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Lloyd Hutchinson PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUniversity of Massachusetts Medical School
One Innovation Drive, Biotech Three
Worcester MA 01605
Phone508-793-6240
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPathology


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    McMaster University, Hamilton, ON, CanadaPHDMolecular Virology/Immunology

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    Academic Background:

    BS -1987, Microbiology and Chemistry, Univ. of Guelph, Guelph ON Canada

    PhD.- 1996, Molecular Virology and Immunology, McMaster Univ., Hamilton ON Canada

    Postdoctoral Fellow -2004, Molecular Oncology, Vascular Biology Program, Children’s Hospital, Harvard Medical School, Boston MA

    Research Interests :Dr. Hutchinson's picture

    My research encompasses tumor biology including hematopathology and solid tumors. A primary focus is the discovery and development of novel technology and cancer biomarkers for early cancer detection. The eventual goal is to provide oncologists with tools that enable early intervention and better outcomes for patients. Diagnostic assays and biomarkers in development may be used for early detection, to assist in diagnosis, prognosis, and treatment decisions or to monitor levels of minimal residual disease




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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cornejo KM, Cosar EF, Paner GP, Yang P, Tomaszewicz K, Meng X, Mehta V, Sirintrapun SJ, Barkan GA, Hutchinson L. Mutational Profile Using Next-Generation Sequencing May Aid in the Diagnosis and Treatment of Urachal Adenocarcinoma. Int J Surg Pathol. 2019 Sep 08; 1066896919872535. PMID: 31496327.
      View in: PubMed
    2. Javvaji C, Bledsoe JR, Hutchinson L, Cosar EF, McIntosh LJ, Bathini VG. Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival. J Gastrointest Cancer. 2019 Aug 27. PMID: 31456115.
      View in: PubMed
    3. Sakhdari A, Moghaddam PA, Ok CY, Walter O, Tomaszewicz K, Caporelli ML, Meng X, LaFemina J, Whalen G, Belkin E, Zivny J, Wassef W, Woda BA, Hutchinson LM, Cosar EF. Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool. Oncotarget. 2019 Jun 18; 10(40):4026-4037. PMID: 31258847.
      View in: PubMed
    4. Ma L, Pak ML, Ou J, Yu J, St Louis P, Shan Y, Hutchinson L, Li S, Brehm MA, Zhu LJ, Green MR. Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells. Proc Natl Acad Sci U S A. 2019 May 08. PMID: 31068472.
      View in: PubMed
    5. Bai S, Hutchinson LM, Meng X, Bai H, Cosar EF, Khan A, Cornejo K. Dedifferentiated Carcinoma of the Endometrium Associated With Low-Grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. Int J Gynecol Pathol. 2019 Mar 22. PMID: 30908285.
      View in: PubMed
    6. Zhu X, Salhab M, Tomaszewicz K, Meng X, Mathew C, Bathini V, Switzer B, Walter O, Cosar EF, Wang X, Lambert LA, Hutchinson LM. Heterogeneous mutational profile and prognosis conferred by TP53 mutations in Appendiceal mucinous neoplasms. Hum Pathol. 2018 Nov 17. PMID: 30458197.
      View in: PubMed
    7. Zhu S, Ward BM, Yu J, Matthew-Onabanjo AN, Janusis J, Hsieh CC, Tomaszewicz K, Hutchinson L, Zhu LJ, Kandil D, Shaw LM. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018 Apr 19; 3(8). PMID: 29669935.
      View in: PubMed
    8. Liu Q, Cornejo KM, Cheng L, Hutchinson L, Wang M, Zhang S, Tomaszewicz K, Cosar EF, Woda BA, Jiang Z. Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. Am J Pathol. 2018 Apr; 188(4):846-852. PMID: 29353061.
      View in: PubMed
    9. Sakhdari A, Hutchinson L, Vaskas N, Scott M, Cosar EF, Al-Turkmani R. Routine Analysis of Lipase in Cyst Fluid Is Unnecessary and Does Not Help Discriminate Between Nonneoplastic and Neoplastic Cystic Pancreatic Lesions. Pancreas. 2017 Mar; 46(3):e25-e27. PMID: 28187114.
      View in: PubMed
    10. Ahmadi Moghaddam P, Cornejo KM, Hutchinson L, Tomaszewicz K, Dresser K, Deng A, O'Donnell P. Complete Spontaneous Regression of Merkel Cell Carcinoma After Biopsy: A Case Report and Review of the Literature. Am J Dermatopathol. 2016 Nov; 38(11):e154-e158. PMID: 27759689.
