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Ashraf Khan MD

TitleChair and Professor
InstitutionUMass Chan – Baystate Regional Campus
DepartmentPathology at UMass Chan - Baystate
AddressBaystate Health Regional Campus
759 Chestnut Street
Springfield MA 01199
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    Collapse Biography 
    Collapse education and training
    Aligarh Muslim University, Aligarh, , IndiaBSCPre-Med
    Jawaharlal Nehru University, New Delhi, , IndiaMBBS
    Jawaharlal Nehru University, New Delhi, , IndiaMD

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    Academic Background:

    MBBSJN Medical College, Aligarh University, Aligarh, INDIA

    MDPathology, JN Medical College, Aligarh University, Aligarh, INDIA

    ResidencyHistopathology, Lewisham & Guy’s Hospital, University of London, London, UK

    FRCPath Histopathology, Royal College of Pathologists, London, UK

    Fellowship Surgical Pathology, University of Massachusetts Medical Center, Worcester, MA

    Dr. Khan's pictureResearch Interests:

    Dr. Ashraf Khan’s clinical interest includes diagnostic surgical pathology of Breast and Endocrine system. Dr. Khan is actively involved in clinical translational research focused in the field of thyroid and breast cancer investigating biomarkers that help in the diagnosis and prediction of outcome in these tumors. Over the past decade Dr. Khan has published several papers on the role of cell cycle regulatory proteins, translation initiation factors and cell adhesion molecules in the diagnosis of thyroid follicular tumors and progression of thyroid cancer. Dr. Khan was a key contributor of one large multi-institution international study published in The Lancet on the role of galectin 3 and CD44 in the diagnosis of thyroid malignancy. Dr. Khan’s collaboration with the basic scientists in the department of cancer biology at UMass has resulted in multiple projects includingb4-integrin signature in basal-like breast cancer which was recently published and Sox-9 expression in breast cancer which is work in progress. In addition Dr. Khan is a PI on a Department of Defense Grant in collaboration with Dr. Leslie Shaw in department of cancer biology looking at the Insulin Receptor Substrate Proteins (IRS1 and IRS2) in breast cancer with special focus on potential role they may play in Herceptin resistance in HER-2 positive breast cancer. He is also currently involved in studying the micro RNA signature in breast cancer especially estrogen receptor positive node negative tumors with potential therapeutic implications. Dr. Khan is a member of the UMASS graduate school of biomedical sciences representing cancer biology.

