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Phillip D Zamore PhD

TitleChair and Professor
Endowed TitleGretchen Stone Cook Chair in Biomedical Sciences
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUniversity of Massachusetts Medical School
368 Plantation Street, AS4-2053
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABBiochemistry & Molecular Bio
    Harvard University, Cambridge, MA, United StatesPHDBiochemistry & Molecular Bio

    Collapse Overview 
    Collapse overview


    Phillip D. Zamore, Ph.D., the Gretchen Stone Cook Professor of Biomedical Sciences, Professor of Biochemistry and Molecular Pharmacology, and Investigator of the Howard Hughes Medical Institute, is Chair of the RNA Therapeutics Institute, which was established at the University of Massachusetts Medical School in 2009. Zamore received his A.B. and Ph.D. degrees in Biochemistry and Molecular Biology from Harvard University. He then pursued postdoctoral studies at MIT and the Whitehead Institute for Biomedical Research.



    The Zamore laboratory studies small RNA silencing pathways in eukaryotes and prokaryotes, including the RNA interference (RNAi), microRNA, and PIWI-interacting RNA pathways. Zamore and his collaborators seek to use the fundamental insights gained from studies in model and non-model bacteria, insects, and mammals to design therapies for human diseases, including Huntington’s disease. 



    In 2015, Zamore was awarded the Chancellor’s Medal for Excellence in Scholarship at the University of Massachusetts Medical School. To date, Zamore has more than 125 publications and has been among the most highly cited researchers for more than a decade. 



    Zamore was elected a Fellow of the National Academy of Inventors in 2014 and was selected in 2015 by Nature Biotechnology as one of the Top 20 Translational Researchers of 2014. In 2002, Zamore co-founded Alnylam Pharmaceuticals, a publicly traded biotech company which now has more than 200 employees and currently has more than six drugs in clinical trials. In 2014, he co-founded Voyager Therapeutics. He serves on the scientific advisory boards of Alnylam, Voyager, and RaNA Therapeutics.




    Understanding the molecular mechanisms of post-transcriptional gene regulation.


     


    How do animal embryos regulate the localization, translation, and stability of mRNAs?


    In Drosophila, mRNA encoding the transcription factor, hunchback, is present throughout the embryo, but is translated into protein only in the anterior half of the cell. Two proteins, NANOS and PUMILIO. are required to repress hunchback translation in the posterior half of the fly embryo. PUMILIO binds RNA through a novel RNA-binding motif found in proteins that control developmental decisions in yeast, slime mold, and worms, and is more than 80% identical to a protein of unknown function in humans. A major goal of our laboratory is to learn how PUMILIO and NANOS control hunchback mRNA translation and to determine the biological role of the human PUMILIO protein.


     


    For more information, please visit our lab website and our Howard Hughes Medical Institute web page. 


     



     


     



    Phillip D. Zamore, Ph.D., the Gretchen Stone Cook Professor of Biomedical Sciences, Professor of Biochemistry and Molecular Pharmacology, and Investigator of the Howard Hughes Medical Institute, is Chair of the RNA Therapeutics Institute, which was established at the University of Massachusetts Medical School in 2009. Zamore received his A.B. and Ph.D. degrees in Biochemistry and Molecular Biology from Harvard University. He then pursued postdoctoral studies at MIT and the Whitehead Institute for Biomedical Research.


    The Zamore laboratory studies small RNA silencing pathways in eukaryotes and prokaryotes, including the RNA interference (RNAi), microRNA, and PIWI-interacting RNA pathways. Zamore and his collaborators seek to use the fundamental insights gained from studies in model and non-model bacteria, insects, and mammals to design therapies for human diseases, including Huntington’s disease. 


    In 2015, Zamore was awarded the Chancellor’s Medal for Excellence in Scholarship at the University of Massachusetts Medical School. To date, Zamore has more than 125 publications and has been among the most highly cited researchers for more than a decade. 


    Zamore was elected a Fellow of the National Academy of Inventors in 2014 and was selected in 2015 by Nature Biotechnology as one of the Top 20 Translational Researchers of 2014. In 2002, Zamore co-founded Alnylam Pharmaceuticals, a publicly traded biotech company which now has more than 200 employees and currently has more than six drugs in clinical trials. In 2014, he co-founded Voyager Therapeutics. He serves on the scientific advisory boards of Alnylam, Voyager, and RaNA Therapeutics.



    Understanding the molecular mechanisms of post-transcriptional gene regulation.

     

    How do animal embryos regulate the localization, translation, and stability of mRNAs?

    In Drosophila, mRNA encoding the transcription factor, hunchback, is present throughout the embryo, but is translated into protein only in the anterior half of the cell. Two proteins, NANOS and PUMILIO. are required to repress hunchback translation in the posterior half of the fly embryo. PUMILIO binds RNA through a novel RNA-binding motif found in proteins that control developmental decisions in yeast, slime mold, and worms, and is more than 80% identical to a protein of unknown function in humans. A major goal of our laboratory is to learn how PUMILIO and NANOS control hunchback mRNA translation and to determine the biological role of the human PUMILIO protein.

     

    For more information, please visit our lab website and our Howard Hughes Medical Institute web page. 

     


     

     


    Collapse Rotation Projects

    Potential Rotation Projects

    Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.



