Header Logo

Patrick Emery PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentNeurobiology
AddressUMass Chan Medical School
364 Plantation Street LRB 703
Worcester MA 01605
Phone508-856-6599
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurobiology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    University of Geneva, Geneva, GE, SwitzerlandBSBiology
    University of Geneva, Geneva, GE, SwitzerlandMSBiology
    University of Geneva, Geneva, GE, SwitzerlandPHDBiology

    Collapse Overview 
    Collapse overview

      Circadian and Circatidal Rhythms 

    Our environment is constantly changing.  The Sun rises and sets every day, causing rhythmic changes in light and temperature.  At most latitudes, weather and day length vary as seasons pass.  On the coastline, tides rise and fall.  Because these environmental cycles occur with precise periodicities, most organisms on Earth have acquired biological clocks that can track and predict them.  Organisms can thus adapt and anticipate changes in light intensity, temperature, day length or water level by adjusting their physiology and behavior in a time-dependent manner.  

    Circadian clocks have a period of 24 hours and synchronize to daily environmental cycles.  They regulate complex behaviors such as the sleep/wake cycle, as well as metabolism and physiology throughout our body. Their disruption - for instance due to shift work - can have serious detrimental health consequences. Circatidal clocks are found in coastal organisms.  They have a period of 12.4 hours and synchronize to tides. Our lab’s overall objective is to elucidate basic molecular and neural mechanisms that underlie circadian and circatidal rhythms, and to understand how biological clocks allow for behavioral adaptations to environmental cycles.  Most of our work is performed in Drosophila melanogaster, a fantastic model organism to study the fundamental mechanisms underlying circadian rhythms and one of its critical outputs: sleep.  We have also recently started to use Parhyale hawaiensis, a genetically-tractable crustacean, to study circatidal clocks, the mechanisms of which are very poorly understood.

    For more information, please visit our lab page at:  https://www.umassmed.edu/emerylab/


    Collapse Rotation Projects

    Biological clocks play an essential role in the temporal organization of animal physiology and behavior. We combine the powerful genetics of Drosophila with molecular, cell culture and behavioral approaches to obtain a comprehensive view of the mechanisms regulating circadian clocks and one of their critical output: sleep. We also now study the mechanisms enabling marine organisms to anticipate tides.  Indeed, we have developed a model organism to study circatidal rhythms: Parhyale hawaiensis.

    Rotation projects could for example focus on characterizing new candudate post-transcriptional regulators of circadian rhythms, the role of glial genes in the control of sleep, or studying the molecular mechanisms of circatidal clocks. 


    Collapse Post Docs


    A postdoc position is available to study circadian rhythms in Drosophila.  Contact Patrick Emery (patrick.emery@umassmed.edu).



