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Vanni Bucci PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMicrobiology
AddressUMass Chan Medical School
368 Plantation Street AS8-2057
Worcester MA 01605
Phone774-455-3854
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Microbial Dynamics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentSystems Biology


    Collapse Biography 
    Collapse education and training
    University of Florence, Florence, , ItalyBSEnvironmental Engineering
    Northeastern University, Boston, MA, United StatesMSCivil Engineering
    Northeastern University, Boston, MA, United StatesPHDCivil Engineering

    Collapse Overview 
    Collapse Summary
    Focus: Host-microbiome interaction, computational biology, synthetic biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bradley ES, Stansky C, Zeamer AL, Huang Z, Cincotta L, Lopes A, Potter L, Fontes T, Ward DV, Bucci V, McCormick BA, Haran JP. The urinary microbiome distinguishes symptomatic urinary tract infection from asymptomatic older adult patients presenting to the emergency department. Virulence. 2025 Dec; 16(1):2546063. PMID: 40782046.
      Citations:    
    2. Haran JP, Barrett AM, Lai Y, Odjidja SN, Dutta P, McGrath PM, Samari I, Romeiro L, Lopes A, Bucci V, McCormick BA. Executive functioning and processing speed as predictors of global cognitive decline in Alzheimer's disease. J Alzheimers Dis Rep. 2025 Jan-Dec; 9:25424823251363549. PMID: 40786525.
      Citations:    
    3. Bhattarai SK, Bucci V, Mortzfeld BM. Ec W: A Novel Narrow-Spectrum Class IIb Microcin from Escherichia coli. Probiotics Antimicrob Proteins. 2025 Apr 24. PMID: 40272760.
      Citations:    
    4. Huang Z, Li Y, Bucci V, Haran JP. Decoding cancer prognosis with deep learning: the ASD-cancer framework for tumor microenvironment analysis. mSystems. 2025 May 20; 10(5):e0145524. PMID: 40237527.
      Citations:    
    5. Zeamer AL, Lai Y, Sanborn V, Loew E, Tracy M, Jo C, Ward DV, Bhattarai SK, Drake J, McCormick BA, Bucci V, Haran JP. Microbiome functional gene pathways predict cognitive performance in older adults with Alzheimer's disease. bioRxiv. 2025 Mar 10. PMID: 40161798.
      Citations:    
    6. Menon R, Bhattarai SK, Crossette E, Prince AL, Olle B, Silber JL, Bucci V, Faith J, Norman JM. Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection. Nat Med. 2025 Jan; 31(1):223-234. PMID: 39747680.
      Citations:    
    7. Mortzfeld BM, Bhattarai SK, Bucci V. Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens. Elife. 2024 Dec 11; 13. PMID: 39660611.
      Citations:    
    8. Kellogg TD, Ceglia S, Mortzfeld BM, Tanna TM, Zeamer AL, Mancini MR, Foley SE, Ward DV, Bhattarai SK, McCormick BA, Reboldi A, Bucci V. Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile. J Exp Med. 2025 Jan 06; 222(1). PMID: 39589553.
      Citations:    
    9. Haran JP, Barrett AM, Lai Y, Odjidja SN, Dutta P, McGrath PM, Samari I, Romeiro L, Lopes A, Bucci V, McCormick BA. Executive Functioning and Processing Speed as Predictors of Global Cognitive Decline in Alzheimer Disease. medRxiv. 2024 Nov 02. PMID: 39574871.
      Citations:    
    10. van Lingen E, Nooij S, Terveer EM, Crossette E, Prince AL, Bhattarai SK, Watson A, Galazzo G, Menon R, Szabady RL, Bucci V, Norman JM, van der Woude CJ, van der Marel S, Verspaget HW, van der Meulen-de Jong AE, Keller JJ. Faecal Microbiota Transplantation Engraftment After Budesonide or Placebo in Patients With Active Ulcerative Colitis Using Pre-selected Donors: A Randomized Pilot Study. J Crohns Colitis. 2024 Sep 03; 18(9):1381-1393. PMID: 38572716.
