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Jean A Frazier MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPsychiatry
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North, S3-301
Worcester MA 01655
Phone774-455-4120
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentPediatrics

    InstitutionUMMS - School of Medicine
    DepartmentPsychiatry

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Wellesley College, Wellesley, MA, United StatesBAMusic
    Dartmouth Medical School, Hanover, NH, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background

    B.A. Wellesley College-Music Major, 1982
    M.D. Dartmouth Medical School, 1987

    Post Doctoral Training

    Intern in Psychiatry, Tufts-New England Medical Center, Boston, 1987-1988

    Adult Psychiatry Residency, New England Medical Center, Boston, 1988-1990

    Chief Resident, Adult Psychiatry Outpatient Department, New England Medical Center, Boston, 1990-1991

    Child and Adolescent Psychiatry Fellowship, Emma Pendleton, Bradley Hospital, Brown University, East Providence, Rhode Island, 1991-1993

    Research Fellowship, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 1993-1995

    Current Appointments:

    2008-present Robert M. and Shirley S. Siff Chair in Autism, UMASS Medical School, Worcester, MA

    2008-present Professor of Psychiatry, UMASS Medical School, Worcester, MA

    2008-present Professor of Pediatrics, UMASS Medical School, Worcester, MA

    2008-present Vice Chair and Director, Division of Child and Adolescent Psychiatry, UMASS Medical School, Worcester, MA

    2008-present Co-Director, Child and Adolescent Neurodevelopment Initiative (CANDI), UMASS Medical School, Worcester, MA

    Professional Service:

    2003-presentProfessional Advisory Council for the Child and Adolescent Bipolar Foundation
    Field Editor, Harvard Review of Psychiatry
    2005-2008Work Group on Research, American Academy of Child and Adolescent Psychiatry
    2005-presentScientific Advisory Board for Step-Up for Kids
    2005-presentData Safety Monitoring Board for Stanley Early Onset Bipolar Disorder Treatment Study at University of Cincinnati:Â PI Robert Kowatch
    2006-presentAssociate Editor of Psychotic Disorders: Journal of Child and Adolescent Psychopharmacology
    2006-2007Committee on Integrated Research Training Programs in Child Psychiatry, American Academy of Child and Adolescent Psychiatry.
    2006-presentData Safety Monitoring Board for All Clinical Trials in Child and Adolescent and Adult Psychiatry at Zucker Hillside Hospital, New York.
    2006-presentÂSteering Committee of the Autism Consortium in Boston
    2006-presentPsychopharmacology Experts Workgroup, Department of Mental Health, Massachusetts
    2007 -2008Selection Committee for the EOP and CAP travel awards given by the American Academy of Child and Adolescent Psychiatry
    2007-2009History Committee, American College of Neuropsychopharmacology
    2007-presentMassachusetts Department of Mental Health Advisory Committee on Psychoactive Medication for Children and Adolescents
    2007National Institute of Mental Health Review Committee ZMH 1 ERB-B 03 R- March 20th 2007
    2009-presentDepartment of Mental Health-Mental Health Parity Advisory Group
    2009National Institutes of Health Review Committee-NPAS- Ad Hoc Reviewer- June 2009
    2009Work group Member-National Institute of Mental Health. Pediatric Bipolar Disorder Classification Meeting
    2009

    National Institute of Mental Health BSC-Ad hoc Reviewer June 2009

    2009Autism Spectrum Clinical Trials Network Reviewer
    2009-2015

    Member, Neural Basis of Psychopathology, Addictions and Sleep disorders Study Section, Center for Scientific Review, National Institutes of Health

    2009-2011

    Credentials Committee, American College of Neuropsychopharmacology

    2009Advisory Committee for Girls in Action, Girls Inc. in Worcester

    Honors/Awards

    2002National Alliance For The Mentally Ill- Annual Exemplary Psychiatrist Award
    2003Massachusetts Psychiatric Society-Outstanding Psychiatrist Award for Research
    2006Distinguished Fellow of the American Psychiatric Association
    2006New England Educational Institute’s Outstanding Educator Award for Mental Health Education
    2007Step up for Kids, Inc. Leadership Award
    2009Best Doctors in America

    Research Interests

    Dr. Jean Frazier Dr. Frazier directs a broad research program that addresses a variety of scientific problems relevant to advancing the understanding, diagnosis and treatment of individuals with neurodevelopmental disorders such as early onset bipolar disorder (BPD), schizophrenia and autism. The Child and Adolescent Neurodevelopment Initiative (CANDI) team studies all three diagnostic groups since there is often overlap in the clinical symptoms, genetics, and the neuroimaging findings of these disorders and in the clinical interventions used to treat them. Research with each diagnostic group of children informs the work done with the other diagnostic groups. For example, children with autism can have mood dysregulation when asked to shift activities and a significant subset can suffer from a comorbid bipolar disorder or depressive disorder.Children with schizophrenia can also look like they have bipolar disorder with psychotic features and figuring out the diagnostic boundaries can be challenging. By studying all three groups of children, Dr. Frazier hopes to find biomarkers that might be specific to each diagnosis. In addition, she hopes to find biomarkers that may be less specific to diagnosis but more pertinent to disorders of neurodevelopment in general. The overarching goal is for Dr. Frazier's research efforts to lead to improved care of children and families affected by these disorders.

