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Beth A McCormick PhD

TitleProfessor
Endowed TitleWorcester Foundation for Biomedical Research Chair II
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North AS8-2049
Worcester MA 01655
Phone508-856-6048
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Microbial Dynamics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    University of New Hampshire Durham, Durham, NH, United StatesBAArts
    University of Rhode Island, Kingston, RI, United StatesPHDMicrobiology

    Collapse Overview 
    Collapse Summary
    Focus: Mucosal inflammation, host: pathogen interactions, and cancer biology
    Collapse overview

    Beth McCormickB.A. University of New Hampshire
    Ph.D. University of Rhode Island
    Post-doctoral training Harvard Medical School

    Research Summary:

    Work in my laboratory is centered around three major research programs: Mucosal inflammation, host:pathogen interactions, and cancer biology.

    Image 1The objective of the mucosal inflammatory program is to investigate the molecular mechanisms by which bacterial pathogens induce mucosal inflammation at sites of the intestinal and respiratory epithelium. This work is based on longstanding pathologic observations that attachment of an array of bacterial pathogens to epithelial surfaces is accompanied by recruitment of host defense cells, as manifested by neutrophil infiltration of the epithelium. While neutrophils and their responses in the context of an inflammatory response are integral to the control of bacterial infection, when their responses become excessive or unregulated, injury to the host tissues ensues. To understand what goes awry under pathologic conditions, we originally used Salmonella typhimurium as a prototypical enteric pathogen to study the transepithelial migration of neutrophils across intestinal epithelia, a hallmark of gastroenteritis. This research effort has been expanded to include the following intestinal and lung pathogens: Shigella flexneri, E. coli, Pseudomonas aeruginosa, and S. pneumoniae. In response to these pathogens we have discovered a novel inflammatory signaling cascade in which epithelial cells lining mucosal surfaces release the potent neutrophil chemoattractant hepoxilin A3, (HXA3). HXA3 functions as the “gate keeper” of the mucosal epithelium, as it emanates from the site of infection to establish a chemotactic gradient that guides neutrophils across mucosal surfaces. We are now investigating the mechanisms that orchestrate the synthesis/release of HXA3 for the design of more targeted and effective anti-inflammatory therapies for the treatment of infectious, allergic, and idiopathic mucosal inflammatory conditions (i.e., salmonellosis, shigellosis, inflammatory bowel diseases, pneumonia, cystic fibrosis, and chronic obstructive pulmonary disease).

    SopA StructureThe second research program in my laboratory is centered on the study of host-pathogen interactions. Specifically, we investigate strategies used by enteric and respiratory pathogens to induce proinflammatory responses. Using S. typhimurium as an example, we have uncovered a novel mechanism by which this pathogen sabotages host defense mechanisms. Salmonella tricks the host into synthesizing and secreting the apoptotic enzyme caspase-3, diverting this host enzyme to its own use. The Salmonella effector protein SipA has amino acid motifs that are recognized by caspase-3, which cleaves the bacterial protein into active virulence effectors: one stimulates actin polymerization to help cell entry and the other induces inflammation. If the caspase motif contains a single-point mutation, then virulence is lost in mouse models of infection. This straregy isn’t limited to SipA. Other proteins that are injected by Salmonella, such as SopA (see crystal structure) and those from other gut bacteria like E. coli and Shigella flexneri, also carry targets for caspase-3, demonstrating the broad significance of this finding. This discovery unveils a new paradigm in the field of bacterial pathogenesis and opens the door to novel investigation on the tactics used by bacterial pathogens to promote disease.

