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Last Name

Michael J Lee PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
368 Plantation Street, Sherman Center, AS5.1047
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentSystems Biology

    Collapse Biography 
    Collapse education and training
    University of Washington, Seattle, WA, United StatesBSCell & Molecular Biology
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesPHDPharmacology

    Collapse Overview 
    Collapse overview

    Michael Lee received his BS degree in Cell Biology from the University of Washington in 2002, where he studied the function and regulation of non-receptor tyrosine kinases in the immune system, first in the laboratory of Steven D. Levin, and subsequently with Michael J. Bevan. Working in Henrik G. Dohlman's lab, Mike went on to receive his PhD in Pharmacology from the University of North Carolina at Chapel Hill in 2008 for work studying the subcellular localization and mechanisms of activation of heterotrimeric G proteins. For postdoctoral training, Mike moved to the Koch Institute for Integrative Cancer Research at MIT, where he worked with Michael B. Yaffe, studying crosstalk between growth factor and DNA damage signaling networks. Mike joined the Program in Systems Biology in late 2013. His lab studies complex behaviors of signaling networks that control cell death, how network state and network architecture are perturbed in various forms of cancer, and how these perturbations contribute to treatment responses. They aim to identify guiding principles for designing rational combination drug therapies for breast and other types of cancer.

    Please click on links below for access to websites:

    Lab Info: The Lee Lab

    Department: Program in Systems Biology


    Program in Molecular Medicine

    Department of Cancer Biology


    Collapse Rotation Projects

    We are always very excited to have students rotate in the Lee Lab! Projects are available for those interested in developing an experimental and/or computational skill set, and those interested in training across these disciplines are always encouraged to do so. By rotating in the Lee Lab, you will gain expertise in a variety of quantitative high-throughput techniques in the area of proteomics, signal transduction, network biology, and genomics. We aim to actively promote an interactive and fun atmosphere. Students will participate in various lab and PSB functions, including weekly lab meetings, weekly Systems Biology journal club, and at the end of the rotation, students will present their work to the lab/department.

    Collapse Post Docs
    A postdoctoral position is available within the Lee Lab.  Please see our webpage for more information (http://labs.umassmed.edu/LeeLab). Application materials can be sent directly to Dr. Lee, and please have 3 letters of reference sent by email directly to Dr. Lee, including the applicants name in the subject line.  

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Heijink AM, Everts M, Honeywell ME, Richards R, Kok YP, de Vries EGE, Lee MJ, van Vugt MATM. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019 Aug 27; 28(9):2345-2357.e5. PMID: 31461651.
      View in: PubMed
    2. Shu Y, Wu K, Zeng Z, Huang S, Ji X, Yuan C, Zhang L, Liu W, Huang B, Feng Y, Zhang B, Dai Z, Shen Y, Luo W, Wang X, Liu B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Luu HH, Reid RR, Wolf JM, Lee MJ, He TC. A Simplified System to Express Circularized Inhibitors of miRNA for Stable and Potent Suppression of miRNA Functions. Mol Ther Nucleic Acids. 2018 Oct 04; 13:556-567. PMID: 30414569.
      View in: PubMed
    3. Landry BD, Leete T, Richards R, Cruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018 Aug 06; 14(8):e8322. PMID: 30082272.
      View in: PubMed
    4. Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harb Perspect Biol. 2016; 8(6). PMID: 27252361.
      View in: PubMed
    5. Landry BD, Clarke DC, Lee MJ. Studying Cellular Signal Transduction with OMIC Technologies. J Mol Biol. 2015 Oct 23; 427(21):3416-40. PMID: 26244521.
      View in: PubMed
    6. Lee MJ. Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy. Mol Cell. 2015 Mar 5; 57(5):763-4. PMID: 25747655.
      View in: PubMed
    7. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014 May 13; 7(325):ra44. PMID: 24825919.
      View in: PubMed
    8. Wang X, Beitler JJ, Wang H, Lee MJ, Huang W, Koenig L, Nannapaneni S, Amin AR, Bonner M, Shin HJ, Chen ZG, Arbiser JL, Shin DM. Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis. PLoS One. 2014; 9(2):e86369. PMID: 24586249.
      View in: PubMed
    9. Lee MJ, Schep D, McLaughlin B, Kaufmann M, Jia Z. Structural analysis and identification of PhuS as a heme-degrading enzyme from Pseudomonas aeruginosa. J Mol Biol. 2014 May 1; 426(9):1936-46. PMID: 24560694.
      View in: PubMed
    10. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50. PMID: 23728299.
      View in: PubMed
    11. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283.
      View in: PubMed
    12. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012 Jan 31; 8:568. PMID: 22294094.
      View in: PubMed
    13. Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG. G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem. 2009 Mar 27; 284(13):8940-50. PMID: 19176477.
      View in: PubMed
    14. Lee MJ, Dohlman HG. Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol. 2008 Feb 12; 18(3):211-5. PMID: 18261907.
      View in: PubMed
    15. Wang Y, Marotti LA, Lee MJ, Dohlman HG. Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. J Biol Chem. 2005 Jan 7; 280(1):284-91. PMID: 15519996.
      View in: PubMed
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