    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chaturvedi R, Emery P. Fly into tranquility: GABA's role in Drosophila sleep. Curr Opin Insect Sci. 2024 Jun 05; 64:101219. PMID: 38848811.
      Citations:    
    2. Kwiatkowski ER, Emery P. Cnidarians are CLOCKing in. Elife. 2024 May 08; 13. PMID: 38716806.
      Citations:    
    3. Kwiatkowski ER, Rosenthal JJC, Emery P. Clocks at sea: the genome-editing tide is rising. Trends Genet. 2024 May; 40(5):387-397. PMID: 38336520.
      Citations:    Fields:    
    4. Chitre M, Emery P. ATXN2 is a target of N-terminal proteolysis. PLoS One. 2023; 18(12):e0296085. PMID: 38128014.
      Citations:    Fields:    Translation:HumansCells
    5. Emery P, Klarsfeld A, Stanewsky R, Shafer OT. Sensitive Timing: A Reappraisal of Chronobiology's Foundational Texts. J Biol Rhythms. 2023 Jun; 38(3):245-258. PMID: 37226809.
      Citations:    Fields:    Translation:Animals
    6. Kwiatkowski ER, Schnytzer Y, Rosenthal JJC, Emery P. Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis. Curr Biol. 2023 05 22; 33(10):1867-1882.e5. PMID: 36977416.
      Citations: 1     Fields:    Translation:Animals
    7. Joshi R, Cai YD, Xia Y, Chiu JC, Emery P. PERIOD Phosphoclusters Control Temperature Compensation of the Drosophila Circadian Clock. Front Physiol. 2022; 13:888262. PMID: 35721569.
      Citations:    
    8. Chaturvedi R, Stork T, Yuan C, Freeman MR, Emery P. Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons. Curr Biol. 2022 05 09; 32(9):1895-1908.e5. PMID: 35303417.
      Citations: 4     Fields:    Translation:AnimalsCells
    9. Fagan RR, Kearney PJ, Luethi D, Bolden NC, Sitte HH, Emery P, Melikian HE. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Mol Psychiatry. 2021 12; 26(12):7793-7802. PMID: 34471250.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Foley LE, Ling J, Joshi R, Evantal N, Kadener S, Emery P. Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing. Elife. 2019 11 08; 8. PMID: 31702555.
      Citations: 13     Fields:    Translation:AnimalsCells
    11. Foley LE, Emery P. Drosophila Cryptochrome: Variations in Blue. J Biol Rhythms. 2020 02; 35(1):16-27. PMID: 31599203.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Chatterjee A, Lamaze A, De J, Mena W, Ch?lot E, Martin B, Hardin P, Kadener S, Emery P, Rouyer F. Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock. Curr Biol. 2018 07 09; 28(13):2007-2017.e4. PMID: 29910074.
      Citations: 40     Fields:    Translation:AnimalsCells
    13. Lamba P, Foley LE, Emery P. Neural Network Interactions Modulate CRY-Dependent Photoresponses in Drosophila. J Neurosci. 2018 07 04; 38(27):6161-6171. PMID: 29875268.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Fujii S, Emery P, Amrein H. SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6669-E6677. PMID: 28743754.
      Citations: 13     Fields:    Translation:AnimalsCells
    15. Zhang Y, Lamba P, Guo P, Emery P. miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior. J Neurosci. 2016 Feb 10; 36(6):2007-13. PMID: 26865623.
      Citations: 20     Fields:    Translation:AnimalsCells
    16. Emery P. Connecting Circadian Genes to Neurodegenerative Pathways in Fruit Flies. PLoS Genet. 2015 Jun; 11(6):e1005266. PMID: 26068245.
      Citations:    Fields:    Translation:Animals
    17. Tataroglu O, Emery P. The molecular ticks of the Drosophila circadian clock. Curr Opin Insect Sci. 2015 Feb 01; 7:51-57. PMID: 26120561.
      Citations: 52     Fields:    
    18. Lamba P, Bilodeau-Wentworth D, Emery P, Zhang Y. Morning and evening oscillators cooperate to reset circadian behavior in response to light input. Cell Rep. 2014 May 08; 7(3):601-8. PMID: 24746814.
      Citations: 21     Fields:    Translation:AnimalsCells
    19. Tataroglu O, Emery P. Studying circadian rhythms in Drosophila melanogaster. Methods. 2014 Jun 15; 68(1):140-50. PMID: 24412370.
      Citations: 37     Fields:    Translation:AnimalsCells
    20. Zhang Y, Ling J, Yuan C, Dubruille R, Emery P. A role for Drosophila ATX2 in activation of PER translation and circadian behavior. Science. 2013 May 17; 340(6134):879-82. PMID: 23687048.
      Citations: 75     Fields:    Translation:AnimalsCells
    21. Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. The circadian clock gates the intestinal stem cell regenerative state. Cell Rep. 2013 Apr 25; 3(4):996-1004. PMID: 23583176.
      Citations: 66     Fields:    Translation:AnimalsCells
    22. Zhang Y, Emery P. GW182 controls Drosophila circadian behavior and PDF-receptor signaling. Neuron. 2013 Apr 10; 78(1):152-65. PMID: 23583112.
      Citations: 25     Fields:    Translation:AnimalsCells
    23. Ling J, Dubruille R, Emery P. KAYAK-a modulates circadian transcriptional feedback loops in Drosophila pacemaker neurons. J Neurosci. 2012 Nov 21; 32(47):16959-70. PMID: 23175847.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Emery P. Circadian rhythms: An electric jolt to the clock. Curr Biol. 2012 Oct 23; 22(20):R876-8. PMID: 23098596.
