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Lawrence M Schwartz PhD

TitleE&R Isenberg Prof Intg Env Sci
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address417 Morrill Science Center III
Amherst, MA 01003
Phone413-545-2435
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schwartz LM. Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis. Front Physiol. 2018; 9:1887. PMID: 30740060.
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    2. Hayes KL, Messina LM, Schwartz LM, Yan J, Burnside AS, Witkowski S. Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice. Am J Physiol Cell Physiol. 2018 May 01; 314(5):C534-C544. PMID: 29351404.
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    3. Ngernyuang N, Yan W, Schwartz LM, Oh D, Liu YB, Chen H, Shao R. A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40. Neoplasia. 2018 Feb; 20(2):182-192. PMID: 29274508.
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    4. Schwartz LM, Brown C, McLaughlin K, Smith W, Bigelow C. The myonuclear domain is not maintained in skeletal muscle during either atrophy or programmed cell death. Am J Physiol Cell Physiol. 2016 Oct 1; 311(4):C607-C615. PMID: 27558160.
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    5. Kanost MR, Arrese EL, Cao X, Chen YR, Chellapilla S, Goldsmith MR, Grosse-Wilde E, Heckel DG, Herndon N, Jiang H, Papanicolaou A, Qu J, Soulages JL, Vogel H, Walters J, Waterhouse RM, Ahn SJ, Almeida FC, An C, Aqrawi P, Bretschneider A, Bryant WB, Bucks S, Chao H, Chevignon G, Christen JM, Clarke DF, Dittmer NT, Ferguson LC, Garavelou S, Gordon KH, Gunaratna RT, Han Y, Hauser F, He Y, Heidel-Fischer H, Hirsh A, Hu Y, Jiang H, Kalra D, Klinner C, K├Ânig C, Kovar C, Kroll AR, Kuwar SS, Lee SL, Lehman R, Li K, Li Z, Liang H, Lovelace S, Lu Z, Mansfield JH, McCulloch KJ, Mathew T, Morton B, Muzny DM, Neunemann D, Ongeri F, Pauchet Y, Pu LL, Pyrousis I, Rao XJ, Redding A, Roesel C, Sanchez-Gracia A, Schaack S, Shukla A, Tetreau G, Wang Y, Xiong GH, Traut W, Walsh TK, Worley KC, Wu D, Wu W, Wu YQ, Zhang X, Zou Z, Zucker H, Briscoe AD, Burmester T, Clem RJ, Feyereisen R, Grimmelikhuijzen CJ, Hamodrakas SJ, Hansson BS, Huguet E, Jermiin LS, Lan Q, Lehman HK, Lorenzen M, Merzendorfer H, Michalopoulos I, Morton DB, Muthukrishnan S, Oakeshott JG, Palmer W, Park Y, Passarelli AL, Rozas J, Schwartz LM, Smith W, Southgate A, Vilcinskas A, Vogt R, Wang P, Werren J, Yu XQ, Zhou JJ, Brown SJ, Scherer SE, Richards S, Blissard GW. Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta. Insect Biochem Mol Biol. 2016 Sep; 76:118-47. PMID: 27522922.
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    6. Shao R, Taylor SL, Oh DS, Schwartz LM. Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization. Oncotarget. 2015 Dec 01; 6(38):40507-18. PMID: 26439689.
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    7. Johnson DL, Schwartz LM. Three-state analytic theory of two-dimensional nuclear magnetic resonance in systems with coupled macro- and micropores. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jun; 91(6):062406. PMID: 26172724.
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    8. Cao X, He Y, Hu Y, Wang Y, Chen YR, Bryant B, Clem RJ, Schwartz LM, Blissard G, Jiang H. The immune signaling pathways of Manduca sexta. Insect Biochem Mol Biol. 2015 Jul; 62:64-74. PMID: 25858029.
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    9. Song YQ, Carneiro G, Schwartz LM, Johnson DL. Experimental identification of diffusive coupling using 2D NMR. Phys Rev Lett. 2014 Dec 5; 113(23):235503. PMID: 25526135.