    Colonic TumorThe third research program in my laboratory is focused on cancer biology. My original interest in this field of study was cultivated by the observation that Salmonella is able to preferentially locate to sites of tumor growth (achieving tumor/normal tissue ratios of approximately 1,000:1). Work in my laboratory has shown that Salmonella causes a profound reduction on the multidrug resistance (MDR) transporter P-glycoprotein (Pgp) in colon cancer cells. Pgp over-expression is one form of the MDR phenotype that is commonly acquired by cancer patients initially responsive to chemotherapy. We are interested in uncovering the mechanism used by Salmonella to downregulate Pgp. The ultimate goal of this work is to exploit Salmonella for the development of a new and robust class of multidrug resistance inhibitors designed as an adjuvant to chemotherapeutics for cancers that are known to express high levels of Pgp, such as colorectal cancers and breast cancer.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Grey MJ, De Luca H, Ward DV, Kreulen IA, Bugda Gwilt K, Foley SE, Thiagarajah JR, McCormick BA, Turner JR, Lencer WI. The epithelial-specific ER stress sensor ERN2/IRE1? enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 09 01; 132(17). PMID: 35727638.
      Citations:    Fields:    
    2. Shi Q, Herbert C, Ward DV, Simin K, McCormick BA, Ellison Iii RT, Zai AH. COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study. JMIR Form Res. 2022 Jun 13; 6(6):e37858. PMID: 35658093.
      Citations:    
    3. Bradley ES, Zeamer AL, Bucci V, Cincotta L, Salive MC, Dutta P, Mutaawe S, Anya O, Tocci C, Moormann A, Ward DV, McCormick BA, Haran JP. Oropharyngeal Microbiome Profiled at Admission is Predictive of the Need for Respiratory Support Among COVID-19 Patients. medRxiv. 2022 Feb 28. PMID: 35262096.
      Citations:    
    4. Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022 11; 71(11):2233-2252. PMID: 35017199.
      Citations: 1     Fields:    
    5. Olendzki B, Bucci V, Cawley C, Maserati R, McManus M, Olednzki E, Madziar C, Chiang D, Ward DV, Pellish R, Foley C, Bhattarai S, McCormick BA, Maldonado-Contreras A. Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study. Gut Microbes. 2022 Jan-Dec; 14(1):2046244. PMID: 35311458.
      Citations:    Fields:    Translation:Humans
    6. Meza-Segura M, Birtley JR, Maldonado-Contreras A, Mueller C, Simin KJ, Stern LJ, McCormick BA. SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant. mBio. 2021 12 21; 12(6):e0283321. PMID: 34724811.
      Citations: 2     Fields:    Translation:HumansCells
    7. Haran JP, Bradley E, Zeamer AL, Cincotta L, Salive MC, Dutta P, Mutaawe S, Anya O, Meza-Segura M, Moormann AM, Ward DV, McCormick BA, Bucci V. Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID. JCI Insight. 2021 10 22; 6(20). PMID: 34403368.
      Citations: 7     Fields:    Translation:HumansCells
    8. Haran JP, Zeamer A, Ward DV, Dutta P, Bucci V, McCormick BA. The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and Is Influenced by Medication Exposures, Age, Environment, and Frailty. J Gerontol A Biol Sci Med Sci. 2021 10 13; 76(11):1930-1938. PMID: 34125200.
      Citations:    Fields:    Translation:Humans
    9. Foley SE, Tuohy C, Dunford M, Grey MJ, De Luca H, Cawley C, Szabady RL, Maldonado-Contreras A, Houghton JM, Ward DV, Mrsny RJ, McCormick BA. Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis. Microbiome. 2021 09 07; 9(1):183. PMID: 34493329.
      Citations: 1     Fields:    Translation:HumansAnimals
    10. Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 06 08; 54(6):1137-1153.e8. PMID: 34051146.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    11. Haran JP, Ward DV, Bhattarai SK, Loew E, Dutta P, Higgins A, McCormick BA, Bucci V. The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome. Gut Microbes. 2021 Jan-Dec; 13(1):1-15. PMID: 33764826.
      Citations:    Fields:    Translation:HumansCells
    12. McCormick BA, Chang EB. The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine. Gastroenterology. 2021 01; 160(2):479-482. PMID: 33382981.
