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Kadambavanasund Papavinasasundaram PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-6861
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    Tamil Nadu Agricultural University, Coimbatore, TN, IndiaBSScience
    Tamil Nadu Agricultural University, Coimbatore, TN, IndiaMSMicrobiology
    University of Sydney, Sydney, NSW, AustraliaPHDMicrobiology

    Collapse Overview 
    Collapse Summary
    Focus: Mycobacterial cell wall synthesis, mycobacterial genetic manipulation

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mott D, Yang J, Baer C, Papavinasasundaram K, Sassetti CM, Behar SM. High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis-Infected Macrophages to CD8 T Cells. J Immunol. 2023 May 15; 210(10):1531-1542. PMID: 37000471.
      Citations:    Fields:    Translation:AnimalsCells
    2. Koh EI, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A, Zimmerman MD, Aslebagh R, Baker RE, Shaffer SA, Guinn KM, Fitzgerald M, Dartois V, Ehrt S, Hung DT, Ioerger TR, Rubin EJ, Rhee KY, Schnappinger D, Sassetti CM. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2201632119. PMID: 35380903.
      Citations: 9     Fields:    Translation:HumansCells
    3. Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SW, Lee HN, Kiritsy MC, Bellerose MM, Olive AJ, Murphy KC, Papavinasasundaram K, Boehm FJ, Reames CJ, Meade RK, Hampton BK, Linnertz CL, Shaw GD, Hock P, Bell TA, Ehrt S, Schnappinger D, Pardo-Manuel de Villena F, Ferris MT, Ioerger TR, Sassetti CM. Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. Elife. 2022 02 03; 11. PMID: 35112666.
      Citations: 14     Fields:    Translation:AnimalsCells
    4. Cai Y, Jaecklein E, Mackenzie JS, Papavinasasundaram K, Olive AJ, Chen X, Steyn AJC, Sassetti CM. Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase. PLoS Pathog. 2021 07; 17(7):e1008911. PMID: 34320028.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Shamma F, Papavinasasundaram K, Quintanilla SY, Bandekar A, Sassetti C, Boutte CC. Phosphorylation on PstP Regulates Cell Wall Metabolism and Antibiotic Tolerance in Mycobacterium smegmatis. J Bacteriol. 2021 01 25; 203(4). PMID: 33257524.
      Citations: 4     Fields:    Translation:Cells
    6. Grover S, Engelhart CA, P?rez-Herr?n E, Li W, Abrahams KA, Papavinasasundaram K, Bean JM, Sassetti CM, Mendoza-Losana A, Besra GS, Jackson M, Schnappinger D. Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis. ACS Infect Dis. 2021 01 08; 7(1):141-152. PMID: 33319550.
      Citations: 5     Fields:    Translation:Cells
    7. Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog. 2020 10; 16(10):e1009000. PMID: 33075106.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    8. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78. PMID: 31217586.
      Citations: 55     Fields:    Translation:Cells
    9. Murphy KC, Nelson SJ, Nambi S, Papavinasasundaram K, Baer CE, Sassetti CM. ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes. mBio. 2018 12 11; 9(6). PMID: 30538179.
      Citations: 42     Fields:    Translation:Cells
    10. K?ster S, Klevorn T, Papavinasasundaram K, Sassetti CM, Portal-Celhay C, Philips JA. Consequence of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine. 2018 02 08; 36(7):939-944. PMID: 29343411.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB. A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization. Curr Biol. 2017 Nov 06; 27(21):3367-3374.e7. PMID: 29107550.
      Citations: 28     Fields:    Translation:Cells
    12. Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. mBio. 2017 10 24; 8(5). PMID: 29066547.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    13. K?ster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby SJ, Mittal E, Park HS, Jones V, Hsu FF, Jackson M, Sassetti CM, Philips JA. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8711-E8720. PMID: 28973896.