    Collapse Post Docs
    A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen Z, Devi G, Arif A, Zamore PD, Sontheimer EJ, Watts JK. Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. ACS Chem Biol. 2022 Apr 21. PMID: 35446558.
      Citations:    Fields:    
    2. Jouravleva K, Vega-Badillo J, Zamore PD. Principles and pitfalls of high-throughput analysis of microRNA-binding thermodynamics and kinetics by RNA Bind-n-Seq. Cell Rep Methods. 2022 Mar 28; 2(3):100185. PMID: 35475222.
      Citations:    
    3. Ober-Reynolds B, Becker WR, Jouravleva K, Jolly SM, Zamore PD, Greenleaf WJ. High-throughput biochemical profiling reveals functional adaptation of a bacterial Argonaute. Mol Cell. 2022 Apr 07; 82(7):1329-1342.e8. PMID: 35298909.
      Citations:    Fields:    Translation:Cells
    4. Gainetdinov I, Colpan C, Cecchini K, Arif A, Jouravleva K, Albosta P, Vega-Badillo J, Lee Y, Özata DM, Zamore PD. Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability. Mol Cell. 2021 12 02; 81(23):4826-4842.e8. PMID: 34626567.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Wu PH, Zamore PD. Defining the functions of PIWI-interacting RNAs. Nat Rev Mol Cell Biol. 2021 04; 22(4):239-240. PMID: 33483697.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Wu PH, Zamore PD. To Degrade a MicroRNA, Destroy Its Argonaute Protein. Mol Cell. 2021 01 21; 81(2):223-225. PMID: 33482091.
      Citations:    Fields:    
    7. Yu T, Fan K, Özata DM, Zhang G, Fu Y, Theurkauf WE, Zamore PD, Weng Z. Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes. Nat Commun. 2021 01 04; 12(1):73. PMID: 33397987.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Zamore PD. One small step for worms, one giant leap for small RNAs. Nat Rev Mol Cell Biol. 2020 10; 21(10):565. PMID: 32764585.
      Citations:    Fields:    
    9. Jolly SM, Gainetdinov I, Jouravleva K, Zhang H, Strittmatter L, Bailey SM, Hendricks GM, Dhabaria A, Ueberheide B, Zamore PD. Thermus thermophilus Argonaute Functions in the Completion of DNA Replication. Cell. 2020 09 17; 182(6):1545-1559.e18. PMID: 32846159.
      Citations: 12     Fields:    Translation:Cells
    10. Wu PH, Fu Y, Cecchini K, Özata DM, Arif A, Yu T, Colpan C, Gainetdinov I, Weng Z, Zamore PD. The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility. Nat Genet. 2020 07; 52(7):728-739. PMID: 32601478.
      Citations: 25     Fields:    Translation:AnimalsCells
    11. Özata DM, Yu T, Mou H, Gainetdinov I, Colpan C, Cecchini K, Kaymaz Y, Wu PH, Fan K, Kucukural A, Weng Z, Zamore PD. Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans. Nat Ecol Evol. 2020 01; 4(1):156-168. PMID: 31900453.
      Citations: 19     Fields:    Translation:HumansAnimals
    12. Xie J, Tai PWL, Brown A, Gong S, Zhu S, Wang Y, Li C, Colpan C, Su Q, He R, Ma H, Li J, Ye H, Ko J, Zamore PD, Gao G. Effective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold. Mol Ther. 2020 02 05; 28(2):422-430. PMID: 31843447.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Becker WR, Ober-Reynolds B, Jouravleva K, Jolly SM, Zamore PD, Greenleaf WJ. High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2. Mol Cell. 2019 08 22; 75(4):741-755.e11. PMID: 31324449.
      Citations: 27     Fields:    Translation:Animals
    14. Ge DT, Wang W, Tipping C, Gainetdinov I, Weng Z, Zamore PD. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Mol Cell. 2019 06 06; 74(5):982-995.e6. PMID: 31076285.
      Citations: 22     Fields:    Translation:AnimalsCells
    15. Li C, Zamore PD. Preparation of siRNA Duplexes. Cold Spring Harb Protoc. 2019 04 01; 2019(4). PMID: 30936382.
      Citations: 1     Fields:    
    16. Li C, Zamore PD. RNA Interference and Small RNA Analysis. Cold Spring Harb Protoc. 2019 04 01; 2019(4). PMID: 30936388.
      Citations: 2     Fields:    Translation:HumansAnimals
    17. Li C, Zamore PD. RNAi in Mammalian Cells by siRNA Duplex Transfection. Cold Spring Harb Protoc. 2019 04 01; 2019(4). PMID: 30936383.
      Citations:    Fields:    Translation:AnimalsCells
    18. Jouravleva K, Zamore PD. MicroRNAs tame CRISPR-Cas9. Nat Cell Biol. 2019 Apr; 21(4):416-417. PMID: 30936471.
      Citations:    Fields:    
    19. Li C, Zamore PD. RNAi in Drosophila S2 Cells by siRNA Duplex or dsRNA Transfection. Cold Spring Harb Protoc. 2019 04 01; 2019(4). PMID: 30936384.
      Citations:    Fields:    Translation:AnimalsCells
    20. Li C, Zamore PD. RNAi in Drosophila S2 Cells by dsRNA Soaking. Cold Spring Harb Protoc. 2019 03 01; 2019(3). PMID: 30824620.
      Citations: 1     Fields:    Translation:AnimalsCells
    21. Li C, Zamore PD. Preparation of dsRNAs for RNAi by In Vitro Transcription. Cold Spring Harb Protoc. 2019 03 01; 2019(3). PMID: 30824619.
      Citations:    Fields:    Translation:Cells
    22. Ozata DM, Gainetdinov I, Zoch A, O'Carroll D, Zamore PD. PIWI-interacting RNAs: small RNAs with big functions. Nat Rev Genet. 2019 02; 20(2):89-108. PMID: 30446728.
      Citations: 242     Fields:    Translation:HumansAnimalsCells