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    10. Johnson DL, Schwartz LM. Analytic theory of two-dimensional NMR in systems with coupled macro- and micropores. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Sep; 90(3):032407. PMID: 25314457.
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    11. Schwartz LM. Muscle nuclei remember to cheat death. J Physiol. 2013 Dec 15; 591(24):6133-4. PMID: 24339150.
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    12. Schwartz LM, Johnson DL, Mitchell J, Chandrasekera TC, Fordham EJ. Modeling two-dimensional magnetic resonance measurements in coupled pore systems. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Sep; 88(3):032813. PMID: 24125318.
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    13. Hyldahl RD, Schwartz LM, Clarkson PM. NF-KB activity functions in primary pericytes in a cell- and non-cell-autonomous manner to affect myotube formation. Muscle Nerve. 2013 Apr; 47(4):522-31. PMID: 23364895.
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    14. Zhang Z, Johnson DL, Schwartz LM. Simulating the time-dependent diffusion coefficient in mixed-pore-size materials. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep; 84(3 Pt 1):031129. PMID: 22060350.
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    15. Parelkar SS, Cadena JG, Kim C, Wang Z, Sugal R, Bentley B, Moral L, Ardley HC, Schwartz LM. The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies. J Mol Neurosci. 2012 Jan; 46(1):109-21. PMID: 21590270.
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    16. Shao R, Scully SJ, Yan W, Bentley B, Mueller J, Brown C, Bigelow C, Schwartz LM. The novel lupus antigen related protein acheron enhances the development of human breast cancer. Int J Cancer. 2012 Feb 1; 130(3):544-54. PMID: 21387291.
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    17. Kim C, Srivastava S, Rice M, Godenschwege TA, Bentley B, Ravi S, Shao S, Woodard CT, Schwartz LM. Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness. BMC Physiol. 2011 Apr 25; 11:7. PMID: 21518451.
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    18. Hyldahl RD, O'Fallon KS, Schwartz LM, Clarkson PM. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. J Appl Physiol (1985). 2010 Nov; 109(5):1515-23. PMID: 20798270.
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    19. Glenn HL, Wang Z, Schwartz LM. Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C46-55. PMID: 19889961.
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    20. Wang Z, Glenn H, Brown C, Valavanis C, Liu JX, Seth A, Thomas JE, Karlstrom RO, Schwartz LM. Regulation of muscle differentiation and survival by Acheron. Mech Dev. 2009 Aug-Sep; 126(8-9):700-9. PMID: 19481601.
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    21. Yu JG, Sewright K, Hubal MJ, Liu JX, Schwartz LM, Hoffman EP, Clarkson PM. Investigation of gene expression in C(2)C(12) myotubes following simvastatin application and mechanical strain. J Atheroscler Thromb. 2009 Mar; 16(1):21-9. PMID: 19262002.
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    22. Myer A, Mason HA, Smith W, Brown C, Schwartz LM. Differential control of cell death and gene expression during two distinct phases of hormonally-regulated muscle death in the tobacco hawkmoth Manduca sexta. J Insect Physiol. 2009 Apr; 55(4):314-20. PMID: 19135059.
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    23. Weng H, Kim C, Valavanis C, Wang Z, Schwartz LM. Erratum: Acheron, an novel LA antigen family member, binds to cask and forms a complex with id transcription factors. Cell Mol Biol Lett. 2009 Jun; 14(2):288. PMID: 30534160.
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    24. Schwartz LM, Gao Z, Brown C, Parelkar SS, Glenn H. Cell death in myoblasts and muscles. Methods Mol Biol. 2009; 559:313-32. PMID: 19609766.
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    25. Weng H, Kim C, Valavanis C, Wang Z, Schwartz LM. Acheron, an novel LA antigen family member, binds to CASK and forms a complex with Id transcription factors. Cell Mol Biol Lett. 2009; 14(2):273-87. PMID: 19096764.
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    26. Schwartz LM. Atrophy and programmed cell death of skeletal muscle. Cell Death Differ. 2008 Jul; 15(7):1163-9. PMID: 18483492.