      Citations:    
    11. Heston SM, Young RR, Jenkins K, Martin PL, Stokhuyzen A, Ward DV, Bhattarai SK, Bucci V, Arshad M, Chao NJ, Seed PC, Kelly MS. The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children. Gut Microbes. 2024 Jan-Dec; 16(1):2333748. PMID: 38555499.
      Citations:    
    12. Kellogg TD, Ceglia S, Mortzfeld BM, Zeamer AL, Foley SE, Ward DV, Bhattarai SK, McCormick BA, Reboldi A, Bucci V. Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine. bioRxiv. 2024 Jan 31. PMID: 38352546.
      Citations:    
    13. Bhattarai SK, Du M, Zeamer AL, M Morzfeld B, Kellogg TD, Firat K, Benjamin A, Bean JM, Zimmerman M, Mardi G, Vilbrun SC, Walsh KF, Fitzgerald DW, Glickman MS, Bucci V. Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption. Sci Transl Med. 2024 01 17; 16(730):eadi9711. PMID: 38232140.
      Citations:    
    14. Zeamer AL, Salive MC, An X, Beaudoin FL, House SL, Stevens JS, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Rauch SL, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Kessler RC, Koenen KC, McLean SA, Bucci V, Haran JP. Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure. Transl Psychiatry. 2023 11 18; 13(1):354. PMID: 37980332.
      Citations: 1     Fields:    Translation:Humans
    15. Honda K, Furuichi M, Kawaguchi T, Pust MM, Yasuma-Mitobe K, Plichta D, Hasegawa N, Ohya T, Bhattarai S, Sasajima S, Yoshimasa A, Tuganbaev T, Yaginuma M, Ueda M, Okahashi N, Amafuji K, Kiridooshi Y, Sugita K, Stra?ar M, Skelly A, Suda W, Hattori M, Nakamoto N, Caballero S, Norman J, Olle B, Tanoue T, Arita M, Bucci V, Atarashi K, Xavier R. Rationally-defined microbial consortia suppress multidrug-resistant proinflammatory Enterobacteriaceae via ecological control. Res Sq. 2023 Oct 23. PMID: 37961431.
      Citations:    
    16. Bucci V, Ward DV, Bhattarai S, Rojas-Correa M, Purkayastha A, Holler D, Qu MD, Mitchell WG, Yang J, Fountain S, Zeamer A, Forconi CS, Fujimori G, Odwar B, Cawley C, Moormann AM, Wessolossky M, Maldonado-Contreras A. The intestinal microbiota predicts COVID-19 severity and fatality regardless of hospital feeding method. mSystems. 2023 08 31; 8(4):e0031023. PMID: 37548476.
      Citations:    Fields:    Translation:HumansCells
    17. Leftwich HK, Vargas-Robles D, Rojas-Correa M, Yap YR, Bhattarai S, Ward DV, Fujimori G, Forconi CS, Yeboah T, Carter A, Kastrinakis A, Asirwatham AM, Bucci V, Moormann AM, Maldonado-Contreras A. The microbiota of pregnant women with SARS-CoV-2 and their infants. Microbiome. 2023 06 26; 11(1):141. PMID: 37365606.
      Citations:    Fields:    Translation:HumansCells
    18. Ceglia S, Berthelette A, Howley K, Li Y, Mortzfeld B, Bhattarai SK, Yiew NKH, Xu Y, Brink R, Cyster JG, Hooper LV, Randolph GJ, Bucci V, Reboldi A. An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells. Nat Immunol. 2023 03; 24(3):531-544. PMID: 36658240.
      Citations: 9     Fields:    Translation:AnimalsCells
    19. Bradley ES, Zeamer AL, Bucci V, Cincotta L, Salive MC, Dutta P, Mutaawe S, Anya O, Tocci C, Moormann A, Ward DV, McCormick BA, Haran JP. Oropharyngeal microbiome profiled at admission is predictive of the need for respiratory support among COVID-19 patients. Front Microbiol. 2022; 13:1009440. PMID: 36246273.
      Citations:    
    20. Maringanti VS, Bucci V, Gerber GK. MDITRE: Scalable and Interpretable Machine Learning for Predicting Host Status from Temporal Microbiome Dynamics. mSystems. 2022 10 26; 7(5):e0013222. PMID: 36069455.
