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Shelly R Peyton BS, MS, PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Engineering
Address154D Goessmann Laboratory
Amherst, MA 01003
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peyton SR. Engineering the endometrium. Med. 2023 08 11; 4(8):495-496. PMID: 37572649.
    2. Cosgriff-Hernandez EM, Aguado BA, Akpa B, Fleming GC, Moore E, Porras AM, Boyle PM, Chan DD, Chesler N, Christman KL, Desai TA, Harley BAC, Hudalla GA, Killian ML, Maisel K, Maitland KC, Peyton SR, Pruitt BL, Stabenfeldt SE, Stevens KR, Bowden AK. Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023 08; 7(8):961-968. PMID: 37580521.
      Citations:    Fields:    Translation:Humans
    3. Kundu AN, Dougan CE, Mahmoud S, Kilic A, Panagiotou A, Richbourg NR, Irakoze N, Peyton SR. Tenascin-C Activation of Lung Fibroblasts in a 3D Synthetic Lung Extracellular Matrix Mimic. Adv Mater. 2023 Aug; 35(33):e2301493. PMID: 37227134.
      Citations:    Fields:    Translation:HumansCells
    4. Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 04 19; 14(4):252-257. PMID: 37080161.
      Citations:    Fields:    Translation:Humans
    5. Kundu AN, Dougan CE, Mahmoud S, Kilic A, Panagiotou A, Irakoze N, Richbourg N, Peyton SR. Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic. bioRxiv. 2023 Mar 20. PMID: 36865293.
    6. Sonu KP, Zhou L, Biswas S, Klier J, Balazs AC, Emrick T, Peyton SR. Strain-Stiffening Hydrogels with Dynamic, Secondary Cross-Linking. Langmuir. 2023 02 21; 39(7):2659-2666. PMID: 36752594.
      Citations:    Fields:    
    7. Kim H, Wirasaputra A, Mohammadi F, Kundu AN, Esteves JAE, Heiser LM, Meyer AS, Peyton SR. Live Cell Lineage Tracing of Dormant Cancer Cells. Adv Healthc Mater. 2023 06; 12(14):e2202275. PMID: 36625629.
      Citations: 1     Fields:    Translation:Humans
    8. Peyton SR, Platt MO, Cukierman E. Challenges and Opportunities Modeling the Dynamic Tumor Matrisome. BME Front. 2023; 4:0006. PMID: 37849664.
    9. Leighow SM, Landry B, Lee MJ, Peyton SR, Pritchard JR. Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes. Cell Mol Bioeng. 2022 Oct; 15(5):521-533. PMID: 36444351.
    10. Dougan CE, Song Z, Fu H, Crosby AJ, Cai S, Peyton SR. Cavitation induced fracture of intact brain tissue. Biophys J. 2022 07 19; 121(14):2721-2729. PMID: 35711142.
      Citations:    Fields:    Translation:Humans
    11. Creixell M, Kim H, Mohammadi F, Peyton SR, Meyer AS. Systems approaches to uncovering the contribution of environment-mediated drug resistance. Curr Opin Solid State Mater Sci. 2022 Oct; 26(5). PMID: 36321161.
    12. Pritchard JR, Lee MJ, Peyton SR. Materials-driven approaches to understand extrinsic drug resistance in cancer. Soft Matter. 2022 May 11; 18(18):3465-3472. PMID: 35445686.
      Citations:    Fields:    Translation:HumansCells
    13. Jansen LE, Kim H, Hall CL, McCarthy TP, Lee MJ, Peyton SR. A poly(ethylene glycol) three-dimensional bone marrow hydrogel. Biomaterials. 2022 01; 280:121270. PMID: 34890973.
      Citations: 9     Fields:    Translation:Cells
    14. Schwartz AD, Adusei A, Tsegaye S, Moskaluk CA, Schneider SS, Platt MO, Seifu D, Peyton SR, Babbitt CC. Genetic Mutations Associated with Hormone-Positive Breast Cancer in a Small Cohort of Ethiopian Women. Ann Biomed Eng. 2021 Aug; 49(8):1900-1908. PMID: 34142276.
      Citations: 1     Fields:    Translation:Humans
    15. Mijailovic AS, Galarza S, Raayai-Ardakani S, Birch NP, Schiffman JD, Crosby AJ, Cohen T, Peyton SR, Van Vliet KJ. Localized characterization of brain tissue mechanical properties by needle induced cavitation rheology and volume controlled cavity expansion. J Mech Behav Biomed Mater. 2021 02; 114:104168. PMID: 33218928.
