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Feng He PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-3361
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    Beijing University of Agriculture, Haidian, , ChinaBSAnimal Science
    National Institute of Agronomy, Paris, , FranceMSGenetic & Molecular Biology
    National Institute of Agronomy, Paris, , FrancePHDGenetic & Molecular Biology

    Collapse Overview 
    Collapse Summary
    Focus: Post-transcriptional gene regulation in eukaryotes

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. He F, Wu C, Jacobson A. Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes. Elife. 2022 05 23; 11. PMID: 35604319.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Mangkalaphiban K, He F, Ganesan R, Wu C, Baker R, Jacobson A. Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae. PLoS Genet. 2021 04; 17(4):e1009538. PMID: 33878104.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Wu C, Roy B, He F, Yan K, Jacobson A. Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination. Cell Rep. 2020 11 17; 33(7):108399. PMID: 33207198.
      Citations: 8     Fields:    Translation:AnimalsCells
    4. Shen Q, Peng X, He F, Li S, Xiao Z, Wang H, Tang X, Zhou M. First Report of Nigrospora osmanthi Causing Leaf Spot on Tartary Buckwheat in China. Plant Dis. 2020 Oct 06. PMID: 33021909.
      Citations:    Fields:    
    5. He F, Celik A, Wu C, Jacobson A. General decapping activators target different subsets of inefficiently translated mRNAs. Elife. 2018 12 06; 7. PMID: 30520724.
      Citations: 18     Fields:    Translation:AnimalsCells
    6. He F, Celik A, Baker R, Jacobson A. High-Resolution Profiling of NMD Targets in Yeast. Methods Enzymol. 2018; 612:147-181. PMID: 30502940.
      Citations:    Fields:    Translation:Animals
    7. Celik A, He F, Jacobson A. NMD monitors translational fidelity 24/7. Curr Genet. 2017 Dec; 63(6):1007-1010. PMID: 28536849.
      Citations: 24     Fields:    Translation:AnimalsCells
    8. Celik A, Baker R, He F, Jacobson A. High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection. RNA. 2017 05; 23(5):735-748. PMID: 28209632.
      Citations: 43     Fields:    Translation:AnimalsCells
    9. He F, Jacobson A. Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. Annu Rev Genet. 2015; 49:339-66. PMID: 26436458.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    10. He F, Jacobson A. Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain. RNA. 2015 Sep; 21(9):1633-47. PMID: 26184073.
      Citations: 28     Fields:    Translation:AnimalsCells
    11. Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila. Development. 2014 Jul; 141(13):2621-32. PMID: 24961799.
      Citations: 5     Fields:    Translation:AnimalsCells
    12. He F, Li C, Roy B, Jacobson A. Yeast Edc3 targets RPS28B mRNA for decapping by binding to a 3' untranslated region decay-inducing regulatory element. Mol Cell Biol. 2014 Apr; 34(8):1438-51. PMID: 24492965.
      Citations: 15     Fields:    Translation:AnimalsCells
    13. He F, Ganesan R, Jacobson A. Intra- and intermolecular regulatory interactions in Upf1, the RNA helicase central to nonsense-mediated mRNA decay in yeast. Mol Cell Biol. 2013 Dec; 33(23):4672-84. PMID: 24100012.
      Citations: 11     Fields:    Translation:AnimalsCells
    14. Min EE, Roy B, Amrani N, He F, Jacobson A. Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA. 2013 Aug; 19(8):1105-15. PMID: 23801788.
      Citations: 21     Fields:    Translation:AnimalsCells
    15. Dong S, Jacobson A, He F. Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. PLoS Biol. 2010 Apr 27; 8(4):e1000360. PMID: 20463951.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. He F, Amrani N, Johansson MJ, Jacobson A. Chapter 6. Qualitative and quantitative assessment of the activity of the yeast nonsense-mediated mRNA decay pathway. Methods Enzymol. 2008; 449:127-47. PMID: 19215756.
      Citations: 15     Fields:    Translation:AnimalsCells
    17. Johansson MJ, He F, Spatrick P, Li C, Jacobson A. Association of yeast Upf1p with direct substrates of the NMD pathway. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20872-7. PMID: 18087042.
      Citations: 53     Fields:    Translation:AnimalsCells
    18. Dong S, Li C, Zenklusen D, Singer RH, Jacobson A, He F. YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA. Mol Cell. 2007 Feb 23; 25(4):559-73. PMID: 17317628.
      Citations: 50     Fields:    Translation:AnimalsCells
    19. Wang S, Farfan-Arribas DJ, Shen S, Chou TH, Hirsch A, He F, Lu S. Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine. Vaccine. 2006 May 22; 24(21):4531-40. PMID: 16140431.
      Citations: 60     Fields:    Translation:AnimalsCells
    20. Li L, He F, Litofsky NS, Recht LD, Ross AH. Profiling of genes expressed by PTEN haploinsufficient neural precursor cells. Mol Cell Neurosci. 2003 Dec; 24(4):1051-61. PMID: 14697668.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. He F, Li X, Spatrick P, Casillo R, Dong S, Jacobson A. Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast. Mol Cell. 2003 Dec; 12(6):1439-52. PMID: 14690598.
      Citations: 209     Fields:    Translation:Animals
    22. Maderazo AB, Belk JP, He F, Jacobson A. Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution. Mol Cell Biol. 2003 Feb; 23(3):842-51. PMID: 12529390.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    23. Liu H, Radhakrishnan P, Magoun L, Prabu M, Campellone KG, Savage P, He F, Schiffer CA, Leong JM. Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket. Mol Microbiol. 2002 Sep; 45(6):1557-73. PMID: 12354225.
      Citations: 13     Fields:    Translation:HumansCells
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