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Beth A McCormick PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North, AS8-2049
Worcester MA 01655
Phone508-856-6048
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMolecular Genetics and Microbiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    University of New Hampshire Durham, Durham, NH, United StatesBAArts
    University of Rhode Island, Kingston, RI, United StatesPHDMicrobiology

    Collapse Overview 
    Collapse overview

    Beth McCormickB.A. University of New Hampshire
    Ph.D. University of Rhode Island
    Post-doctoral training Harvard Medical School

    Research Summary:

    Work in my laboratory is centered around three major research programs: Mucosal inflammation, host:pathogen interactions, and cancer biology.

    Image 1The objective of the mucosal inflammatory program is to investigate the molecular mechanisms by which bacterial pathogens induce mucosal inflammation at sites of the intestinal and respiratory epithelium. This work is based on longstanding pathologic observations that attachment of an array of bacterial pathogens to epithelial surfaces is accompanied by recruitment of host defense cells, as manifested by neutrophil infiltration of the epithelium. While neutrophils and their responses in the context of an inflammatory response are integral to the control of bacterial infection, when their responses become excessive or unregulated, injury to the host tissues ensues. To understand what goes awry under pathologic conditions, we originally used Salmonella typhimurium as a prototypical enteric pathogen to study the transepithelial migration of neutrophils across intestinal epithelia, a hallmark of gastroenteritis. This research effort has been expanded to include the following intestinal and lung pathogens: Shigella flexneri, E. coli, Pseudomonas aeruginosa, and S. pneumoniae. In response to these pathogens we have discovered a novel inflammatory signaling cascade in which epithelial cells lining mucosal surfaces release the potent neutrophil chemoattractant hepoxilin A3, (HXA3). HXA3 functions as the “gate keeper” of the mucosal epithelium, as it emanates from the site of infection to establish a chemotactic gradient that guides neutrophils across mucosal surfaces. We are now investigating the mechanisms that orchestrate the synthesis/release of HXA3 for the design of more targeted and effective anti-inflammatory therapies for the treatment of infectious, allergic, and idiopathic mucosal inflammatory conditions (i.e., salmonellosis, shigellosis, inflammatory bowel diseases, pneumonia, cystic fibrosis, and chronic obstructive pulmonary disease).

    SopA StructureThe second research program in my laboratory is centered on the study of host-pathogen interactions. Specifically, we investigate strategies used by enteric and respiratory pathogens to induce proinflammatory responses. Using S. typhimurium as an example, we have uncovered a novel mechanism by which this pathogen sabotages host defense mechanisms. Salmonella tricks the host into synthesizing and secreting the apoptotic enzyme caspase-3, diverting this host enzyme to its own use. The Salmonella effector protein SipA has amino acid motifs that are recognized by caspase-3, which cleaves the bacterial protein into active virulence effectors: one stimulates actin polymerization to help cell entry and the other induces inflammation. If the caspase motif contains a single-point mutation, then virulence is lost in mouse models of infection. This straregy isn’t limited to SipA. Other proteins that are injected by Salmonella, such as SopA (see crystal structure) and those from other gut bacteria like E. coli and Shigella flexneri, also carry targets for caspase-3, demonstrating the broad significance of this finding. This discovery unveils a new paradigm in the field of bacterial pathogenesis and opens the door to novel investigation on the tactics used by bacterial pathogens to promote disease.

