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Jeffrey Alan Nickerson

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentPediatrics
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-2312
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    Michigan State University, East Lansing, MI, United StatesBSPsychology & Biochemistry
    Michigan State University, East Lansing, MI, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse overview

    Cell and Developmental Biology

    Academic Background

    Ph.D., 1985, Michigan State University

    Nuclear Architecture and Gene Expression

    Nucleic acid metabolism is architecturally organized in the eukaryotic nucleus. Nucleic acids themselves- as well as their metabolism in transcription, RNA processing, and RNA export- are structurally constrained to dynamic nuclear domains. Our larger goal is to understand the mechanisms that accomplish the self-assembly of these domains and achieve the spatial organization of gene expression. Our approach is an interdisciplinary one, combining biochemistry and molecular biology with confocal and electron microscopy.

    One ongoing project studies the regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.  Two complexes forming on an mRNA may play a role in its export to the cytoplasm.   The export proteins UAP56, ALY/REF, and NXF1-p15 sequentially bind to a TRanscription/EXport (TREX) complex, located at the 5’ end NXF1 recruited to the complex may subsequently bind at nuclear pores for export of the mRNA to the cytoplasm.   A second complex, the Exon Junction Complex (EJC), with a core of eIF4A3, MLN51, MAGOH, and Y14, forms on the mRNA at sites 24 nucleotides upstream from exon-exon junctions.  We used fluorescence recovery after photobleaching (FRAP) as a live cell screen to find signal transduction pathways that alter the binding of these proteins in mRNA complexes.  Our results show that PI3 kinase/ AKT regulate the binding affinity of UAP56, NXF1, eIF4A3, MAGOH, and Y14 in mRNA-associated complexes in live cells.   In addition, MAGOH binding is strongly reduced by the inhibition of mTORC1.   The active PI3 Kinase/AKT pathway causes increased nuclear retention of a subset of mRNAs in the nucleus, consistent with this signal transduction pathway regulating the export of mRNA.

    A second ongoing project, conducted as a long-term collaboration with the laboratory of Tony Imbalzano, also in this department, studies the role of chromatin remodeling in breast cancer.  This project has shown that the SWI/SNF chromatin remodeling enzymes BRG1 and BRM are required for the proliferation of human mammary epithelial cells in conventional tissue culture and in three dimensional reconstituted basement membrane cultures where these cells develop into tissue-like acini.  In addition, reduction in BRG1 levels causes nuclear shape changes that are independent of nuclear-cytoskeletal connections and are mediated by internal nuclear forces.

    We have presented evidence that nuclear RNA and the ongoing synthesis of RNA are required for maintaining the normal architecture of the nucleus and have proposed that long non-coding RNAs play this structural role.  A goal for future work is to test this hypothesis and identify specific architectural RNAs in the nucleus.

    Director for Cell Biology Confocal Core - Three Dimensional Microscopy - www.umassmed.edu/3dml


    Figure

    Figure

    Figure: Resinless section of a CaSki cell nuclear matrix. Solubleproteins and chromatin have been removed from this nucleus, uncovering thenuclear matrix which consists of two parts. The nuclear lamina isthe outer shell of the matrix which lies just under the nuclear envelopeand is primarily composed to the lamin proteins A, B, and C. Connected tothe lamina and extending throughout the nuclear volume is the internalnuclear matrix, an intricate structure built on a scaffolding of 10nm filaments whose molecular composition remains unknown. The largest massesremaining in the interior are remnants of nucleoli.


    Collapse Rotation Projects

    Potential Rotation Projects

         Identify the AKT phosphorylation sites on mRNA export proteins.  Determine the effect that point mutation of those sites has on mRNA export complex assembly and on the export of specific mRNAs.

         Investigate the role of chromatin remodeling in driving the important metabolic changes occurring during breast tumorigenesis.


    Collapse Post Docs

    POSTDOCTORAL POSITION

    A Postdoctoral Position is available immediately in the Department of Cell and Developmental Biology to study the regulation of RNA processing and export by signal transduction pathways. So far in this project we have found that the assembly of mRNA export complexes in live cells is regulated by the PI3 kinase/AKT signal transduction pathway and that, for a subset of mRNAs, nuclear export is AKT regulated. The experimental approach for this project integrates molecular techniques and microscopy, especially live cell microscopy. The postdoc in this position could also be involved in studies of the role of nuclear architecture in regulating gene expression and in studying the role of chromatin remodeling enzymes in breast cancer.  Candidates with a strong background in cell biology, biochemistry, or molecular biology are especially desirable.