    CANDI is involved in a variety of research pursuits including genetic studies, intervention studies and neuroimaging efforts. Dr. Frazier collaborates with a number of investigators both locally and nationally in order to tackle difficult questions. The neuroimaging studies use technologies such as magnetic resonance imaging (MRI) to investigate the development of brain structure and function. Using these techniques Dr. Frazier's team hopes to characterize normal development and advance the understanding of issues surrounding mental illness and atypical development and their interventions.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Landersdorfer CB, Findling RL, Frazier JA, Kafantaris V, Kirkpatrick CM. Lithium in Paediatric Patients with Bipolar Disorder: Implications for Selection of Dosage Regimens via Population Pharmacokinetics/Pharmacodynamics. Clin Pharmacokinet. 2017 Jan; 56(1):77-90. PMID: 27393139.
      View in: PubMed
    2. Joseph RM, Korzeniewski SJ, Allred EN, O'Shea TM, Heeren T, Frazier JA, Ware J, Hirtz D, Leviton A, Kuban K. Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks' gestation. Am J Obstet Gynecol. 2016 Nov 12. PMID: 27847193.
      View in: PubMed
    3. Kuban KC, Joseph RM, O'Shea TM, Heeren T, Fichorova RN, Douglass L, Jara H, Frazier JA, Hirtz D, Rollins JV, Paneth N. Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm. J Pediatr. 2017 Jan; 180:116-123.e1. PMID: 27788929.
      View in: PubMed
    4. Honor LB, Haselgrove C, Frazier JA, Kennedy DN. Corrigendum: Data Citation in Neuroimaging: Proposed Best Practices for Data Identification and Attribution. Front Neuroinform. 2016; 10:43. PMID: 27708574.
      View in: PubMed
    5. Wood ME, Frazier JA, Nordeng HM, Lapane KL. Longitudinal changes in neurodevelopmental outcomes between 18 and 36 months in children with prenatal triptan exposure: findings from the Norwegian Mother and Child Cohort Study. BMJ Open. 2016 Sep 13; 6(9):e011971. PMID: 27625061.
      View in: PubMed
    6. Fitzpatrick P, Frazier JA, Cochran DM, Mitchell T, Coleman C, Schmidt RC. Impairments of Social Motor Synchrony Evident in Autism Spectrum Disorder. Front Psychol. 2016; 7:1323. PMID: 27630599.
      View in: PubMed
    7. Kim SH, Joseph RM, Frazier JA, O'Shea TM, Chawarska K, Allred EN, Leviton A, Kuban KK. Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm. J Pediatr. 2016 Nov; 178:101-107.e2. PMID: 27592094.
      View in: PubMed
    8. Honor LB, Haselgrove C, Frazier JA, Kennedy DN. Data Citation in Neuroimaging: Proposed Best Practices for Data Identification and Attribution. Front Neuroinform. 2016; 10:34. PMID: 27570508.
      View in: PubMed
    9. Chang L, Douet V, Bloss C, Lee K, Pritchett A, Jernigan TL, Akshoomoff N, Murray SS, Frazier J, Kennedy DN, Amaral DG, Gruen J, Kaufmann WE, Casey BJ, Sowell E, Ernst T. Gray matter maturation and cognition in children with different APOE e genotypes. Neurology. 2016 Aug 09; 87(6):585-94. PMID: 27412137.
      View in: PubMed
    10. Kuban KC, Joseph RM, O'Shea TM, Allred EN, Heeren T, Douglass L, Stafstrom CE, Jara H, Frazier JA, Hirtz D, Leviton A. Girls and Boys Born before 28 Weeks Gestation: Risks of Cognitive, Behavioral, and Neurologic Outcomes at Age 10 Years. J Pediatr. 2016 Jun; 173:69-75.e1. PMID: 27004675.
      View in: PubMed
    11. Wood ME, Frazier JA, Nordeng HM, Lapane KL. Prenatal triptan exposure and parent-reported early childhood neurodevelopmental outcomes: an application of propensity score calibration to adjust for unmeasured confounding by migraine severity. Pharmacoepidemiol Drug Saf. 2016 May; 25(5):493-502. PMID: 26554750.
      View in: PubMed
    12. Wood ME, Lapane K, Frazier JA, Ystrom E, Mick EO, Nordeng H. Prenatal Triptan Exposure and Internalising and Externalising Behaviour Problems in 3-Year-Old Children: Results from the Norwegian Mother and Child Cohort Study. Paediatr Perinat Epidemiol. 2016 Mar; 30(2):190-200. PMID: 26525300.
      View in: PubMed
    13. Findling RL, Robb A, McNamara NK, Pavuluri MN, Kafantaris V, Scheffer R, Frazier JA, Rynn M, DelBello M, Kowatch RA, Rowles BM, Lingler J, Martz K, Anand R, Clemons TE, Taylor-Zapata P. Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study. Pediatrics. 2015 Nov; 136(5):885-94. PMID: 26459650.
      View in: PubMed
    14. Frazier JA, Wood ME, Ware J, Joseph RM, Kuban KC, O'Shea M, Allred EN, Leviton A. Antecedents of the child behavior checklist-dysregulation profile in children born extremely preterm. J Am Acad Child Adolesc Psychiatry. 2015 Oct; 54(10):816-23. PMID: 26407491.
      View in: PubMed