      Citations:    
    21. Bradley ES, Schell B, Ward DV, Bucci V, Zeamer A, Haran JP. The Urinary Microbiome of Older Adults Residing in a Nursing Home Varies With Duration of Residence and Shows Increases in Potential Pathogens. J Gerontol A Biol Sci Med Sci. 2022 07 05; 77(7):1313-1320. PMID: 34791238.
      Citations: 2     Fields:    Translation:Humans
    22. Dsouza M, Menon R, Crossette E, Bhattarai SK, Schneider J, Kim YG, Reddy S, Caballero S, Felix C, Cornacchione L, Hendrickson J, Watson AR, Minot SS, Greenfield N, Schopf L, Szabady R, Patarroyo J, Smith W, Harrison P, Kuijper EJ, Kelly CP, Olle B, Bobilev D, Silber JL, Bucci V, Roberts B, Faith J, Norman JM. Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers. Cell Host Microbe. 2022 04 13; 30(4):583-598.e8. PMID: 35421353.
      Citations:    
    23. Bradley ES, Zeamer AL, Bucci V, Cincotta L, Salive MC, Dutta P, Mutaawe S, Anya O, Tocci C, Moormann A, Ward DV, McCormick BA, Haran JP. Oropharyngeal Microbiome Profiled at Admission is Predictive of the Need for Respiratory Support Among COVID-19 Patients. medRxiv. 2022 Feb 28. PMID: 35262096.
      Citations:    
    24. Mortzfeld BM, Palmer JD, Bhattarai SK, Dupre HL, Mercado-Lubio R, Silby MW, Bang C, McCormick BA, Bucci V. Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic. Gut Microbes. 2022 Jan-Dec; 14(1):2127633. PMID: 36175830.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Olendzki B, Bucci V, Cawley C, Maserati R, McManus M, Olednzki E, Madziar C, Chiang D, Ward DV, Pellish R, Foley C, Bhattarai S, McCormick BA, Maldonado-Contreras A. Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study. Gut Microbes. 2022 Jan-Dec; 14(1):2046244. PMID: 35311458.
      Citations: 15     Fields:    Translation:Humans
    26. Haran JP, Bradley E, Zeamer AL, Cincotta L, Salive MC, Dutta P, Mutaawe S, Anya O, Meza-Segura M, Moormann AM, Ward DV, McCormick BA, Bucci V. Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID. JCI Insight. 2021 10 22; 6(20). PMID: 34403368.
      Citations: 68     Fields:    Translation:HumansCells
    27. Haran JP, Zeamer A, Ward DV, Dutta P, Bucci V, McCormick BA. The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and Is Influenced by Medication Exposures, Age, Environment, and Frailty. J Gerontol A Biol Sci Med Sci. 2021 10 13; 76(11):1930-1938. PMID: 34125200.
      Citations: 6     Fields:    Translation:Humans
    28. Neto CC, Mortzfeld BM, Turbitt JR, Bhattarai SK, Yeliseyev V, DiBenedetto N, Bry L, Bucci V. Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model. Microb Cell. 2021 Apr 29; 8(6):131-142. PMID: 34055966.
      Citations:    
    29. Wipperman MF, Bhattarai SK, Vorkas CK, Maringati VS, Taur Y, Mathurin L, McAulay K, Vilbrun SC, Francois D, Bean J, Walsh KF, Nathan C, Fitzgerald DW, Glickman MS, Bucci V. Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis. Nat Commun. 2021 02 18; 12(1):1141. PMID: 33602926.
      Citations:    
    30. Haran JP, Ward DV, Bhattarai SK, Loew E, Dutta P, Higgins A, McCormick BA, Bucci V. The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome. Gut Microbes. 2021 Jan-Dec; 13(1):1-15. PMID: 33764826.
      Citations: 2     Fields:    Translation:HumansCells
    31. Mallick H, Bucci V, An L. Editorial: Statistical and Computational Methods for Microbiome Multi-Omics Data. Front Genet. 2020; 11:927. PMID: 33061936.