    23. Smith CS, Jouravleva K, Huisman M, Jolly SM, Zamore PD, Grunwald D. An automated Bayesian pipeline for rapid analysis of single-molecule binding data. Nat Commun. 2019 01 17; 10(1):272. PMID: 30655518.
      Citations: 7     Fields:    Translation:Cells
    24. Chang TH, Mattei E, Gainetdinov I, Colpan C, Weng Z, Zamore PD. Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster. Mol Cell. 2019 01 17; 73(2):291-303.e6. PMID: 30527661.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Gainetdinov I, Colpan C, Arif A, Cecchini K, Zamore PD. A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. Mol Cell. 2018 09 06; 71(5):775-790.e5. PMID: 30193099.
      Citations: 56     Fields:    Translation:AnimalsCells
    26. Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nat Biotechnol. 2018 10; 36(9):839-842. PMID: 30102296.
      Citations: 19     Fields:    Translation:AnimalsCells
    27. Li C, Zamore PD. Analysis of Small RNAs by Northern Hybridization. Cold Spring Harb Protoc. 2018 08 01; 2018(8). PMID: 30068587.
      Citations: 1     Fields:    Translation:Cells
    28. Fu Y, Wu PH, Beane T, Zamore PD, Weng Z. Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers. BMC Genomics. 2018 Jul 13; 19(1):531. PMID: 30001700.
      Citations: 49     Fields:    Translation:Animals
    29. Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Res. 2018 03 16; 46(5):2185-2196. PMID: 29432571.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    30. Li C, Zamore PD. Inhibiting miRNA Function by Antisense Oligonucleotides in Drosophila S2 Cells. Cold Spring Harb Protoc. 2018 02 01; 2018(2). PMID: 29438062.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Li C, Zamore PD. Preparation of Antisense Oligonucleotides to Inhibit miRNA Function. Cold Spring Harb Protoc. 2018 02 01; 2018(2). PMID: 29438060.
      Citations: 1     Fields:    Translation:Cells
    32. Li C, Zamore PD. Inhibiting miRNA Function by Antisense Oligonucleotides in Cultured Mammalian Cells. Cold Spring Harb Protoc. 2018 02 01; 2018(2). PMID: 29438061.
      Citations: 1     Fields:    Translation:AnimalsCells
    33. Fu Y, Yang Y, Zhang H, Farley G, Wang J, Quarles KA, Weng Z, Zamore PD. The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology. Elife. 2018 01 29; 7. PMID: 29376823.
      Citations: 21     Fields:    Translation:AnimalsCells
    34. Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X, Gao G. Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs. Mol Ther Nucleic Acids. 2018 Mar 02; 10:349-360. PMID: 29499946.
      Citations:    
    35. Lewis SH, Quarles KA, Yang Y, Tanguy M, Frézal L, Smith SA, Sharma PP, Cordaux R, Gilbert C, Giraud I, Collins DH, Zamore PD, Miska EA, Sarkies P, Jiggins FM. Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements. Nat Ecol Evol. 2018 Jan; 2(1):174-181. PMID: 29203920.
      Citations: 88     Fields:    Translation:AnimalsCells
    36. Zamore PD. Molecular biology: Rhino gives voice to silent chromatin. Nature. 2017 09 06; 549(7670):38-39. PMID: 28880287.
      Citations:    Fields:    Translation:HumansAnimalsCells
    37. Koh CS, Madireddy R, Beane TJ, Zamore PD, Korostelev AA. Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine. Sci Rep. 2017 04 20; 7(1):969. PMID: 28428565.
      Citations: 6     Fields:    Translation:Cells
    38. Ge DT, Tipping C, Brodsky MH, Zamore PD. Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion. G3 (Bethesda). 2016 10 13; 6(10):3197-3206. PMID: 27543296.
      Citations: 23     Fields:    Translation:AnimalsCells
    39. Salomon WE, Jolly SM, Moore MJ, Zamore PD, Serebrov V. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell. 2016 07 14; 166(2):517-520. PMID: 28777949.
      Citations: 6     Fields:    
    40. Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA, Moore KJ. Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism. Nat Immunol. 2016 06; 17(6):677-86. PMID: 27089382.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    41. Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest. 2015 Oct 26; 125(12):4334-48. PMID: 26517695.
      Citations: 141     Fields:    Translation:AnimalsCells
    42. Wang W, Han BW, Tipping C, Ge DT, Zhang Z, Weng Z, Zamore PD. Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms. Mol Cell. 2015 Sep 03; 59(5):819-30. PMID: 26340424.
      Citations: 52     Fields:    Translation:AnimalsCells
    43. Salomon WE, Jolly SM, Moore MJ, Zamore PD, Serebrov V. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell. 2015 Jul 02; 162(1):84-95. PMID: 26140592.
      Citations: 114     Fields:    Translation:AnimalsCells
    44. Chou MT, Han BW, Hsiao CP, Zamore PD, Weng Z, Hung JH. Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs. Nucleic Acids Res. 2015 Sep 30; 43(17):e109. PMID: 26007652.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Han BW, Wang W, Li C, Weng Z, Zamore PD. Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science. 2015 May 15; 348(6236):817-21. PMID: 25977554.
      Citations: 165     Fields:    Translation:AnimalsCells
    46. Roy CK, Olson S, Graveley BR, Zamore PD, Moore MJ. Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation. Elife. 2015 Apr 13; 4. PMID: 25866926.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    47. Marinov GK, Wang J, Handler D, Wold BJ, Weng Z, Hannon GJ, Aravin AA, Zamore PD, Brennecke J, Toth KF. Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. Dev Cell. 2015 Mar 23; 32(6):765-71. PMID: 25805138.
      Citations: 14     Fields:    Translation:AnimalsCells
    48. Wang W, Yoshikawa M, Han BW, Izumi N, Tomari Y, Weng Z, Zamore PD. The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs. Mol Cell. 2014 Dec 04; 56(5):708-16. PMID: 25453759.
      Citations: 47     Fields:    Translation:Animals
    49. Han BW, Wang W, Zamore PD, Weng Z. piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing. Bioinformatics. 2015 Feb 15; 31(4):593-5. PMID: 25342065.
      Citations: 63     Fields:    Translation:AnimalsCells
    50. Zamore P. Startups on the menu: Alnylam. Nat Biotechnol. 2014 Sep; 32(9):866. PMID: 25203029.
      Citations:    Fields:    Translation:HumansAnimals
    51. Han BW, Zamore PD. piRNAs. Curr Biol. 2014 Aug 18; 24(16):R730-3. PMID: 25137579.
      Citations: 28     Fields:    Translation:HumansAnimals
    52. Babcock GJ, Iyer S, Smith HL, Wang Y, Rowley K, Ambrosino DM, Zamore PD, Pierce BG, Molrine DC, Weng Z. High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody. PLoS One. 2014; 9(6):e100325. PMID: 24956119.
      Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
    53. Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE. The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell. 2014 Jun 05; 157(6):1353-1363. PMID: 24906152.
      Citations: 98     Fields:    Translation:AnimalsCells
    54. Broderick JA, Zamore PD. Competitive endogenous RNAs cannot alter microRNA function in vivo. Mol Cell. 2014 Jun 05; 54(5):711-3. PMID: 24905003.
      Citations: 36     Fields:    Translation:Animals
    55. Fukunaga R, Zamore PD. A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle. 2014; 13(11):1671-6. PMID: 24787225.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    56. Moran Y, Fredman D, Praher D, Li XZ, Wee LM, Rentzsch F, Zamore PD, Technau U, Seitz H. Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res. 2014 Apr; 24(4):651-63. PMID: 24642861.
      Citations: 47     Fields:    Translation:AnimalsCells
    57. Zhang Z, Koppetsch BS, Wang J, Tipping C, Weng Z, Theurkauf WE, Zamore PD. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J. 2014 Mar 18; 33(6):536-9. PMID: 24652836.
      Citations: 11     Fields:    Translation:AnimalsCells
    58. Fukunaga R, Colpan C, Han BW, Zamore PD. Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J. 2014 Feb 18; 33(4):371-84. PMID: 24488111.
      Citations: 22     Fields:    Translation:AnimalsCells
    59. Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 2013 Aug; 14(8):475-88. PMID: 23800994.
      Citations: 510     Fields:    Translation:HumansAnimalsCells
    60. Li XZ, Roy CK, Moore MJ, Zamore PD. Defining piRNA primary transcripts. Cell Cycle. 2013 Jun 01; 12(11):1657-8. PMID: 23673320.
      Citations: 10     Fields:    Translation:AnimalsCells
    61. Ge DT, Zamore PD. Small RNA-directed silencing: the fly finds its inner fission yeast? Curr Biol. 2013 Apr 22; 23(8):R318-20. PMID: 23618667.
      Citations: 8     Fields:    Translation:AnimalsCells
    62. Li XZ, Roy CK, Dong X, Bolcun-Filas E, Wang J, Han BW, Xu J, Moore MJ, Schimenti JC, Weng Z, Zamore PD. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell. 2013 Apr 11; 50(1):67-81. PMID: 23523368.
      Citations: 155     Fields:    Translation:AnimalsCells
    63. Chung RT, Gordon FD, Curry MP, Schiano TD, Emre S, Corey K, Markmann JF, Hertl M, Pomposelli JJ, Pomfret EA, Florman S, Schilsky M, Broering TJ, Finberg RW, Szabo G, Zamore PD, Khettry U, Babcock GJ, Ambrosino DM, Leav B, Leney M, Smith HL, Molrine DC. Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study. Am J Transplant. 2013 Apr; 13(4):1047-1054. PMID: 23356386.
      Citations: 53     Fields:    Translation:HumansCells
    64. Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N. Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. J Huntingtons Dis. 2013; 2(4):491-500. PMID: 25062733.
      Citations: 8     Fields:    Translation:HumansCells
    65. Zhang Z, Theurkauf WE, Weng Z, Zamore PD. Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection. Silence. 2012 Dec 28; 3(1):9. PMID: 23273270.
      Citations:    
    66. Flores-Jasso CF, Salomon WE, Zamore PD. Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA. 2013 Feb; 19(2):271-9. PMID: 23249751.
      Citations: 29     Fields:    Translation:AnimalsCells
    67. Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell. 2012 Nov 21; 151(5):1055-67. PMID: 23178124.
      Citations: 183     Fields:    Translation:AnimalsCells
    68. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch BS, Schultz N, Vreven T, Meignin C, Davis I, Zamore PD, Weng Z, Theurkauf WE. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell. 2012 Nov 09; 151(4):871-884. PMID: 23141543.