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    27. Gao ZL, Deblis R, Glenn H, Schwartz LM. Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis. Exp Cell Res. 2007 Nov 15; 313(19):4000-14. PMID: 17935713.
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    28. Valavanis C, Wang Z, Sun D, Vaine M, Schwartz LM. Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Gene. 2007 May 15; 393(1-2):101-9. PMID: 17383118.
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    29. Gao Z, Schwartz LM. Identification and analysis of Hic-5/ARA55 isoforms: Implications for integrin signaling and steroid hormone action. FEBS Lett. 2005 Oct 24; 579(25):5651-7. PMID: 16219310.
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    30. Makse HA, Gland N, Johnson DL, Schwartz L. Granular packings: nonlinear elasticity, sound propagation, and collective relaxation dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec; 70(6 Pt 1):061302. PMID: 15697350.
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    31. Schwartz LM, Ruff RL. Changes in contractile properties of skeletal muscle during developmentally programmed atrophy and death. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1270-7. PMID: 11997241.
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    32. Wing JP, Schreader BA, Yokokura T, Wang Y, Andrews PS, Huseinovic N, Dong CK, Ogdahl JL, Schwartz LM, White K, Nambu JR. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol. 2002 Jun; 4(6):451-6. PMID: 12021772.
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    33. Schwartz LM, Nambu JR, Wang Z. Parkinsonism proteolysis and proteasomes. Cell Death Differ. 2002 May; 9(5):479-82. PMID: 11973605.
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    34. Wing JP, Karres JS, Ogdahl JL, Zhou L, Schwartz LM, Nambu JR. Drosophila sickle is a novel grim-reaper cell death activator. Curr Biol. 2002 Jan 22; 12(2):131-5. PMID: 11818064.
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    35. Shumway L, Schwartz LM. Generalized 96-well format for quantitative and qualitative monitoring of altered protein expression and posttranslational modification in cells. Biotechniques. 2001 Nov; 31(5):996, 998, 1000. PMID: 11730029.
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    36. Cascone PJ, Schwartz LM. Post-transcriptional regulation of gene expression during the programmed death of insect skeletal muscle. Dev Genes Evol. 2001 Sep; 211(8-9):397-405. PMID: 11685573.
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    37. Wing JP, Schwartz LM, Nambu JR. The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities. Mech Dev. 2001 Apr; 102(1-2):193-203. PMID: 11287192.
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    38. Valavanis C, Naber S, Schwartz LM. In situ detection of dying cells in normal and pathological tissues. Methods Cell Biol. 2001; 66:393-415. PMID: 11396013.
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    39. Jones ME, Schwartz LM. Not all muscles meet the same fate when they die. Cell Biol Int. 2001; 25(6):539-45. PMID: 11407859.
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    40. Valavanis C, Hu Y, Yang Y, Osborne BA, Chouaib S, Greene L, Ashwell JD, Schwartz LM. Model cell lines for the study of apoptosis in vitro. Methods Cell Biol. 2001; 66:417-36. PMID: 11396014.
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    41. Kuelzer F, Kuah P, Bishoff ST, Cheng L, Nambu JR, Schwartz LM. Cloning and analysis of small cytoplasmic leucine-rich repeat protein (SCLP), a novel, phylogenetically-conserved protein that is dramatically up-regulated during the programmed death of moth skeletal muscle. J Neurobiol. 1999 Dec; 41(4):482-94. PMID: 10590172.
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    42. Hu Y, Cascone PJ, Cheng L, Sun D, Nambu JR, Schwartz LM. Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10218-23. PMID: 10468589.
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    43. Wing JP, Zhou L, Schwartz LM, Nambu JR. Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes. Cell Death Differ. 1998 Nov; 5(11):930-9. PMID: 9846179.
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    44. Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan CE. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J Neurosci. 1998 Aug 1; 18(15):5869-80. PMID: 9671674.
