Michael Heneka to Inflammasomes
This is a "connection" page, showing publications Michael Heneka has written about Inflammasomes.
Connection Strength
6.369
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Li T, Castro-Gomez S, Botella Lucena P, Vieira-Saecker A, Schwartz S, Ding Y, Deng Y, Gou M, Stein V, Golenbock DT, Latz E, Heneka MT. Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model. J Clin Invest. 2026 Apr 01; 136(7).
Score: 0.734
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Owona BA, Mary A, Messi AN, Ravichandran KA, Mbing JN, Pegnyemb E, Moundipa PF, Heneka MT. Biflavonoid Methylchamaejasmin and Khaya grandifoliola?Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Mol Neurobiol. 2025 Feb; 62(2):1605-1619.
Score: 0.657
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Ravichandran KA, Heneka MT. Inflammasome activation in neurodegenerative diseases. Essays Biochem. 2021 12 22; 65(7):885-904.
Score: 0.550
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Scheiblich H, Bousset L, Schwartz S, Griep A, Latz E, Melki R, Heneka MT. Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies. J Immunol. 2021 10 15; 207(8):2143-2154.
Score: 0.539
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Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Bu?e L, Heneka MT. NLRP3 inflammasome activation drives tau pathology. Nature. 2019 11; 575(7784):669-673.
Score: 0.476
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Venegas C, Heneka MT. Inflammasome-mediated innate immunity in Alzheimer's disease. FASEB J. 2019 12; 33(12):13075-13084.
Score: 0.474
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Heneka MT, McManus RM, Latz E. Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2018 10; 19(10):610-621.
Score: 0.439
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Scheiblich H, Schl?tter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. J Neurochem. 2017 12; 143(5):534-550.
Score: 0.412
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Heneka MT. Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathol. 2017 03; 27(2):220-222.
Score: 0.394
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Ravichandran KA, Brosseron F, McManus RM, Ising C, G?rgen S, Schmidt SV, Santarelli F, Lee SY, Jung H, Chung WS, Kim CH, Ruiz Laza A, Ruiz de Almod?var C, Ramirez A, Latz E, Heneka MT. Enhancing Tyro3 signaling ameliorates IL-1? production through STAT1 in Alzheimer's disease models. J Leukoc Biol. 2025 Dec 01; 117(12).
Score: 0.181
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McManus RM, Komes MP, Griep A, Santarelli F, Schwartz S, Ram?n Perea J, Schlachetzki JCM, Bouvier DS, Khalil MA, Lauterbach MA, Heinemann L, Schl?ter T, Pour MS, Lovotti M, Stahl R, Duthie F, Rodr?guez-Alc?zar JF, Schmidt SV, Spitzer J, Noori P, Maillo A, Boettcher A, Herron B, McConville J, Gomez-Cabrero D, Tegn?r J, Glass CK, Hiller K, Latz E, Heneka MT. NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression. Immunity. 2025 Feb 11; 58(2):326-343.e11.
Score: 0.171
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Karabag D, Heneka MT, Ising C. The putative contribution of cellular senescence to driving tauopathies. Trends Immunol. 2024 10; 45(10):837-848.
Score: 0.166
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Ravichandran KA, Heneka MT. Inflammasomes in neurological disorders - mechanisms and therapeutic potential. Nat Rev Neurol. 2024 02; 20(2):67-83.
Score: 0.158
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Braatz C, Komes MP, Ravichandran KA, de Fragas MG, Griep A, Schwartz S, McManus RM, Heneka MT. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. J Neurochem. 2024 Oct; 168(10):3467-3481.
Score: 0.150
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Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K. Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021 09 21; 36(12):109720.
Score: 0.135
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Beyer MMS, Lonnemann N, Remus A, Latz E, Heneka MT, Korte M. Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent. J Neurosci. 2020 07 08; 40(28):5480-5494.
Score: 0.123
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Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Rep. 2020 03 17; 30(11):3743-3754.e6.
Score: 0.122
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Luciunaite A, McManus RM, Jankunec M, R?cz I, Dansokho C, Dalgediene I, Schwartz S, Brosseron F, Heneka MT. Soluble A? oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. J Neurochem. 2020 12; 155(6):650-661.
Score: 0.120
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Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT. Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):9002-9007.
Score: 0.109
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Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease. Nature. 2017 12 20; 552(7685):355-361.
Score: 0.104
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Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014 Jul; 14(7):463-77.
Score: 0.082
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Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Jan 31; 493(7434):674-8.
Score: 0.074