    Colonic TumorThe third research program in my laboratory is focused on cancer biology. My original interest in this field of study was cultivated by the observation that Salmonella is able to preferentially locate to sites of tumor growth (achieving tumor/normal tissue ratios of approximately 1,000:1). Work in my laboratory has shown that Salmonella causes a profound reduction on the multidrug resistance (MDR) transporter P-glycoprotein (Pgp) in colon cancer cells. Pgp over-expression is one form of the MDR phenotype that is commonly acquired by cancer patients initially responsive to chemotherapy. We are interested in uncovering the mechanism used by Salmonella to downregulate Pgp. The ultimate goal of this work is to exploit Salmonella for the development of a new and robust class of multidrug resistance inhibitors designed as an adjuvant to chemotherapeutics for cancers that are known to express high levels of Pgp, such as colorectal cancers and breast cancer.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Szabady RL, Louissaint C, Lubben A, Xie B, Reeksting S, Tuohy C, Demma Z, Foley SE, Faherty CS, Llanos-Chea A, Olive AJ, Mrsny RJ, McCormick BA. Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis. J Clin Invest. 2018 Aug 13. PMID: 30102254.
      View in: PubMed
    2. Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA. Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere. 2018 07 05; 3(4). PMID: 29976647.
      View in: PubMed
    3. Daniel VT, Ayturk D, Ward DV, McCormick BA, Santry HP. The influence of payor status on outcomes associated with surgical repair of upper gastrointestinal perforations due to peptic ulcer disease in the United States. Am J Surg. 2018 Jul 02. PMID: 30017307.
      View in: PubMed
    4. Haran JP, Bucci V, Dutta P, Ward D, McCormick B. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location. J Med Microbiol. 2017 Nov 14. PMID: 29134939.
      View in: PubMed
    5. Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA. Cytosolic Phospholipase A2a Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection. Infect Immun. 2017 11; 85(11). PMID: 28808157.
      View in: PubMed
    6. Palmer JD, Piattelli E, McCormick BA, Silby MW, Brigham CJ, Bucci V. Engineered Probiotic for the Inhibition of Salmonella via Tetrathionate-Induced Production of Microcin H47. ACS Infect Dis. 2018 Jan 12; 4(1):39-45. PMID: 28918634.
      View in: PubMed
    7. McIntosh A, Meikle LM, Ormsby M, McCormick BA, Christie JM, Brewer JM, Roberts M, Wall DM. SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella Typhimurium infection. Infect Immun. 2017 Jun 19. PMID: 28630067.
      View in: PubMed
    8. Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA. Shigella Depends on SepA to Destabilize the Intestinal Epithelial Integrity via Cofilin Activation. Gut Microbes. 2017 Jun 09; 0. PMID: 28598765.
      View in: PubMed
    9. Boll EJ, Ayala-Lujan J, Szabady RL, Louissaint C, Smith RZ, Krogfelt KA, Nataro JP, Ruiz-Perez F, McCormick BA. Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1. MBio. 2017 Jun 06; 8(3). PMID: 28588132.
      View in: PubMed
    10. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15; 2:17072. PMID: 28504669.
      View in: PubMed
    11. Mercado-Lubo R, McCormick BA. Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance? Nanomedicine (Lond). 2017 Mar 21. PMID: 28322607.
      View in: PubMed
    12. Mercado-Lubo R, Zhang Y, Zhao L, Rossi K, Wu X, Zou Y, Castillo A, Leonard J, Bortell R, Greiner DL, Shultz LD, Han G, McCormick BA. A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun. 2016 Jul 25; 7:12225. PMID: 27452236.
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    13. Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI. Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30. PMID: 26864627.
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    14. Hallstrom KN, McCormick BA. The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection. Gut Microbes. 2016; 7(2):136-45. PMID: 27078059.
      View in: PubMed
    15. McCormick BA. ELMO1: More Than Just a Director of Phagocytosis. Cell Mol Gastroenterol Hepatol. 2015 May; 1(3):262-263. PMID: 28210678.
      View in: PubMed
    16. Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA. PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. 2015 Jun; 17(6):843-59. PMID: 25486861.
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    17. Wall DM, McCormick BA. Bacterial secreted effectors and caspase-3 interactions. Cell Microbiol. 2014 Dec; 16(12):1746-56. PMID: 25262664.
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    18. Patel S, McCormick BA. Mucosal Inflammatory Response to Salmonella typhimurium Infection. Front Immunol. 2014; 5:311. PMID: 25071772.