    Dr. Khan is the past President and Secretary of the Endocrine Pathology Society, a companion society of the US and Canadian Academy of Pathology. He is a reviewer for a number of pathology and endocrinology journals, serves on the editorial board of the journal Endocrine Pathology and is the Section Editor (Endocrine Pathology) of the Archives of Pathology and Laboratory Medicine. In addition to numerous original articles, Dr. Khan has authored many book chapters and invited reviews and is currently editing a text book on surgical pathology of endocrine tumors.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jermain PR, Kandil DH, Muzikansky A, Khan A, Yaroslavsky AN. Translational Potential of Fluorescence Polarization for Breast Cancer Cytopathology. Cancers (Basel). 2023 Feb 27; 15(5). PMID: 36900291.
    2. Mitrou A, Feng X, Khan A, Yaroslavsky AN. Feasibility of dual-contrast fluorescence imaging of pathological breast tissues. J Biophotonics. 2021 08; 14(8):e202100007. PMID: 34010507.
      Citations: 1     Fields:    Translation:Humans
    3. Makarenko VV, Kandil D, Cosar EF, Hutchinson L, Khan A. Molecular analysis of a rare case of low-grade primary peritoneal serous carcinoma in a male. Rare Tumors. 2020; 12:2036361320979219. PMID: 33354307.
    4. Azimi N, Azar A, Khan A, DeBenedectis CM. Benign Breast Cyst in a Young Male. Cureus. 2019 Jun 03; 11(6):e4814. PMID: 31404321.
    5. Liao H, Khan A, Miron PM, Cornejo KM. Mammary Analogue Secretory Carcinoma of the Thyroid Mimicking Locally Advanced Papillary Thyroid Carcinoma: A Rare Case Report. Int J Surg Pathol. 2018 Aug; 26(5):459-463. PMID: 29228842.
      Citations: 2     Fields:    Translation:Humans
    6. Galera P, Khan A, Kandil D. Diagnosis of Metaplastic Breast Carcinoma: Keratin OSCAR Versus Other Cytokeratins. Appl Immunohistochem Mol Morphol. 2016 10; 24(9):622-626. PMID: 26371435.
      Citations: 2     Fields:    Translation:Humans
    7. Moghaddam PA, Virk R, Sakhdari A, Prasad ML, Cosar EF, Khan A. Five Top Stories in Thyroid Pathology. Arch Pathol Lab Med. 2016 Feb; 140(2):158-70. PMID: 26910221.
      Citations: 1     Fields:    Translation:Humans
    8. Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L. The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol. 2015 Jun; 46(6):868-75. PMID: 25864386.
      Citations: 17     Fields:    Translation:Humans
    9. Patel R, Khan A, Quinlan R, Yaroslavsky AN. Polarization-sensitive multimodal imaging for detecting breast cancer. Cancer Res. 2014 Sep 01; 74(17):4685-93. PMID: 24958468.
      Citations: 27     Fields:    Translation:Humans
    10. Rao SN, Swami A, Khan A, Toke M, Whalen G, Fischer A, Torres MS. Metastatic mesothelioma to the thyroid. Cytojournal. 2014; 11:11. PMID: 24987442.
    11. Goodman S, Khan A. Florid Cystic Endosalpingiosis. Int J Surg Pathol. 2014 Jun; 22(4):336. PMID: 24771255.
      Citations: 1     Fields:    Translation:Humans
    12. Uddin T, Aktar A, Xu P, Johnson RA, Rahman MA, Leung DT, Afrin S, Akter A, Alam MM, Rahman A, Chowdhury F, Khan AI, Bhuiyan TR, Bufano MK, Rashu R, Yu Y, Wu-Freeman Y, Harris JB, LaRocque RC, Charles RC, Kov?c P, Calderwood SB, Ryan ET, Qadri F. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera. Am J Trop Med Hyg. 2014 May; 90(5):873-81. PMID: 24686738.
      Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
    13. Leidy J, Khan A, Kandil D. Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features. Arch Pathol Lab Med. 2014 Jan; 138(1):37-43. PMID: 24377810.
      Citations: 22     Fields:    Translation:Humans
    14. Cornejo KM, Kandil D, Khan A, Cosar EF. Theranostic and molecular classification of breast cancer. Arch Pathol Lab Med. 2014 Jan; 138(1):44-56. PMID: 24377811.
      Citations: 15     Fields:    Translation:Humans
    15. Yang X, Kandil D, Cosar EF, Khan A. Fibroepithelial tumors of the breast: pathologic and immunohistochemical features and molecular mechanisms. Arch Pathol Lab Med. 2014 Jan; 138(1):25-36. PMID: 24377809.
      Citations: 19     Fields:    Translation:Humans
    16. Khan A. Five top stories in breast pathology. Arch Pathol Lab Med. 2014 Jan; 138(1):14-5. PMID: 24377807.
      Citations:    Fields:    Translation:Humans
    17. Zhao L, Yang X, Khan A, Kandil D. Diagnostic role of immunohistochemistry in the evaluation of breast pathology specimens. Arch Pathol Lab Med. 2014 Jan; 138(1):16-24. PMID: 24377808.
      Citations: 5     Fields:    Translation:Humans
    18. Goodman S, O'Connor A, Kandil D, Khan A. The ever-changing role of sentinel lymph node biopsy in the management of breast cancer. Arch Pathol Lab Med. 2014 Jan; 138(1):57-64. PMID: 24377812.
      Citations: 2     Fields:    Translation:Humans
    19. Moghaddam PA, Cornejo KM, Khan A. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. Endocr Pathol. 2013 Sep; 24(3):116-24. PMID: 23872914.
      Citations: 22     Fields:    Translation:Humans
    20. Karam AR, Vijayaraghavan G, Khan A, Ustun B, Hussain S. Renal biopsy: comparative yield of cranial versus caudal needle trajectory. An ex vivo analysis. Nephrology (Carlton). 2013 Apr; 18(4):304-6. PMID: 23414122.
      Citations: 2     Fields:    Translation:Animals
    21. Patel R, Khan A, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography. J Biophotonics. 2013 Sep; 6(9):679-86. PMID: 23008236.
      Citations: 4     Fields:    Translation:Humans
    22. Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Multimodal optical imaging for detecting breast cancer. J Biomed Opt. 2012 Jun; 17(6):066008. PMID: 22734764.