      Citations: 2     Fields:    Translation:Animals
    16. King MR, Peyton S, Simon SI. The 2020 Young Innovators of Cellular and Molecular Bioengineering. Cell Mol Bioeng. 2020 Oct; 13(5):391-392. PMID: 33184572.
    17. Tiwari S, Kazemi-Moridani A, Zheng Y, Barney CW, McLeod KR, Dougan CE, Crosby AJ, Tew GN, Peyton SR, Cai S, Lee JH. Seeded laser-induced cavitation for studying high-strain-rate irreversible deformation of soft materials. Soft Matter. 2020 Aug 20. PMID: 33021618.
      Citations: 4     Fields:    
    18. Hasnain Z, Fraser AK, Georgess D, Choi A, Macklin P, Bader JS, Peyton SR, Ewald AJ, Newton PK. OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics. Bioinformatics. 2020 05 01; 36(10):3292-3294. PMID: 32091578.
      Citations: 2     Fields:    Translation:Animals
    19. Barney CW, Dougan CE, McLeod KR, Kazemi-Moridani A, Zheng Y, Ye Z, Tiwari S, Sacligil I, Riggleman RA, Cai S, Lee JH, Peyton SR, Tew GN, Crosby AJ. Cavitation in soft matter. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9157-9165. PMID: 32291337.
      Citations: 19     Fields:    
    20. Barney LE, Hall CL, Schwartz AD, Parks AN, Sparages C, Galarza S, Platt MO, Mercurio AM, Peyton SR. Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. Sci Adv. 2020 03; 6(11):eaaz4157. PMID: 32195352.
      Citations: 51     Fields:    Translation:HumansCells
    21. Bittner KR, Jim?nez JM, Peyton SR. Vascularized Biomaterials to Study Cancer Metastasis. Adv Healthc Mater. 2020 04; 9(8):e1901459. PMID: 31977160.
      Citations: 9     Fields:    Translation:HumansCells
    22. Angelou CC, Wells AC, Vijayaraghavan J, Dougan CE, Lawlor R, Iverson E, Lazarevic V, Kimura MY, Peyton SR, Minter LM, Osborne BA, Pobezinskaya EL, Pobezinsky LA. Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis. Front Immunol. 2019; 10:3125. PMID: 32010153.
      Citations: 22     Fields:    Translation:AnimalsCells
    23. Galarza S, Crosby AJ, Pak C, Peyton SR. Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel. Adv Healthc Mater. 2020 02; 9(4):e1901419. PMID: 31943839.
      Citations: 19     Fields:    Translation:Cells
    24. Galarza S, Kim H, Atay N, Peyton SR, Munson JM. 2D or 3D? How cell motility measurements are conserved across dimensions in vitro and translate in vivo. Bioeng Transl Med. 2020 Jan; 5(1):e10148. PMID: 31989037.
    25. Lele TP, Brock A, Peyton SR. Emerging Concepts and Tools in Cell Mechanomemory. Ann Biomed Eng. 2020 Jul; 48(7):2103-2112. PMID: 31745676.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    26. Brooks EA, Galarza S, Gencoglu MF, Cornelison RC, Munson JM, Peyton SR. Applicability of drug response metrics for cancer studies using biomaterials. Philos Trans R Soc Lond B Biol Sci. 2019 08 19; 374(1779):20180226. PMID: 31431182.
      Citations: 24     Fields:    Translation:HumansCells
    27. Brooks EA, Gencoglu MF, Corbett DC, Stevens KR, Peyton SR. An omentum-inspired 3D PEG hydrogel for identifying ECM-drivers of drug resistant ovarian cancer. APL Bioeng. 2019 Jun; 3(2):026106. PMID: 31263798.
    28. Zhu P, Tseng NH, Xie T, Li N, Fitts-Sprague I, Peyton SR, Sun Y. Biomechanical Microenvironment Regulates Fusogenicity of Breast Cancer Cells. ACS Biomater Sci Eng. 2019 Aug 12; 5(8):3817-3827. PMID: 33438422.
      Citations: 2     Fields:    
    29. Carpenter RA, Kwak JG, Peyton SR, Lee J. Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells. Nat Biomed Eng. 2018 Dec; 2(12):915-929. PMID: 30906645.
      Citations: 32     Fields:    
    30. Polio SR, Kundu AN, Dougan CE, Birch NP, Aurian-Blajeni DE, Schiffman JD, Crosby AJ, Peyton SR. Cross-platform mechanical characterization of lung tissue. PLoS One. 2018; 13(10):e0204765. PMID: 30332434.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    31. Landry BD, Leete T, Richards R, Cruz-Gordillo P, Schwartz HR, Honeywell ME, Ren G, Schwartz AD, Peyton SR, Lee MJ. Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells. Mol Syst Biol. 2018 08 06; 14(8):e8322. PMID: 30082272.