      View in: PubMed
    19. Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM. The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cell Microbiol. 2014 Sep; 16(9):1405-24. PMID: 24780054.
      View in: PubMed
    20. Agbor TA, Demma Z, Mrsny RJ, Castillo A, Boll EJ, McCormick BA. The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. Cell Microbiol. 2014 Sep; 16(9):1339-53. PMID: 24617613.
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    21. Bhowmick R, Tin Maung NH, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol. 2013 Nov 15; 191(10):5115-23. PMID: 24089193.
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    22. Szabady RL, McCormick BA. Control of neutrophil inflammation at mucosal surfaces by secreted epithelial products. Front Immunol. 2013; 4:220. PMID: 23914188.
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    23. Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM. Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infect Dis Clin North Am. 2013 Sep; 27(3):631-49. PMID: 24011834.
      View in: PubMed
    24. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. PMID: 23045615.
      View in: PubMed
    25. Boll EJ, McCormick BA. A new understanding of enteroaggregative Escherichia coli as an inflammatory pathogen. Cell Adh Migr. 2012 Sep-Oct; 6(5):413-8. PMID: 23076052.
      View in: PubMed
    26. Boll EJ, Struve C, Sander A, Demma Z, Nataro JP, McCormick BA, Krogfelt KA. The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model. J Infect Dis. 2012 Sep 1; 206(5):714-22. PMID: 22723643.
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    27. McCormick B, Finlay B. Special edition of gut microbes. Gut Microbes. 2012 Mar-Apr; 3(2):61. PMID: 22555468.
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    28. Boll EJ, Struve C, Sander A, Demma Z, Krogfelt KA, McCormick BA. Enteroaggregative Escherichia coli promotes transepithelial migration of neutrophils through a conserved 12-lipoxygenase pathway. Cell Microbiol. 2012 Jan; 14(1):120-32. PMID: 21951973.
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    29. Agbor TA, McCormick BA. Salmonella effectors: important players modulating host cell function during infection. Cell Microbiol. 2011 Dec; 13(12):1858-69. PMID: 21902796.
      View in: PubMed
    30. Srikanth CV, Mercado-Lubo R, Hallstrom K, McCormick BA. Salmonella effector proteins and host-cell responses. Cell Mol Life Sci. 2011 Nov; 68(22):3687-97. PMID: 21984608.
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    31. Agbor TA, Demma ZC, Mumy KL, Bien JD, McCormick BA. The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection. Cell Microbiol. 2011 Dec; 13(12):2007-21. PMID: 21899702.
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    32. McCormick BA. Shigella gets captured to gain entry. Cell Host Microbe. 2011 Jun 16; 9(6):449-50. PMID: 21669393.
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    33. Hallstrom K, McCormick BA. Salmonella Interaction with and Passage through the Intestinal Mucosa: Through the Lens of the Organism. Front Microbiol. 2011; 2:88. PMID: 21747800.
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    34. Wall DM, Srikanth CV, McCormick BA. Targeting tumors with salmonella Typhimurium- potential for therapy. Oncotarget. 2010 Dec; 1(8):721-8. PMID: 21321381.
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    35. Maldonado-Contreras AL, McCormick BA. Intestinal epithelial cells and their role in innate mucosal immunity. Cell Tissue Res. 2011 Jan; 343(1):5-12. PMID: 21104188.
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    36. Hurley BP, Pirzai W, Mumy KL, Gronert K, McCormick BA. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L286-94. PMID: 21097525.
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    37. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi HN, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15; 330(6002):390-3. PMID: 20947770.
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    38. Mercado-Lubo R, McCormick BA. The interaction of gut microbes with host ABC transporters. Gut Microbes. 2010 Sep; 1(5):301-306. PMID: 21327038.
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    39. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect. 2010 Mar; 12(3):190-8. PMID: 19961952.
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    40. Mercado-Lubo R, McCormick BA. A unique subset of Peyer's patches express lysozyme. Gastroenterology. 2010 Jan; 138(1):36-9. PMID: 19932663.
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    41. Mumy KL, McCormick BA. The role of neutrophils in the event of intestinal inflammation. Curr Opin Pharmacol. 2009 Dec; 9(6):697-701. PMID: 19854677.
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    42. Figueiredo JF, Lawhon SD, Gokulan K, Khare S, Raffatellu M, Tsolis RM, Bäumler AJ, McCormick BA, Adams LG. Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. Microbes Infect. 2009 Feb; 11(2):302-10. PMID: 19114119.
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    43. Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. J Immunol. 2008 Dec 1; 181(11):8044-52. PMID: 19017997.
      View in: PubMed
    44. Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog. 2008 Nov; 4(11):e1000228. PMID: 19043560.
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    45. Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Mol Microbiol. 2009 Jan; 71(2):350-68. PMID: 19017275.
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    46. Srikanth CV, McCormick BA. Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk. Interdiscip Perspect Infect Dis. 2008; 2008:626827. PMID: 19259328.
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    47. Mumy KL, Bien JD, Pazos MA, Gronert K, Hurley BP, McCormick BA. Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. Infect Immun. 2008 Aug; 76(8):3614-27. PMID: 18505810.
      View in: PubMed
    48. Siccardi D, Mumy KL, Wall DM, Bien JD, McCormick BA. Salmonella enterica serovar Typhimurium modulates P-glycoprotein in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294(6):G1392-400. PMID: 18403618.
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    49. McCormick BA. Using Salmonella enterica serotype typhimurium to model intestinal fibrosis. Gastroenterology. 2008 Mar; 134(3):872-5. PMID: 18242605.
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    50. Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G599-609. PMID: 18032477.
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    51. Hurley BP, Sin A, McCormick BA. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. Clin Exp Immunol. 2008 Feb; 151(2):297-305. PMID: 18005361.
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    52. Zurawski DV, Mumy KL, Badea L, Prentice JA, Hartland EL, McCormick BA, Maurelli AT. The NleE/OspZ family of effector proteins is required for polymorphonuclear transepithelial migration, a characteristic shared by enteropathogenic Escherichia coli and Shigella flexneri infections. Infect Immun. 2008 Jan; 76(1):369-79. PMID: 17984206.
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    53. McCormick BA. Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. FEBS J. 2007 Jul; 274(14):3513-8. PMID: 17608718.
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    54. Prunier AL, Schuch R, Fernández RE, Mumy KL, Kohler H, McCormick BA, Maurelli AT. nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity. Microbiology. 2007 Jul; 153(Pt 7):2363-72. PMID: 17600080.
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    55. Köhler H, Sakaguchi T, Hurley BP, Kase BA, Kase BJ, Reinecker HC, McCormick BA. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G178-87. PMID: 17615177.
      View in: PubMed
    56. Wall DM, Nadeau WJ, Pazos MA, Shi HN, Galyov EE, McCormick BA. Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cell Microbiol. 2007 Sep; 9(9):2299-313. PMID: 17697195.
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    57. Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D. The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol Microbiol. 2006 Nov; 62(3):786-93. PMID: 17076670.
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    58. Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infect Immun. 2006 Oct; 74(10):5964-76. PMID: 16988276.
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    59. Salazar-Gonzalez RM, Niess JH, Zammit DJ, Ravindran R, Srinivasan A, Maxwell JR, Stoklasek T, Yadav R, Williams IR, Gu X, McCormick BA, Pazos MA, Vella AT, Lefrancois L, Reinecker HC, McSorley SJ. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity. 2006 May; 24(5):623-32. PMID: 16713979.
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    60. Canny G, Swidsinski A, McCormick BA. Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional consequences. Methods Mol Biol. 2006; 341:17-35. PMID: 16799186.
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    61. Hurley BP, Williams NL, McCormick BA. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L703-L709. PMID: 16272174.