      Citations:    Fields:    Translation:AnimalsCells
    25. Kaneko H, Head LM, Ling J, Tang X, Liu Y, Hardin PE, Emery P, Hamada FN. Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol. 2012 Oct 09; 22(19):1851-7. PMID: 22981774.
      Citations: 51     Fields:    Translation:AnimalsCells
    26. Zhang Y, Liu Y, Bilodeau-Wentworth D, Hardin PE, Emery P. Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior. Curr Biol. 2010 Apr 13; 20(7):600-5. PMID: 20362449.
      Citations: 98     Fields:    Translation:AnimalsCells
    27. Dubruille R, Murad A, Rosbash M, Emery P. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet. 2009 Dec; 5(12):e1000787. PMID: 20041201.
      Citations: 21     Fields:    Translation:AnimalsCells
    28. Emery P, Francis M. Circadian rhythms: timing the sense of smell. Curr Biol. 2008 Jul 08; 18(13):R569-71. PMID: 18606130.
      Citations: 1     Fields:    Translation:AnimalsCells
    29. Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4. PMID: 18184036.
      Citations: 100     Fields:    Translation:AnimalsCells
    30. Busza A, Murad A, Emery P. Interactions between circadian neurons control temperature synchronization of Drosophila behavior. J Neurosci. 2007 Oct 03; 27(40):10722-33. PMID: 17913906.
      Citations: 45     Fields:    Translation:AnimalsCells
    31. Emery P, Freeman MR. Glia got rhythm. Neuron. 2007 Aug 02; 55(3):337-9. PMID: 17678846.
      Citations: 1     Fields:    Translation:AnimalsCells
    32. Murad A, Emery-Le M, Emery P. A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Neuron. 2007 Mar 01; 53(5):689-701. PMID: 17329209.
      Citations: 61     Fields:    Translation:AnimalsCells
    33. Emery P. RNA extraction from Drosophila heads. Methods Mol Biol. 2007; 362:305-7. PMID: 17417017.
      Citations: 4     Fields:    Translation:Animals
    34. Emery P. Protein extraction from Drosophila heads. Methods Mol Biol. 2007; 362:375-7. PMID: 17417024.
      Citations: 12     Fields:    Translation:AnimalsCells
    35. Emery P. Mutagenesis with Drosophila. Methods Mol Biol. 2007; 362:187-95. PMID: 17417010.
      Citations: 1     Fields:    Translation:AnimalsCells
    36. Emery P. RNase protection assay. Methods Mol Biol. 2007; 362:343-8. PMID: 17417021.
      Citations: 1     Fields:    Translation:Cells
    37. Rush BL, Murad A, Emery P, Giebultowicz JM. Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary. J Biol Rhythms. 2006 Aug; 21(4):272-8. PMID: 16864647.
      Citations: 14     Fields:    Translation:Animals
    38. Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6. PMID: 15312644.
      Citations: 50     Fields:    Translation:HumansAnimals
    39. Martin G, Puig S, Pietrzykowski A, Zadek P, Emery P, Treistman S. Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. J Neurosci. 2004 Jul 21; 24(29):6563-72. PMID: 15269268.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    40. Busza A, Emery-Le M, Rosbash M, Emery P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science. 2004 Jun 04; 304(5676):1503-6. PMID: 15178801.
      Citations: 128     Fields:    Translation:AnimalsCells
    41. Zhao J, Kilman VL, Keegan KP, Peng Y, Emery P, Rosbash M, Allada R. Drosophila clock can generate ectopic circadian clocks. Cell. 2003 Jun 13; 113(6):755-66. PMID: 12809606.
      Citations: 64     Fields:    Translation:AnimalsCells
    42. McDonald MJ, Rosbash M, Emery P. Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol Cell Biol. 2001 Feb; 21(4):1207-17. PMID: 11158307.
      Citations: 36     Fields:    Translation:AnimalsCells
    43. Allada R, Emery P, Takahashi JS, Rosbash M. Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci. 2001; 24:1091-119. PMID: 11520929.
      Citations: 107     Fields:    Translation:AnimalsCells
    44. Emery P, Stanewsky R, Helfrich-F?rster C, Emery-Le M, Hall JC, Rosbash M. Drosophila CRY is a deep brain circadian photoreceptor. Neuron. 2000 May; 26(2):493-504. PMID: 10839367.
      Citations: 144     Fields:    Translation:AnimalsCells
    45. Emery P, Stanewsky R, Hall JC, Rosbash M. A unique circadian-rhythm photoreceptor. Nature. 2000 Mar 30; 404(6777):456-7. PMID: 10761904.
      Citations: 84     Fields:    Translation:AnimalsCells
    46. Emery P, So WV, Kaneko M, Hall JC, Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 1998 Nov 25; 95(5):669-79. PMID: 9845369.
      Citations: 301     Fields:    Translation:AnimalsCells
    47. Stanewsky R, Kaneko M, Emery P, Beretta B, Wager-Smith K, Kay SA, Rosbash M, Hall JC. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell. 1998 Nov 25; 95(5):681-92. PMID: 9845370.
      Citations: 311     Fields:    Translation:AnimalsCells
    Emery's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (178)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _