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Michael J Lee PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentSystems Biology
AddressUMass Chan Medical School
368 Plantation Street AS5.1047
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentSystems Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentSystems Computational and Quantitative Biology

    Collapse Biography 
    Collapse education and training
    University of Washington, Seattle, WA, United StatesBSCell & Molecular Biology
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesPHDPharmacology

    Collapse Overview 
    Collapse overview


    Michael Lee received his BS degree in Cell Biology from the University of Washington in 2002, where he studied the function and regulation of non-receptor tyrosine kinases in the immune system, first in the laboratory of Steven D. Levin, and subsequently with Michael J. Bevan. Working in Henrik G. Dohlman's lab, Mike went on to receive his PhD in Pharmacology from the University of North Carolina at Chapel Hill in 2008 for work studying the subcellular localization and mechanisms of activation of heterotrimeric G proteins. For postdoctoral training, Mike moved to the Koch Institute for Integrative Cancer Research at MIT, where he worked with Michael B. Yaffe, studying crosstalk between growth factor and DNA damage signaling networks. Mike joined the Department of Systems Biology in late 2013. His lab studies complex behaviors of signaling networks that control cell death, how network state and network architecture are perturbed in various forms of cancer, and how these perturbations contribute to treatment responses. They aim to identify guiding principles for designing rational combination drug therapies for breast and other types of cancer.

    Please click on links below for access to websites:

    Lab Info: The Lee Lab

    Department: Department of Systems Biology



    Program in Molecular Medicine

    Department of Cancer Biology



    Collapse Rotation Projects

    We are always very excited to have students rotate in the Lee Lab! Projects are available for those interested in developing an experimental and/or computational skill set, and those interested in training across these disciplines are always encouraged to do so. By rotating in the Lee Lab, you will gain expertise in a variety of quantitative high-throughput techniques in the area of proteomics, signal transduction, network biology, and genomics. We aim to actively promote an interactive and fun atmosphere. Students will participate in various lab and PSB functions, including weekly lab meetings, weekly Systems Biology journal club, and at the end of the rotation, students will present their work to the lab/department.

    Collapse Post Docs

    A postdoctoral position is available within the Lee Lab.  Please see our webpage for more information. Application materials can be sent directly to Dr. Lee, and please have 3 letters of reference sent by email directly to Dr. Lee, including the applicants name in the subject line.  

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Flynn MJ, Harper NW, Li R, Zhu LJ, Lee MJ, Benanti JA. Calcineurin promotes adaptation to chronic stress through two distinct mechanisms. bioRxiv. 2024 Mar 20. PMID: 38562881.
    2. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Functional genomic screens with death rate analyses reveal mechanisms of drug action. Nat Chem Biol. 2024 Mar 13. PMID: 38480981.
    3. Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, R?sler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, T?ting T, Schadendorf D, R?cken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B. Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nat Cancer. 2024 Mar; 5(3):433-447. PMID: 38286827.
      Citations:    Fields:    
    4. Leylek O, Honeywell ME, Lee MJ, Hemann MT, Ozcan G. Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy. bioRxiv. 2023 Nov 19. PMID: 37873383.
    5. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv. 2023 May 16. PMID: 36712034.
    6. Leighow SM, Landry B, Lee MJ, Peyton SR, Pritchard JR. Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes. Cell Mol Bioeng. 2022 Oct; 15(5):521-533. PMID: 36444351.
    7. Pritchard JR, Lee MJ, Peyton SR. Materials-driven approaches to understand extrinsic drug resistance in cancer. Soft Matter. 2022 May 11; 18(18):3465-3472. PMID: 35445686.
      Citations:    Fields:    Translation:HumansCells
    8. Jansen LE, Kim H, Hall CL, McCarthy TP, Lee MJ, Peyton SR. A poly(ethylene glycol) three-dimensional bone marrow hydrogel. Biomaterials. 2022 01; 280:121270. PMID: 34890973.
      Citations: 12     Fields:    Translation:Cells
    9. Richards R, Honeywell ME, Lee MJ. FLICK: an optimized plate reader-based assay to infer cell death kinetics. STAR Protoc. 2021 03 19; 2(1):100327. PMID: 33659903.
      Citations: 4     Fields:    Translation:HumansCells
    10. Cruz-Gordillo P, Honeywell ME, Harper NW, Leete T, Lee MJ. ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells. Sci Signal. 2020 11 17; 13(658). PMID: 33203722.
      Citations: 9     Fields:    Translation:HumansCells
    11. Schrimpf M, Kubilius J, Lee MJ, Ratan Murty NA, Ajemian R, DiCarlo JJ. Integrative Benchmarking to Advance Neurally Mechanistic Models of Human Intelligence. Neuron. 2020 11 11; 108(3):413-423. PMID: 32918861.
      Citations: 37     Fields:    Translation:Humans
    12. Schwartz HR, Richards R, Fontana RE, Joyce AJ, Honeywell ME, Lee MJ. Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response Profiles. Cell Rep. 2020 06 23; 31(12):107800. PMID: 32579927.
      Citations: 10     Fields:    Translation:HumansCells
    13. Richards R, Schwartz HR, Honeywell ME, Stewart MS, Cruz-Gordillo P, Joyce AJ, Landry BD, Lee MJ. Drug antagonism and single-agent dominance result from differences in death kinetics. Nat Chem Biol. 2020 07; 16(7):791-800. PMID: 32251407.
      Citations: 18     Fields:    Translation:HumansCells
    14. Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM. Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation. Cancer Res. 2020 01 15; 80(2):249-262. PMID: 31744816.
      Citations: 10     Fields:    Translation:HumansCells
    15. Heijink AM, Everts M, Honeywell ME, Richards R, Kok YP, de Vries EGE, Lee MJ, van Vugt MATM. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019 08 27; 28(9):2345-2357.e5. PMID: 31461651.
      Citations: 13     Fields:    Translation:HumansCells
    16. Zhao C, Qazvini NT, Sadati M, Zeng Z, Huang S, De La Lastra AL, Zhang L, Feng Y, Liu W, Huang B, Zhang B, Dai Z, Shen Y, Wang X, Luo W, Liu B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Athiviraham A, Lee MJ, Wolf JM, Reid RR, Tirrell M, Huang W, de Pablo JJ, He TC. A pH-Triggered, Self-Assembled, and Bioprintable Hybrid Hydrogel Scaffold for Mesenchymal Stem Cell Based Bone Tissue Engineering. ACS Appl Mater Interfaces. 2019 Mar 06; 11(9):8749-8762. PMID: 30734555.
      Citations: 45     Fields:    Translation:HumansCells
    17. Shu Y, Wu K, Zeng Z, Huang S, Ji X, Yuan C, Zhang L, Liu W, Huang B, Feng Y, Zhang B, Dai Z, Shen Y, Luo W, Wang X, Liu B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Luu HH, Reid RR, Wolf JM, Lee MJ, He TC. A Simplified System to Express Circularized Inhibitors of miRNA for Stable and Potent Suppression of miRNA Functions. Mol Ther Nucleic Acids. 2018 Dec 07; 13:556-567. PMID: 30414569.
    18. Landry BD, Leete T, Richards R, Cruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018 08 06; 14(8):e8322. PMID: 30082272.
      Citations: 13     Fields:    Translation:HumansCells
    19. Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harb Perspect Biol. 2016 Jun 01; 8(6). PMID: 27252361.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    20. Landry BD, Clarke DC, Lee MJ. Studying Cellular Signal Transduction with OMIC Technologies. J Mol Biol. 2015 Oct 23; 427(21):3416-40. PMID: 26244521.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Lee MJ. Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy. Mol Cell. 2015 Mar 05; 57(5):763-764. PMID: 25747655.
      Citations: 1     Fields:    Translation:HumansCells
    22. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014 May 13; 7(325):ra44. PMID: 24825919.
      Citations: 70     Fields:    Translation:Animals
    23. Wang X, Beitler JJ, Wang H, Lee MJ, Huang W, Koenig L, Nannapaneni S, Amin AR, Bonner M, Shin HJ, Chen ZG, Arbiser JL, Shin DM. Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis. PLoS One. 2014; 9(2):e86369. PMID: 24586249.
      Citations: 20     Fields:    Translation:HumansCells
    24. Lee MJ, Schep D, McLaughlin B, Kaufmann M, Jia Z. Structural analysis and identification of PhuS as a heme-degrading enzyme from Pseudomonas aeruginosa. J Mol Biol. 2014 May 01; 426(9):1936-46. PMID: 24560694.
      Citations: 9     Fields:    Translation:Cells
    25. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50. PMID: 23728299.
      Citations: 171     Fields:    Translation:HumansCells
    26. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283.
      Citations: 331     Fields:    Translation:HumansCells
    27. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012 Jan 31; 8:568. PMID: 22294094.
      Citations: 43     Fields:    Translation:HumansCells
    28. Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG. G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem. 2009 Mar 27; 284(13):8940-50. PMID: 19176477.
      Citations: 21     Fields:    Translation:AnimalsCells
    29. Lee MJ, Dohlman HG. Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol. 2008 Feb 12; 18(3):211-5. PMID: 18261907.
      Citations: 65     Fields:    Translation:AnimalsCells
    30. Wang Y, Marotti LA, Lee MJ, Dohlman HG. Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination. J Biol Chem. 2005 Jan 07; 280(1):284-91. PMID: 15519996.
      Citations: 20     Fields:    Translation:Animals
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