      View in: PubMed
    62. Mumy KL, McCormick BA. Events at the host-microbial interface of the gastrointestinal tract. II. Role of the intestinal epithelium in pathogen-induced inflammation. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G854-9. PMID: 15826933.
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    63. Do T, Stephens C, Townsend K, Wu X, Chapman T, Chin J, McCormick B, Bara M, Trott DJ. Rapid identification of virulence genes in enterotoxigenic Escherichia coli isolates associated with diarrhoea in Queensland piggeries. Aust Vet J. 2005 May; 83(5):293-9. PMID: 15957392.
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    64. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005 Jan 14; 307(5707):254-8. PMID: 15653504.
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    65. Hurley BP, Siccardi D, Mrsny RJ, McCormick BA. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. J Immunol. 2004 Nov 1; 173(9):5712-20. PMID: 15494523.
      View in: PubMed
    66. Tenor JL, McCormick BA, Ausubel FM, Aballay A. Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Curr Biol. 2004 Jun 8; 14(11):1018-24. PMID: 15182677.
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    67. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795.
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    68. Silva M, Song C, Nadeau WJ, Matthews JB, McCormick BA. Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-alpha-dependent signal transduction pathway. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1024-31. PMID: 14739142.
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    69. Hurley BP, McCormick BA. Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends Microbiol. 2003 Dec; 11(12):562-9. PMID: 14659688.
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    70. Hisamatsu T, Suzuki M, Reinecker HC, Nadeau WJ, McCormick BA, Podolsky DK. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology. 2003 Apr; 124(4):993-1000. PMID: 12671896.
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    71. McCormick BA. The use of transepithelial models to examine host-pathogen interactions. Curr Opin Microbiol. 2003 Feb; 6(1):77-81. PMID: 12615224.
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    72. Köhler H, McCormick BA, Walker WA. Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr. 2003 Feb; 36(2):175-85. PMID: 12548051.
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    73. Nadeau WJ, Pistole TG, McCormick BA. Polymorphonuclear leukocyte migration across model intestinal epithelia enhances Salmonella typhimurium killing via the epithelial derived cytokine, IL-6. Microbes Infect. 2002 Nov; 4(14):1379-87. PMID: 12475628.
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    74. Köhler H, Rodrigues SP, Maurelli AT, McCormick BA. Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine. J Infect Dis. 2002 Oct 15; 186(8):1122-30. PMID: 12355363.
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    75. Sakaguchi T, Köhler H, Gu X, McCormick BA, Reinecker HC. Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Cell Microbiol. 2002 Jun; 4(6):367-81. PMID: 12067320.
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    76. Köhler H, Rodrigues SP, McCormick BA. Shigella flexneri Interactions with the Basolateral Membrane Domain of Polarized Model Intestinal Epithelium: Role of Lipopolysaccharide in Cell Invasion and in Activation of the Mitogen-Activated Protein Kinase ERK. Infect Immun. 2002 Mar; 70(3):1150-8. PMID: 11854195.
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    77. Criss AK, Silva M, Casanova JE, McCormick BA. Regulation of Salmonella-induced neutrophil transmigration by epithelial ADP-ribosylation factor 6. J Biol Chem. 2001 Dec 21; 276(51):48431-9. PMID: 11641400.
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    78. Fernandez IM, Silva M, Schuch R, Walker WA, Siber AM, Maurelli AT, McCormick BA. Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling. J Infect Dis. 2001 Sep 15; 184(6):743-53. PMID: 11517436.
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    79. Criss AK, Ahlgren DM, Jou TS, McCormick BA, Casanova JE. The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells. J Cell Sci. 2001 Apr; 114(Pt 7):1331-41. PMID: 11256999.
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    80. Lee CA, Silva M, Siber AM, Kelly AJ, Galyov E, McCormick BA. A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12283-8. PMID: 11050248.