    Quaresma, A.J., Sievert, R. & Nickerson, J.A. Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. Mol Biol Cell 24, 1208-1221 (2013).

    The University of Massachusetts Medical School is located in Worcester, at the western edge of the Boston Metropolitan Area. The Department of Cell and Developmental Biology has especially strong research programs in nuclear and chromatin structure, cytoskeletal function, and mitotic architecture.


    Interested candidates should contact:

    Jeffrey A. Nickerson, Ph.D.
    Department of Cell and Developmental Biology S7-214
    University of Massachusetts Medical School
    55 Lake Avenue North
    Worcester, MA 01655
    (508) 856-2312
    jeffrey.nickerson@umassmed.edu



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin YC, Kumar MS, Ramesh N, Anderson EN, Nguyen AT, Kim B, Cheung S, McDonough JA, Skarnes WC, Lopez-Gonzalez R, Landers JE, Fawzi NL, Mackenzie IRA, Lee EB, Nickerson JA, Grunwald D, Pandey UB, Bosco DA. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nat Neurosci. 2021 08; 24(8):1077-1088. PMID: 34059832.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    2. Muthuswami R, Bailey L, Rakesh R, Imbalzano AN, Nickerson JA, Hockensmith JW. BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer. J Cell Physiol. 2019 Jan 22. PMID: 30667054.
      Citations: 14     Fields:    
    3. Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1-dependent mechanisms in biological control and dysregulation in cancer. J Cell Physiol. 2019 06; 234(6):8597-8609. PMID: 30515788.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    4. Zaidi SK, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes. Mol Cancer Res. 2018 11; 16(11):1617-1624. PMID: 30002192.
      Citations: 5     Fields:    Translation:Humans
    5. Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity. J Cell Physiol. 2018 12; 233(12):9136-9144. PMID: 29968906.
      Citations: 34     Fields:    Translation:HumansCells
    6. Zaidi SK, Fritz AJ, Tracy KM, Gordon JA, Tye CE, Boyd J, Van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Nuclear organization mediates cancer-compromised genetic and epigenetic control. Adv Biol Regul. 2018 08; 69:1-10. PMID: 29759441.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Padilla-Benavides T, Nasipak BT, Paskavitz AL, Haokip DT, Schnabl JM, Nickerson JA, Imbalzano AN. Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition. J Biol Chem. 2017 11 10; 292(45):18592-18607. PMID: 28939766.
      Citations: 14     Fields:    Translation:AnimalsCells
    8. Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN. The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017 06; 9(6):919-931. PMID: 28521512.
      Citations: 48     Fields:    Translation:HumansAnimals
    9. Nickerson JA, Wu Q, Imbalzano AN. Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming. Front Oncol. 2017; 7:49. PMID: 28421159.
      Citations:    
    10. Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS. Identifying Nuclear Matrix-Attached DNA Across the Genome. J Cell Physiol. 2017 Jun; 232(6):1295-1305. PMID: 27627025.
      Citations: 10     Fields:    Translation:HumansCells
    11. Underwood JM, Becker KA, Stein GS, Nickerson JA. The Ultrastructural Signature of Human Embryonic Stem Cells. J Cell Biochem. 2017 04; 118(4):764-774. PMID: 27632380.
      Citations: 7     Fields:    Translation:HumansCells
    12. Alam SG, Zhang Q, Prasad N, Li Y, Chamala S, Kuchibhotla R, Kc B, Aggarwal V, Shrestha S, Jones AL, Levy SE, Roux KJ, Nickerson JA, Lele TP. The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep. 2016 12 01; 6:38063. PMID: 27905489.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    13. Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN. SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells. Genome Res. 2016 09; 26(9):1188-201. PMID: 27435934.
      Citations: 45     Fields:    Translation:HumansCells
    14. Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA. The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation. Oncotarget. 2016 Jun 21; 7(25):38270-38281. PMID: 27223259.
      Citations: 28     Fields:    Translation:HumansCells
    15. Wu Q, Sharma S, Cui H, LeBlanc SE, Zhang H, Muthuswami R, Nickerson JA, Imbalzano AN. Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells. Oncotarget. 2016 May 10; 7(19):27158-75. PMID: 27029062.
      Citations: 25     Fields:    Translation:HumansCells