      Citations: 109     Fields:    Translation:AnimalsCells
    69. Fukunaga R, Han BW, Hung JH, Xu J, Weng Z, Zamore PD. Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals. Cell. 2012 11 09; 151(4):912. PMID: 30360291.
      Citations: 8     Fields:    
    70. Fukunaga R, Han BW, Hung JH, Xu J, Weng Z, Zamore PD. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell. 2012 Oct 26; 151(3):533-46. PMID: 23063653.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    71. Zamore PD. RNA: methods and protocols - a new series. Silence. 2012 Jun 07; 3(1):7. PMID: 22676652.
      Citations:    
    72. Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012 Mar 04; 9(4):403-9. PMID: 22388288.
      Citations: 115     Fields:    Translation:AnimalsCells
    73. Mueller C, Tang Q, Gruntman A, Blomenkamp K, Teckman J, Song L, Zamore PD, Flotte TR. Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Mol Ther. 2012 03; 20(3):590-600. PMID: 22252449.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    74. Khurana JS, Wang J, Xu J, Koppetsch BS, Thomson TC, Nowosielska A, Li C, Zamore PD, Weng Z, Theurkauf WE. Adaptation to P element transposon invasion in Drosophila melanogaster. Cell. 2011 Dec 23; 147(7):1551-63. PMID: 22196730.
      Citations: 112     Fields:    Translation:AnimalsCells
    75. Zhang Z, Xu J, Koppetsch BS, Wang J, Tipping C, Ma S, Weng Z, Theurkauf WE, Zamore PD. Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell. 2011 Nov 18; 44(4):572-84. PMID: 22099305.
      Citations: 96     Fields:    Translation:AnimalsCells
    76. Han BW, Hung JH, Weng Z, Zamore PD, Ameres SL. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol. 2011 Nov 22; 21(22):1878-87. PMID: 22055293.
      Citations: 92     Fields:    Translation:AnimalsCells
    77. Broderick JA, Salomon WE, Ryder SP, Aronin N, Zamore PD. Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA. 2011 Oct; 17(10):1858-69. PMID: 21878547.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    78. Cenik ES, Zamore PD. Argonaute proteins. Curr Biol. 2011 Jun 21; 21(12):R446-9. PMID: 21683893.
      Citations: 49     Fields:    Translation:HumansAnimals
    79. Seitz H, Tushir JS, Zamore PD. A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence. 2011 Jun 07; 2:4. PMID: 21649885.
      Citations:    
    80. Zamore PD, Ma S. Isolation of Drosophila melanogaster testes. J Vis Exp. 2011 May 13; (51). PMID: 21610676.
      Citations: 7     Fields:    Translation:Animals
    81. Broderick JA, Zamore PD. MicroRNA therapeutics. Gene Ther. 2011 Dec; 18(12):1104-10. PMID: 21525952.
      Citations: 168     Fields:    Translation:Humans
    82. Cenik ES, Fukunaga R, Lu G, Dutcher R, Wang Y, Tanaka Hall TM, Zamore PD. Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell. 2011 Apr 22; 42(2):172-84. PMID: 21419681.
      Citations: 65     Fields:    Translation:AnimalsCells
    83. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell. 2010 Dec 23; 143(7):1084-96. PMID: 21183072.
      Citations: 434     Fields:    Translation:HumansAnimalsCells
    84. Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, Perrimon N, Lai EC. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res. 2011 Feb; 21(2):203-15. PMID: 21177969.
      Citations: 148     Fields:    Translation:AnimalsCells
    85. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther. 2011 Mar; 19(3):526-35. PMID: 21179009.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    86. Ameres SL, Hung JH, Xu J, Weng Z, Zamore PD. Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA. 2011 Jan; 17(1):54-63. PMID: 21106652.
      Citations: 32     Fields:    Translation:AnimalsCells
    87. Zamore PD. Somatic piRNA biogenesis. EMBO J. 2010 Oct 06; 29(19):3219-21. PMID: 20924396.
      Citations: 19     Fields:    Translation:Animals
    88. Ameres SL, Horwich MD, Hung JH, Xu J, Ghildiyal M, Weng Z, Zamore PD. Target RNA-directed trimming and tailing of small silencing RNAs. Science. 2010 Jun 18; 328(5985):1534-9. PMID: 20558712.
      Citations: 273     Fields:    Translation:HumansAnimalsCells
    89. Baulcombe DC, Zamore PD. Welcome to silence. Silence. 2010 Jan 12; 1(1):1. PMID: 20226068.
      Citations:    
    90. Ghildiyal M, Xu J, Seitz H, Weng Z, Zamore PD. Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA. 2010 Jan; 16(1):43-56. PMID: 19917635.
      Citations: 166     Fields:    Translation:AnimalsCells
    91. Tushir JS, Zamore PD, Zhang Z. SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009 Nov 13; 139(4):830-830.e1. PMID: 19914174.
      Citations: 5     Fields:    Translation:Animals
    92. Tushir JS, Zamore PD, Zhang Z. SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell. 2009 Oct 30; 139(3):634, 634.e1. PMID: 19879848.
      Citations: 6     Fields:    Translation:AnimalsCells
    93. Pfister EL, Zamore PD. Huntington's disease: silencing a brutal killer. Exp Neurol. 2009 Dec; 220(2):226-9. PMID: 19786020.
      Citations: 9     Fields:    Translation:HumansAnimals
    94. Klattenhoff C, Xi H, Li C, Lee S, Xu J, Khurana JS, Zhang F, Schultz N, Koppetsch BS, Nowosielska A, Seitz H, Zamore PD, Weng Z, Theurkauf WE. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell. 2009 Sep 18; 138(6):1137-49. PMID: 19732946.
      Citations: 206     Fields:    Translation:AnimalsCells
    95. Kadener S, Menet JS, Sugino K, Horwich MD, Weissbein U, Nawathean P, Vagin VV, Zamore PD, Nelson SB, Rosbash M. A role for microRNAs in the Drosophila circadian clock. Genes Dev. 2009 Sep 15; 23(18):2179-91. PMID: 19696147.
      Citations: 84     Fields:    Translation:AnimalsCells
    96. Izaurralde E, Zamore PD. Nucleus and gene expression. Curr Opin Cell Biol. 2009 Jun; 21(3):331-4. PMID: 19447016.
      Citations:    Fields:    Translation:HumansAnimalsCells
    97. Barringhaus KG, Zamore PD. MicroRNAs: regulating a change of heart. Circulation. 2009 Apr 28; 119(16):2217-24. PMID: 19398677.
      Citations: 39     Fields:    Translation:HumansAnimals
    98. Li C, Vagin VV, Lee S, Xu J, Ma S, Xi H, Seitz H, Horwich MD, Syrzycka M, Honda BM, Kittler EL, Zapp ML, Klattenhoff C, Schulz N, Theurkauf WE, Weng Z, Zamore PD. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell. 2009 May 01; 137(3):509-21. PMID: 19395009.
      Citations: 290     Fields:    Translation:AnimalsCells
    99. Pfister EL, Kennington L, Straubhaar J, Wagh S, Liu W, DiFiglia M, Landwehrmeyer B, Vonsattel JP, Zamore PD, Aronin N. Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol. 2009 May 12; 19(9):774-8. PMID: 19361997.
      Citations: 123     Fields:    Translation:Humans
    100. Ghildiyal M, Zamore PD. Small silencing RNAs: an expanding universe. Nat Rev Genet. 2009 Feb; 10(2):94-108. PMID: 19148191.
      Citations: 1037     Fields:    
    101. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3. PMID: 18931668.
      Citations: 17     Fields:    Translation:HumansCells
    102. Rossi J, Zamore P, Kay MA. Wandering eye for RNAi. Nat Med. 2008 Jun; 14(6):611. PMID: 18535575.
      Citations: 4     Fields:    Translation:HumansAnimals
    103. Ghildiyal M, Seitz H, Horwich MD, Li C, Du T, Lee S, Xu J, Kittler EL, Zapp ML, Weng Z, Zamore PD. Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science. 2008 May 23; 320(5879):1077-81. PMID: 18403677.
      Citations: 340     Fields:    Translation:AnimalsCells
    104. Seitz H, Ghildiyal M, Zamore PD. Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol. 2008 Jan 22; 18(2):147-51. PMID: 18207740.
      Citations: 111     Fields:    Translation:AnimalsCells
    105. Horwich MD, Zamore PD. Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc. 2008; 3(10):1537-49. PMID: 18802435.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    106. DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17204-9. PMID: 17940007.
      Citations: 181     Fields:    Translation:HumansAnimalsCells
    107. Matranga C, Zamore PD. Small silencing RNAs. Curr Biol. 2007 Sep 18; 17(18):R789-93. PMID: 17878043.
      Citations: 28     Fields:    Translation:Animals
    108. Du T, Zamore PD. Beginning to understand microRNA function. Cell Res. 2007 Aug; 17(8):661-3. PMID: 17694094.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    109. Tomari Y, Du T, Zamore PD. Sorting of Drosophila small silencing RNAs. Cell. 2007 Jul 27; 130(2):299-308. PMID: 17662944.
      Citations: 181     Fields:    Translation:AnimalsCells
    110. Förstemann K, Horwich MD, Wee L, Tomari Y, Zamore PD. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell. 2007 Jul 27; 130(2):287-97. PMID: 17662943.
      Citations: 197     Fields:    Translation:AnimalsCells
    111. Horwich MD, Li C, Matranga C, Vagin V, Farley G, Wang P, Zamore PD. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol. 2007 Jul 17; 17(14):1265-72. PMID: 17604629.
      Citations: 255     Fields:    Translation:AnimalsCells
    112. Zamore PD. RNA silencing: genomic defence with a slice of pi. Nature. 2007 Apr 19; 446(7138):864-5. PMID: 17443172.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    113. Zamore PD. RNA interference: big applause for silencing in Stockholm. Cell. 2006 Dec 15; 127(6):1083-6. PMID: 17174883.
      Citations: 18     Fields:    Translation:AnimalsCells
    114. Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2006 Sep 08; 2(9):e140. PMID: 16965178.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    115. Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. A distinct small RNA pathway silences selfish genetic elements in the germline. Science. 2006 Jul 21; 313(5785):320-4. PMID: 16809489.
      Citations: 582     Fields:    Translation:AnimalsCells
    116. Seitz H, Zamore PD. Rethinking the microprocessor. Cell. 2006 Jun 02; 125(5):827-9. PMID: 16751089.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    117. Sigova A, Vagin V, Zamore PD. Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on. Cold Spring Harb Symp Quant Biol. 2006; 71:335-41. PMID: 17381314.
      Citations: 2     Fields:    Translation:AnimalsCells
    118. Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 2005 Nov 18; 123(4):607-20. PMID: 16271386.
      Citations: 462     Fields:    Translation:HumansAnimalsCells