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    45. Cheng L, Roemer N, Smyth KA, Belote J, Nambu JR, Schwartz LM. Cloning and characterization of Pros45, the Drosophila SUG1 proteasome subunit homolog. Mol Gen Genet. 1998 Jul; 259(1):13-20. PMID: 9738875.
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    46. Sun D, Swaffield JC, Johnston SA, Milligan CE, Zoeller RT, Schwartz LM. Identification of a phylogenetically conserved Sug1 CAD family member that is differentially expressed in the mouse nervous system. J Neurobiol. 1997 Dec; 33(7):877-90. PMID: 9407011.
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    47. Zhou L, Schnitzler A, Agapite J, Schwartz LM, Steller H, Nambu JR. Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5131-6. PMID: 9144202.
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    48. Schwartz LM, Milligan CE. Cold thoughts of death: the role of ICE proteases in neuronal cell death. Trends Neurosci. 1996 Dec; 19(12):555-62. PMID: 8961485.
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    49. Myer A, Schwartz LM. Allelic variation of the polyubiquitin gene in the tobacco hawkmoth, Manduca sexta, and its regulation by heat shock and programmed cell death. Insect Biochem Mol Biol. 1996 Dec; 26(10):1037-46. PMID: 9035386.
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    50. Grimm LM, Goldberg AL, Poirier GG, Schwartz LM, Osborne BA. Proteasomes play an essential role in thymocyte apoptosis. EMBO J. 1996 Aug 1; 15(15):3835-44. PMID: 8670888.
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    51. Hashimoto MK, Mykles DL, Schwartz LM, Fahrbach SE. Imaginal cell-specific accumulation of the multicatalytic proteinase complex (proteasome) during post-embryonic development in the tobacco hornworm, Manduca sexta. J Comp Neurol. 1996 Feb 5; 365(2):329-41. PMID: 8822173.
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    52. Sun D, Sathyanarayana UG, Johnston SA, Schwartz LM. A member of the phylogenetically conserved CAD family of transcriptional regulators is dramatically up-regulated during the programmed cell death of skeletal muscle in the tobacco hawkmoth Manduca sexta. Dev Biol. 1996 Feb 1; 173(2):499-509. PMID: 8606008.
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    53. Osborne BA, Smith SW, McLaughlin KA, Grimm L, Kallinch T, Liu Z, Schwartz LM. Genes that regulate apoptosis in the mouse thymus. J Cell Biochem. 1996 Jan; 60(1):18-22. PMID: 8825411.
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    54. Milligan CE, Prevette D, Yaginuma H, Homma S, Cardwell C, Fritz LC, Tomaselli KJ, Oppenheim RW, Schwartz LM. Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron. 1995 Aug; 15(2):385-93. PMID: 7646891.
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    55. Zhou L, Hashimi H, Schwartz LM, Nambu JR. Programmed cell death in the Drosophila central nervous system midline. Curr Biol. 1995 Jul 1; 5(7):784-90. PMID: 7583125.
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    56. Jones ME, Haire MF, Kloetzel PM, Mykles DL, Schwartz LM. Changes in the structure and function of the multicatalytic proteinase (proteasome) during programmed cell death in the intersegmental muscles of the hawkmoth, Manduca sexta. Dev Biol. 1995 Jun; 169(2):436-47. PMID: 7781889.
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    57. Osborne BA, Schwartz LM. Cell death suffers a TKO. Bioessays. 1995 Jun; 17(6):557-9. PMID: 7575499.
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    58. Haas AL, Baboshina O, Williams B, Schwartz LM. Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle. J Biol Chem. 1995 Apr 21; 270(16):9407-12. PMID: 7721865.
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    59. Haire MF, Clark JJ, Jones ME, Hendil KB, Schwartz LM, Mykles DL. The multicatalytic proteinase (proteasome) of the hawkmoth, Manduca sexta: catalytic properties and immunological comparison with the lobster enzyme complex. Arch Biochem Biophys. 1995 Apr 1; 318(1):15-24. PMID: 7726556.
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    60. Schwartz LM. The faces of death. Cell Death Differ. 1995 Apr; 2(2):83-5. PMID: 17180069.