      Citations: 16     Fields:    Translation:HumansCells
    23. Gerson KD, Maddula VS, Seligmann BE, Shearstone JR, Khan A, Mercurio AM. Effects of ?4 integrin expression on microRNA patterns in breast cancer. Biol Open. 2012 Jul 15; 1(7):658-66. PMID: 23213459.
      Citations: 13     Fields:    
    24. Yngvesson SK, St Peter B, Siqueira P, Kelly P, Glick S, Karellas A, Khan A. Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8221. PMID: 24353380.
    25. Ortiz-Pagan S, Cunto-Amesty G, Narayan S, Crawford S, Derrick C, Larkin A, Khan A, Quinlan R, Layeequr Rahman R. Effect of Paget's disease on survival in breast cancer: an exploratory study. Arch Surg. 2011 Nov; 146(11):1267-70. PMID: 22106318.
      Citations: 5     Fields:    Translation:Humans
    26. Buttar A, Mittal K, Khan A, Bathini V. Effective role of hormonal therapy in metastatic primary neuroendocrine breast carcinoma. Clin Breast Cancer. 2011 Oct; 11(5):342-5. PMID: 21729664.
      Citations: 7     Fields:    Translation:Humans
    27. Clark JL, Dresser K, Hsieh CC, Sabel M, Kleer CG, Khan A, Shaw LM. Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer. Breast Cancer Res Treat. 2011 Dec; 130(3):759-72. PMID: 21258861.
      Citations: 7     Fields:    Translation:HumansCells
    28. Virk RK, Khan A. Pseudoangiomatous stromal hyperplasia: an overview. Arch Pathol Lab Med. 2010 Jul; 134(7):1070-4. PMID: 20586640.
      Citations: 32     Fields:    Translation:HumansCells
    29. Karam AR, Nugent W, Khan A, Desai D, Shankar S. Curved stylet core biopsy results in larger cores. AJR Am J Roentgenol. 2010 Jul; 195(1):242-4. PMID: 20566823.
      Citations: 1     Fields:    Translation:Animals
    30. Karam AR, Nugent W, Falardeau J, Desai D, Khan A, Shankar S. Multifocal extra-adrenal myelolipoma arising in the greater omentum. J Radiol Case Rep. 2009; 3(11):20-3. PMID: 22470626.
      Citations: 7     Fields:    
    31. Walter O, Prasad M, Lu S, Quinlan RM, Edmiston KL, Khan A. IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype. Hum Pathol. 2009 Nov; 40(11):1528-33. PMID: 19695680.
      Citations: 42     Fields:    Translation:Humans
    32. Jaffar R, Mohanty SK, Khan A, Fischer AH. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms. Cytojournal. 2009 Jan 19; 6:3. PMID: 19495407.
    33. Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A. Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. Endocr Pathol. 2009; 20(3):149-57. PMID: 19449140.
      Citations: 13     Fields:    Translation:Humans
    34. Lee CW, Simin K, Liu Q, Plescia J, Guha M, Khan A, Hsieh CC, Altieri DC. A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res. 2008; 10(6):R97. PMID: 19025652.
      Citations: 62     Fields:    Translation:HumansCells
    35. Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8. PMID: 18281537.
      Citations: 66     Fields:    Translation:Humans
    36. Sharma V, Cui H, Whalen G, Khan A, Torres M. A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid. 2007 Jun; 17(6):593-4. PMID: 17614784.
      Citations:    Fields:    Translation:Humans
    37. Istvanic S, Fischer AH, Banner BF, Eaton DM, Larkin AC, Khan A. Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes. Diagn Cytopathol. 2007 May; 35(5):263-9. PMID: 17427225.
      Citations: 3     Fields:    Translation:Humans
    38. Khan A, Vohra P, Quinlan RF. The role of sentinel lymph node biopsy in the management of breast cancer. Indian J Pathol Microbiol. 2007 Apr; 50(2):261-9. PMID: 17883042.
      Citations:    Fields:    Translation:Humans
    39. Schmidt M, Khan A, Schmidt AM, Heinze B, Hack E, Waltenberger J, Kreienberg R. A novel breast cancer cell line initially established from pleural effusion: evolution towards a more aggressive phenotype. Int J Oncol. 2007 Mar; 30(3):565-72. PMID: 17273757.
      Citations: 2     Fields:    Translation:HumansCells
    40. Ciampa A, Xu B, Ayata G, Baiyee D, Wallace J, Wertheimer M, Edmiston K, Khan A. HER-2 status in breast cancer: correlation of gene amplification by FISH with immunohistochemistry expression using advanced cellular imaging system. Appl Immunohistochem Mol Morphol. 2006 Jun; 14(2):132-7. PMID: 16785779.
      Citations: 14     Fields:    Translation:Humans
    41. Rezk S, Khan A. Role of immunohistochemistry in the diagnosis and progression of follicular epithelium-derived thyroid carcinoma. Appl Immunohistochem Mol Morphol. 2005 Sep; 13(3):256-64. PMID: 16082252.
      Citations: 7     Fields:    Translation:Humans
    42. Brooks WA, Santosham M, Roy SK, Faruque AS, Wahed MA, Nahar K, Khan AI, Khan AF, Fuchs GJ, Black RE. Efficacy of zinc in young infants with acute watery diarrhea. Am J Clin Nutr. 2005 Sep; 82(3):605-10. PMID: 16155274.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    43. Ciampa A, Fanger G, Khan A, Rock KL, Xu B. Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas. Cancer. 2004 Dec 25; 102(6):368-72. PMID: 15558786.
      Citations: 8     Fields:    Translation:Humans
    44. Rezk S, Yousef M, Zamansky M, Khan A. Solitary fibrous tumor of the auditory canal. Arch Pathol Lab Med. 2004 Dec; 128(12):e169-71. PMID: 15578904.
      Citations: 6     Fields:    Translation:Humans
    45. Khan A, Tischler AS, Patwardhan NA, DeLellis RA. Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study. Endocr Pathol. 2003; 14(3):249-55. PMID: 14586070.
      Citations: 2     Fields:    Translation:Humans
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