Loading...
Header Logo
Keywords
Last Name
Institution

Eric H Baehrecke PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-6733
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    University of Massachusetts Amherst, Amherst, MA, United StatesBSBiology
    Texas A&M University College Station, College Station, TX, United StatesMSBiology
    University of Wisconsin, Madison, Madison, WI, United StatesPH DCancer Biology

    Collapse Overview 
    Collapse overview

    Cell Death and Autophagy

    Our laboratory studies the mechanisms that regulate autophagy, cell survival and programmed cell death EricBaehrecke inthe context of normal and abnormal development. Altered autophagy, cell survival and cell death are associated with a variety of human disorders including cancer. We use global genomic approaches, including DNA microarrays, proteomics and forward genetic screens,to identify genes and proteins involved in programmed cell death and development. The Drosophila model system allows us to functionally validate our gene discovery, and also enables the identification of novel genes using forward genetic screens. Our studies have focused on steroid activation of cell death, and the role of autophagy and other degradation mechanisms during cell survival and death.

    Steroid Activation of Programmed Cell Death

    At least two morphological forms of programmed cell killing occur during development of all higher animals. While much is known about apoptotic cell death, little is known about autophagic cell death. Autophagic cell death in Drosophila salivary glands involves the activation of diverse protein degradation programs that include both caspases and autophagy. Fly salivary glands provide an in vivo genetic model system for elucidating the complex functions of autophagy in cell survival and cell death during development.

    The steroid hormone ecdysone triggers salivary gland cell death by activation of a two-step nuclear hormone receptor-activated gene transcription hierarchy (Figure 1). The ecdysone receptor, encoded by the nuclear receptors EcR and Usp, in the presence of the competence factor ßFTZ-F1, triggers the first step in this hierarchy by activating transcription of BR-C, E74, and E93. Mutations in each of these transcriptional regulators prevent the death of salivary glands, and alter transcription of secondary response genes that carry out the cell death program. By analyzing mutants with phenotypes similar to those seen in BR-C, E74 and E93 mutants, we expect to identify novel cell death regulatory molecules.

    Our microarray analysis demonstrated the robust nature of this steroid-triggered transcriptional hierarchy through the identification of genes known to function in apoptosis but which had not been previously associated with autophagic cell death, as well as many candidate BR-C, E74 and E93 target genes. Although autophagic cell death is morphologically distinct from apoptosis, our studies have shown that during autophagic death of salivary glands, caspases are activated and caspase substrates are cleaved, suggesting that much of the apoptotic machinery is utilized during autophagic cell death. Our microarray and proteomics analyses also indicate that several caspase-independent protein degradation mechanisms including matrix metallo-protease, serine protease and autophagy RNAs and proteins are expressed during cell death. Projects in the Baehrecke lab are aimed toward understanding how steroid-triggered transcription factors regulate secondary response gene transcription, and how these multiple protein degradation programs are coordinated to mediate programmed cell death.

    Degradation of Dying Cells by Autophagy

    Although our studies indicate that much of the apoptotic machinery is utilized during autophagic cell death, dying salivary glands are destroyed without the association of engulfing phagocytes that are necessary for the removal of cell corpses during apoptosis. This indicates that salivary gland cells contain the machinery needed to dismantle and recycle their own cellular components, and this is supported by the presence of autophagic vacuoles (also known as autophagosomes) in the cytoplasm of salivary gland cells. Autophagic vacuoles are a hallmark of autophagy, a conserved catabolic process that functions in the degradation of long-lived proteins and in organelle turnover and recycling (Figure 2).

    The role of autophagy during cell death remains controversial. It is important to understand the relationship between autophagy and cell death, as the association of autophagy with cell growth, nutrient utilization, survival and death indicates that this catabolic process is relevant to the treatment of many human disorders including cancer. Our recent studies indicate that autophagy is required for degradation of dying salivary glands during Drosophila development. In collaboration with Michael Lenardo at the National Institutes of Health, we have shown that autophagy is required for the caspase-independent death in mammalian cells. In contrast, our work in collaboration with Paul Taylor at the University of Pennsylvania has shown that autophagy is protective in a fly model of polyglutamine-induced neurodegeneration. Phosphoinositide 3-kinase (PI3K) pathways regulate cell growth, cell death and autophagy, but the mechanisms that coordinate these cell processes remains uncertain. We are investigating the role(s) of autophagy in cell growth and cell death, and how steroids and PI3K signaling mechanisms are integrated to regulate autophagy in the context of development (Figure 3). As in our studies of neurodegeneration, we hope to extend our studies of the genes that are required for autophagy and cell death in fly salivary glands into models of cancer.