      Citations: 12     Fields:    Translation:HumansCells
    32. Luzhansky ID, Schwartz AD, Cohen JD, MacMunn JP, Barney LE, Jansen LE, Peyton SR. Anomalously diffusing and persistently migrating cells in 2D and 3D culture environments. APL Bioeng. 2018 Jun; 2(2):026112. PMID: 31069309.
    33. Jansen LE, Amer LD, Chen EY, Nguyen TV, Saleh LS, Emrick T, Liu WF, Bryant SJ, Peyton SR. Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner. Biomacromolecules. 2018 07 09; 19(7):2880-2888. PMID: 29698603.
      Citations: 19     Fields:    Translation:AnimalsCells
    34. Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S, Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, Freedman BD, Wellen KE. Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling. Genes Dev. 2018 04 01; 32(7-8):497-511. PMID: 29674394.
      Citations: 59     Fields:    Translation:AnimalsCells
    35. Jansen LE, Negr?n-Pi?eiro LJ, Galarza S, Peyton SR. Control of thiol-maleimide reaction kinetics in PEG hydrogel networks. Acta Biomater. 2018 04 01; 70:120-128. PMID: 29452274.
      Citations: 30     Fields:    Translation:HumansCells
    36. Brooks EA, Jansen LE, Gencoglu MF, Yurkevicz AM, Peyton SR. Complementary, Semiautomated Methods for Creating Multidimensional PEG-Based Biomaterials. ACS Biomater Sci Eng. 2018 Feb 12; 4(2):707-718. PMID: 33418758.
      Citations: 8     Fields:    
    37. Peyton SR, Gencoglu MF, Galarza S, Schwartz AD. Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer. Adv Exp Med Biol. 2018; 1092:253-287. PMID: 30368757.
      Citations: 2     Fields:    Translation:HumansCells
    38. Schwartz AD, Barney LE, Jansen LE, Nguyen TV, Hall CL, Meyer AS, Peyton SR. A biomaterial screening approach reveals microenvironmental mechanisms of drug resistance. Integr Biol (Camb). 2017 Dec 11; 9(12):912-924. PMID: 29159332.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    39. Tran YH, Rasmuson MJ, Emrick T, Klier J, Peyton SR. Strain-stiffening gels based on latent crosslinking. Soft Matter. 2017 Dec 06; 13(47):9007-9014. PMID: 29164222.
      Citations: 4     Fields:    
    40. Gencoglu MF, Barney LE, Hall CL, Brooks EA, Schwartz AD, Corbett DC, Stevens KR, Peyton SR. Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening. ACS Biomater Sci Eng. 2018 Feb 12; 4(2):410-420. PMID: 29527571.
      Citations: 42     Fields:    
    41. Wilder CL, Walton C, Watson V, Stewart FAA, Johnson J, Peyton SR, Payne CK, Odero-Marah V, Platt MO. Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol. 2016 10; 79:199-208. PMID: 27592448.
      Citations: 12     Fields:    Translation:HumansCells
    42. Yoshii T, Geng Y, Peyton S, Mercurio AM, Rotello VM. Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine. Drug Discov Today. 2016 09; 21(9):1489-1494. PMID: 27238384.
      Citations: 6     Fields:    Translation:Humans
    43. Kolewe KW, Peyton SR, Schiffman JD. Fewer Bacteria Adhere to Softer Hydrogels. ACS Appl Mater Interfaces. 2015 Sep 09; 7(35):19562-9. PMID: 26291308.
      Citations: 36     Fields:    Translation:Cells
    44. Jansen LE, Birch NP, Schiffman JD, Crosby AJ, Peyton SR. Mechanics of intact bone marrow. J Mech Behav Biomed Mater. 2015 Oct; 50:299-307. PMID: 26189198.
      Citations: 66     Fields:    Translation:Animals
    45. Herrick WG, Rattan S, Nguyen TV, Grunwald MS, Barney CW, Crosby AJ, Peyton SR. Smooth Muscle Stiffness Sensitivity is Driven by Soluble and Insoluble ECM Chemistry. Cell Mol Bioeng. 2015 Sep 01; 8(3):333-348. PMID: 26495043.
    46. Birch NP, Barney LE, Pandres E, Peyton SR, Schiffman JD. Thermal-Responsive Behavior of a Cell Compatible Chitosan/Pectin Hydrogel. Biomacromolecules. 2015 Jun 08; 16(6):1837-43. PMID: 25932898.