      View in: PubMed
    11. Magotra M, Sakhdari A, Lee PJ, Tomaszewicz K, Dresser K, Hutchinson LM, Woda BA, Chen BJ. Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways. Histopathology. 2016 Dec; 69(6):1055-1065. PMID: 27458708.
      View in: PubMed
    12. Fischer AH, Hutchinson LM. Technical and US regulatory issues in triaging material for the molecular laboratory. Cancer Cytopathol. 2016 Sep 6. PMID: 27598019.
      View in: PubMed
    13. Cornejo KM, Hutchinson L, Meng X, O'Donnell P, Deng A. Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid: A Report of a Case With Molecular Analysis. Am J Dermatopathol. 2016 Aug; 38(8):636-8. PMID: 26675355.
      View in: PubMed
    14. Liu Q, Tomaszewicz K, Hutchinson L, Hornick JL, Woda B, Yu H. Somatic mutations in histiocytic sarcoma identified by next generation sequencing. Virchows Arch. 2016 Aug; 469(2):233-41. PMID: 27259537.
      View in: PubMed
    15. Zhou AG, Liu Y, Cyr MS, Garver J, Woda BA, Cosar EF, Hutchinson LM. Role of Tetrasomy for the Diagnosis of Urothelial Carcinoma Using UroVysion Fluorescent In Situ Hybridization. Arch Pathol Lab Med. 2016 Jun; 140(6):552-9. PMID: 27232347.
      View in: PubMed
    16. Kamionek M, Ahmadi Moghaddam P, Sakhdari A, Kovach AE, Welch M, Meng X, Dresser K, Tomaszewicz K, Cosar EF, Mark EJ, Fraire AE, Hutchinson L. Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease. Histopathology. 2016 Sep; 69(3):499-509. PMID: 26915300.
      View in: PubMed
    17. Fang M, Hutchinson L, Deng A, Green MR. Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma. Proc Natl Acad Sci U S A. 2016 Feb 2; 113(5):1250-5. PMID: 26787892.
      View in: PubMed
    18. Cornejo KM, Hutchinson L, Cyr MS, Nose V, McLaughlin PJ, Iafrate AJ, Sadow PM. MYC Analysis by Fluorescent In Situ Hybridization and Immunohistochemistry in Primary Adrenal Angiosarcoma (PAA): a Series of Four Cases. Endocr Pathol. 2015 Dec; 26(4):334-41. PMID: 26223194.
      View in: PubMed
    19. Zhou AG, Hutchinson L, Cosar EF. 2015. Ancillary Tests for the Detection of Urothelial Carcinoma. In Xiaoqi Lin, Longwen Chen, Ritu Nayar, editors. Cytology, Histology, Cystoscopy, and Radiology of the Urinary System Atlas and Practical Guide. Peoples Medical Publishing House-USA. ISBN 978-1-60795-185-8. 2015.
    20. Sakhdari A, Hutchinson L, Cosar EF. 2015. Chapter 7: Molecular Pathology of Lobular Carcinoma. Chapter 9: Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2. Evaluation and Role in Targeted Therapy. Chapter 19: Specimens for Molecular Testing in Breast Cancer . In Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors. Molecular Pathology Library, Volume 10. Precision Molecular Pathology of Breast Cancer. Springer, New York, p. 95,119,317. DOI: http://dx.doi.org/10.1007/978-1-4939-2886-6. 2015.
    21. Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L. The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol. 2015 Jun; 46(6):868-75. PMID: 25864386.
      View in: PubMed
    22. Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014 Sep 18; 55(6):904-15. PMID: 25219500.
      View in: PubMed
    23. Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR. A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia. Sci Transl Med. 2014 Sep 3; 6(252):252ra121. PMID: 25186176.
      View in: PubMed
    24. Rosenblum F, Hutchinson LM, Garver J, Woda B, Cosar E, Kurian EM. Cytology specimens offer an effective alternative to formalin-fixed tissue as demonstrated by novel automated detection for ALK break-apart FISH testing and immunohistochemistry in lung adenocarcinoma. Cancer Cytopathol. 2014 Nov; 122(11):810-21. PMID: 25099128.
      View in: PubMed
    25. Lee, P.J., Owens, C.L., Hutchinson, L., Fischer, A.H. Intranuclear cytoplasmic inclusions are a specific feature of intraductal papillary mucinous neoplasms that distinguish contaminating gastric epithelium. DOI: http://dx.doi.org/10.1016/j.jasc.2013.12.003. Journal of the American Society of Cytopathology. 2014; 3(2):108-113.
    26. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12; 3:e02313. PMID: 24623306.
      View in: PubMed