    EBfigures



    Collapse Post Docs

    Postdoctoral positions are available for this lab. Please contact Eric Baehrecke directly, 508-856-6733 or via email, Eric.Baehrecke@umassmed.edu




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter RHG, Wood W, Baehrecke EH. Complement-Related Regulates Autophagy in Neighboring Cells. Cell. 2017 Jun 29; 170(1):158-171.e8. PMID: 28666117.
      View in: PubMed
    2. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 Jun 08. PMID: 28596378.
      View in: PubMed
    3. Anding AL, Baehrecke EH. Cleaning House: Selective Autophagy of Organelles. Dev Cell. 2017 Apr 10; 41(1):10-22. PMID: 28399394.
      View in: PubMed
    4. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    5. Behar SM, Baehrecke EH. Tuberculosis: Autophagy is not the answer. Nature. 2015 Dec 24; 528(7583):482-3. PMID: 26649822.
      View in: PubMed
    6. Tracy K, Velentzas PD, Baehrecke EH. Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner. EMBO Rep. 2016 Jan; 17(1):110-21. PMID: 26598552.
      View in: PubMed
    7. Lindqvist LM, Simon AK, Baehrecke EH. Current questions and possible controversies in autophagy. Cell Death Discov. 2015; 1. PMID: 26682061.
      View in: PubMed
    8. Anding AL, Baehrecke EH. Autophagy in Cell Life and Cell Death. Curr Top Dev Biol. 2015; 114:67-91. PMID: 26431564.
      View in: PubMed
    9. Zhang H, Baehrecke EH. Eaten alive: novel insights into autophagy from multicellular model systems. Trends Cell Biol. 2015 Jul; 25(7):376-87. PMID: 25862458.
      View in: PubMed
    10. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Apr 1; 34(7):856-80. PMID: 25712477.
      View in: PubMed
    11. Rohatgi RA, Janusis J, Leonard D, Bellvé KD, Fogarty KE, Baehrecke EH, Corvera S, Shaw LM. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015 Oct 16; 34(42):5352-62. PMID: 25639875.
      View in: PubMed
    12. Lin L, Baehrecke EH. Autophagy, cell death, and cancer. Mol Cell Oncol. 2015 Jul-Sep; 2(3):e985913. PMID: 27308466.
      View in: PubMed
    13. Nelson C, Baehrecke EH. Eaten to death. FEBS J. 2014 Dec; 281(24):5411-7. PMID: 25323556.
      View in: PubMed
    14. Anding AL, Baehrecke EH. Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila. Cell Death Differ. 2015 Mar; 22(3):457-64. PMID: 25342466.
      View in: PubMed
    15. Nelson C, Ambros V, Baehrecke EH. miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell. 2014 Nov 6; 56(3):376-88. PMID: 25306920.
      View in: PubMed
    16. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. PMID: 25236395.
      View in: PubMed
    17. Pérez E, Das G, Bergmann A, Baehrecke EH. Autophagy regulates tissue overgrowth in a context-dependent manner. Oncogene. 2015 Jun; 34(26):3369-76. PMID: 25174403.
      View in: PubMed
    18. Mariño G, Niso-Santano M, Baehrecke EH, Kroemer G. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 2014 Feb; 15(2):81-94. PMID: 24401948.
      View in: PubMed
    19. Nelson C, Baehrecke EH. Autophagy and cell death in the fly. Methods Enzymol. 2014; 545:181-99. PMID: 25065891.
      View in: PubMed
    20. Chang TK, Shravage BV, Hayes SD, Powers CM, Simin RT, Wade Harper J, Baehrecke EH. Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol. 2013 Sep; 15(9):1067-78. PMID: 23873149.
      View in: PubMed
    21. Shravage BV, Hill JH, Powers CM, Wu L, Baehrecke EH. Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development. 2013 Mar; 140(6):1321-9. PMID: 23406899.
      View in: PubMed
    22. Tracy K, Baehrecke EH. The role of autophagy in Drosophila metamorphosis. Curr Top Dev Biol. 2013; 103:101-25. PMID: 23347517.
      View in: PubMed