      Citations: 1     Fields:    Translation:Humans
    13. Haran JP, McCormick BA. Aging, Frailty, and the Microbiome-How Dysbiosis Influences Human Aging and Disease. Gastroenterology. 2021 01; 160(2):507-523. PMID: 33307030.
      Citations: 9     Fields:    Translation:HumansAnimals
    14. Palmer JD, Mortzfeld BM, Piattelli E, Silby MW, McCormick BA, Bucci V. Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant Enterobacteriaceae. ACS Infect Dis. 2020 04 10; 6(4):672-679. PMID: 32096972.
      Citations: 5     Fields:    Translation:Cells
    15. Daniel VT, Francalancia S, Amir NS, Ayturk MD, Sanders SB, Wisler JR, Collins CE, Ward DV, Kiefe CI, McCormick BA, Santry HP. Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse. J Gastrointest Surg. 2020 12; 24(12):2730-2736. PMID: 31845145.
      Citations:    Fields:    Translation:Humans
    16. Adams W, Bhowmick R, Bou Ghanem EN, Wade K, Shchepetov M, Weiser JN, McCormick BA, Tweten RK, Leong JM. Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. J Immunol. 2020 01 01; 204(1):101-111. PMID: 31776202.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, McCormick BA. Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway. mBio. 2019 05 07; 10(3). PMID: 31064831.
      Citations: 77     Fields:    Translation:HumansCells
    18. Patel S, Wall DM, Castillo A, McCormick BA. Caspase-3 cleavage of Salmonella type III secreted effector protein SifA is required for localization of functional domains and bacterial dissemination. Gut Microbes. 2019; 10(2):172-187. PMID: 30727836.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    19. Szabady RL, Louissaint C, Lubben A, Xie B, Reeksting S, Tuohy C, Demma Z, Foley SE, Faherty CS, Llanos-Chea A, Olive AJ, Mrsny RJ, McCormick BA. Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis. J Clin Invest. 2018 08 31; 128(9):4044-4056. PMID: 30102254.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA. Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere. 2018 07 05; 3(4). PMID: 29976647.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Daniel VT, Ayturk D, Ward DV, McCormick BA, Santry HP. The influence of payor status on outcomes associated with surgical repair of upper gastrointestinal perforations due to peptic ulcer disease in the United States. Am J Surg. 2019 01; 217(1):121-125. PMID: 30017307.
      Citations: 1     Fields:    Translation:Humans
    22. Haran JP, Bucci V, Dutta P, Ward D, McCormick B. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location. J Med Microbiol. 2018 Jan; 67(1):40-51. PMID: 29134939.
      Citations: 28     Fields:    Translation:HumansCells
    23. Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA. Cytosolic Phospholipase A2? Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection. Infect Immun. 2017 11; 85(11). PMID: 28808157.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Palmer JD, Piattelli E, McCormick BA, Silby MW, Brigham CJ, Bucci V. Engineered Probiotic for the Inhibition of Salmonella via Tetrathionate-Induced Production of Microcin H47. ACS Infect Dis. 2018 01 12; 4(1):39-45. PMID: 28918634.
      Citations: 24     Fields:    Translation:Cells
    25. McIntosh A, Meikle LM, Ormsby MJ, McCormick BA, Christie JM, Brewer JM, Roberts M, Wall DM. SipA Activation of Caspase-3 Is a Decisive Mediator of Host Cell Survival at Early Stages of Salmonella enterica Serovar Typhimurium Infection. Infect Immun. 2017 09; 85(9). PMID: 28630067.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    26. Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA. Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation. Gut Microbes. 2017 11 02; 8(6):544-560. PMID: 28598765.
      Citations: 17     Fields:    Translation:HumansCells
    27. Boll EJ, Ayala-Lujan J, Szabady RL, Louissaint C, Smith RZ, Krogfelt KA, Nataro JP, Ruiz-Perez F, McCormick BA. Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1. mBio. 2017 06 06; 8(3). PMID: 28588132.
