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Carol E Schrader PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    Collapse Biography 
    Collapse education and training
    Wesleyan University, Middleton, CT, United StatesB ABiochemistry
    University of Pennsylvania, Philadelphia, PA, United StatesPH DImmunology

    Collapse Overview 
    Collapse Summary
    Focus: Director of Flow Cytometry Core
    Collapse overview


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schrader CE, Williams T, Pechhold K, Linehan EK, Tsuchimoto D, Nakabeppu Y. APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. J Immunol. 2023 06 01; 210(11):1804-1814. PMID: 37074207.
      Citations:    Fields:    Translation:AnimalsCells
    2. Ochodnicka-Mackovicova K, Bahjat M, Maas C, van der Veen A, Bloedjes TA, de Bruin AM, van Andel H, Schrader CE, Hendriks RW, Verhoeyen E, Bende RJ, van Noesel CJ, Guikema JE. The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling. J Immunol. 2016 10 01; 197(7):2918-29. PMID: 27559048.
      Citations: 16     Fields:    Translation:HumansCells
    3. Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J. Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS One. 2015; 10(8):e0134397. PMID: 26267846.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Khair L, Baker RE, Linehan EK, Schrader CE, Stavnezer J. Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells. PLoS Genet. 2015 Aug; 11(8):e1005438. PMID: 26263206.
      Citations: 9     Fields:    Translation:AnimalsCells
    5. Stavnezer J, Schrader CE. Response to comment on "IgH chain class switch recombination: mechanism and regulation". J Immunol. 2015 Mar 01; 194(5):2040. PMID: 25710955.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Stavnezer J, Schrader CE. IgH chain class switch recombination: mechanism and regulation. J Immunol. 2014 Dec 01; 193(11):5370-8. PMID: 25411432.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    7. Ucher AJ, Ranjit S, Kadungure T, Linehan EK, Khair L, Xie E, Limauro J, Rauch KS, Schrader CE, Stavnezer J. Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching. J Immunol. 2014 Aug 01; 193(3):1440-50. PMID: 24973444.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. J Immunol. 2014 Jul 15; 193(2):931-9. PMID: 24935922.
      Citations: 11     Fields:    Translation:AnimalsCells
    9. Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y, Schrader CE. Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9217-22. PMID: 24927551.
      Citations: 36     Fields:    Translation:AnimalsCells
    10. Khair L, Guikema JE, Linehan EK, Ucher AJ, Leus NG, Ogilvie C, Lou Z, Schrader CE, Stavnezer J. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol. 2014 May 15; 192(10):4887-96. PMID: 24729610.
      Citations: 13     Fields:    Translation:AnimalsCells
    11. Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J. DNA polymerases ? and ? do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst). 2013 Dec; 12(12):1087-93. PMID: 24084171.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Ucher AJ, Linehan EK, Teebor GW, Schrader CE, Stavnezer J. The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells. PLoS One. 2012; 7(4):e36061. PMID: 22536455.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J. AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol. 2011 Sep 01; 187(5):2464-75. PMID: 21804017.
      Citations: 35     Fields:    Translation:AnimalsCells
    14. Guikema JE, Gerstein RM, Linehan EK, Cloherty EK, Evan-Browning E, Tsuchimoto D, Nakabeppu Y, Schrader CE. Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. J Immunol. 2011 Feb 15; 186(4):1943-50. PMID: 21228350.
      Citations: 20     Fields:    Translation:AnimalsCells
    15. Pei DS, Yang XJ, Liu W, Guikema JE, Schrader CE, Strauss PR. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic Acids Res. 2011 Apr; 39(8):3156-65. PMID: 21172930.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, El Falaky N, Li DH, Sluss HK, Szomolanyi-Tsuda E, Stavnezer J. p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol. 2010 Jun 01; 184(11):6177-87. PMID: 20483782.
      Citations: 13     Fields:    Translation:Animals
    17. Guikema JE, Stavnezer J, Schrader CE. The role of Apex2 in class-switch recombination of immunoglobulin genes. Int Immunol. 2010 Mar; 22(3):213; author reply 213-4. PMID: 20185435.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Eccleston J, Schrader CE, Yuan K, Stavnezer J, Selsing E. Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J Immunol. 2009 Jul 15; 183(2):1222-8. PMID: 19553545.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Schrader CE, Guikema JE, Wu X, Stavnezer J. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):645-52. PMID: 19010771.
      Citations: 33     Fields:    Translation:Cells
    20. Guikema JE, Schrader CE, Leus NG, Ucher A, Linehan EK, Werling U, Edelmann W, Stavnezer J. Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching. J Immunol. 2008 Dec 15; 181(12):8450-9. PMID: 19050263.
      Citations: 7     Fields:    Translation:AnimalsCells
    21. Stavnezer J, Guikema JE, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol. 2008; 26:261-92. PMID: 18370922.
      Citations: 503     Fields:    Translation:HumansAnimals
    22. Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med. 2007 Nov 26; 204(12):3017-26. PMID: 18025127.
      Citations: 95     Fields:    Translation:AnimalsCells
    23. Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J. Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J Immunol. 2007 Nov 01; 179(9):6064-71. PMID: 17947680.
      Citations: 78     Fields:    Translation:AnimalsCells
    24. Stavnezer J, Schrader CE. Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination. Trends Genet. 2006 Jan; 22(1):23-8. PMID: 16309779.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    25. Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8. PMID: 16103411.
      Citations: 94     Fields:    Translation:AnimalsCells
    26. Min IM, Rothlein LR, Schrader CE, Stavnezer J, Selsing E. Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J Exp Med. 2005 Jun 20; 201(12):1885-90. PMID: 15955838.
      Citations: 17     Fields:    Translation:AnimalsCells
    27. Schrader CE, Vardo J, Linehan E, Twarog MZ, Niedernhofer LJ, Hoeijmakers JH, Stavnezer J. Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med. 2004 Aug 02; 200(3):321-30. PMID: 15280420.
      Citations: 15     Fields:    Translation:AnimalsCells
    28. Schrader CE, Bradley SP, Vardo J, Mochegova SN, Flanagan E, Stavnezer J. Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. EMBO J. 2003 Nov 03; 22(21):5893-903. PMID: 14592986.
      Citations: 40     Fields:    Translation:AnimalsCells
    29. Min IM, Schrader CE, Vardo J, Luby TM, D'Avirro N, Stavnezer J, Selsing E. The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2. Immunity. 2003 Oct; 19(4):515-24. PMID: 14563316.
      Citations: 37     Fields:    Translation:AnimalsCells
    30. Schrader CE, Vardo J, Stavnezer J. Mlh1 can function in antibody class switch recombination independently of Msh2. J Exp Med. 2003 May 19; 197(10):1377-83. PMID: 12743174.
      Citations: 23     Fields:    Translation:AnimalsCells
    31. Drouin EE, Schrader CE, Stavnezer J, Hansen U. The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA. J Immunol. 2002 Mar 15; 168(6):2847-56. PMID: 11884454.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    32. Schrader CE, Vardo J, Stavnezer J. Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J Exp Med. 2002 Feb 04; 195(3):367-73. PMID: 11828012.
      Citations: 57     Fields:    Translation:AnimalsCells
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