    27. Wu X, Tomaszewicz K, Hutchinson L, Cosar E, Deng A. . Next Generation Sequencing in Differential Diagnosis of Childhood Melanoma from Spitz Nevus: A case report. DOI: http://ijcp.elmerpress.com/index.php/ijcp/article/view/152/108. International Journal of Clinical Pediatrics. 2014; 3(1):22-28..
    28. Zhou AG, Hutchinson LM, Cosar EF. Urine Cytopathology and Ancillary Methods (Review). DOI: http://dx.doi.org/10.1016/j.path.2013.10.003. Surgical Pathology Clinics. 2014; 7(1):77-88.
    29. Cornejo KM, Hutchinson L, Deng A, Tomaszewicz K, Welch M, Lyle S, Dresser K, Cosar EF. BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. Hum Pathol. 2014 Jun; 45(6):1213-20. PMID: 24767862.
      View in: PubMed
    30. Lee PJ, Owens CL, Hutchinson L, Fischer AH. Intranuclear cytoplasmic inclusions are a specific feature of intraductal papillary mucinous neoplasms that distinguish contaminating gastric epithelium. J Am Soc Cytopathol. 2014 Mar - Apr; 3(2):108-113. PMID: 31051700.
      View in: PubMed
    31. Ramanathan M, Cerny J, Tomaszewicz K, Hutchinson L, Bednarik J, Woda BA, Nath R. . Isolated Extra Medullary Relapse after Allogeneic Stem Cell Transplant in FLT3 Mutated Acute Myeloid leukemia (AML) While on FLT3 Inhibitor Sorafenib. DOI: http://dx.doi.org/10.4172/2329-8790.1000116. J Hematol Thromb Dis. 2013; 1(4):116.
    32. Zhou AG, Hutchinson LM, Cosar EF. Urine Cytopathology and Ancillary Methods. Surg Pathol Clin. 2014 Mar; 7(1):77-88. PMID: 26839270.
      View in: PubMed
    33. Cornejo KM, Hutchinson L, Cosar EF, Smith T, Tomaszewicz K, Dresser K, Deng A. Is it a primary or metastatic melanocytic neoplasm of the central nervous system?: A molecular based approach. Pathol Int. 2013 Nov; 63(11):559-64. PMID: 24274719.
      View in: PubMed
    34. Wang SA, Hutchinson L, Tang G, Chen SS, Miron PM, Huh YO, Jones DM, Bueso-Ramos C, Verstovsek S, Medeiros LJ, Miranda RN. Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components. Am J Hematol. 2013 Mar; 88(3):219-24. PMID: 23440662.
      View in: PubMed
    35. Menon MP, Hutchinson L, Garver J, Jaffe ES, Woda BA. Transformation of follicular lymphoma to Epstein-Barr virus-related Hodgkin-like lymphoma. J Clin Oncol. 2013 Feb 10; 31(5):e53-6. PMID: 23295788.
      View in: PubMed
    36. Cerny J, Yu H, Ramanathan M, Raffel GD, Walsh WV, Fortier N, Shanahan L, O'Rourke E, Bednarik J, Barton B, Kroll-Desrosiers A, Hao S, Woda B, Hutchinson L, Evens AM, Rosmarin AG, Nath R. Expression of CD25 independently predicts early treatment failure of acute myeloid leukaemia (AML). Br J Haematol. 2013 Jan; 160(2):262-6. PMID: 23116454.
      View in: PubMed
    37. Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Li S. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet. 2012 Jul 15; 44(8):861-71. PMID: 22797726.
      View in: PubMed
    38. Piperdi B, Walsh WV, Bradley K, Zhou Z, Bathini V, Hanrahan-Boshes M, Hutchinson L, Perez-Soler R. Phase-I/II study of bortezomib in combination with carboplatin and bevacizumab as first-line therapy in patients with advanced non-small-cell lung cancer. J Thorac Oncol. 2012 Jun; 7(6):1032-40. PMID: 22534815.
      View in: PubMed
    39. Hure MC, Elco CP, Ward D, Hutchinson L, Meng X, Dorfman DM, Yu H. Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol. 2012 Feb 10; 30(5):e49-53. PMID: 22184374.
      View in: PubMed
    40. Kurian EM, Caporelli ML, Baker S, Woda B, Cosar EF, Hutchinson L. Cervista HR and HPV 16/18 assays vs hybrid capture 2 assay: outcome comparison in women with negative cervical cytology. Am J Clin Pathol. 2011 Nov; 136(5):808-16. PMID: 22031321.
      View in: PubMed
    41. Dvorak K, Goldman A, Kong J, Lynch JP, Hutchinson L, Houghton JM, Chen H, Chen X, Krishnadath KK, Westra WM. Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Ann N Y Acad Sci. 2011 Sep; 1232:381-91. PMID: 21950830.
      View in: PubMed
    42. Shi M, Miron PM, Hutchinson L, Woda BA, Nath R, Cerny J, Yu H. Anaplastic lymphoma kinase-positive large B-cell lymphoma with complex karyotype and novel ALK gene rearrangements. Hum Pathol. 2011 Oct; 42(10):1562-7. PMID: 21497367.
      View in: PubMed