      Citations: 10     Fields:    Translation:HumansCells
    47. Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. A cell-ECM screening method to predict breast cancer metastasis. Integr Biol (Camb). 2015 Feb; 7(2):198-212. PMID: 25537447.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    48. Nguyen TV, Sleiman M, Moriarty T, Herrick WG, Peyton SR. Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening. Biomaterials. 2014 Jul; 35(22):5749-59. PMID: 24726537.
      Citations: 59     Fields:    Translation:HumansCells
    49. McRae Page S, Parelkar S, Gerasimenko A, Shin DY, Peyton SR, Emrick T. Promoting cell adhesion on slippery phosphorylcholine hydrogel surfaces. J Mater Chem B. 2014 Feb 14; 2(6):620-624. PMID: 32261278.
      Citations: 3     Fields:    
    50. Minsky BB, Nguyen TV, Peyton SR, Kaltashov IA, Dubin PL. Heparin decamer bridges a growth factor and an oligolysine by different charge-driven interactions. Biomacromolecules. 2013 Nov 11; 14(11):4091-8. PMID: 24107074.
      Citations: 4     Fields:    Translation:HumansCells
    51. Herrick WG, Nguyen TV, Sleiman M, McRae S, Emrick TS, Peyton SR. PEG-phosphorylcholine hydrogels as tunable and versatile platforms for mechanobiology. Biomacromolecules. 2013 Jul 08; 14(7):2294-304. PMID: 23738528.
      Citations: 17     Fields:    Translation:HumansCells
    52. Kim HD, Peyton SR. Bio-inspired materials for parsing matrix physicochemical control of cell migration: a review. Integr Biol (Camb). 2012 Jan; 4(1):37-52. PMID: 22025169.
      Citations: 14     Fields:    Translation:Cells
    53. Williams CM, Mehta G, Peyton SR, Zeiger AS, Van Vliet KJ, Griffith LG. Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays. Tissue Eng Part A. 2011 Apr; 17(7-8):1055-68. PMID: 21121876.
      Citations: 19     Fields:    Translation:AnimalsCells
    54. Peyton SR, Kalcioglu ZI, Cohen JC, Runkle AP, Van Vliet KJ, Lauffenburger DA, Griffith LG. Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnol Bioeng. 2011 May; 108(5):1181-93. PMID: 21449030.
      Citations: 47     Fields:    Translation:HumansCells
    55. Kim PD, Peyton SR, VanStrien AJ, Putnam AJ. The influence of ascorbic acid, TGF-beta1, and cell-mediated remodeling on the bulk mechanical properties of 3-D PEG-fibrinogen constructs. Biomaterials. 2009 Aug; 30(23-24):3854-64. PMID: 19443026.
      Citations: 10     Fields:    Translation:HumansCells
    56. Khatiwala CB, Kim PD, Peyton SR, Putnam AJ. ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J Bone Miner Res. 2009 May; 24(5):886-98. PMID: 19113908.
      Citations: 90     Fields:    Translation:AnimalsCells
    57. Peyton SR, Kim PD, Ghajar CM, Seliktar D, Putnam AJ. The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials. 2008 Jun; 29(17):2597-607. PMID: 18342366.
      Citations: 78     Fields:    Translation:HumansCells
    58. Khatiwala CB, Peyton SR, Metzke M, Putnam AJ. The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation. J Cell Physiol. 2007 Jun; 211(3):661-72. PMID: 17348033.
      Citations: 44     Fields:    Translation:AnimalsCells
    59. Ghajar CM, Suresh V, Peyton SR, Raub CB, Meyskens FL, George SC, Putnam AJ. A novel three-dimensional model to quantify metastatic melanoma invasion. Mol Cancer Ther. 2007 Feb; 6(2):552-61. PMID: 17267658.
      Citations: 12     Fields:    Translation:HumansCells
    60. Peyton SR, Ghajar CM, Khatiwala CB, Putnam AJ. The emergence of ECM mechanics and cytoskeletal tension as important regulators of cell function. Cell Biochem Biophys. 2007; 47(2):300-20. PMID: 17652777.
      Citations: 75     Fields:    Translation:AnimalsCells
    61. Peyton SR, Raub CB, Keschrumrus VP, Putnam AJ. The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells. Biomaterials. 2006 Oct; 27(28):4881-93. PMID: 16762407.
      Citations: 125     Fields:    Translation:HumansCells
    62. Khatiwala CB, Peyton SR, Putnam AJ. Intrinsic mechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3-E1 cells. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1640-50. PMID: 16407416.
      Citations: 70     Fields:    Translation:AnimalsCells
    63. Peyton SR, Putnam AJ. Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. J Cell Physiol. 2005 Jul; 204(1):198-209. PMID: 15669099.
      Citations: 240     Fields:    Translation:HumansCells
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