    15. Newman E, Thompson WK, Bartsch H, Hagler DJ, Chen CH, Brown TT, Kuperman JM, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2016 Jul; 221(6):3013-25. PMID: 26183468.
      View in: PubMed
    16. Rane P, Cochran D, Hodge SM, Haselgrove C, Kennedy DN, Frazier JA. Connectivity in Autism: A Review of MRI Connectivity Studies. Harv Rev Psychiatry. 2015 Jul-Aug; 23(4):223-44. PMID: 26146755.
      View in: PubMed
    17. Sikoglu EM, Navarro AA, Starr D, Dvir Y, Nwosu BU, Czerniak SM, Rogan RC, Castro MC, Edden RA, Frazier JA, Moore CM. Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders. J Child Adolesc Psychopharmacol. 2015 Jun; 25(5):415-24. PMID: 26091195.
      View in: PubMed
    18. Jernigan TL, Brown TT, Hagler DJ, Akshoomoff N, Bartsch H, Newman E, Thompson WK, Bloss CS, Murray SS, Schork N, Kennedy DN, Kuperman JM, McCabe C, Chung Y, Libiger O, Maddox M, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Sowell ER, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM. The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage. 2016 Jan 01; 124(Pt B):1149-54. PMID: 25937488.
      View in: PubMed
    19. Cochran DM, Sikoglu EM, Hodge SM, Edden RA, Foley A, Kennedy DN, Moore CM, Frazier JA. Relationship among Glutamine, ?-Aminobutyric Acid, and Social Cognition in Autism Spectrum Disorders. J Child Adolesc Psychopharmacol. 2015 May; 25(4):314-22. PMID: 25919578.
      View in: PubMed
    20. Noble KG, Houston SM, Brito NH, Bartsch H, Kan E, Kuperman JM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Murray SS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Van Zijl P, Mostofsky S, Kaufmann WE, Kenet T, Dale AM, Jernigan TL, Sowell ER. Family income, parental education and brain structure in children and adolescents. Nat Neurosci. 2015 May; 18(5):773-8. PMID: 25821911.
      View in: PubMed
    21. Byron G, Ziedonis DM, McGrath C, Frazier JA, deTorrijos F, Fulwiler C. Implementation of Mindfulness Training for Mental Health Staff: Organizational Context and Stakeholder Perspectives. Mindfulness (N Y). 2015 Aug; 6(4):861-872. PMID: 26500708.
      View in: PubMed
    22. Woodberry KA, Serur RA, Hallinan SB, Mesholam-Gately RI, Giuliano AJ, Wojcik JD, Keshavan MS, Frazier JA, Goldstein JM, Shenton ME, McCarley RW, Seidman LJ. Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth. Schizophr Res. 2014 Sep; 158(1-3):45-51. PMID: 24924404.
      View in: PubMed
    23. Maloney A, Mick EO, Frazier J. Aripiprazole decreases irritability in 12 out of 14 youth with autism spectrum disorders. J Child Adolesc Psychopharmacol. 2014 Aug; 24(6):357-9. PMID: 24828130.
      View in: PubMed
    24. Dvir Y, Ford JD, Hill M, Frazier JA. Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities. Harv Rev Psychiatry. 2014 May-Jun; 22(3):149-61. PMID: 24704784.
      View in: PubMed
    25. Rane P, Haselgrove C, Hodge SM, Frazier JA, Kennedy DN. Structure-centered portal for child psychiatry research. Front Neuroinform. 2014; 8:47. PMID: 24817850.
      View in: PubMed
    26. Frazier JA, McDougle CJ. Special issue on autism spectrum disorders. Introduction. Harv Rev Psychiatry. 2014 Mar-Apr; 22(2):61-4. PMID: 24614761.
      View in: PubMed
    27. Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D, Goldberg RJ. Genome-wide association study of proneness to anger. PLoS One. 2014; 9(1):e87257. PMID: 24489884.
      View in: PubMed
    28. Akshoomoff N, Newman E, Thompson WK, McCabe C, Bloss CS, Chang L, Amaral DG, Casey BJ, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Libiger O, Mostofsky S, Murray SS, Sowell ER, Schork N, Dale AM, Jernigan TL. The NIH Toolbox Cognition Battery: results from a large normative developmental sample (PING). Neuropsychology. 2014 Jan; 28(1):1-10. PMID: 24219608.
      View in: PubMed
    29. Cochran DM, Fallon D, Hill M, Frazier JA. The role of oxytocin in psychiatric disorders: a review of biological and therapeutic research findings. Harv Rev Psychiatry. 2013 Sep-Oct; 21(5):219-47. PMID: 24651556.
      View in: PubMed
    30. Dvir Y, Denietolis B, Frazier JA. Childhood trauma and psychosis. Child Adolesc Psychiatr Clin N Am. 2013 Oct; 22(4):629-41. PMID: 24012077.
      View in: PubMed
    31. Cochran DM, Dvir Y, Frazier JA. "Autism-plus" spectrum disorders: intersection with psychosis and the schizophrenia spectrum. Child Adolesc Psychiatr Clin N Am. 2013 Oct; 22(4):609-27. PMID: 24012076.
      View in: PubMed
    32. Dvir Y, Frazier JA. Psychotic disorders in youth: diagnostic and treatment challenges. Child Adolesc Psychiatr Clin N Am. 2013 Oct; 22(4):xiii-xiv. PMID: 24012085.
      View in: PubMed