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    81. Cherayil BJ, McCormick BA, Bosley J. Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2. Infect Immun. 2000 Oct; 68(10):5567-74. PMID: 10992455.
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    82. Wood MW, Jones MA, Watson PR, Siber AM, McCormick BA, Hedges S, Rosqvist R, Wallis TS, Galyov EE. The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritis. Cell Microbiol. 2000 Aug; 2(4):293-303. PMID: 11207586.
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    83. Allen JH, Utley M, van Den Bosch H, Nuijten P, Witvliet M, McCormick BA, Krogfelt KA, Licht TR, Brown D, Mauel M, Leatham MP, Laux DC, Cohen PS. A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice. Infect Immun. 2000 Jun; 68(6):3772-5. PMID: 10816546.
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    84. McCormick BA, Fernandez MI, Siber AM, Maurelli AT. Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine. Cell Microbiol. 1999 Sep; 1(2):143-55. PMID: 11207548.
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    85. Gewirtz AT, Siber AM, Madara JL, McCormick BA. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infect Immun. 1999 Feb; 67(2):608-17. PMID: 9916066.
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    86. McCormick BA, Siber AM, Maurelli AT. Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium. Infect Immun. 1998 Sep; 66(9):4237-43. PMID: 9712773.
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    87. Shaw SK, Hermanowski-Vosatka A, Shibahara T, McCormick BA, Parkos CA, Carlson SL, Ebert EC, Brenner MB, Madara JL. Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer. Am J Physiol. 1998 Sep; 275(3 Pt 1):G584-91. PMID: 9724272.
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    88. Gewirtz AT, McCormick B, Neish AS, Petasis NA, Gronert K, Serhan CN, Madara JL. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. J Clin Invest. 1998 May 1; 101(9):1860-9. PMID: 9576749.
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    89. McCormick BA, Parkos CA, Colgan SP, Carnes DK, Madara JL. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J Immunol. 1998 Jan 1; 160(1):455-66. PMID: 9552004.
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    90. McCormick BA, Nusrat A, Parkos CA, D'Andrea L, Hofman PM, Carnes D, Liang TW, Madara JL. Unmasking of intestinal epithelial lateral membrane beta1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yersinia pseudotuberculosis. Infect Immun. 1997 Apr; 65(4):1414-21. PMID: 9119482.
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    91. McCormick BA, Hofman PM, Kim J, Carnes DK, Miller SI, Madara JL. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils. J Cell Biol. 1995 Dec; 131(6 Pt 1):1599-608. PMID: 8522615.
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    92. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993 Nov; 123(4):895-907. PMID: 8227148.
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    93. McCormick BA, Klemm P, Krogfelt KA, Burghoff RL, Pallesen L, Laux DC, Cohen PS. Escherichia coli F-18 phase locked 'on' for expression of type 1 fimbriae is a poor colonizer of the streptomycin-treated mouse large intestine. Microb Pathog. 1993 Jan; 14(1):33-43. PMID: 8100608.
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    94. Krogfelt KA, McCormick BA, Burghoff RL, Laux DC, Cohen PS. Expression of Escherichia coli F-18 type 1 fimbriae in the streptomycin-treated mouse large intestine. Infect Immun. 1991 Apr; 59(4):1567-8. PMID: 1672304.
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    95. McCormick BA, Franklin DP, Laux DC, Cohen PS. Type 1 pili are not necessary for colonization of the streptomycin-treated mouse large intestine by type 1-piliated Escherichia coli F-18 and E. coli K-12. Infect Immun. 1989 Oct; 57(10):3022-9. PMID: 2570752.
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    96. McCormick BA, Stocker BA, Laux DC, Cohen PS. Roles of motility, chemotaxis, and penetration through and growth in intestinal mucus in the ability of an avirulent strain of Salmonella typhimurium to colonize the large intestine of streptomycin-treated mice. Infect Immun. 1988 Sep; 56(9):2209-17. PMID: 3044995.
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