      Citations: 16     Fields:    Translation:HumansCells
    28. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15; 2:17072. PMID: 28504669.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    29. Mercado-Lubo R, McCormick BA. Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance? Nanomedicine (Lond). 2017 04; 12(7):705-710. PMID: 28322607.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Mercado-Lubo R, Zhang Y, Zhao L, Rossi K, Wu X, Zou Y, Castillo A, Leonard J, Bortell R, Greiner DL, Shultz LD, Han G, McCormick BA. A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun. 2016 07 25; 7:12225. PMID: 27452236.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    31. Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI. Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30. PMID: 26864627.
      Citations: 4     Fields:    Translation:HumansCells
    32. Hallstrom KN, McCormick BA. The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection. Gut Microbes. 2016; 7(2):136-45. PMID: 27078059.
      Citations: 8     Fields:    Translation:HumansCells
    33. McCormick BA. ELMO1: More Than Just a Director of Phagocytosis. Cell Mol Gastroenterol Hepatol. 2015 May; 1(3):262-263. PMID: 28210678.
      Citations: 4     Fields:    
    34. Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA. PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. 2015 Jun; 17(6):843-59. PMID: 25486861.
      Citations: 7     Fields:    Translation:HumansCells
    35. Wall DM, McCormick BA. Bacterial secreted effectors and caspase-3 interactions. Cell Microbiol. 2014 Dec; 16(12):1746-56. PMID: 25262664.
      Citations: 22     Fields:    Translation:Cells
    36. Patel S, McCormick BA. Mucosal Inflammatory Response to Salmonella typhimurium Infection. Front Immunol. 2014; 5:311. PMID: 25071772.
      Citations: 30     Fields:    
    37. Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM. The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cell Microbiol. 2014 Sep; 16(9):1405-24. PMID: 24780054.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    38. Agbor TA, Demma Z, Mrsny RJ, Castillo A, Boll EJ, McCormick BA. The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. Cell Microbiol. 2014 Sep; 16(9):1339-53. PMID: 24617613.
      Citations: 7     Fields:    Translation:HumansCells
    39. Bhowmick R, Maung N, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol. 2013 Nov 15; 191(10):5115-23. PMID: 24089193.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    40. Szabady RL, McCormick BA. Control of neutrophil inflammation at mucosal surfaces by secreted epithelial products. Front Immunol. 2013; 4:220. PMID: 23914188.
      Citations: 29     Fields:    
    41. Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM. Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infect Dis Clin North Am. 2013 Sep; 27(3):631-49. PMID: 24011834.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    42. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. PMID: 23045615.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    43. Boll EJ, McCormick BA. A new understanding of enteroaggregative Escherichia coli as an inflammatory pathogen. Cell Adh Migr. 2012 Sep-Oct; 6(5):413-8. PMID: 23076052.
      Citations: 3     Fields:    Translation:HumansCells
    44. Boll EJ, Struve C, Sander A, Demma Z, Nataro JP, McCormick BA, Krogfelt KA. The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model. J Infect Dis. 2012 Sep 01; 206(5):714-22. PMID: 22723643.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    45. McCormick B, Finlay B. Special edition of gut microbes. Gut Microbes. 2012 Mar-Apr; 3(2):61. PMID: 22555468.
      Citations:    Fields:    Translation:HumansAnimalsCells
    46. Boll EJ, Struve C, Sander A, Demma Z, Krogfelt KA, McCormick BA. Enteroaggregative Escherichia coli promotes transepithelial migration of neutrophils through a conserved 12-lipoxygenase pathway. Cell Microbiol. 2012 Jan; 14(1):120-32. PMID: 21951973.
      Citations: 24     Fields:    Translation:HumansCells
    47. Agbor TA, McCormick BA. Salmonella effectors: important players modulating host cell function during infection. Cell Microbiol. 2011 Dec; 13(12):1858-69. PMID: 21902796.