    33. Czerniak SM, Sikoglu EM, King JA, Kennedy DN, Mick E, Frazier J, Moore CM. Areas of the brain modulated by single-dose methylphenidate treatment in youth with ADHD during task-based fMRI: a systematic review. Harv Rev Psychiatry. 2013 May-Jun; 21(3):151-62. PMID: 23660970.
      View in: PubMed
    34. Findling RL, Kafantaris V, Pavuluri M, McNamara NK, Frazier JA, Sikich L, Kowatch R, Rowles BM, Clemons TE, Taylor-Zapata P. Post-acute effectiveness of lithium in pediatric bipolar I disorder. J Child Adolesc Psychopharmacol. 2013 Mar; 23(2):80-90. PMID: 23510444.
      View in: PubMed
    35. Sikoglu EM, Jensen JE, Vitaliano G, Liso Navarro AA, Renshaw PF, Frazier JA, Moore CM. Bioenergetic measurements in children with bipolar disorder: a pilot 31P magnetic resonance spectroscopy study. PLoS One. 2013; 8(1):e54536. PMID: 23382910.
      View in: PubMed
    36. Maloney AE, Yakutis LJ, Frazier JA. Empirical evidence for psychopharmacologic treatment in early-onset psychosis and schizophrenia. Child Adolesc Psychiatr Clin N Am. 2012 Oct; 21(4):885-909. PMID: 23040906.
      View in: PubMed
    37. Brown TT, Kuperman JM, Chung Y, Erhart M, McCabe C, Hagler DJ, Venkatraman VK, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Murray SS, Sowell ER, Jernigan TL, Dale AM. Neuroanatomical assessment of biological maturity. Curr Biol. 2012 Sep 25; 22(18):1693-8. PMID: 22902750.
      View in: PubMed
    38. Kennedy DN, Haselgrove C, Hodge SM, Rane PS, Makris N, Frazier JA. CANDIShare: a resource for pediatric neuroimaging data. Neuroinformatics. 2012 Jul; 10(3):319-22. PMID: 22006352.
      View in: PubMed
    39. Kennedy DN, Hodge SM, Gao Y, Frazier JA, Haselgrove C. The internet brain volume database: a public resource for storage and retrieval of volumetric data. Neuroinformatics. 2012 Apr; 10(2):129-40. PMID: 21931990.
      View in: PubMed
    40. Frazier JA, Giuliano AJ, Johnson JL, Yakutis L, Youngstrom EA, Breiger D, Sikich L, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA, Hooper SR. Neurocognitive outcomes in the Treatment of Early-Onset Schizophrenia Spectrum Disorders study. J Am Acad Child Adolesc Psychiatry. 2012 May; 51(5):496-505. PMID: 22525956.
      View in: PubMed
    41. Chen Y, Norton DJ, McBain R, Gold J, Frazier JA, Coyle JT. Enhanced local processing of dynamic visual information in autism: evidence from speed discrimination. Neuropsychologia. 2012 Apr; 50(5):733-9. PMID: 22261399.
      View in: PubMed
    42. O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ. Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods. Psychiatry Res. 2011 Aug 30; 193(2):113-22. PMID: 21684724.
      View in: PubMed
    43. Frazier JA. Limited evidence for use of second-generation antipsychotics in anxiety disorders. Evid Based Ment Health. 2011 Aug; 14(3):76. PMID: 21764875.
      View in: PubMed
    44. Findling RL, Kafantaris V, Pavuluri M, McNamara NK, McClellan J, Frazier JA, Sikich L, Kowatch R, Lingler J, Faber J, Rowles BM, Clemons TE, Taylor-Zapata P. Dosing strategies for lithium monotherapy in children and adolescents with bipolar I disorder. J Child Adolesc Psychopharmacol. 2011 Jun; 21(3):195-205. PMID: 21663422.
      View in: PubMed
    45. Nwosu BU, Meltzer B, Maranda L, Ciccarelli C, Reynolds D, Curtis L, King J, Frazier JA, Lee MM. A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics. J Pediatr Endocrinol Metab. 2011; 24(9-10):619-26. PMID: 22145446.
      View in: PubMed
    46. Lopez-Larson M, Breeze JL, Kennedy DN, Hodge SM, Tang L, Moore C, Giuliano AJ, Makris N, Caviness VS, Frazier JA. Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements. Brain Imaging Behav. 2010 Dec; 4(3-4):220-31. PMID: 20686873.
      View in: PubMed
    47. Gönenç A, Frazier JA, Crowley DJ, Moore CM. Combined diffusion tensor imaging and transverse relaxometry in early-onset bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2010 Dec; 49(12):1260-8. PMID: 21093775.
      View in: PubMed
    48. Findling RL, Landersdorfer CB, Kafantaris V, Pavuluri M, McNamara NK, McClellan J, Frazier JA, Sikich L, Kowatch R, Lingler J, Faber J, Taylor-Zapata P, Jusko WJ. First-dose pharmacokinetics of lithium carbonate in children and adolescents. J Clin Psychopharmacol. 2010 Aug; 30(4):404-10. PMID: 20531219.
      View in: PubMed
    49. Findling RL, Johnson JL, McClellan J, Frazier JA, Vitiello B, Hamer RM, Lieberman JA, Ritz L, McNamara NK, Lingler J, Hlastala S, Pierson L, Puglia M, Maloney AE, Kaufman EM, Noyes N, Sikich L. Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study. J Am Acad Child Adolesc Psychiatry. 2010 Jun; 49(6):583-94; quiz 632. PMID: 20494268.
