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Oliver D. King PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressWellstone Program
55 Lake Avenue North, S5-141
Worcester MA 01655
Phone774-455-1572
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    University of Hawaii at Manoa, Manoa, HI, United StatesBAMathematics
    University of California, Berkeley, Berkeley, CA, United StatesMSComputer Sciences
    University of California, Berkeley, Berkeley, CA, United StatesPHDMathematics

    Collapse Overview 
    Collapse overview

    Wellstone Program / Neurology


    Academic Background



    • 2016-present: Assistant Professor, Neurology, UMMS

    • 2013-2016: Assistant Professor, Cell and Developmental Biology, UMMS

    • 2007-2013: Scientist, Boston Biomedical Research Institute

    • 2004-2007: Postdoctoral Associate, Whitehead Institute

    • 2001-2004: Postdoctoral Fellow, Harvard Medical School

    • 2001: PhD in Mathematics, University of California, Berkeley

    • 1999: MS in Computer Science, University of California, Berkeley

    • 1992: BA in Mathematics, University of Hawaii, Manoa


     




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19; 173(3):677-692.e20. PMID: 29677512.
      View in: PubMed
    2. King OD, Poor C, Shurman J, Yuen DS. Using Katsurada's determination of the Eisenstein series to compute Siegel eigenforms. Mathematics of Computation. 2018; 87:879-892.
    3. Chen JC, King OD, Zhang Y, Clayton NP, Spencer C, Wentworth BM, Emerson CP, Wagner KR. Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics. Mol Ther. 2016 Aug; 24(8):1405-11. PMID: 27378237.
      View in: PubMed
    4. March ZM, King OD, Shorter J. Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Res. 2016 Sep 15; 1647:9-18. PMID: 26996412.
      View in: PubMed
    5. Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7:37. PMID: 25904990.
      View in: PubMed
    6. Jones TI, Yan C, Sapp PC, McKenna-Yasek D, Kang PB, Quinn C, Salameh JS, King OD, Jones PL. Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing. Clin Epigenetics. 2014; 6(1):23. PMID: 25400706.
      View in: PubMed
    7. Lancaster AK, Nutter-Upham A, Lindquist S, King OD. PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition. Bioinformatics. 2014 Sep 1; 30(17):2501-2. PMID: 24825614.
      View in: PubMed
    8. Zhang Y, King OD, Rahimov F, Jones TI, Ward CW, Kerr JP, Liu N, Emerson CP, Kunkel LM, Partridge TA, Wagner KR. Human skeletal muscle xenograft as a new preclinical model for muscle disorders. Hum Mol Genet. 2014 Jun 15; 23(12):3180-8. PMID: 24452336.
      View in: PubMed
    9. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
      View in: PubMed
    10. Jackson WS, Borkowski AW, Watson NE, King OD, Faas H, Jasanoff A, Lindquist S. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14759-64. PMID: 23959875.
      View in: PubMed
    11. Stadler G, King OD, Robin JD, Shay JW, Wright WE. Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story? Rare Dis. 2013; 1:e26142. PMID: 25003004.
      View in: PubMed
    12. Chesi A, Staahl BT, Jovicic A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013 Jul; 16(7):851-5. PMID: 23708140.
      View in: PubMed
    13. Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP, Wright WE. Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nat Struct Mol Biol. 2013 Jun; 20(6):671-8. PMID: 23644600.
      View in: PubMed
    14. Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. J Cell Biol. 2013 Apr 29; 201(3):361-72. PMID: 23629963.
      View in: PubMed
    15. Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 2013 Mar 28; 495(7442):467-73. PMID: 23455423.
      View in: PubMed
    16. Rahimov F, King OD, Leung DG, Bibat GM, Emerson CP, Kunkel LM, Wagner KR. Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16234-9. PMID: 22988124.
      View in: PubMed
    17. Gallardo CM, Gunapala KM, King OD, Steele AD. Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation. PLoS One. 2012; 7(7):e41161. PMID: 22815954.
      View in: PubMed
    18. Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30. PMID: 22798623.
      View in: PubMed
    19. McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chem Biol. 2012 Sep 21; 7(9):1520-8. PMID: 22724584.
      View in: PubMed
    20. Luby MD, Hsu CT, Shuster SA, Gallardo CM, Mistlberger RE, King OD, Steele AD. Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals. PLoS One. 2012; 7(5):e37992. PMID: 22662260.
      View in: PubMed
    21. Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet. 2012 Jul 1; 21(13):2899-911. PMID: 22454397.
      View in: PubMed
    22. King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res. 2012 Jun 26; 1462:61-80. PMID: 22445064.
      View in: PubMed
    23. Zarringhalam K, Ka M, Kook YH, Terranova JI, Suh Y, King OD, Um M. An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease. Behav Brain Res. 2012 Apr 1; 229(1):216-25. PMID: 22266926.
      View in: PubMed
    24. Matsumiya LC, Sorge RE, Sotocinal SG, Tabaka JM, Wieskopf JS, Zaloum A, King OD, Mogil JS. Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J Am Assoc Lab Anim Sci. 2012 Jan; 51(1):42-9. PMID: 22330867.
      View in: PubMed