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    61. Schwartz LM, Milligan CE, Bielke W, Robinson SJ. Cloning cell death genes. Methods Cell Biol. 1995; 46:107-38. PMID: 7541882.
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    62. Osborne BA, Smith SW, Liu ZG, McLaughlin KA, Schwartz LM. Transient transfection assays to examine the requirement of putative cell death genes. Methods Cell Biol. 1995; 46:99-106. PMID: 7541887.
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    63. Sun D, Ziegler R, Milligan CE, Fahrbach S, Schwartz LM. Apolipophorin III is dramatically up-regulated during the programmed death of insect skeletal muscle and neurons. J Neurobiol. 1995 Jan; 26(1):119-29. PMID: 7714521.
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    64. Osborne BA, Smith SW, Liu ZG, McLaughlin KA, Grimm L, Schwartz LM. Identification of genes induced during apoptosis in T lymphocytes. Immunol Rev. 1994 Dec; 142:301-20. PMID: 7698798.
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    65. Osborne BA, Schwartz LM. Essential genes that regulate apoptosis. Trends Cell Biol. 1994 Nov; 4(11):394-9. PMID: 14731815.
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    66. Milligan CE, Oppenheim RW, Schwartz LM. Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death. J Neurobiol. 1994 Aug; 25(8):1005-16. PMID: 7964701.
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    67. Schwartz LM, Osborne BA. Ced-3/ICE: evolutionarily conserved regulation of cell death. Bioessays. 1994 Jun; 16(6):387-9. PMID: 8080427.
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    68. Fahrbach SE, Schwartz LM. Localization of immunoreactive ubiquitin in the nervous system of the Manduca sexta moth. J Comp Neurol. 1994 May 15; 343(3):464-82. PMID: 7517966.
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    69. Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature. 1994 Jan 20; 367(6460):281-4. PMID: 8121494.
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    70. Schwartz LM, Osborne BA. Programmed cell death, apoptosis and killer genes. Immunol Today. 1993 Dec; 14(12):582-90. PMID: 8305131.
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    71. Schwartz LM, Jones ME, Kosz L, Kuah K. Selective repression of actin and myosin heavy chain expression during the programmed death of insect skeletal muscle. Dev Biol. 1993 Aug; 158(2):448-55. PMID: 8344462.
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    72. Schwartz LM, Smith SW, Jones ME, Osborne BA. Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci U S A. 1993 Feb 1; 90(3):980-4. PMID: 8430112.
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    73. Schwartz LM. Insect muscle as a model for programmed cell death. J Neurobiol. 1992 Nov; 23(9):1312-26. PMID: 1469390.
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    74. Liu ZG, Schwartz LM. An efficient method for blunt-end ligation of PCR products. Biotechniques. 1992 Jan; 12(1):28, 30. PMID: 1734919.
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    75. Schwartz LM. The role of cell death genes during development. Bioessays. 1991 Aug; 13(8):389-95. PMID: 1659391.
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    76. Bishoff ST, Schwartz LM. Characterization of a ubiquitin-fusion gene from the tobacco hawkmoth, Manduca sexta. Nucleic Acids Res. 1990 Oct 25; 18(20):6039-43. PMID: 1700368.
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    77. Schwartz LM, Myer A, Kosz L, Engelstein M, Maier C. Activation of polyubiquitin gene expression during developmentally programmed cell death. Neuron. 1990 Oct; 5(4):411-9. PMID: 2169771.
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    78. Schwartz LM, Kosz L, Kay BK. Gene activation is required for developmentally programmed cell death. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6594-8. PMID: 2395862.
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    79. Schwartz LM, Kay BK. Differential expression of the Ca2+-binding protein parvalbumin during myogenesis in Xenopus laevis. Dev Biol. 1988 Aug; 128(2):441-52. PMID: 3294065.
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    80. Schwartz LM, Truman JW. Hormonal control of rates of metamorphic development in the tobacco hornworm Manduca sexta. Dev Biol. 1983 Sep; 99(1):103-14. PMID: 6617995.
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