    23. McPhee CK, Balgley BM, Nelson C, Hill JH, Batlevi Y, Fang X, Lee CS, Baehrecke EH. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. Cell Death Differ. 2013 Feb; 20(2):218-25. PMID: 22935612.
      View in: PubMed
    24. Das G, Shravage BV, Baehrecke EH. Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol. 2012 Jun 01; 4(6). PMID: 22661635.
      View in: PubMed
    25. Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S. Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 2012 Aug; 19(8):1299-307. PMID: 22555456.
      View in: PubMed
    26. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      View in: PubMed
    27. Mou X, Duncan DM, Baehrecke EH, Duncan I. Control of target gene specificity during metamorphosis by the steroid response gene E93. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2949-54. PMID: 22308414.
      View in: PubMed
    28. Chan FK, Baehrecke EH. RIP3 finds partners in crime. Cell. 2012 Jan 20; 148(1-2):17-8. PMID: 22265396.
      View in: PubMed
    29. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94. PMID: 21997368.
      View in: PubMed
    30. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012 Jan; 19(1):107-20. PMID: 21760595.
      View in: PubMed
    31. Rong Y, McPhee CK, McPhee C, Deng S, Huang L, Chen L, Liu M, Tracy K, Baehrecke EH, Baehreck EH, Yu L, Lenardo MJ. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7826-31. PMID: 21518918.
      View in: PubMed
    32. Nezis IP, Shravage BV, Sagona AP, Johansen T, Baehrecke EH, Stenmark H. Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Autophagy. 2010 Nov; 6(8):1214-5. PMID: 20935512.
      View in: PubMed
    33. McPhee CK, Baehrecke EH. The engulfment receptor Draper is required for autophagy during cell death. Autophagy. 2010 Nov; 6(8):1192-3. PMID: 20864812.
      View in: PubMed
    34. Ryoo HD, Baehrecke EH. Distinct death mechanisms in Drosophila development. Curr Opin Cell Biol. 2010 Dec; 22(6):889-95. PMID: 20846841.
      View in: PubMed
    35. Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H. Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol. 2010 Aug 23; 190(4):523-31. PMID: 20713604.
      View in: PubMed
    36. McPhee CK, Logan MA, Freeman MR, Baehrecke EH. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 2010 Jun 24; 465(7301):1093-6. PMID: 20577216.
      View in: PubMed
    37. McPhee CK, Baehrecke EH. Autophagy shows its animal side. Cell. 2010 Jun 11; 141(6):922-4. PMID: 20550928.
      View in: PubMed
    38. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17; 465(7300):942-6. PMID: 20526321.
      View in: PubMed
    39. Denton D, Shravage B, Simin R, Baehrecke EH, Kumar S. Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy. 2010 Jan; 6(1):163-5. PMID: 20009534.
      View in: PubMed
    40. Batlevi Y, Martin DN, Pandey UB, Simon CR, Powers CM, Taylor JP, Baehrecke EH. Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):742-7. PMID: 20080745.
      View in: PubMed
    41. Denton D, Shravage B, Simin R, Mills K, Berry DL, Baehrecke EH, Kumar S. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol. 2009 Nov 3; 19(20):1741-6. PMID: 19818615.
      View in: PubMed
    42. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug; 16(8):1093-107. PMID: 19373242.
      View in: PubMed
    43. McPhee CK, Baehrecke EH. Autophagy in Drosophila melanogaster. Biochim Biophys Acta. 2009 Sep; 1793(9):1452-60. PMID: 19264097.
      View in: PubMed
    44. Baehrecke EH. Autophagy SEPArates germline and somatic cells. Cell. 2009 Jan 23; 136(2):207-8. PMID: 19167322.
      View in: PubMed
    45. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2009 Jan; 16(1):3-11. PMID: 18846107.
      View in: PubMed
    46. Dutta S, Baehrecke EH. Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol. 2008 Oct 14; 18(19):1466-75. PMID: 18818081.