      View in: PubMed
    50. Zhang N, Rane P, Huang W, Liang Z, Kennedy D, Frazier JA, King J. Mapping resting-state brain networks in conscious animals. J Neurosci Methods. 2010 Jun 15; 189(2):186-96. PMID: 20382183.
      View in: PubMed
    51. Shen Y, Dies KA, Holm IA, Bridgemohan C, Sobeih MM, Caronna EB, Miller KJ, Frazier JA, Silverstein I, Picker J, Weissman L, Raffalli P, Jeste S, Demmer LA, Peters HK, Brewster SJ, Kowalczyk SJ, Rosen-Sheidley B, McGowan C, Duda AW, Lincoln SA, Lowe KR, Schonwald A, Robbins M, Hisama F, Wolff R, Becker R, Nasir R, Urion DK, Milunsky JM, Rappaport L, Gusella JF, Walsh CA, Wu BL, Miller DT. Clinical genetic testing for patients with autism spectrum disorders. Pediatrics. 2010 Apr; 125(4):e727-35. PMID: 20231187.
      View in: PubMed
    52. Hodge SM, Makris N, Kennedy DN, Caviness VS, Howard J, McGrath L, Steele S, Frazier JA, Tager-Flusberg H, Harris GJ. Cerebellum, language, and cognition in autism and specific language impairment. J Autism Dev Disord. 2010 Mar; 40(3):300-16. PMID: 19924522.
      View in: PubMed
    53. Hooper SR, Giuliano AJ, Youngstrom EA, Breiger D, Sikich L, Frazier JA, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA. Neurocognition in early-onset schizophrenia and schizoaffective disorders. J Am Acad Child Adolesc Psychiatry. 2010 Jan; 49(1):52-60. PMID: 20215926.
      View in: PubMed
    54. Shin L, Bregman H, Breeze JL, Noyes N, Frazier JA. Metformin for weight control in pediatric patients on atypical antipsychotic medication. J Child Adolesc Psychopharmacol. 2009 Jun; 19(3):275-9. PMID: 19519262.
      View in: PubMed
    55. Terry J, Lopez-Larson M, Frazier JA. Magnetic resonance imaging studies in early onset bipolar disorder: an updated review. Child Adolesc Psychiatr Clin N Am. 2009 Apr; 18(2):421-39, ix-x. PMID: 19264271.
      View in: PubMed
    56. Lopez-Larson M, Michael ES, Terry JE, Breeze JL, Hodge SM, Tang L, Kennedy DN, Moore CM, Makris N, Caviness VS, Frazier JA. Subcortical differences among youths with attention-deficit/hyperactivity disorder compared to those with bipolar disorder with and without attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2009 Feb; 19(1):31-9. PMID: 19232021.
      View in: PubMed
    57. Frazier JA, Soares JC. Neurobiology of pediatric mood disorders: Part II. J Child Adolesc Psychopharmacol. 2009 Feb; 19(1):1-2. PMID: 19232017.
      View in: PubMed
    58. Soares JC, Frazier JA. Neurobiology of pediatric mood disorders: are we there yet? J Child Adolesc Psychopharmacol. 2008 Dec; 18(6):549. PMID: 19108658.
      View in: PubMed
    59. Sikich L, Frazier JA, McClellan J, Findling RL, Vitiello B, Ritz L, Ambler D, Puglia M, Maloney AE, Michael E, De Jong S, Slifka K, Noyes N, Hlastala S, Pierson L, McNamara NK, Delporto-Bedoya D, Anderson R, Hamer RM, Lieberman JA. Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. Am J Psychiatry. 2008 Nov; 165(11):1420-31. PMID: 18794207.
      View in: PubMed
    60. Findling RL, Frazier JA, Kafantaris V, Kowatch R, McClellan J, Pavuluri M, Sikich L, Hlastala S, Hooper SR, Demeter CA, Bedoya D, Brownstein B, Taylor-Zapata P. The Collaborative Lithium Trials (CoLT): specific aims, methods, and implementation. Child Adolesc Psychiatry Ment Health. 2008 Aug 12; 2(1):21. PMID: 18700004.
      View in: PubMed
    61. Frazier JA. Child psychiatry: addressing emerging clinical challenges. Introduction. Harv Rev Psychiatry. 2008; 16(2):67-8. PMID: 18415879.
      View in: PubMed
    62. Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, Howard JD, Rohan MP, Caviness VS, Makris N. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007 Dec; 9(8):799-809. PMID: 18076529.
      View in: PubMed
    63. Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull. 2008 Jan; 34(1):37-46. PMID: 18003631.
      View in: PubMed
    64. McClellan J, Sikich L, Findling RL, Frazier JA, Vitiello B, Hlastala SA, Williams E, Ambler D, Hunt-Harrison T, Maloney AE, Ritz L, Anderson R, Hamer RM, Lieberman JA. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry. 2007 Aug; 46(8):969-78. PMID: 17667476.
      View in: PubMed
    65. Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, Williams E, McNamara NK, Jackson JA, Ritz L, Hlastala SA, Pierson L, Varley JA, Puglia M, Maloney AE, Ambler D, Hunt-Harrison T, Hamer RM, Noyes N, Lieberman JA, Sikich L. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. J Am Acad Child Adolesc Psychiatry. 2007 Aug; 46(8):979-88. PMID: 17667477.
      View in: PubMed