      Citations: 62     Fields:    Translation:HumansCells
    48. Srikanth CV, Mercado-Lubo R, Hallstrom K, McCormick BA. Salmonella effector proteins and host-cell responses. Cell Mol Life Sci. 2011 Nov; 68(22):3687-97. PMID: 21984608.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    49. Agbor TA, Demma ZC, Mumy KL, Bien JD, McCormick BA. The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection. Cell Microbiol. 2011 Dec; 13(12):2007-21. PMID: 21899702.
      Citations: 14     Fields:    Translation:HumansCells
    50. McCormick BA. Shigella gets captured to gain entry. Cell Host Microbe. 2011 Jun 16; 9(6):449-50. PMID: 21669393.
      Citations:    Fields:    Translation:HumansCells
    51. Hallstrom K, McCormick BA. Salmonella Interaction with and Passage through the Intestinal Mucosa: Through the Lens of the Organism. Front Microbiol. 2011; 2:88. PMID: 21747800.
      Citations:    
    52. Wall DM, Srikanth CV, McCormick BA. Targeting tumors with salmonella Typhimurium- potential for therapy. Oncotarget. 2010 Dec; 1(8):721-8. PMID: 21321381.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    53. Maldonado-Contreras AL, McCormick BA. Intestinal epithelial cells and their role in innate mucosal immunity. Cell Tissue Res. 2011 Jan; 343(1):5-12. PMID: 21104188.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    54. Hurley BP, Pirzai W, Mumy KL, Gronert K, McCormick BA. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L286-94. PMID: 21097525.
      Citations: 20     Fields:    Translation:HumansCells
    55. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15; 330(6002):390-393. PMID: 20947770.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    56. Mercado-Lubo R, McCormick BA. The interaction of gut microbes with host ABC transporters. Gut Microbes. 2010 Sep; 1(5):301-306. PMID: 21327038.
      Citations: 9     Fields:    
    57. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect. 2010 Mar; 12(3):190-8. PMID: 19961952.
      Citations: 10     Fields:    Translation:HumansCells
    58. Mercado-Lubo R, McCormick BA. A unique subset of Peyer's patches express lysozyme. Gastroenterology. 2010 Jan; 138(1):36-9. PMID: 19932663.
      Citations: 2     Fields:    Translation:HumansAnimals
    59. Mumy KL, McCormick BA. The role of neutrophils in the event of intestinal inflammation. Curr Opin Pharmacol. 2009 Dec; 9(6):697-701. PMID: 19854677.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    60. Figueiredo JF, Lawhon SD, Gokulan K, Khare S, Raffatellu M, Tsolis RM, Bäumler AJ, McCormick BA, Adams LG. Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. Microbes Infect. 2009 Feb; 11(2):302-10. PMID: 19114119.
      Citations: 14     Fields:    Translation:HumansCells
    61. Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. J Immunol. 2008 Dec 01; 181(11):8044-52. PMID: 19017997.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    62. Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog. 2008 Nov; 4(11):e1000228. PMID: 19043560.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    63. Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Mol Microbiol. 2009 Jan; 71(2):350-68. PMID: 19017275.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    64. Srikanth CV, McCormick BA. Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk. Interdiscip Perspect Infect Dis. 2008; 2008:626827. PMID: 19259328.
      Citations:    
    65. Mumy KL, Bien JD, Pazos MA, Gronert K, Hurley BP, McCormick BA. Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. Infect Immun. 2008 Aug; 76(8):3614-27. PMID: 18505810.
      Citations: 28     Fields:    Translation:HumansCells
    66. Siccardi D, Mumy KL, Wall DM, Bien JD, McCormick BA. Salmonella enterica serovar Typhimurium modulates P-glycoprotein in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294(6):G1392-400. PMID: 18403618.
      Citations: 17     Fields:    Translation:HumansCells
    67. McCormick BA. Using Salmonella enterica serotype typhimurium to model intestinal fibrosis. Gastroenterology. 2008 Mar; 134(3):872-5. PMID: 18242605.
      Citations: 2     Fields:    Translation:AnimalsCells
    68. Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G599-609. PMID: 18032477.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    69. Hurley BP, Sin A, McCormick BA. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. Clin Exp Immunol. 2008 Feb; 151(2):297-305. PMID: 18005361.