      View in: PubMed
    47. Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008 May 19; 181(4):655-66. PMID: 18474623.
      View in: PubMed
    48. Neufeld TP, Baehrecke EH. Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila. Autophagy. 2008 Jul; 4(5):557-62. PMID: 18319640.
      View in: PubMed
    49. Berry DL, Baehrecke EH. Autophagy functions in programmed cell death. Autophagy. 2008 Apr; 4(3):359-60. PMID: 18212526.
      View in: PubMed
    50. Berry DL, Baehrecke EH. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell. 2007 Dec 14; 131(6):1137-48. PMID: 18083103.
      View in: PubMed
    51. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. PMID: 18188003.
      View in: PubMed
    52. Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy. 2007 Nov-Dec; 3(6):643-5. PMID: 17912024.
      View in: PubMed
    53. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007 Jun 14; 447(7146):859-63. PMID: 17568747.
      View in: PubMed
    54. Martin DN, Balgley B, Dutta S, Chen J, Rudnick P, Cranford J, Kantartzis S, DeVoe DL, Lee C, Baehrecke EH. Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development. Cell Death Differ. 2007 May; 14(5):916-23. PMID: 17256009.
      View in: PubMed
    55. Baehrecke EH. Growth control: p53, the guardian angel of compensatory proliferation. Curr Biol. 2006 Oct 10; 16(19):R840-2. PMID: 17027478.
      View in: PubMed
    56. Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 2006 Sep; 133(17):3305-15. PMID: 16887831.
      View in: PubMed
    57. Fortier TM, Chatterjee R, Klinedinst S, Baehrecke EH, Woodard CT. How functions in leg development during Drosophila metamorphosis. Dev Dyn. 2006 Aug; 235(8):2248-59. PMID: 16732586.
      View in: PubMed
    58. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4952-7. PMID: 16547133.
      View in: PubMed
    59. Debnath J, Baehrecke EH, Kroemer G. Does autophagy contribute to cell death? Autophagy. 2005 Jul; 1(2):66-74. PMID: 16874022.
      View in: PubMed
    60. Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol. 2005 Jun; 6(6):505-10. PMID: 15928714.
      View in: PubMed
    61. Yu L, Lenardo MJ, Baehrecke EH. Autophagy and caspases: a new cell death program. Cell Cycle. 2004 Sep; 3(9):1124-6. PMID: 15326383.
      View in: PubMed
    62. Alva AS, Gultekin SH, Baehrecke EH. Autophagy in human tumors: cell survival or death? Cell Death Differ. 2004 Sep; 11(9):1046-8. PMID: 15143348.
      View in: PubMed
    63. Baehrecke EH, Dang N, Babaria K, Shneiderman B. Visualization and analysis of microarray and gene ontology data with treemaps. BMC Bioinformatics. 2004 Jun 28; 5:84. PMID: 15222902.
      View in: PubMed
    64. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004 Jun 4; 304(5676):1500-2. PMID: 15131264.
      View in: PubMed
    65. Martin DN, Baehrecke EH. Caspases function in autophagic programmed cell death in Drosophila. Development. 2004 Jan; 131(2):275-84. PMID: 14668412.
      View in: PubMed
    66. Baehrecke EH. Autophagic programmed cell death in Drosophila. Cell Death Differ. 2003 Sep; 10(9):940-5. PMID: 12934068.
      View in: PubMed
    67. Baehrecke EH. miRNAs: micro managers of programmed cell death. Curr Biol. 2003 Jun 17; 13(12):R473-5. PMID: 12814564.
      View in: PubMed
    68. Baehrecke EH. Caspase activation finds fertile ground. Dev Cell. 2003 May; 4(5):608-9. PMID: 12737795.
      View in: PubMed
    69. Oberst A, Baehrecke E, Mehmet H, Ichijo H, Gupta S. A place to die for: apoptosis in cancer and infection, Capri 2002. Cell Death Differ. 2003 Mar; 10(3):393-5. PMID: 12700641.
      View in: PubMed
    70. Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH. Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr Biol. 2003 Feb 18; 13(4):350-7. PMID: 12593803.