    119. Du T, Zamore PD. microPrimer: the biogenesis and function of microRNA. Development. 2005 Nov; 132(21):4645-52. PMID: 16224044.
      Citations: 310     Fields:    Translation:HumansAnimals
    120. Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005 Sep 02; 309(5740):1519-24. PMID: 16141061.
      Citations: 491     Fields:    Translation:HumansAnimalsCells
    121. Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD. Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 2005 Jul; 3(7):e236. PMID: 15918770.
      Citations: 237     Fields:    Translation:AnimalsCells
    122. Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev. 2005 Mar 01; 19(5):517-29. PMID: 15741316.
      Citations: 319     Fields:    Translation:HumansAnimalsCells
    123. Tomari Y, Zamore PD. MicroRNA biogenesis: drosha can't cut it without a partner. Curr Biol. 2005 Jan 26; 15(2):R61-4. PMID: 15668159.
      Citations: 52     Fields:    Translation:HumansAnimals
    124. Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD. A protein sensor for siRNA asymmetry. Science. 2004 Nov 19; 306(5700):1377-80. PMID: 15550672.
      Citations: 234     Fields:    Translation:AnimalsCells
    125. Sigova A, Rhind N, Zamore PD. A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes Dev. 2004 Oct 01; 18(19):2359-67. PMID: 15371329.
      Citations: 61     Fields:    Translation:AnimalsCells
    126. Mallory AC, Reinhart BJ, Jones-Rhoades MW, Tang G, Zamore PD, Barton MK, Bartel DP. MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J. 2004 Aug 18; 23(16):3356-64. PMID: 15282547.
      Citations: 235     Fields:    Translation:AnimalsCells
    127. Haley B, Zamore PD. Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol. 2004 Jul; 11(7):599-606. PMID: 15170178.
      Citations: 221     Fields:    Translation:AnimalsCells
    128. Schwarz DS, Tomari Y, Zamore PD. The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol. 2004 May 04; 14(9):787-91. PMID: 15120070.
      Citations: 90     Fields:    Translation:AnimalsCells
    129. Tomari Y, Du T, Haley B, Schwarz DS, Bennett R, Cook HA, Koppetsch BS, Theurkauf WE, Zamore PD. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell. 2004 Mar 19; 116(6):831-41. PMID: 15035985.
      Citations: 158     Fields:    Translation:AnimalsCells
    130. Zamore PD. Plant RNAi: How a viral silencing suppressor inactivates siRNA. Curr Biol. 2004 Mar 09; 14(5):R198-200. PMID: 15028237.
      Citations: 19     Fields:    Translation:AnimalsCells
    131. Hutvágner G, Simard MJ, Mello CC, Zamore PD. Sequence-specific inhibition of small RNA function. PLoS Biol. 2004 Apr; 2(4):E98. PMID: 15024405.
      Citations: 252     Fields:    Translation:HumansAnimalsCells
    132. Matranga C, Zamore PD. Plant RNA interference in vitro. Cold Spring Harb Symp Quant Biol. 2004; 69:403-8. PMID: 16117674.
      Citations: 1     Fields:    Translation:AnimalsCells
    133. Tang G, Zamore PD. Biochemical dissection of RNA silencing in plants. Methods Mol Biol. 2004; 257:223-44. PMID: 14770009.
      Citations: 8     Fields:    Translation:AnimalsCells
    134. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003 Oct 17; 115(2):199-208. PMID: 14567917.
      Citations: 1037     Fields:    Translation:AnimalsCells
    135. Haley B, Tang G, Zamore PD. In vitro analysis of RNA interference in Drosophila melanogaster. Methods. 2003 Aug; 30(4):330-6. PMID: 12828947.
      Citations: 55     Fields:    Translation:Animals
    136. Ding H, Schwarz DS, Keene A, Affar el B, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z. Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell. 2003 08; 2(4):209-17. PMID: 12934714.
      Citations: 53     Fields:    Translation:HumansAnimals
    137. Zamore PD, Aronin N. siRNAs knock down hepatitis. Nat Med. 2003 Mar; 9(3):266-7. PMID: 12612573.
      Citations: 6     Fields:    Translation:HumansAnimals
    138. Tang G, Reinhart BJ, Bartel DP, Zamore PD. A biochemical framework for RNA silencing in plants. Genes Dev. 2003 Jan 01; 17(1):49-63. PMID: 12514099.
      Citations: 301     Fields:    Translation:AnimalsCells
    139. Schwarz DS, Hutvágner G, Haley B, Zamore PD. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell. 2002 Sep; 10(3):537-48. PMID: 12408822.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    140. Wang X, McLachlan J, Zamore PD, Hall TM. Modular recognition of RNA by a human pumilio-homology domain. Cell. 2002 Aug 23; 110(4):501-12. PMID: 12202039.
      Citations: 239     Fields:    Translation:HumansCells
    141. Hutvágner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science. 2002 Sep 20; 297(5589):2056-60. PMID: 12154197.
      Citations: 715     Fields:    Translation:HumansAnimalsCells
    142. Zamore PD. Ancient pathways programmed by small RNAs. Science. 2002 May 17; 296(5571):1265-9. PMID: 12016303.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    143. Feldbrügge M, Arizti P, Sullivan ML, Zamore PD, Belasco JG, Green PJ. Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells. Plant Mol Biol. 2002 May; 49(2):215-23. PMID: 11999376.