      Citations: 84     Fields:    Translation:AnimalsCells
    14. Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Molecular and functional analysis of the mce4 operon in Mycobacterium smegmatis. Environ Microbiol. 2017 09; 19(9):3689-3699. PMID: 28752922.
      Citations: 9     Fields:    Translation:Cells
    15. Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis. Environ Microbiol. 2017 07; 19(7):2564-2576. PMID: 28447386.
      Citations: 5     Fields:    Translation:Cells
    16. Prigozhin DM, Papavinasasundaram KG, Baer CE, Murphy KC, Moskaleva A, Chen TY, Alber T, Sassetti CM. Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site. J Biol Chem. 2016 10 28; 291(44):22961-22969. PMID: 27601474.
      Citations: 12     Fields:    Translation:HumansCells
    17. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 2016 06 15; 5. PMID: 27304077.
      Citations: 41     Fields:    Translation:Cells
    18. Murphy KC, Papavinasasundaram K, Sassetti CM. Mycobacterial recombineering. Methods Mol Biol. 2015; 1285:177-99. PMID: 25779316.
      Citations: 41     Fields:    Translation:Cells
    19. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24; 5(208):ra7. PMID: 22275220.
      Citations: 91     Fields:    Translation:Cells
    20. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. 2011 Mar 31; 6(3):e18367. PMID: 21483832.
      Citations: 71     Fields:    Translation:AnimalsCells
    21. Chao JD, Papavinasasundaram KG, Zheng X, Ch?vez-Steenbock A, Wang X, Lee GQ, Av-Gay Y. Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J Biol Chem. 2010 Sep 17; 285(38):29239-46. PMID: 20630871.
      Citations: 46     Fields:    Translation:Cells
    22. Bach H, Papavinasasundaram KG, Wong D, Hmama Z, Av-Gay Y. Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell Host Microbe. 2008 May 15; 3(5):316-22. PMID: 18474358.
      Citations: 106     Fields:    Translation:HumansCells
    23. Zheng X, Papavinasasundaram KG, Av-Gay Y. Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem Biophys Res Commun. 2007 Mar 30; 355(1):162-8. PMID: 17286964.
      Citations: 21     Fields:    Translation:Cells
    24. Papavinasasundaram KG, Chan B, Chung JH, Colston MJ, Davis EO, Av-Gay Y. Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol. 2005 Aug; 187(16):5751-60. PMID: 16077122.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    25. Frota CC, Papavinasasundaram KG, Davis EO, Colston MJ. The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis. Infect Immun. 2004 Sep; 72(9):5483-6. PMID: 15322050.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    26. Durbach SI, Springer B, Machowski EE, North RJ, Papavinasasundaram KG, Colston MJ, B?ttger EC, Mizrahi V. DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis. Infect Immun. 2003 Feb; 71(2):997-1000. PMID: 12540583.
      Citations: 17     Fields:    Translation:AnimalsCells
    27. Springer B, Master S, Sander P, Zahrt T, McFalone M, Song J, Papavinasasundaram KG, Colston MJ, Boettger E, Deretic V. Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. Infect Immun. 2001 Oct; 69(10):5967-73. PMID: 11553532.
      Citations: 44     Fields:    Translation:AnimalsCells
    28. Papavinasasundaram KG, Colston MJ, Davis EO. Construction and complementation of a recA deletion mutant of Mycobacterium smegmatis reveals that the intein in Mycobacterium tuberculosis recA does not affect RecA function. Mol Microbiol. 1998 Nov; 30(3):525-34. PMID: 9822818.
      Citations: 25     Fields:    Translation:Cells
    29. Senaratne RH, Mobasheri H, Papavinasasundaram KG, Jenner P, Lea EJ, Draper P. Expression of a gene for a porin-like protein of the OmpA family from Mycobacterium tuberculosis H37Rv. J Bacteriol. 1998 Jul; 180(14):3541-7. PMID: 9657995.
      Citations: 35     Fields:    Translation:Cells
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