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J. Kevin Donahue MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
368 Plantation Street, AS7-1043
Worcester MA 01605
Phone774-455-3866
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Washington University, Saint Louis, MO, United StatesBAChemistry
    Washington University School of Medicine, St. Louis, MO, United StatesMD

    Collapse Overview 
    Collapse overview


    Dr. Donahue completed undergraduate and medical education at Washington University in St. Louis, followed by an internal medicine residency at the Hospital of the University of Pennsylvania and fellowships in cardiology and cardiac electrophysiology at the Johns Hopkins University.  After completion of his medical training in 1999, Dr. Donahue served on the medical faculty at Johns Hopkins, where he attained the rank of Associate Professor prior to his 2005 relocation to Case Western Reserve University-MetroHealth Campus.  He was promoted to Professor at Case Western in 2011.  In 2013, Dr. Donahue relocated to the University of Massachusetts Medical School to start a position as Director of Electrophysiology Research. 



    Dr. Donahue’s primary research interests are the elucidation of mechanisms, and from that, the development of therapies for cardiac arrhythmias.  As a means to that end, the Donahue lab has developed several gene therapy methods and created novel animal models of cardiac arrhythmias.  The Donahue lab was first to show efficacy of gene therapy for a cardiac arrhythmia in a 12/2000 Nature Medicine publication documenting heart rate control in atrial fibrillation after atrioventricular nodal gene transfer of Gαi2.  More recently, the lab demonstrated complete elimination of post-myocardial infarction ventricular arrhythmias(Nature Medicine 12/2006) and reduction in atrial fibrillation vulnerability in porcine disease models after potassium channel and connexin gene transfer.  Ongoing interests include the investigation of mechanisms for ischemic and post-infarct ventricular arrhythmias and chronic atrial fibrillation, the development of improved gene delivery methods, and the use of these methods for arrhythmia gene therapy.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Donahue JK. Editorial commentary: Epigenetics and cardiovascular disease-From concept to reality. Trends Cardiovasc Med. 2018 Feb 14. PMID: 29496409.
      View in: PubMed
    2. Donahue JK. Sequencing of uncertain significance. J Cardiovasc Electrophysiol. 2018 Jan; 29(1):105-106. PMID: 29120076.
      View in: PubMed
    3. Finet JE, Wan X, Donahue JK. Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer. Virology. 2018 01 01; 513:43-51. PMID: 29032346.
      View in: PubMed
    4. Donahue JK. Current state of the art for cardiac arrhythmia gene therapy. Pharmacol Ther. 2017 Jun 19. PMID: 28642118.
      View in: PubMed
    5. Liu Z, Hutt JA, Rajeshkumar B, Azuma Y, Duan KL, Donahue JK. Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation. J Thorac Cardiovasc Surg. 2017 Nov; 154(5):1644-1651.e8. PMID: 28676183.
      View in: PubMed
    6. Donahue JK. Gene Therapy for Post-infarction Ventricular Tachycardia. Methods Mol Biol. 2017; 1521:307-321. PMID: 27910059.
      View in: PubMed
    7. Sardana M, Ogunsua AA, Spring M, Shaikh A, Asamoah O, Stokken G, Browning C, Ennis C, Donahue JK, Rosenthal LS, Floyd KC, Aurigemma GP, Parikh NI, McManus DD. Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation. J Cardiovasc Electrophysiol. 2016 Dec; 27(12):1411-1419. PMID: 27569695.
      View in: PubMed
    8. Donahue JK. Cardiac gene therapy: a call for basic methods development. Lancet. 2016 Mar 19; 387(10024):1137-9. PMID: 26806516.
      View in: PubMed
    9. Donahue JK. Biological Therapies for Atrial Fibrillation: Ready for Prime Time? J Cardiovasc Pharmacol. 2016 Jan; 67(1):19-25. PMID: 26222989.
