt S, Schnappinger D, Pardo-Manuel de Villena F, Ferris MT, Ioerger TR, Sassetti CM. Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. Elife. 2022 02 03; 11.
PMID: 35112666.
Citations:
24 Fields:
Translation:
AnimalsCells
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Cai Y, Jaecklein E, Mackenzie JS, Papavinasasundaram K, Olive AJ, Chen X, Steyn AJC, Sassetti CM. Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase. PLoS Pathog. 2021 07; 17(7):e1008911.
PMID: 34320028.
Citations:
5 Fields:
Translation:
HumansAnimalsCells
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Shamma F, Papavinasasundaram K, Quintanilla SY, Bandekar A, Sassetti C, Boutte CC. Phosphorylation on PstP Regulates Cell Wall Metabolism and Antibiotic Tolerance in Mycobacterium smegmatis. J Bacteriol. 2021 01 25; 203(4).
PMID: 33257524.
Citations:
4 Fields:
Translation:
Cells
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Grover S, Engelhart CA, P?rez-Herr?n E, Li W, Abrahams KA, Papavinasasundaram K, Bean JM, Sassetti CM, Mendoza-Losana A, Besra GS, Jackson M, Schnappinger D. Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis. ACS Infect Dis. 2021 01 08; 7(1):141-152.
PMID: 33319550.
Citations:
8 Fields:
Translation:
Cells
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Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog. 2020 10; 16(10):e1009000.
PMID: 33075106.
Citations:
14 Fields:
Translation:
HumansAnimalsCells
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Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78.
PMID: 31217586.
Citations:
63 Fields:
Translation:
Cells
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Murphy KC, Nelson SJ, Nambi S, Papavinasasundaram K, Baer CE, Sassetti CM. ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes. mBio. 2018 12 11; 9(6).
PMID: 30538179.
Citations:
54 Fields:
Translation:
Cells
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K?ster S, Klevorn T, Papavinasasundaram K, Sassetti CM, Portal-Celhay C, Philips JA. Consequence of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine. 2018 02 08; 36(7):939-944.
PMID: 29343411.
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Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB. A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization. Curr Biol. 2017 Nov 06; 27(21):3367-3374.e7.
PMID: 29107550.
Citations:
31 Fields:
Translation:
Cells
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Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. mBio. 2017 10 24; 8(5).
PMID: 29066547.
Citations:
42 Fields:
Translation:
HumansAnimalsCells
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K?ster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby SJ, Mittal E, Park HS, Jones V, Hsu FF, Jackson M, Sassetti CM, Philips JA. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8711-E8720.
PMID: 28973896.
Citations:
93 Fields:
Translation:
AnimalsCells
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Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Molecular and functional analysis of the mce4 operon in Mycobacterium smegmatis. Environ Microbiol. 2017 09; 19(9):3689-3699.
PMID: 28752922.
Citations:
12 Fields:
Translation:
Cells
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Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis. Environ Microbiol. 2017 07; 19(7):2564-2576.
PMID: 28447386.
Citations:
6 Fields:
Translation:
Cells
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Prigozhin DM, Papavinasasundaram KG, Baer CE, Murphy KC, Moskaleva A, Chen TY, Alber T, Sassetti CM. Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site. J Biol Chem. 2016 10 28; 291(44):22961-22969.
PMID: 27601474.
Citations:
12 Fields:
Translation:
HumansCells
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Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 2016 06 15; 5.
PMID: 27304077.
Citations:
45 Fields:
Translation:
Cells
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Murphy KC, Papavinasasundaram K, Sassetti CM. Mycobacterial recombineering. Methods Mol Biol. 2015; 1285:177-99.
PMID: 25779316.
Citations:
45 Fields:
Translation:
Cells
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Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24; 5(208):ra7.
PMID: 22275220.
Citations:
91 Fields:
Translation:
Cells
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Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. 2011 Mar 31; 6(3):e18367.
PMID: 21483832.
Citations:
73 Fields:
Translation:
AnimalsCells
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Chao JD, Papavinasasundaram KG, Zheng X, Ch?vez-Steenbock A, Wang X, Lee GQ, Av-Gay Y. Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J Biol Chem. 2010 Sep 17; 285(38):29239-46.
PMID: 20630871.
Citations:
47 Fields:
Translation:
Cells
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Bach H, Papavinasasundaram KG, Wong D, Hmama Z, Av-Gay Y. Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell Host Microbe. 2008 May 15; 3(5):316-22.
PMID: 18474358.
Citations:
117 Fields:
Translation:
HumansCells
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Zheng X, Papavinasasundaram KG, Av-Gay Y. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem Biophys Res Commun. 2007 Mar 30; 355(1):162-8.
PMID: 17286964.
Citations:
21 Fields:
Translation:
Cells
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Papavinasasundaram KG, Chan B, Chung JH, Colston MJ, Davis EO, Av-Gay Y. Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol. 2005 Aug; 187(16):5751-60.
PMID: 16077122.
Citations:
51 Fields:
Translation:
HumansAnimalsCells
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Frota CC, Papavinasasundaram KG, Davis EO, Colston MJ. The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis. Infect Immun. 2004 Sep; 72(9):5483-6.
PMID: 15322050.
Citations:
18 Fields:
Translation:
HumansAnimalsCells
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Durbach SI, Springer B, Machowski EE, North RJ, Papavinasasundaram KG, Colston MJ, B?ttger EC, Mizrahi V. DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis. Infect Immun. 2003 Feb; 71(2):997-1000.
PMID: 12540583.
Citations:
17 Fields:
Translation:
AnimalsCells
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Raynaud C, Papavinasasundaram KG, Speight RA, Springer B, Sander P, B?ttger EC, Colston MJ, Draper P. The functions of OmpATb, a pore-forming protein of Mycobacterium tuberculosis. Mol Microbiol. 2002 Oct; 46(1):191-201.
PMID: 12366842.
Citations:
39 Fields:
Translation:
AnimalsCells
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Springer B, Master S, Sander P, Zahrt T, McFalone M, Song J, Papavinasasundaram KG, Colston MJ, Boettger E, Deretic V. Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. Infect Immun. 2001 Oct; 69(10):5967-73.
PMID: 11553532.
Citations:
44 Fields:
Translation:
AnimalsCells
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Papavinasasundaram KG, Colston MJ, Davis EO. Construction and complementation of a recA deletion mutant of Mycobacterium smegmatis reveals that the intein in Mycobacterium tuberculosis recA does not affect RecA function. Mol Microbiol. 1998 Nov; 30(3):525-34.
PMID: 9822818.
Citations:
25 Fields:
Translation:
Cells
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Senaratne RH, Mobasheri H, Papavinasasundaram KG, Jenner P, Lea EJ, Draper P. Expression of a gene for a porin-like protein of the OmpA family from Mycobacterium tuberculosis H37Rv. J Bacteriol. 1998 Jul; 180(14):3541-7.
PMID: 9657995.
Citations:
35 Fields:
Translation:
Cells
This graph shows the total number of publications by year. To see the data as text,
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Year | Publications |
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1998 | 2 |
2001 | 1 |
2002 | 1 |
2003 | 1 |
2004 | 1 |
2005 | 1 |
2007 | 1 |
2008 | 1 |
2010 | 1 |
2011 | 1 |
2012 | 1 |
2015 | 1 |
2016 | 2 |
2017 | 5 |
2018 | 2 |
2019 | 1 |
2020 | 2 |
2021 | 2 |
2022 | 2 |
2023 | 2 |
2024 | 2 |
2025 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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