    66. Ahn MS, Breeze JL, Makris N, Kennedy DN, Hodge SM, Herbert MR, Seidman LJ, Biederman J, Caviness VS, Frazier JA. Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder. J Affect Disord. 2007 Dec; 104(1-3):147-54. PMID: 17532475.
      View in: PubMed
    67. Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, Finn CT, Frederick Bd, Renshaw PF. Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Am Acad Child Adolesc Psychiatry. 2007 Apr; 46(4):524-34. PMID: 17420688.
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    68. Findling RL, Frazier JA, Gerbino-Rosen G, Kranzler HN, Kumra S, Kratochvil CJ. Is there a role for clozapine in the treatment of children and adolescents? J Am Acad Child Adolesc Psychiatry. 2007 Mar; 46(3):423-8. PMID: 17314729.
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    69. Lopez-Larson M, Frazier JA. Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders. Harv Rev Psychiatry. 2006 Nov-Dec; 14(6):285-304. PMID: 17162653.
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    70. Navalta CP, Goldstein J, Ruegg L, Perna DA, Frazier JA. Integrating treatment and education for mood disorders: an adolescent case report. Clin Child Psychol Psychiatry. 2006 Oct; 11(4):555-68. PMID: 17163224.
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    71. Rappaport N, Frazier JA, Connor DF, Mattison R. From zero to a hundred in a split second: understanding aggression in an eight-year-old child. Harv Rev Psychiatry. 2006 May-Jun; 14(3):165-76. PMID: 16787888.
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    72. O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ, Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods. Harv Rev Psychiatry. 2006 May-Jun; 14(3):141-51. PMID: 16787886.
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    73. Frazier JA, Breeze JL, Makris N, Giuliano AS, Herbert MR, Seidman L, Biederman J, Hodge SM, Dieterich ME, Gerstein ED, Kennedy DN, Rauch SL, Cohen BM, Caviness VS. Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disord. 2005 Dec; 7(6):555-69. PMID: 16403181.
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    74. Tillman R, Geller B, Frazier J, Beringer L, Zimerman B, Klages T, Bolhofner K. Children with a prepubertal and early adolescent bipolar disorder phenotype from pediatric versus psychiatric facilities. J Am Acad Child Adolesc Psychiatry. 2005 Aug; 44(8):776-81. PMID: 16034279.
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    75. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry. 2005 Jul; 162(7):1256-65. PMID: 15994707.
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    76. Ahn MS, Sims KB, Frazier JA. Risperidone-induced psychosis and depression in a child with a mitochondrial disorder. J Child Adolesc Psychopharmacol. 2005 Jun; 15(3):520-5. PMID: 16092915.
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    77. Frazier JA, Carlson GA. Diagnostically homeless and needing appropriate placement. J Child Adolesc Psychopharmacol. 2005 Jun; 15(3):337-42. PMID: 16092901.
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    78. Frazier JA, Ahn MS, DeJong S, Bent EK, Breeze JL, Giuliano AJ. Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review. Harv Rev Psychiatry. 2005 May-Jun; 13(3):125-40. PMID: 16020026.
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    79. Hirshberg LM, Chiu S, Frazier JA. Emerging brain-based interventions for children and adolescents: overview and clinical perspective. Child Adolesc Psychiatr Clin N Am. 2005 Jan; 14(1):1-19, v. PMID: 15564050.
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    80. Hirshberg LM, Chiu S, Frazier JA. Emerging interventions. Child Adolesc Psychiatr Clin N Am. 2005 Jan; 14(1):xiii-xvii. PMID: 15564049.
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    81. De Fossé L, Hodge SM, Makris N, Kennedy DN, Caviness VS, McGrath L, Steele S, Ziegler DA, Herbert MR, Frazier JA, Tager-Flusberg H, Harris GJ. Language-association cortex asymmetry in autism and specific language impairment. Ann Neurol. 2004 Dec; 56(6):757-66. PMID: 15478219.
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    82. Ahn MS, Frazier JA. Diagnostic and treatment issues in childhood-onset bipolar disorder. Essent Psychopharmacol. 2004; 6(1):25-44. PMID: 15612652.
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    83. Breeze JL, Hesdorffer DC, Hong X, Frazier JA, Renshaw PF. Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness. Harv Rev Psychiatry. 2003 Sep-Oct; 11(5):269-83. PMID: 14555427.
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    84. Frazier JA, Cohen LG, Jacobsen L, Grothe D, Flood J, Baldessarini RJ, Piscitelli S, Kim GS, Rapoport JL. Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia. J Clin Psychopharmacol. 2003 Feb; 23(1):87-91. PMID: 12544379.