      Citations: 10     Fields:    Translation:AnimalsCells
    144. Schwarz DS, Zamore PD. Why do miRNAs live in the miRNP? Genes Dev. 2002 May 01; 16(9):1025-31. PMID: 12000786.
      Citations: 25     Fields:    Translation:HumansAnimals
    145. Hutvágner G, Zamore PD. RNAi: nature abhors a double-strand. Curr Opin Genet Dev. 2002 Apr; 12(2):225-32. PMID: 11893497.
      Citations: 142     Fields:    Translation:AnimalsCells
    146. Zamore PD. Thirty-three years later, a glimpse at the ribonuclease III active site. Mol Cell. 2001 Dec; 8(6):1158-60. PMID: 11885596.
      Citations: 8     Fields:    Translation:Cells
    147. Nykänen A, Haley B, Zamore PD. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell. 2001 Nov 02; 107(3):309-21. PMID: 11701122.
      Citations: 280     Fields:    Translation:AnimalsCells
    148. Zamore PD. RNA interference: listening to the sound of silence. Nat Struct Biol. 2001 Sep; 8(9):746-50. PMID: 11524674.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    149. Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001 Aug 03; 293(5531):834-8. PMID: 11452083.
      Citations: 1086     Fields:    Translation:HumansAnimalsCells
    150. Wang X, Zamore PD, Hall TM. Crystal structure of a Pumilio homology domain. Mol Cell. 2001 Apr; 7(4):855-65. PMID: 11336708.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    151. Sharp PA, Zamore PD. Molecular biology. RNA interference. Science. 2000 Mar 31; 287(5462):2431-3. PMID: 10766620.
      Citations: 27     Fields:    Translation:AnimalsCells
    152. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000 Mar 31; 101(1):25-33. PMID: 10778853.
      Citations: 761     Fields:    Translation:AnimalsCells
    153. Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev. 1999 Dec 15; 13(24):3191-7. PMID: 10617568.
      Citations: 218     Fields:    Translation:AnimalsCells
    154. Zamore PD, Bartel DP, Lehmann R, Williamson JR. The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence. Biochemistry. 1999 Jan 12; 38(2):596-604. PMID: 9888799.
      Citations: 44     Fields:    Translation:AnimalsCells
    155. Zamore PD, Williamson JR, Lehmann R. The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins. RNA. 1997 Dec; 3(12):1421-33. PMID: 9404893.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    156. Curtis D, Treiber DK, Tao F, Zamore PD, Williamson JR, Lehmann R. A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J. 1997 Feb 17; 16(4):834-43. PMID: 9049312.
      Citations: 46     Fields:    Translation:AnimalsCells
    157. Zamore PD, Lehmann R. Drosophila development: homeodomains and translational control. Curr Biol. 1996 Jul 01; 6(7):773-5. PMID: 8805294.
      Citations: 2     Fields:    Translation:AnimalsCells
    158. Curtis D, Lehmann R, Zamore PD. Translational regulation in development. Cell. 1995 Apr 21; 81(2):171-8. PMID: 7736569.
      Citations: 109     Fields:    Translation:AnimalsCells
    159. Lee CG, Zamore PD, Green MR, Hurwitz J. RNA annealing activity is intrinsically associated with U2AF. J Biol Chem. 1993 Jun 25; 268(18):13472-8. PMID: 7685763.
      Citations: 26     Fields:    Translation:HumansCells
    160. Valcárcel J, Singh R, Zamore PD, Green MR. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature. 1993 Mar 11; 362(6416):171-5. PMID: 7680770.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    161. Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR. Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8769-73. PMID: 1388271.
      Citations: 90     Fields:    Translation:HumansCells
    162. Zamore PD, Patton JG, Green MR. Cloning and domain structure of the mammalian splicing factor U2AF. Nature. 1992 Feb 13; 355(6361):609-14. PMID: 1538748.
      Citations: 262     Fields:    Translation:HumansAnimalsCells
    163. Carmo-Fonseca M, Tollervey D, Pepperkok R, Barabino SM, Merdes A, Brunner C, Zamore PD, Green MR, Hurt E, Lamond AI. Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J. 1991 Jan; 10(1):195-206. PMID: 1824936.
      Citations: 102     Fields:    Translation:HumansCells
    164. Zamore PD, Green MR. Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. EMBO J. 1991 Jan; 10(1):207-14. PMID: 1824937.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    165. Zamore PD, Zapp ML, Green MR. Gene expression. RNA binding: beta s and basics. Nature. 1990 Dec 06; 348(6301):485-6. PMID: 1701031.
      Citations: 10     Fields:    Translation:Cells
    166. Zamore PD, Green MR. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9243-7. PMID: 2531895.
      Citations: 193     Fields:    Translation:HumansCells
    167. Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 1988 Feb 23; 27(4):1158-67. PMID: 3365378.
      Citations: 70     Fields:    Translation:AnimalsCells
    168. Ruskin B, Zamore PD, Green MR. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell. 1988 Jan 29; 52(2):207-19. PMID: 2963698.
      Citations: 239     Fields:    Translation:HumansCells
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