    25. Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD. A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):20881-90. PMID: 22065782.
      View in: PubMed
    26. Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JC, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain. 2011; 7:55. PMID: 21801409.
      View in: PubMed
    27. Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S. Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell. 2011 Jul 8; 43(1):72-84. PMID: 21726811.
      View in: PubMed
    28. Rahimov F, King OD, Warsing LC, Powell RE, Emerson CP, Kunkel LM, Wagner KR. Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. Physiol Genomics. 2011 Apr 27; 43(8):398-407. PMID: 21266502.
      View in: PubMed
    29. Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64. PMID: 21217751.
      View in: PubMed
    30. Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci. 2010 Apr 15; 123(Pt 8):1191-201. PMID: 20356930.
      View in: PubMed
    31. Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, Lindquist S. Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron. 2009 Aug 27; 63(4):438-50. PMID: 19709627.
      View in: PubMed
    32. Alberti S, Halfmann R, King O, Kapila A, Lindquist S. A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell. 2009 Apr 3; 137(1):146-58. PMID: 19345193.
      View in: PubMed
    33. Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet. 2009 Mar; 41(3):316-23. PMID: 19234470.
      View in: PubMed
    34. Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. 2008 Sep 9; 105(36):13626-31. PMID: 18757733.
      View in: PubMed
    35. Tian W, Zhang LV, Tasan M, Gibbons FD, King OD, Park J, Wunderlich Z, Cherry JM, Roth FP. Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol. 2008; 9 Suppl 1:S7. PMID: 18613951.
      View in: PubMed
    36. Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci. 2007 Nov 21; 27(47):13022-7. PMID: 18032675.
      View in: PubMed
    37. King OD, Masel J. The evolution of bet-hedging adaptations to rare scenarios. Theor Popul Biol. 2007 Dec; 72(4):560-75. PMID: 17915273.
      View in: PubMed
    38. Steele AD, Jackson WS, King OD, Lindquist S. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A. 2007 Feb 6; 104(6):1983-8. PMID: 17261803.
      View in: PubMed
    39. King OD, Gaborit P. Binary templates for comma-free DNA codes. Discrete Appl Math (Computational Molecular Biology Series, Issue V). 2007; 155(6-7):831-839.
    40. Masel J, King OD, Maughan H. The loss of adaptive plasticity during long periods of environmental stasis. Am Nat. 2007 Jan; 169(1):38-46. PMID: 17206583.
      View in: PubMed
    41. Zhang LV, King OD, Wong SL, Goldberg DS, Tong AH, Lesage G, Andrews B, Bussey H, Boone C, Roth FP. Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol. 2005; 4(2):6. PMID: 15982408.
      View in: PubMed
    42. Gaborit P, King OD. Linear constructions for DNA codes. Theor Comput Sci. 2005; 334:99-113.
    43. King OD. Comment on "Subgraphs in random networks". Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Nov; 70(5 Pt 2):058101; author reply 058102. PMID: 15600808.
      View in: PubMed
    44. Wong SL, Zhang LV, Tong AH, Li Z, Goldberg DS, King OD, Lesage G, Vidal M, Andrews B, Bussey H, Boone C, Roth FP. Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44):15682-7. PMID: 15496468.
      View in: PubMed
    45. Asthana S, King OD, Gibbons FD, Roth FP. Predicting protein complex membership using probabilistic network reliability. Genome Res. 2004 Jun; 14(6):1170-5. PMID: 15140827.
      View in: PubMed
    46. Zhang LV, Wong SL, King OD, Roth FP. Predicting co-complexed protein pairs using genomic and proteomic data integration. BMC Bioinformatics. 2004 Apr 16; 5:38. PMID: 15090078.
      View in: PubMed
    47. Elias JE, Gibbons FD, King OD, Roth FP, Gygi SP. Intensity-based protein identification by machine learning from a library of tandem mass spectra. Nat Biotechnol. 2004 Feb; 22(2):214-9. PMID: 14730315.
      View in: PubMed
    48. Berriz GF, King OD, Bryant B, Sander C, Roth FP. Characterizing gene sets with FuncAssociate. Bioinformatics. 2003 Dec 12; 19(18):2502-4. PMID: 14668247.
      View in: PubMed
    49. King OD, Roth FP. A non-parametric model for transcription factor binding sites. Nucleic Acids Res. 2003 Oct 1; 31(19):e116. PMID: 14500844.
      View in: PubMed
    50. King OD, Foulger RE, Dwight SS, White JV, Roth FP. Predicting gene function from patterns of annotation. Genome Res. 2003 May; 13(5):896-904. PMID: 12695322.
      View in: PubMed
    51. Berriz GF, White JV, King OD, Roth FP. GoFish finds genes with combinations of Gene Ontology attributes. Bioinformatics. 2003 Apr 12; 19(6):788-9. PMID: 12691998.
      View in: PubMed
    52. King OD, Lee JC, Dudley AM, Janse DM, Church GM, Roth FP. Predicting phenotype from patterns of annotation. Bioinformatics. 2003; 19 Suppl 1:i183-9. PMID: 12855456.
      View in: PubMed
    53. King OD. A mass formula for unimodular lattices with no roots. Math Comput. 2003; 72(242):839-863.
    54. King OD. Bounds for DNA codes with constant GC-content. Electron J Comb. 2003; 10(1):#33.
    55. King OD. The mass of extremal doubly-even self-dual codes of length 40. IEEE Trans Inform Theory. 2001; 47(6):2558-2560.
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