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Robert T Woodland PhD

TitleProfessor Emeritus
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-2465
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    Villanova University, Villanova, PA, United StatesBSBiology
    Ohio State University Columbus, Columbus, OH, United StatesMSMicrobiology
    University of Pennsylvania, Philadelphia, PA, United StatesPHDMicrobiology

    Collapse Overview 
    Collapse overview

    Academic Background

    Ph. D. (1974) University of Pennsylvania

    Regulation of B Cell Survival Control of Virus Expression by Lymphocyte Activators

    Photo: Robert 
T. Woodland Our laboratory is determining the soluble and cell associated ligands that maintain virgin B lymphocytes in the long-lived lumphocyte pool. In particular, we are interested in the transcriptional and post translational regulation of pro-apoptotic and anti-apoptotic proteins that control B cell homeostasis and B cell survival during stress. For these experiments we are comparing B cells from normal mice to those from mice with an X-chromosome linked immunodeficiency, as this mutation significantly reduces peripheral B cell survival. Other studies in the laboratory focus on the mechanism by which a virus infection is controlled in lymphocytes by lymphocyte activators. We have shown that virus transcription, protein translation, assembly and release of infectious particles are all processes regulated by lymphocyte activators acting on resting infected cells. We are using these observations to develope new modalities to control both acute and chronic virus infections.


    Collapse Rotation Projects

    Rotation Projects

    1. Aged mice have severely diminished numbers of naïve B cells and mount poor responses to "new antigens" despite the fact that B cell lymphogenesis continues for the life of the animal. We hypothesize this may be due to dysregulation of HP. We would like to determine if HP of immature B cells is impaired and/or if inhibition of HP by peripheral B cells is more active in aged mice. These studies require lymphocyte transfers between young and aged mice and the analysis of developmentally regulated antigens by flow cytometry.


    2. To attempt to suppress innate immune responses by using adenovirus to transfer genes encoding dominant-negative regulators of critical signal pathways. These studies will use cells from hCAR mice as targets and in vitro assays for proliferation and cytokine secretion to determine the effect of gene transfers.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nündel K, Mande P, Moses SL, Busto P, Cullen JL, Schmidt MR, Shlomchik MJ, Woodland RT, Marshak-Rothstein A. Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V?8 B Cells. J Immunol. 2019 Sep 18. PMID: 31534009.
      Citations:    Fields:    
    2. McGinnes Cullen L, Schmidt MR, Kenward SA, Woodland RT, Morrison TG. Murine immune responses to virus-like particle-associated pre- and postfusion forms of the respiratory syncytial virus F protein. J Virol. 2015 Jul; 89(13):6835-47. PMID: 25903340.
      Citations: 26     Fields:    Translation:AnimalsCells
    3. Schmidt MR, McGinnes-Cullen LW, Kenward SA, Willems KN, Woodland RT, Morrison TG. Modification of the respiratory syncytial virus f protein in virus-like particles impacts generation of B cell memory. J Virol. 2014 Sep 01; 88(17):10165-76. PMID: 24965456.
      Citations: 12     Fields:    Translation:AnimalsCells
    4. Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells. J Immunol. 2014 Jul 15; 193(2):931-9. PMID: 24935922.
      Citations: 7     Fields:    Translation:AnimalsCells
    5. Schmidt MR, McGinnes LW, Kenward SA, Willems KN, Woodland RT, Morrison TG. Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains. J Virol. 2012 Nov; 86(21):11654-62. PMID: 22896618.
      Citations: 19     Fields:    Translation:AnimalsCells
    6. Castro I, Wright JA, Damdinsuren B, Hoek KL, Carlesso G, Shinners NP, Gerstein RM, Woodland RT, Sen R, Khan WN. B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J Immunol. 2009 Jun 15; 182(12):7729-37. PMID: 19494297.
      Citations: 27     Fields:    Translation:AnimalsCells
    7. Schmidt MR, Appel MC, Giassi LJ, Greiner DL, Shultz LD, Woodland RT. Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One. 2008 Sep 11; 3(9):e3192. PMID: 18784835.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    8. Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood). 2008 Aug; 233(8):997-1012. PMID: 18653783.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    9. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol. 2008 Mar; 126(3):303-14. PMID: 18096436.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    10. Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 2008 Jan 15; 111(2):750-60. PMID: 17942753.
      Citations: 88     Fields:    Translation:AnimalsCells
    11. Shinners NP, Carlesso G, Castro I, Hoek KL, Corn RA, Woodland RT, Woodland RL, Scott ML, Wang D, Khan WN. Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family. J Immunol. 2007 Sep 15; 179(6):3872-80. PMID: 17785824.
      Citations: 56     Fields:    Translation:AnimalsCells
    12. Woodland RT, Schmidt MR, Thompson CB. BLyS and B cell homeostasis. Semin Immunol. 2006 Oct; 18(5):318-26. PMID: 16931037.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    13. Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8. PMID: 16103411.
      Citations: 91     Fields:    Translation:AnimalsCells
    14. Woodland RT, Schmidt MR. Homeostatic proliferation of B cells. Semin Immunol. 2005 Jun; 17(3):209-17. PMID: 15826826.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004 Sep; 21(3):379-90. PMID: 15357949.
      Citations: 193     Fields:    Translation:AnimalsCells
    16. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 01; 170(7):3819-27. PMID: 12646649.
      Citations: 102     Fields:    Translation:AnimalsCells
    17. Cabatingan MS, Schmidt MR, Sen R, Woodland RT. Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit. J Immunol. 2002 Dec 15; 169(12):6795-805. PMID: 12471111.
      Citations: 28     Fields:    Translation:AnimalsCells
    18. Tumang JR, Negm RS, Solt LA, Schneider TJ, Colarusso TP, Hastings WD, Woodland RT, Rothstein TL. BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase. J Immunol. 2002 Mar 15; 168(6):2712-9. PMID: 11884437.
      Citations: 3     Fields:    Translation:AnimalsCells
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