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Ashraf Khan MD

TitleChair and Professor
InstitutionUMMS - Baystate Regional Campus
DepartmentPathology at UMMS-Baystate
AddressBaystate Health Regional Campus
759 Chestnut Street
Springfield MA 01199
Phone508-856-6214
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    Collapse Biography 
    Collapse education and training
    Aligarh Muslim University, Aligarh, , IndiaBSCPre-Med
    Jawaharlal Nehru University, New Delhi, , IndiaMBBS
    Jawaharlal Nehru University, New Delhi, , IndiaMD

    Collapse Overview 
    Collapse overview

    Academic Background:

    MBBSJN Medical College, Aligarh University, Aligarh, INDIA

    MDPathology, JN Medical College, Aligarh University, Aligarh, INDIA

    ResidencyHistopathology, Lewisham & Guy’s Hospital, University of London, London, UK

    FRCPath Histopathology, Royal College of Pathologists, London, UK

    Fellowship Surgical Pathology, University of Massachusetts Medical Center, Worcester, MA

    Dr. Khan's pictureResearch Interests:

    Dr. Ashraf Khan’s clinical interest includes diagnostic surgical pathology of Breast and Endocrine system. Dr. Khan is actively involved in clinical translational research focused in the field of thyroid and breast cancer investigating biomarkers that help in the diagnosis and prediction of outcome in these tumors. Over the past decade Dr. Khan has published several papers on the role of cell cycle regulatory proteins, translation initiation factors and cell adhesion molecules in the diagnosis of thyroid follicular tumors and progression of thyroid cancer. Dr. Khan was a key contributor of one large multi-institution international study published in The Lancet on the role of galectin 3 and CD44 in the diagnosis of thyroid malignancy. Dr. Khan’s collaboration with the basic scientists in the department of cancer biology at UMass has resulted in multiple projects includingb4-integrin signature in basal-like breast cancer which was recently published and Sox-9 expression in breast cancer which is work in progress. In addition Dr. Khan is a PI on a Department of Defense Grant in collaboration with Dr. Leslie Shaw in department of cancer biology looking at the Insulin Receptor Substrate Proteins (IRS1 and IRS2) in breast cancer with special focus on potential role they may play in Herceptin resistance in HER-2 positive breast cancer. He is also currently involved in studying the micro RNA signature in breast cancer especially estrogen receptor positive node negative tumors with potential therapeutic implications. Dr. Khan is a member of the UMASS graduate school of biomedical sciences representing cancer biology.

    Dr. Khan is the past President and Secretary of the Endocrine Pathology Society, a companion society of the US and Canadian Academy of Pathology. He is a reviewer for a number of pathology and endocrinology journals, serves on the editorial board of the journal Endocrine Pathology and is the Section Editor (Endocrine Pathology) of the Archives of Pathology and Laboratory Medicine. In addition to numerous original articles, Dr. Khan has authored many book chapters and invited reviews and is currently editing a text book on surgical pathology of endocrine tumors.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Azimi N, Azar A, Khan A, DeBenedectis CM. Benign Breast Cyst in a Young Male. Cureus. 2019 Jun 03; 11(6):e4814. PMID: 31404321.
      View in: PubMed
    2. Bai S, Hutchinson LM, Meng X, Bai H, Cosar EF, Khan A, Cornejo K. Dedifferentiated Carcinoma of the Endometrium Associated With Low-Grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. Int J Gynecol Pathol. 2019 Mar 22. PMID: 30908285.
      View in: PubMed
    3. Liao H, Khan A, Miron PM, Cornejo KM. Mammary Analogue Secretory Carcinoma of the Thyroid Mimicking Locally Advanced Papillary Thyroid Carcinoma: A Rare Case Report. Int J Surg Pathol. 2017 Dec 01; 1066896917747076. PMID: 29228842.
      View in: PubMed
    4. Galera P, Khan A, Kandil D. Diagnosis of Metaplastic Breast Carcinoma: Keratin OSCAR Versus Other Cytokeratins. Appl Immunohistochem Mol Morphol. 2016 Oct; 24(9):622-626. PMID: 26371435.
      View in: PubMed
    5. Moghaddam PA, Virk R, Sakhdari A, Prasad ML, Cosar EF, Khan A. Five Top Stories in Thyroid Pathology. Arch Pathol Lab Med. 2016 Feb; 140(2):158-70. PMID: 26910221.
      View in: PubMed
    6. Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L. The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol. 2015 Jun; 46(6):868-75. PMID: 25864386.
      View in: PubMed
    7. Patel R, Khan A, Quinlan R, Yaroslavsky AN. Polarization-sensitive multimodal imaging for detecting breast cancer. Cancer Res. 2014 Sep 1; 74(17):4685-93. PMID: 24958468.
      View in: PubMed
    8. Rao SN, Swami A, Khan A, Toke M, Whalen G, Fischer A, Torres MS. Metastatic mesothelioma to the thyroid. Cytojournal. 2014; 11:11. PMID: 24987442.
      View in: PubMed
    9. Goodman S, Khan A. Florid Cystic Endosalpingiosis. Int J Surg Pathol. 2014 Jun; 22(4):336. PMID: 24771255.
      View in: PubMed
    10. Uddin T, Aktar A, Xu P, Johnson RA, Rahman MA, Leung DT, Afrin S, Akter A, Alam MM, Rahman A, Chowdhury F, Khan AI, Bhuiyan TR, Bufano MK, Rashu R, Yu Y, Wu-Freeman Y, Harris JB, LaRocque RC, Charles RC, Kovác P, Calderwood SB, Ryan ET, Qadri F. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera. Am J Trop Med Hyg. 2014 May; 90(5):873-81. PMID: 24686738.
      View in: PubMed
    11. Leidy J, Khan A, Kandil D. Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features. Arch Pathol Lab Med. 2014 Jan; 138(1):37-43. PMID: 24377810.
      View in: PubMed
    12. Cornejo KM, Kandil D, Khan A, Cosar EF. Theranostic and molecular classification of breast cancer. Arch Pathol Lab Med. 2014 Jan; 138(1):44-56. PMID: 24377811.
      View in: PubMed
    13. Yang X, Kandil D, Cosar EF, Khan A. Fibroepithelial tumors of the breast: pathologic and immunohistochemical features and molecular mechanisms. Arch Pathol Lab Med. 2014 Jan; 138(1):25-36. PMID: 24377809.
      View in: PubMed
    14. Khan A. Five top stories in breast pathology. Arch Pathol Lab Med. 2014 Jan; 138(1):14-5. PMID: 24377807.
      View in: PubMed
    15. Zhao L, Yang X, Khan A, Kandil D. Diagnostic role of immunohistochemistry in the evaluation of breast pathology specimens. Arch Pathol Lab Med. 2014 Jan; 138(1):16-24. PMID: 24377808.
      View in: PubMed
    16. Goodman S, O'Connor A, Kandil D, Khan A. The ever-changing role of sentinel lymph node biopsy in the management of breast cancer. Arch Pathol Lab Med. 2014 Jan; 138(1):57-64. PMID: 24377812.
      View in: PubMed
    17. Moghaddam PA, Cornejo KM, Khan A. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. Endocr Pathol. 2013 Sep; 24(3):116-24. PMID: 23872914.
      View in: PubMed
    18. Karam AR, Vijayaraghavan G, Khan A, Ustun B, Hussain S. Renal biopsy: comparative yield of cranial versus caudal needle trajectory. An ex vivo analysis. Nephrology (Carlton). 2013 Apr; 18(4):304-6. PMID: 23414122.
      View in: PubMed
    19. Patel R, Khan A, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography. J Biophotonics. 2013 Sep; 6(9):679-86. PMID: 23008236.
      View in: PubMed
    20. Patel R, Khan A, Wirth D, Kamionek M, Kandil D, Quinlan R, Yaroslavsky AN. Multimodal optical imaging for detecting breast cancer. J Biomed Opt. 2012 Jun; 17(6):066008. PMID: 22734764.
      View in: PubMed
    21. Gerson KD, Maddula VS, Seligmann BE, Shearstone JR, Khan A, Mercurio AM. Effects of ß4 integrin expression on microRNA patterns in breast cancer. Biol Open. 2012 Jul 15; 1(7):658-66. PMID: 23213459.
      View in: PubMed
    22. Yngvesson SK, St Peter B, Siqueira P, Kelly P, Glick S, Karellas A, Khan A. Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination. Proc SPIE Int Soc Opt Eng. 2012 Feb 9; 8221. PMID: 24353380.
      View in: PubMed
    23. Ortiz-Pagan S, Cunto-Amesty G, Narayan S, Crawford S, Derrick C, Larkin A, Khan A, Quinlan R, Layeequr Rahman R. Effect of Paget's disease on survival in breast cancer: an exploratory study. Arch Surg. 2011 Nov; 146(11):1267-70. PMID: 22106318.
      View in: PubMed
    24. Buttar A, Mittal K, Khan A, Bathini V. Effective role of hormonal therapy in metastatic primary neuroendocrine breast carcinoma. Clin Breast Cancer. 2011 Oct; 11(5):342-5. PMID: 21729664.
      View in: PubMed
    25. Clark JL, Dresser K, Hsieh CC, Sabel M, Kleer CG, Khan A, Shaw LM. Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer. Breast Cancer Res Treat. 2011 Dec; 130(3):759-72. PMID: 21258861.
      View in: PubMed
    26. Virk RK, Khan A. Pseudoangiomatous stromal hyperplasia: an overview. Arch Pathol Lab Med. 2010 Jul; 134(7):1070-4. PMID: 20586640.
      View in: PubMed
    27. Karam AR, Nugent W, Khan A, Desai D, Shankar S. Curved stylet core biopsy results in larger cores. AJR Am J Roentgenol. 2010 Jul; 195(1):242-4. PMID: 20566823.
      View in: PubMed
    28. Karam AR, Nugent W, Falardeau J, Desai D, Khan A, Shankar S. Multifocal extra-adrenal myelolipoma arising in the greater omentum. J Radiol Case Rep. 2009; 3(11):20-3. PMID: 22470626.
      View in: PubMed
    29. Walter O, Prasad M, Lu S, Quinlan RM, Edmiston KL, Khan A. IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype. Hum Pathol. 2009 Nov; 40(11):1528-33. PMID: 19695680.
      View in: PubMed
    30. Jaffar R, Mohanty SK, Khan A, Fischer AH. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms. Cytojournal. 2009; 6:3. PMID: 19495407.
      View in: PubMed
    31. Slosar M, Vohra P, Prasad M, Fischer A, Quinlan R, Khan A. Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. Endocr Pathol. 2009; 20(3):149-57. PMID: 19449140.
      View in: PubMed
    32. Lee CW, Simin K, Liu Q, Plescia J, Guha M, Khan A, Hsieh CC, Altieri DC. A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res. 2008; 10(6):R97. PMID: 19025652.
      View in: PubMed
    33. Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8. PMID: 18281537.
      View in: PubMed
    34. Sharma V, Cui H, Whalen G, Khan A, Torres M. A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid. 2007 Jun; 17(6):593-4. PMID: 17614784.
      View in: PubMed
    35. Istvanic S, Fischer AH, Banner BF, Eaton DM, Larkin AC, Khan A. Cell blocks of breast FNAs frequently allow diagnosis of invasion or histological classification of proliferative changes. Diagn Cytopathol. 2007 May; 35(5):263-9. PMID: 17427225.
      View in: PubMed
    36. Khan A, Vohra P, Quinlan RF. The role of sentinel lymph node biopsy in the management of breast cancer. Indian J Pathol Microbiol. 2007 Apr; 50(2):261-9. PMID: 17883042.
      View in: PubMed
    37. Schmidt M, Khan A, Schmidt AM, Heinze B, Hack E, Waltenberger J, Kreienberg R. A novel breast cancer cell line initially established from pleural effusion: evolution towards a more aggressive phenotype. Int J Oncol. 2007 Mar; 30(3):565-72. PMID: 17273757.
      View in: PubMed
    38. Ciampa A, Xu B, Ayata G, Baiyee D, Wallace J, Wertheimer M, Edmiston K, Khan A. HER-2 status in breast cancer: correlation of gene amplification by FISH with immunohistochemistry expression using advanced cellular imaging system. Appl Immunohistochem Mol Morphol. 2006 Jun; 14(2):132-7. PMID: 16785779.
      View in: PubMed
    39. Rezk S, Khan A. Role of immunohistochemistry in the diagnosis and progression of follicular epithelium-derived thyroid carcinoma. Appl Immunohistochem Mol Morphol. 2005 Sep; 13(3):256-64. PMID: 16082252.
      View in: PubMed
    40. Ciampa A, Fanger G, Khan A, Rock KL, Xu B. Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas. Cancer. 2004 Dec 25; 102(6):368-72. PMID: 15558786.
      View in: PubMed
    41. Rezk S, Yousef M, Zamansky M, Khan A. Solitary fibrous tumor of the auditory canal. Arch Pathol Lab Med. 2004 Dec; 128(12):e169-71. PMID: 15578904.
      View in: PubMed
    42. Khan A, Tischler AS, Patwardhan NA, DeLellis RA. Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study. Endocr Pathol. 2003; 14(3):249-55. PMID: 14586070.
      View in: PubMed
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