      View in: PubMed
    71. Lee CY, Simon CR, Woodard CT, Baehrecke EH. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev Biol. 2002 Dec 1; 252(1):138-48. PMID: 12453466.
      View in: PubMed
    72. Baehrecke EH. How death shapes life during development. Nat Rev Mol Cell Biol. 2002 Oct; 3(10):779-87. PMID: 12360194.
      View in: PubMed
    73. Lee CY, Cooksey BA, Baehrecke EH. Steroid regulation of midgut cell death during Drosophila development. Dev Biol. 2002 Oct 1; 250(1):101-11. PMID: 12297099.
      View in: PubMed
    74. Chen J, Lee CS, Shen Y, Smith RD, Baehrecke EH. Integration of capillary isoelectric focusing with capillary reversed-phase liquid chromatography for two-dimensional proteomics separation. Electrophoresis. 2002 Sep; 23(18):3143-8. PMID: 12298086.
      View in: PubMed
    75. Cakouros D, Daish T, Martin D, Baehrecke EH, Kumar S. Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol. 2002 Jun 10; 157(6):985-95. PMID: 12045184.
      View in: PubMed
    76. Lee CY, Baehrecke EH. Steroid regulation of autophagic programmed cell death during development. Development. 2001 Apr; 128(8):1443-55. PMID: 11262243.
      View in: PubMed
    77. Baehrecke EH. Steroid regulation of programmed cell death during Drosophila development. Cell Death Differ. 2000 Nov; 7(11):1057-62. PMID: 11139278.
      View in: PubMed
    78. Lee CY, Baehrecke EH. Genetic regulation of programmed cell death in Drosophila. Cell Res. 2000 Sep; 10(3):193-204. PMID: 11032171.
      View in: PubMed
    79. Lee CY, Wendel DP, Reid P, Lam G, Thummel CS, Baehrecke EH. E93 directs steroid-triggered programmed cell death in Drosophila. Mol Cell. 2000 Aug; 6(2):433-43. PMID: 10983989.
      View in: PubMed
    80. van den Eijnde SM, Boshart L, Baehrecke EH, De Zeeuw CI, Reutelingsperger CP, Vermeij-Keers C. Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved. Apoptosis. 1998; 3(1):9-16. PMID: 14646513.
      View in: PubMed
    81. Jiang C, Baehrecke EH, Thummel CS. Steroid regulated programmed cell death during Drosophila metamorphosis. Development. 1997 Nov; 124(22):4673-83. PMID: 9409683.
      View in: PubMed
    82. Baehrecke EH. who encodes a KH RNA binding protein that functions in muscle development. Development. 1997 Apr; 124(7):1323-32. PMID: 9118803.
      View in: PubMed
    83. Baehrecke EH. Ecdysone signaling cascade and regulation of Drosophila metamorphosis. Arch Insect Biochem Physiol. 1996; 33(3-4):231-44. PMID: 8913033.
      View in: PubMed
    84. Baehrecke EH, Thummel CS. The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone. Dev Biol. 1995 Sep; 171(1):85-97. PMID: 7556910.
      View in: PubMed
    85. Woodard CT, Baehrecke EH, Thummel CS. A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone. Cell. 1994 Nov 18; 79(4):607-15. PMID: 7954827.
      View in: PubMed
    86. Baehrecke EH, Aiken JM, Dover BA, Strand MR. Ecdysteroid induction of embryonic morphogenesis in a parasitic wasp. Dev Biol. 1993 Aug; 158(2):275-87. PMID: 8344451.
      View in: PubMed
    87. Baehrecke EH, Williams HJ, Vinson SB. Electroantennogram responses ofCampoletis sonorensis (hymenoptera: Ichneumonidae) to chemicals in cotton (Gossypium hirsutum L.). J Chem Ecol. 1989 Jan; 15(1):37-45. PMID: 24271425.
      View in: PubMed
    88. Williams HJ, Scott AI, Woolfenden WR, Grant DM, Vinison SB, Elzen GW, Baehrecke EH. In vivo and solid state 13C nuclear magnetic resonance studies of tyrosine metabolism during insect cuticle formation. Comp Biochem Physiol B. 1988; 89(2):317-21. PMID: 3356137.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Baehrecke's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _