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Adilson L Guilherme PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street
Worcester MA 01605
Phone508-856-6858
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    Federal University of Rio de Janeiro, Rio de Janeiro, RJ, BrazilBSCell Biology
    Federal University of Rio de Janeiro, Rio de Janeiro, RJ, BrazilPH DBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP. Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. Mol Metab. 2018 Oct; 16:116-125. PMID: 30005879.
      View in: PubMed
    2. Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP. Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming. Mol Metab. 2017 Aug; 6(8):781-796. PMID: 28752043.
      View in: PubMed
    3. Henriques FS, Sertié RAL, Franco FO, Knobl P, Neves RX, Andreotti S, Lima FB, Guilherme A, Seelaender M, Batista ML. Early suppression of adipocyte lipid turnover induces immunometabolic modulation in cancer cachexia syndrome. FASEB J. 2017 05; 31(5):1976-1986. PMID: 28138038.
      View in: PubMed
    4. Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S. Activation of mTORC1 is essential for ß-adrenergic stimulation of adipose browning. J Clin Invest. 2016 May 02; 126(5):1704-16. PMID: 27018708.
      View in: PubMed
    5. Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP. A major role of insulin in promoting obesity-associated adipose tissue inflammation. Mol Metab. 2015 Jul; 4(7):507-18. PMID: 26137438.
      View in: PubMed
    6. DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP. The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis. J Biol Chem. 2015 Jun 12; 290(24):15175-84. PMID: 25922078.
      View in: PubMed
    7. Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP. Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res. 2013 Oct; 54(10):2697-707. PMID: 23924694.
      View in: PubMed
    8. Sartorius T, Staiger H, Ketterer C, Heni M, Machicao F, Guilherme A, Grallert H, Schulze MB, Boeing H, Stefan N, Fritsche A, Czech MP, Häring HU. Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans. PLoS One. 2012; 7(10):e47647. PMID: 23094072.
      View in: PubMed
    9. Guntur KV, Guilherme A, Xue L, Chawla A, Czech MP. Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem. 2010 Feb 26; 285(9):6595-603. PMID: 20038583.
      View in: PubMed
    10. Guilherme A, Tesz GJ, Guntur KV, Czech MP. Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem. 2009 Jun 19; 284(25):17082-91. PMID: 19321447.
      View in: PubMed
    11. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 May; 9(5):367-77. PMID: 18401346.
      View in: PubMed
    12. DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007 Nov 30; 28(4):569-83. PMID: 18042453.
      View in: PubMed
    13. Tesz GJ, Guilherme A, Guntur KV, Hubbard AC, Tang X, Chawla A, Czech MP. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem. 2007 Jul 6; 282(27):19302-12. PMID: 17500068.
      View in: PubMed
    14. Tang X, Guilherme A, Chakladar A, Powelka AM, Konda S, Virbasius JV, Nicoloro SM, Straubhaar J, Czech MP. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2087-92. PMID: 16461467.
      View in: PubMed
    15. Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006 Jan; 116(1):125-36. PMID: 16374519.
      View in: PubMed
    16. Bose A, Guilherme A, Huang S, Hubbard AC, Lane CR, Soriano NA, Czech MP. The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes. J Biol Chem. 2005 Nov 4; 280(44):36946-51. PMID: 16131485.
      View in: PubMed
    17. Assunção-Miranda I, Guilherme AL, Reis-Silva C, Costa-Sarmento G, Oliveira MM, Vieyra A. Protein kinase C-mediated inhibition of renal Ca2+ ATPase by physiological concentrations of angiotensin II is reversed by AT1- and AT2-receptor antagonists. Regul Pept. 2005 Apr 15; 127(1-3):151-7. PMID: 15680481.
      View in: PubMed
    18. Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem. 2005 Jun 10; 280(23):22523-9. PMID: 15824124.
      View in: PubMed
    19. Guilherme A, Soriano NA, Furcinitti PS, Czech MP. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem. 2004 Sep 17; 279(38):40062-75. PMID: 15247266.
      View in: PubMed
    20. Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12; 279(11):10593-605. PMID: 14676205.
      View in: PubMed
    21. Einicker-Lamas M, Wenceslau LD, Bernardo RR, Nogaroli L, Guilherme A, Oliveira MM, Vieyra A. Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids. J Biochem. 2003 Oct; 134(4):529-36. PMID: 14607979.
      View in: PubMed
    22. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4. PMID: 12490950.
      View in: PubMed
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