      View in: PubMed
    10. Shaikh AY, Esa N, Martin-Doyle W, Kinno M, Nieto I, Floyd KC, Browning C, Ennis C, Donahue JK, Rosenthal LS, McManus DD. Addition of B-Type Natriuretic Peptide to Existing Clinical Risk Scores Enhances Identification of Patients at Risk for Atrial Fibrillation Recurrence After Pulmonary Vein Isolation. Crit Pathw Cardiol. 2015 Dec; 14(4):157-65. PMID: 26569657.
      View in: PubMed
    11. Nassal MM, Werdich AA, Wan X, Hoshi M, Deschênes I, Rosenbaum DS, Donahue JK. Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress. J Cardiovasc Electrophysiol. 2016 Jan; 27(1):110-9. PMID: 26459193.
      View in: PubMed
    12. Liu Z, Donahue JK. The Use of Gene Therapy for Ablation of Atrial Fibrillation. Arrhythm Electrophysiol Rev. 2014 Nov; 3(3):139-44. PMID: 26835081.
      View in: PubMed
    13. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF, Donahue JK, Benjamin EJ, Freedman JE. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015 Jan; 12(1):3-10. PMID: 25257092.
      View in: PubMed
    14. Panda NC, Zuckerman ST, Mesubi OO, Rosenbaum DS, Penn MS, Donahue JK, Alsberg E, Laurita KR. Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. J Interv Card Electrophysiol. 2014 Nov; 41(2):117-27. PMID: 25234602.
      View in: PubMed
    15. Jennings MM, Donahue JK. Connexin Remodeling Contributes to Atrial Fibrillation. J Atr Fibrillation. 2013 Aug-Sep; 6(2):839. PMID: 28496873.
      View in: PubMed
    16. Wolfram JA, Donahue JK. Gene therapy to treat cardiovascular disease. J Am Heart Assoc. 2013 Aug 20; 2(4):e000119. PMID: 23963752.
      View in: PubMed
    17. Ibrahim MA, Do DV, Sepah YJ, Shah SM, Van Anden E, Hafiz G, Donahue JK, Rivers R, Balkissoon J, Handa JT, Campochiaro PA, Nguyen QD. Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate. BMC Pharmacol Toxicol. 2013 Jan 14; 14:7. PMID: 23316779.
      View in: PubMed
    18. Greener ID, Sasano T, Wan X, Igarashi T, Strom M, Rosenbaum DS, Donahue JK. Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction. J Am Coll Cardiol. 2012 Sep 18; 60(12):1103-10. PMID: 22883636.
      View in: PubMed
    19. Igarashi T, Finet JE, Takeuchi A, Fujino Y, Strom M, Greener ID, Rosenbaum DS, Donahue JK. Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation. Circulation. 2012 Jan 17; 125(2):216-25. PMID: 22158756.
      View in: PubMed
    20. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011 Aug; 121(8):3277-88. PMID: 21785215.
      View in: PubMed
    21. Greener I, Donahue JK. Gene therapy strategies for cardiac electrical dysfunction. J Mol Cell Cardiol. 2011 May; 50(5):759-65. PMID: 20696170.
      View in: PubMed
    22. Amit G, Kikuchi K, Greener ID, Yang L, Novack V, Donahue JK. Selective molecular potassium channel blockade prevents atrial fibrillation. Circulation. 2010 Jun 1; 121(21):2263-70. PMID: 20479154.
      View in: PubMed
    23. Donahue JK. Advice for management of the long-QT patient. J Cardiovasc Electrophysiol. 2010 Aug 1; 21(8):902-4. PMID: 20455972.
      View in: PubMed
    24. Sasano T, Kelemen K, Greener ID, Donahue JK. Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy. Heart Rhythm. 2009 Aug; 6(8 Suppl):S91-7. PMID: 19631912.
      View in: PubMed
    25. Finet JE, Rosenbaum DS, Donahue JK. Information learned from animal models of atrial fibrillation. Cardiol Clin. 2009 Feb; 27(1):45-54, viii. PMID: 19111763.
      View in: PubMed
    26. Donahue JK. Novel strategy to reduce sudden-death risk in the healing phase after myocardial infarction. Circulation. 2009 Jan 06; 119(1):6-8. PMID: 19103983.
      View in: PubMed
    27. Amit G, Qin H, Donahue JK. Biological therapies for atrial fibrillation. J Cardiovasc Pharmacol. 2008 Sep; 52(3):222-7. PMID: 18806602.
      View in: PubMed
    28. Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13; 116(20):2325-45. PMID: 17998470.
      View in: PubMed
    29. Donahue JK, Sasano T, Kelemen K. Gene therapy approaches to ventricular tachyarrhythmias. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S187-91. PMID: 17993320.
      View in: PubMed
    30. Ashikaga H, Sasano T, Dong J, Zviman MM, Evers R, Hopenfeld B, Castro V, Helm RH, Dickfeld T, Nazarian S, Donahue JK, Berger RD, Calkins H, Abraham MR, Marbán E, Lardo AC, McVeigh ER, Halperin HR. Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res. 2007 Oct 26; 101(9):939-47. PMID: 17916777.
      View in: PubMed
    31. Donahue JK. Gene therapy for cardiac arrhythmias: a dream soon to come true? J Cardiovasc Electrophysiol. 2007 May; 18(5):553-9. PMID: 17456137.
      View in: PubMed
    32. Sasano T, Kikuchi K, McDonald AD, Lai S, Donahue JK. Targeted high-efficiency, homogeneous myocardial gene transfer. J Mol Cell Cardiol. 2007 May; 42(5):954-61. PMID: 17484913.
      View in: PubMed
    33. Kapur NK, Deming CB, Kapur S, Bian C, Champion HC, Donahue JK, Kass DA, Rade JJ. Hemodynamic modulation of endocardial thromboresistance. Circulation. 2007 Jan 2; 115(1):67-75. PMID: 17190863.
      View in: PubMed
    34. Sasano T, McDonald AD, Kikuchi K, Donahue JK. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med. 2006 Nov; 12(11):1256-8. PMID: 17072309.
      View in: PubMed
    35. Donahue JK. Gender and the heart. Heart Rhythm. 2006 Jul; 3(7):840-1. PMID: 16818218.
      View in: PubMed
    36. Tandri H, Griffith LS, Tang T, Nasir K, Zardkoohi O, Reddy CV, Capps M, Calkins H, Donahue JK. Clinical course and long-term follow-up of patients receiving implantable cardioverter-defibrillators. Heart Rhythm. 2006 Jul; 3(7):762-8. PMID: 16818202.
      View in: PubMed
    37. Henrikson CA, Brinker JA, Donahue JK. Temporary placement of a defibrillating lead in the treatment of infection and ventricular tachycardia. Heart Rhythm. 2006 Feb; 3(2):222-4. PMID: 16443540.
      View in: PubMed
    38. Reynolds DW, Chen PS, Deal BJ, Donahue JK, Ellenbogen KA, Epstein AE, Friedman PA, Hammill SC, Hohnloser SH, Kanter RJ, Lindsay BD, Natale A, Saffitz J, Stevenson WG. Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana. Heart Rhythm. 2005 Sep; 2(9):1025-33. PMID: 16171766.
      View in: PubMed
    39. Donahue JK, Kikuchi K, Sasano T. Gene therapy for cardiac arrhythmias. Trends Cardiovasc Med. 2005 Aug; 15(6):219-24. PMID: 16182132.
      View in: PubMed
    40. Donahue JK, Bauer A, Kikuchi K, Sasano T. Modification of cellular communication by gene transfer. Ann N Y Acad Sci. 2005 Jun; 1047:157-65. PMID: 16093493.
      View in: PubMed
    41. Roguin A, Donahue JK, Bomma CS, Bluemke DA, Halperin HR. Cardiac magnetic resonance imaging in a patient with implantable cardioverter-defibrillator. Pacing Clin Electrophysiol. 2005 Apr; 28(4):336-8. PMID: 15826272.
      View in: PubMed
    42. Kikuchi K, McDonald AD, Sasano T, Donahue JK. Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation. 2005 Jan 25; 111(3):264-70. PMID: 15642761.
      View in: PubMed
    43. Bauer A, McDonald AD, Nasir K, Peller L, Rade JJ, Miller JM, Heldman AW, Donahue JK. Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation. Circulation. 2004 Nov 9; 110(19):3115-20. PMID: 15505099.
      View in: PubMed
    44. Murata M, Cingolani E, McDonald AD, Donahue JK, Marbán E. Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res. 2004 Aug 20; 95(4):398-405. PMID: 15242970.
      View in: PubMed
    45. Eldadah ZA, Donahue JK. Successful implantable cardioverter defibrillator placement in an ambulatory patient without thoracic venous access. J Cardiovasc Electrophysiol. 2004 Jun; 15(6):716-8. PMID: 15175069.
      View in: PubMed
    46. Donahue JK. Gene therapy for cardiac arrhythmias. Ann N Y Acad Sci. 2004 May; 1015:332-7. PMID: 15201172.
      View in: PubMed
    47. Bauer A, McDonald AD, Donahue JK. Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure. Cardiovasc Res. 2004 Mar 1; 61(4):764-70. PMID: 14985073.
      View in: PubMed
    48. Bauer A, Donahue JK, Voss F, Becker R, Kraft P, Senges JC, Kelemen K, Katus HA, Schoels W. Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome. Naunyn Schmiedebergs Arch Pharmacol. 2004 Apr; 369(4):447-54. PMID: 14985939.
      View in: PubMed
    49. Donahue JK, Bauer A, Kikuchi K, McDonald AD. Gene transfer techniques for cardiac arrhythmias. Ann Med. 2004; 36 Suppl 1:98-105. PMID: 15176431.
      View in: PubMed
    50. Tomaselli GF, Donahue JK. Somatic gene transfer and cardiac arrhythmias: problems and prospects. J Cardiovasc Electrophysiol. 2003 May; 14(5):547-50. PMID: 12776876.
      View in: PubMed
    51. Lehnart SE, Donahue JK. Coronary perfusion cocktails for in vivo gene transfer. Methods Mol Biol. 2003; 219:213-8. PMID: 12597011.
      View in: PubMed
    52. Janssen PM, Schillinger W, Donahue JK, Zeitz O, Emami S, Lehnart SE, Weil J, Eschenhagen T, Hasenfuss G, Prestle J. Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. Cardiovasc Res. 2002 Aug 1; 55(2):300-8. PMID: 12123769.
      View in: PubMed
    53. Neyroud N, Nuss HB, Leppo MK, Marbán E, Donahue JK. Gene delivery to cardiac muscle. Methods Enzymol. 2002; 346:323-34. PMID: 11883077.
      View in: PubMed
    54. Nagata K, Marbán E, Lawrence JH, Donahue JK. Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. J Mol Cell Cardiol. 2001 Mar; 33(3):575-80. PMID: 11181024.
      View in: PubMed
    55. Donahue JK, Heldman AW, Fraser H, McDonald AD, Miller JM, Rade JJ, Eschenhagen T, Marbán E. Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med. 2000 Dec; 6(12):1395-8. PMID: 11100126.
      View in: PubMed
    56. Donahue JK, Kikkawa K, Thomas AD, Marban E, Lawrence JH. Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin. Gene Ther. 1998 May; 5(5):630-4. PMID: 9797867.
      View in: PubMed
    57. Donahue JK, Kikkawa K, Johns DC, Marban E, Lawrence JH. Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4664-8. PMID: 9114048.
      View in: PubMed
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