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    85. Tillman R, Geller B, Craney JL, Bolhofner K, Williams M, Zimerman B, Frazier J, Beringer L. Temperament and character factors in a prepubertal and early adolescent bipolar disorder phenotype compared to attention deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol. 2003; 13(4):531-43. PMID: 14977466.
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    86. Wagner KD, Weller EB, Carlson GA, Sachs G, Biederman J, Frazier JA, Wozniak P, Tracy K, Weller RA, Bowden C. An open-label trial of divalproex in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2002 Oct; 41(10):1224-30. PMID: 12364844.
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    87. Geller B, Zimerman B, Williams M, Delbello MP, Frazier J, Beringer L. Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. J Child Adolesc Psychopharmacol. 2002; 12(1):3-9. PMID: 12014593.
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    88. Geller DA, Biederman J, Faraone SV, Cradock K, Hagermoser L, Zaman N, Frazier JA, Coffey BJ, Spencer TJ. Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact? J Am Acad Child Adolesc Psychiatry. 2002 Jan; 41(1):52-8. PMID: 11800207.
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    89. Frazier JA, Doyle R, Chiu S, Coyle JT. Treating a child with Asperger's disorder and comorbid bipolar disorder. Am J Psychiatry. 2002 Jan; 159(1):13-21. PMID: 11772683.
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    90. Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL, Frazier J, Beringer L, Nickelsburg MJ. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol. 2002; 12(1):11-25. PMID: 12014591.
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    91. Frazier JA, Biederman J, Tohen M, Feldman PD, Jacobs TG, Toma V, Rater MA, Tarazi RA, Kim GS, Garfield SB, Sohma M, Gonzalez-Heydrich J, Risser RC, Nowlin ZM. A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol. 2001; 11(3):239-50. PMID: 11642474.
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    92. Karp BI, Garvey M, Jacobsen LK, Frazier JA, Hamburger SD, Bedwell JS, Rapoport JL. Abnormal neurologic maturation in adolescents with early-onset schizophrenia. Am J Psychiatry. 2001 Jan; 158(1):118-22. PMID: 11136643.
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    93. Coffey BJ, Biederman J, Geller DA, Spencer TJ, Kim GS, Bellordre CA, Frazier JA, Cradock K, Magovcevic M. Distinguishing illness severity from tic severity in children and adolescents with Tourette's disorder. J Am Acad Child Adolesc Psychiatry. 2000 May; 39(5):556-61. PMID: 10802972.
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    94. Frazier JA, Meyer MC, Biederman J, Wozniak J, Wilens TE, Spencer TJ, Kim GS, Shapiro S. Risperidone treatment for juvenile bipolar disorder: a retrospective chart review. J Am Acad Child Adolesc Psychiatry. 1999 Aug; 38(8):960-5. PMID: 10434487.
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    95. Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, Rosen BR, Biederman J. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry. 1999 Jun 15; 45(12):1542-52. PMID: 10376114.
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    96. Kumra S, Jacobsen LK, Lenane M, Karp BI, Frazier JA, Smith AK, Bedwell J, Lee P, Malanga CJ, Hamburger S, Rapoport JL. Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents. J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):377-85. PMID: 9549958.
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    97. Frazier JA, Morrison FJ. The influence of extended-year schooling on growth of achievement and perceived competence in early elementary school. Child Dev. 1998 Apr; 69(2):495-517. PMID: 9586221.
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    98. Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL. Attention deficits in childhood-onset schizophrenia: reaction time studies. J Abnorm Psychol. 1998 Feb; 107(1):97-108. PMID: 9505042.
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    99. Kumra S, Jacobsen LK, Lenane M, Zahn TP, Wiggs E, Alaghband-Rad J, Castellanos FX, Frazier JA, McKenna K, Gordon CT, Smith A, Hamburger S, Rapoport JL. "Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia? J Am Acad Child Adolesc Psychiatry. 1998 Jan; 37(1):91-9. PMID: 9444905.
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    100. Jacobsen LK, Hamburger SD, Van Horn JD, Vaituzis AC, McKenna K, Frazier JA, Gordon CT, Lenane MC, Rapoport JL, Zametkin AJ. Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res. 1997 Oct 31; 75(3):131-44. PMID: 9437771.