      Citations: 19     Fields:    Translation:HumansCells
    70. Zurawski DV, Mumy KL, Badea L, Prentice JA, Hartland EL, McCormick BA, Maurelli AT. The NleE/OspZ family of effector proteins is required for polymorphonuclear transepithelial migration, a characteristic shared by enteropathogenic Escherichia coli and Shigella flexneri infections. Infect Immun. 2008 Jan; 76(1):369-79. PMID: 17984206.
      Citations: 24     Fields:    Translation:HumansCells
    71. McCormick BA. Bacterial-induced hepoxilin A3 secretion as a pro-inflammatory mediator. FEBS J. 2007 Jul; 274(14):3513-3518. PMID: 17608718.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    72. Prunier AL, Schuch R, Fernández RE, Mumy KL, Kohler H, McCormick BA, Maurelli AT. nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity. Microbiology (Reading). 2007 Jul; 153(Pt 7):2363-2372. PMID: 17600080.
      Citations: 32     Fields:    Translation:HumansCells
    73. Köhler H, Sakaguchi T, Hurley BP, Kase BA, Kase BJ, Reinecker HC, McCormick BA. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G178-87. PMID: 17615177.
      Citations: 59     Fields:    Translation:HumansCells
    74. Wall DM, Nadeau WJ, Pazos MA, Shi HN, Galyov EE, McCormick BA. Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cell Microbiol. 2007 Sep; 9(9):2299-313. PMID: 17697195.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    75. Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D. The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol Microbiol. 2006 Nov; 62(3):786-93. PMID: 17076670.
      Citations: 82     Fields:    Translation:HumansCells
    76. Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infect Immun. 2006 Oct; 74(10):5964-76. PMID: 16988276.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    77. Salazar-Gonzalez RM, Niess JH, Zammit DJ, Ravindran R, Srinivasan A, Maxwell JR, Stoklasek T, Yadav R, Williams IR, Gu X, McCormick BA, Pazos MA, Vella AT, Lefrancois L, Reinecker HC, McSorley SJ. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity. 2006 May; 24(5):623-32. PMID: 16713979.
      Citations: 94     Fields:    Translation:AnimalsCells
    78. Canny G, Swidsinski A, McCormick BA. Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional consequences. Methods Mol Biol. 2006; 341:17-35. PMID: 16799186.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    79. Hurley BP, Williams NL, McCormick BA. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L703-L709. PMID: 16272174.
      Citations: 19     Fields:    Translation:HumansCells
    80. Mumy KL, McCormick BA. Events at the host-microbial interface of the gastrointestinal tract. II. Role of the intestinal epithelium in pathogen-induced inflammation. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G854-9. PMID: 15826933.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    81. Do T, Stephens C, Townsend K, Wu X, Chapman T, Chin J, McCormick B, Bara M, Trott DJ. Rapid identification of virulence genes in enterotoxigenic Escherichia coli isolates associated with diarrhoea in Queensland piggeries. Aust Vet J. 2005 May; 83(5):293-9. PMID: 15957392.
      Citations: 9     Fields:    Translation:AnimalsCells
    82. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005 Jan 14; 307(5707):254-8. PMID: 15653504.
      Citations: 590     Fields:    Translation:AnimalsCells
    83. Hurley BP, Siccardi D, Mrsny RJ, McCormick BA. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. J Immunol. 2004 Nov 01; 173(9):5712-20. PMID: 15494523.
      Citations: 42     Fields:    Translation:HumansCells
    84. Tenor JL, McCormick BA, Ausubel FM, Aballay A. Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Curr Biol. 2004 Jun 08; 14(11):1018-24. PMID: 15182677.
      Citations: 65     Fields:    Translation:AnimalsCells
    85. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795.
      Citations: 86     Fields:    Translation:HumansCells
    86. Silva M, Song C, Nadeau WJ, Matthews JB, McCormick BA. Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-alpha-dependent signal transduction pathway. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1024-31. PMID: 14739142.