    16. Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. J Med Chem. 2016 05 26; 59(10):4800-11. PMID: 27115555.
      Citations: 23     Fields:    Translation:HumansCells
    17. Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS. C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization. J Cell Physiol. 2016 Jan; 231(1):31-5. PMID: 26059817.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    18. Zhang Q, Kota KP, Alam SG, Nickerson JA, Dickinson RB, Lele TP. Coordinated Dynamics of RNA Splicing Speckles in the Nucleus. J Cell Physiol. 2016 Jun; 231(6):1269-75. PMID: 26496460.
      Citations: 9     Fields:    Translation:HumansCells
    19. Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN. The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. J Cell Physiol. 2015 Nov; 230(11):2683-94. PMID: 25808524.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    20. Szafran AT, Mancini MG, Nickerson JA, Edwards DP, Mancini MA. Use of HCA in subproteome-immunization and screening of hybridoma supernatants to define distinct antibody binding patterns. Methods. 2016 Mar 01; 96:75-84. PMID: 26521976.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. Tran H, Almeida S, Moore J, Gendron TF, Chalasani U, Lu Y, Du X, Nickerson JA, Petrucelli L, Weng Z, Gao FB. Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS. Neuron. 2015 Sep 23; 87(6):1207-1214. PMID: 26402604.
      Citations: 106     Fields:    Translation:HumansAnimals
    22. Neelam S, Chancellor TJ, Li Y, Nickerson JA, Roux KJ, Dickinson RB, Lele TP. Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell. Proc Natl Acad Sci U S A. 2015 May 05; 112(18):5720-5. PMID: 25901323.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    23. Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. J Cell Sci. 2015 Feb 15; 128(4):728-40. PMID: 25609707.
      Citations: 11     Fields:    Translation:HumansCells
    24. Baron DM, Kaushansky LJ, Ward CL, Sama RR, Chian RJ, Boggio KJ, Quaresma AJ, Nickerson JA, Bosco DA. Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics. Mol Neurodegener. 2013 Aug 31; 8:30. PMID: 24090136.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    25. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBP?-dependent induction of ?5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. PMID: 23770848.
      Citations: 9     Fields:    Translation:HumansCells
    26. Imbalzano AN, Imbalzano KM, Nickerson JA. BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity. Commun Integr Biol. 2013 Sep 01; 6(5):e25153. PMID: 24228137.
      Citations:    
    27. Lovett DB, Shekhar N, Nickerson JA, Roux KJ, Lele TP. Modulation of Nuclear Shape by Substrate Rigidity. Cell Mol Bioeng. 2013 Jun 01; 6(2):230-238. PMID: 23914256.
      Citations:    
    28. Quaresma AJ, Sievert R, Nickerson JA. Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. Mol Biol Cell. 2013 Apr; 24(8):1208-21. PMID: 23427269.
      Citations: 7     Fields:    Translation:HumansCells
    29. Imbalzano KM, Cohet N, Wu Q, Underwood JM, Imbalzano AN, Nickerson JA. Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. PLoS One. 2013; 8(2):e55628. PMID: 23405182.
      Citations: 30     Fields:    Translation:HumansCells
    30. Tortelote GG, Hernández-Hernández JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Pérez JA. Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 01; 374(1):164-73. PMID: 23085236.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    31. Morello LG, Coltri PP, Quaresma AJ, Simabuco FM, Silva TC, Singh G, Nickerson JA, Oliveira CC, Moore MJ, Zanchin NI. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. PLoS One. 2011; 6(12):e29174. PMID: 22195017.
      Citations: 13     Fields:    Translation:HumansCells
    32. Pockwinse SM, Kota KP, Quaresma AJ, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Nickerson JA. Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression. J Cell Physiol. 2011 May; 226(5):1383-9. PMID: 20945391.
      Citations: 11     Fields:    Translation:HumansCells
    33. Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA, Montecino MA, Young DW. An architectural genetic and epigenetic perspective. Integr Biol (Camb). 2011 Apr; 3(4):297-303. PMID: 21184003.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    34. Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7. PMID: 20333644.
      Citations: 21     Fields:    Translation:HumansCells
    35. Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010 Jun; 223(3):667-78. PMID: 20333683.