    43. Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011 Jan; 20(1):11-7. PMID: 20677919.
      View in: PubMed
    44. Cerny J, Wang S, Miron P, Hutchinson L, Brettler D. EBV-negative Hodgkin lymphoma in ZAP-70-positive B-cell lymphocytic leukemia patient. Ann Hematol. 2009 May; 88(5):495-7. PMID: 18843488.
      View in: PubMed
    45. Cerny J, Fadare O, Hutchinson L, Wang SA. Clinicopathological features of extramedullary recurrence/relapse of multiple myeloma. Eur J Haematol. 2008 Jul; 81(1):65-9. PMID: 18462256.
      View in: PubMed
    46. Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May; 183(1):49-52. PMID: 18474297.
      View in: PubMed
    47. Banyard J, Hutchinson LM, Zetter BR. Thymosin beta-NB is the human isoform of rat thymosin beta15. Ann N Y Acad Sci. 2007 Sep; 1112:286-96. PMID: 17567946.
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    48. Wang SA, Yue G, Hutchinson L, Landry ML, Hasserjian RP, Hao S, Galili N, Raza A, Woda BA. Myelodysplastic syndrome with pure red cell aplasia shows characteristic clinicopathological features and clonal T-cell expansion. Br J Haematol. 2007 Jul; 138(2):271-5. PMID: 17542981.
      View in: PubMed
    49. Stachurski D, Miron PM, Al-Homsi S, Hutchinson L, Harris NL, Woda B, Wang SA. Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24. Hum Pathol. 2007 Jun; 38(6):940-5. PMID: 17509395.
      View in: PubMed
    50. Banyard J, Bao L, Hofer MD, Zurakowski D, Spivey KA, Feldman AS, Hutchinson LM, Kuefer R, Rubin MA, Zetter BR. Collagen XXIII expression is associated with prostate cancer recurrence and distant metastases. Clin Cancer Res. 2007 May 1; 13(9):2634-42. PMID: 17473194.
      View in: PubMed
    51. Almog N, Henke V, Flores L, Hlatky L, Kung AL, Wright RD, Berger R, Hutchinson L, Naumov GN, Bender E, Akslen LA, Achilles EG, Folkman J. Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J. 2006 May; 20(7):947-9. PMID: 16638967.
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    52. Hutchinson LM, Chang EL, Becker CM, Shih MC, Brice M, DeWolf WC, Gaston SM, Zetter BR. Use of thymosin beta15 as a urinary biomarker in human prostate cancer. Prostate. 2005 Jul 1; 64(2):116-27. PMID: 15666387.
      View in: PubMed
    53. Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem. 2005 Jun; 38(6):558-71. PMID: 15885237.
      View in: PubMed
    54. Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR. BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. J Biol Chem. 2001 Aug 10; 276(32):30127-32. PMID: 11340068.
      View in: PubMed
    55. Eadie JS, Kim SW, Allen PG, Hutchinson LM, Kantor JD, Zetter BR. C-terminal variations in beta-thymosin family members specify functional differences in actin-binding properties. J Cell Biochem. 2000 Mar; 77(2):277-87. PMID: 10723093.
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    56. Hutchinson L, Johnson DC. Herpes simplex virus glycoprotein K promotes egress of virus particles. J Virol. 1995 Sep; 69(9):5401-13. PMID: 7636985.
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    57. Hutchinson L, Roop-Beauchamp C, Johnson DC. Herpes simplex virus glycoprotein K is known to influence fusion of infected cells, yet is not on the cell surface. J Virol. 1995 Jul; 69(7):4556-63. PMID: 7769723.
      View in: PubMed
    58. Hutchinson L, Graham FL, Cai W, Debroy C, Person S, Johnson DC. Herpes simplex virus (HSV) glycoproteins B and K inhibit cell fusion induced by HSV syncytial mutants. Virology. 1993 Oct; 196(2):514-31. PMID: 8396800.
      View in: PubMed
    59. Roop C, Hutchinson L, Johnson DC. A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J Virol. 1993 Apr; 67(4):2285-97. PMID: 8383241.
      View in: PubMed
    60. Hutchinson L, Goldsmith K, Snoddy D, Ghosh H, Graham FL, Johnson DC. Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. J Virol. 1992 Sep; 66(9):5603-9. PMID: 1323714.
      View in: PubMed
    61. Hutchinson L, Browne H, Wargent V, Davis-Poynter N, Primorac S, Goldsmith K, Minson AC, Johnson DC. A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH. J Virol. 1992 Apr; 66(4):2240-50. PMID: 1312629.
      View in: PubMed
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