      Citations: 23     Fields:    Translation:HumansCells
    87. Hurley BP, McCormick BA. Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends Microbiol. 2003 Dec; 11(12):562-9. PMID: 14659688.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    88. Hisamatsu T, Suzuki M, Reinecker HC, Nadeau WJ, McCormick BA, Podolsky DK. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology. 2003 Apr; 124(4):993-1000. PMID: 12671896.
      Citations: 189     Fields:    Translation:HumansCells
    89. McCormick BA. The use of transepithelial models to examine host-pathogen interactions. Curr Opin Microbiol. 2003 Feb; 6(1):77-81. PMID: 12615224.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    90. Köhler H, McCormick BA, Walker WA. Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr. 2003 Feb; 36(2):175-85. PMID: 12548051.
      Citations: 11     Fields:    Translation:HumansCells
    91. Nadeau WJ, Pistole TG, McCormick BA. Polymorphonuclear leukocyte migration across model intestinal epithelia enhances Salmonella typhimurium killing via the epithelial derived cytokine, IL-6. Microbes Infect. 2002 Nov; 4(14):1379-87. PMID: 12475628.
      Citations: 13     Fields:    Translation:HumansCells
    92. Köhler H, Rodrigues SP, Maurelli AT, McCormick BA. Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine. J Infect Dis. 2002 Oct 15; 186(8):1122-30. PMID: 12355363.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    93. Sakaguchi T, Köhler H, Gu X, McCormick BA, Reinecker HC. Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Cell Microbiol. 2002 Jun; 4(6):367-81. PMID: 12067320.
      Citations: 54     Fields:    Translation:HumansCells
    94. Köhler H, Rodrigues SP, McCormick BA. Shigella flexneri Interactions with the Basolateral Membrane Domain of Polarized Model Intestinal Epithelium: Role of Lipopolysaccharide in Cell Invasion and in Activation of the Mitogen-Activated Protein Kinase ERK. Infect Immun. 2002 Mar; 70(3):1150-8. PMID: 11854195.
      Citations: 30     Fields:    Translation:Cells
    95. Criss AK, Silva M, Casanova JE, McCormick BA. Regulation of Salmonella-induced neutrophil transmigration by epithelial ADP-ribosylation factor 6. J Biol Chem. 2001 Dec 21; 276(51):48431-9. PMID: 11641400.
      Citations: 18     Fields:    Translation:AnimalsCells
    96. Fernandez IM, Silva M, Schuch R, Walker WA, Siber AM, Maurelli AT, McCormick BA. Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling. J Infect Dis. 2001 Sep 15; 184(6):743-53. PMID: 11517436.
      Citations: 25     Fields:    Translation:HumansCells
    97. Criss AK, Ahlgren DM, Jou TS, McCormick BA, Casanova JE. The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells. J Cell Sci. 2001 Apr; 114(Pt 7):1331-41. PMID: 11256999.
      Citations: 37     Fields:    Translation:AnimalsCells
    98. Lee CA, Silva M, Siber AM, Kelly AJ, Galyov E, McCormick BA. A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12283-8. PMID: 11050248.
      Citations: 74     Fields:    Translation:Cells
    99. Cherayil BJ, McCormick BA, Bosley J. Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2. Infect Immun. 2000 Oct; 68(10):5567-74. PMID: 10992455.
      Citations: 15     Fields:    Translation:AnimalsCells
    100. Wood MW, Jones MA, Watson PR, Siber AM, McCormick BA, Hedges S, Rosqvist R, Wallis TS, Galyov EE. The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritis. Cell Microbiol. 2000 Aug; 2(4):293-303. PMID: 11207586.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    101. Allen JH, Utley M, van Den Bosch H, Nuijten P, Witvliet M, McCormick BA, Krogfelt KA, Licht TR, Brown D, Mauel M, Leatham MP, Laux DC, Cohen PS. A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice. Infect Immun. 2000 Jun; 68(6):3772-5. PMID: 10816546.