      Citations: 21     Fields:    Translation:HumansCells
    36. Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 2010; 647:77-93. PMID: 20694661.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL. Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments. Crit Rev Eukaryot Gene Expr. 2010; 20(2):149-55. PMID: 21133844.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    38. Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN, Nickerson JA, Lian JB, Stein GS. Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. Cancer Res. 2009 Sep 01; 69(17):6807-14. PMID: 19690135.
      Citations: 51     Fields:    Translation:HumansCells
    39. Imbalzano KM, Tatarkova I, Imbalzano AN, Nickerson JA. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int. 2009 Mar 16; 9:7. PMID: 19291318.
      Citations:    
    40. Nickerson JA. The biochemistry of RNA metabolism studied in situ. RNA Biol. 2009 Jan-Mar; 6(1):25-30. PMID: 19098457.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    41. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA. Binding of ATP to UAP56 is necessary for mRNA export. J Cell Sci. 2008 May 01; 121(Pt 9):1526-37. PMID: 18411249.
      Citations: 34     Fields:    Translation:HumansCells
    42. Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007 Jan 25; 445(7126):442-6. PMID: 17251981.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    43. Lele T, Wagner SR, Nickerson JA, Ingber DE. Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions. J Cell Biochem. 2006 Dec 01; 99(5):1334-42. PMID: 16795044.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    44. Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006 Jul; 208(1):141-8. PMID: 16607610.
      Citations: 42     Fields:    Translation:HumansCells
    45. Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Doxsey SJ. Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol. 2006 Feb; 206(2):354-62. PMID: 16110492.
      Citations: 32     Fields:    Translation:HumansCells
    46. Vradii D, Wagner S, Doan DN, Nickerson JA, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Imbalzano AN, Stein GS. Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes. J Cell Physiol. 2006 Jan; 206(1):112-8. PMID: 15965950.
      Citations: 22     Fields:    Translation:AnimalsCells
    47. Liu F, Wagner S, Campbell RB, Nickerson JA, Schiffer CA, Ross AH. PTEN enters the nucleus by diffusion. J Cell Biochem. 2005 Oct 01; 96(2):221-34. PMID: 16088943.
      Citations: 49     Fields:    Translation:HumansCells
    48. McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. J Biol Chem. 2005 Dec 23; 280(51):42227-36. PMID: 16159877.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    49. Hill DA, Chiosea S, Jamaluddin S, Roy K, Fischer AH, Boyd DD, Nickerson JA, Imbalzano AN. Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. J Cell Sci. 2004 Nov 15; 117(Pt 24):5847-54. PMID: 15537831.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    50. Lele T, Oh P, Nickerson JA, Ingber DE. An improved mathematical approach for determination of molecular kinetics in living cells with FRAP. Mech Chem Biosyst. 2004 Sep; 1(3):181-90. PMID: 16783931.
      Citations: 10     Fields:    Translation:Cells
    51. Zink D, Fischer AH, Nickerson JA. Nuclear structure in cancer cells. Nat Rev Cancer. 2004 Sep; 4(9):677-87. PMID: 15343274.
      Citations: 364     Fields:    Translation:HumansCells
    52. Wagner S, Chiosea S, Ivshina M, Nickerson JA. In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. J Cell Biol. 2004 Mar 15; 164(6):843-50. PMID: 15024032.
      Citations: 15     Fields:    Translation:HumansCells
    53. Wagner S, Chiosea S, Nickerson JA. The spatial targeting and nuclear matrix binding domains of SRm160. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3269-74. PMID: 12624182.
      Citations: 31     Fields:    Translation:HumansCells
    54. Barseguian K, Lutterbach B, Hiebert SW, Nickerson J, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15434-9. PMID: 12427969.
      Citations: 24     Fields:    Translation:HumansCells
    55. Herbert A, Wagner S, Nickerson JA. Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing. Mol Cell. 2002 Nov; 10(5):1235-46. PMID: 12453429.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    56. Nickerson J. Experimental observations of a nuclear matrix. J Cell Sci. 2001 Feb; 114(Pt 3):463-74. PMID: 11171316.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
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