      Citations:    
    32. Simmons EL, Bond MC, Koskella B, Drescher K, Bucci V, Nadell CD. Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria. mSystems. 2020 Jun 23; 5(3). PMID: 32576653.
      Citations:    
    33. Palmer JD, Mortzfeld BM, Piattelli E, Silby MW, McCormick BA, Bucci V. Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant Enterobacteriaceae. ACS Infect Dis. 2020 04 10; 6(4):672-679. PMID: 32096972.
      Citations: 17     Fields:    Translation:Cells
    34. Kelly MS, Ward DV, Severyn CJ, Arshad M, Heston SM, Jenkins K, Martin PL, McGill L, Stokhuyzen A, Bhattarai SK, Bucci V, Seed PC. Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients. Biol Blood Marrow Transplant. 2019 11; 25(11):2274-2280. PMID: 31326608.
      Citations: 22     Fields:    Translation:HumansCells
    35. Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, McCormick BA. Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway. mBio. 2019 05 07; 10(3). PMID: 31064831.
      Citations: 140     Fields:    Translation:HumansCells
    36. Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019 01; 565(7741):600-605. PMID: 30675064.
      Citations:    
    37. Vorkas CK, Wipperman MF, Li K, Bean J, Bhattarai SK, Adamow M, Wong P, Aub? J, Juste MAJ, Bucci V, Fitzgerald DW, Glickman MS. Mucosal-associated invariant and ?d T cell subsets respond to initial Mycobacterium tuberculosis infection. JCI Insight. 2018 10 04; 3(19). PMID: 30282828.
      Citations:    
    38. Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 2018 06 19; 48(6):1245-1257.e9. PMID: 29858010.
      Citations:    
    39. Stein RR, Tanoue T, Szabady RL, Bhattarai SK, Olle B, Norman JM, Suda W, Oshima K, Hattori M, Gerber GK, Sander C, Honda K, Bucci V. Computer-guided design of optimal microbial consortia for immune system modulation. Elife. 2018 04 17; 7. PMID: 29664397.
      Citations:    
    40. Haran JP, Bucci V, Dutta P, Ward D, McCormick B. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location. J Med Microbiol. 2018 Jan; 67(1):40-51. PMID: 29134939.
      Citations: 42     Fields:    Translation:HumansCells
    41. Simmons EL, Drescher K, Nadell CD, Bucci V. Phage mobility is a core determinant of phage-bacteria coexistence in biofilms. ISME J. 2018 02; 12(2):531-543. PMID: 29125597.
      Citations:    
    42. Palmer JD, Piattelli E, McCormick BA, Silby MW, Brigham CJ, Bucci V. Engineered Probiotic for the Inhibition of Salmonella via Tetrathionate-Induced Production of Microcin H47. ACS Infect Dis. 2018 01 12; 4(1):39-45. PMID: 28918634.
      Citations: 40     Fields:    Translation:Cells
    43. Wipperman MF, Fitzgerald DW, Juste MAJ, Taur Y, Namasivayam S, Sher A, Bean JM, Bucci V, Glickman MS. Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed. Sci Rep. 2017 09 07; 7(1):10767. PMID: 28883399.
      Citations:    
    44. Bucci V, Tzen B, Li N, Simmons M, Tanoue T, Bogart E, Deng L, Yeliseyev V, Delaney ML, Liu Q, Olle B, Stein RR, Honda K, Bry L, Gerber GK. MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses. Genome Biol. 2016 06 03; 17(1):121. PMID: 27259475.
      Citations:    
    45. Haran JP, Wu G, Bucci V, Fischer A, Boyer EW, Hibberd PL. Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice. Am J Emerg Med. 2015 Dec; 33(12):1780-5. PMID: 26381681.
      Citations: 3     Fields:    Translation:Humans
    46. Carter BD, Abnet CC, Feskanich D, Freedman ND, Hartge P, Lewis CE, Ockene JK, Prentice RL, Speizer FE, Thun MJ, Jacobs EJ. Smoking and mortality--beyond established causes. N Engl J Med. 2015 Feb 12; 372(7):631-40. PMID: 24727124.
      Citations:    
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