      Citations: 12     Fields:    Translation:AnimalsCells
    102. McCormick BA, Fernandez MI, Siber AM, Maurelli AT. Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine. Cell Microbiol. 1999 Sep; 1(2):143-55. PMID: 11207548.
      Citations: 27     Fields:    Translation:HumansCells
    103. Gewirtz AT, Siber AM, Madara JL, McCormick BA. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infect Immun. 1999 Feb; 67(2):608-17. PMID: 9916066.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    104. McCormick BA, Siber AM, Maurelli AT. Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium. Infect Immun. 1998 Sep; 66(9):4237-43. PMID: 9712773.
      Citations: 32     Fields:    Translation:HumansCells
    105. Shaw SK, Hermanowski-Vosatka A, Shibahara T, McCormick BA, Parkos CA, Carlson SL, Ebert EC, Brenner MB, Madara JL. Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer. Am J Physiol. 1998 09; 275(3):G584-91. PMID: 9724272.
      Citations: 8     Fields:    Translation:HumansCells
    106. Gewirtz AT, McCormick B, Neish AS, Petasis NA, Gronert K, Serhan CN, Madara JL. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. J Clin Invest. 1998 May 01; 101(9):1860-9. PMID: 9576749.
      Citations: 41     Fields:    Translation:Cells
    107. McCormick BA, Parkos CA, Colgan SP, Carnes DK, Madara JL. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J Immunol. 1998 Jan 01; 160(1):455-66. PMID: 9552004.
      Citations: 72     Fields:    Translation:HumansCells
    108. McCormick BA, Nusrat A, Parkos CA, D'Andrea L, Hofman PM, Carnes D, Liang TW, Madara JL. Unmasking of intestinal epithelial lateral membrane beta1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yersinia pseudotuberculosis. Infect Immun. 1997 Apr; 65(4):1414-21. PMID: 9119482.
      Citations: 22     Fields:    Translation:HumansCells
    109. McCormick BA, Hofman PM, Kim J, Carnes DK, Miller SI, Madara JL. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils. J Cell Biol. 1995 Dec; 131(6 Pt 1):1599-608. PMID: 8522615.
      Citations: 90     Fields:    Translation:HumansCells
    110. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993 Nov; 123(4):895-907. PMID: 8227148.
      Citations: 171     Fields:    Translation:HumansCells
    111. McCormick BA, Klemm P, Krogfelt KA, Burghoff RL, Pallesen L, Laux DC, Cohen PS. Escherichia coli F-18 phase locked 'on' for expression of type 1 fimbriae is a poor colonizer of the streptomycin-treated mouse large intestine. Microb Pathog. 1993 Jan; 14(1):33-43. PMID: 8100608.
      Citations: 16     Fields:    Translation:AnimalsCells
    112. Krogfelt KA, McCormick BA, Burghoff RL, Laux DC, Cohen PS. Expression of Escherichia coli F-18 type 1 fimbriae in the streptomycin-treated mouse large intestine. Infect Immun. 1991 Apr; 59(4):1567-8. PMID: 1672304.
      Citations: 13     Fields:    Translation:AnimalsCells
    113. McCormick BA, Franklin DP, Laux DC, Cohen PS. Type 1 pili are not necessary for colonization of the streptomycin-treated mouse large intestine by type 1-piliated Escherichia coli F-18 and E. coli K-12. Infect Immun. 1989 Oct; 57(10):3022-9. PMID: 2570752.
      Citations: 31     Fields:    Translation:AnimalsCells
    114. McCormick BA, Stocker BA, Laux DC, Cohen PS. Roles of motility, chemotaxis, and penetration through and growth in intestinal mucus in the ability of an avirulent strain of Salmonella typhimurium to colonize the large intestine of streptomycin-treated mice. Infect Immun. 1988 Sep; 56(9):2209-17. PMID: 3044995.
      Citations: 41     Fields:    Translation:AnimalsCells
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