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    101. Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL. Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia. Arch Gen Psychiatry. 1997 Oct; 54(10):904-12. PMID: 9337769.
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    102. Frazier JA, Field CM. Actin cytoskeleton: are FH proteins local organizers? Curr Biol. 1997 Jul 1; 7(7):R414-7. PMID: 9210364.
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    103. Frazier JA, Alaghband-Rad J, Jacobsen L, Lenane MC, Hamburger S, Albus K, Smith A, McKenna K, Rapoport JL. Pubertal development and onset of psychosis in childhood onset schizophrenia. Psychiatry Res. 1997 Apr 18; 70(1):1-7. PMID: 9172272.
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    104. Jacobsen LK, Giedd JN, Rajapakse JC, Hamburger SD, Vaituzis AC, Frazier JA, Lenane MC, Rapoport JL. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Res. 1997 Feb 7; 68(2-3):77-86. PMID: 9104755.
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    105. Alaghband-Rad J, Hamburger SD, Giedd JN, Frazier JA, Rapoport JL. Childhood-onset schizophrenia: biological markers in relation to clinical characteristics. Am J Psychiatry. 1997 Jan; 154(1):64-8. PMID: 8988960.
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    106. Jacobsen LK, Frazier JA, Malhotra AK, Karoum F, McKenna K, Gordon CT, Hamburger SD, Lenane MC, Pickar D, Potter WZ, Rapoport JL. Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia. Am J Psychiatry. 1997 Jan; 154(1):69-74. PMID: 8988961.
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    107. Jacobsen LK, Hommer DW, Hong WL, Castellanos FX, Frazier JA, Giedd JN, Rapoport JL. Blink rate in childhood-onset schizophrenia: comparison with normal and attention-deficit hyperactivity disorder controls. Biol Psychiatry. 1996 Dec 15; 40(12):1222-9. PMID: 8959287.
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    108. Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL. Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. Biol Psychiatry. 1996 Dec 1; 40(11):1144-54. PMID: 8931918.
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    109. Kumra S, Frazier JA, Jacobsen LK, McKenna K, Gordon CT, Lenane MC, Hamburger SD, Smith AK, Albus KE, Alaghband-Rad J, Rapoport JL. Childhood-onset schizophrenia. A double-blind clozapine-haloperidol comparison. Arch Gen Psychiatry. 1996 Dec; 53(12):1090-7. PMID: 8956674.
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    110. Frazier JA, Giedd JN, Hamburger SD, Albus KE, Kaysen D, Vaituzis AC, Rajapakse JC, Lenane MC, McKenna K, Jacobsen LK, Gordon CT, Breier A, Rapoport JL. Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Arch Gen Psychiatry. 1996 Jul; 53(7):617-24. PMID: 8660128.
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    111. Frazier JA, Giedd JN, Kaysen D, Albus K, Hamburger S, Alaghband-Rad J, Lenane MC, McKenna K, Breier A, Rapoport JL. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. Am J Psychiatry. 1996 Apr; 153(4):564-6. PMID: 8599409.
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    112. Jacobsen LK, Giedd JN, Vaituzis AC, Hamburger SD, Rajapakse JC, Frazier JA, Kaysen D, Lenane MC, McKenna K, Gordon CT, Rapoport JL. Temporal lobe morphology in childhood-onset schizophrenia. Am J Psychiatry. 1996 Mar; 153(3):355-61. PMID: 8610822.
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    113. Alaghband-Rad J, McKenna K, Gordon CT, Albus KE, Hamburger SD, Rumsey JM, Frazier JA, Lenane MC, Rapoport JL. Childhood-onset schizophrenia: the severity of premorbid course. J Am Acad Child Adolesc Psychiatry. 1995 Oct; 34(10):1273-83. PMID: 7592264.
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    114. Piscitelli SC, Frazier JA, McKenna K, Albus KE, Grothe DR, Gordon CT, Rapoport JL. Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response. J Clin Psychiatry. 1994 Sep; 55 Suppl B:94-7. PMID: 7961584.
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    115. Frazier JA, Gordon CT, McKenna K, Lenane MC, Jih D, Rapoport JL. An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia. J Am Acad Child Adolesc Psychiatry. 1994 Jun; 33(5):658-63. PMID: 8056728.
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    116. Gordon CT, Frazier JA, McKenna K, Giedd J, Zametkin A, Zahn T, Hommer D, Hong W, Kaysen D, Albus KE, et al. Childhood-onset schizophrenia: an NIMH study in progress. Schizophr Bull. 1994; 20(4):697-712. PMID: 7701277.
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