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Anthony N Imbalzano PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-813
Worcester MA 01605
Phone508-856-1029
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    University of Pennsylvania, Philadelphia, PA, United StatesBABiology
    Harvard University, Cambridge, MA, United StatesPHDMicrobiology & Molecular Genet

    Collapse Overview 
    Collapse overview

    Academic Background


    B.A. (cum laude), University of Pennsylvania, 1986
    Ph.D., Harvard University, 1991
    Post-doctoral Fellow, Massachusetts General Hospital, 1991-1996
    Assistant Professor, Cell Biology, UMass Medical School, 1997-2002
    Scholar of the Leukemia and Lymphoma Society, 1999-2004
    Associate Professor, Cell Biology, UMass Medical School, 2002 - 2008
    Professor, Cell Biology, UMass Medical School, 2008-2016
    Professor, Biochemistry & Mol. Pharmacology, UMass Medical School, 2017-

    Research

    Mammalian SWI/SNF Chromatin Remodeling Enzymes Promote Cell Differentiation
    http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-promote-cell-differentiation/

    Mammalian SWI/SNF Chromatin Remodeling Enzymes as Drivers of Cancer
    http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-as-drivers-of-cancer/


    Laboratory Personnel

    Current Personnel
    http://www.umassmed.edu/imbalzanolab/lab-members/current-lab-members/

    Previous Trainees
    http://www.umassmed.edu/imbalzanolab/lab-members/alumni/



    Collapse Rotation Projects
    Please contact Dr. Imbalzano to discuss the possibility of a rotation project.

    Rotation projects are generally based on current work and tailored to the interests of the student.  See lab research interests and publications for recent topics.

    http://www.umassmed.edu/imbalzanolab/
    http://www.umassmed.edu/imbalzanolab/publications/


    Collapse Post Docs
    Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS. RUNX1-dependent mechanisms in biological control and dysregulation in cancer. J Cell Physiol. 2018 Dec 04. PMID: 30515788.
      View in: PubMed
    2. Zaidi SK, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes. Mol Cancer Res. 2018 Nov; 16(11):1617-1624. PMID: 30002192.
      View in: PubMed
    3. Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity. J Cell Physiol. 2018 Jul 03. PMID: 29968906.
      View in: PubMed
    4. Zaidi SK, Frietze SE, Gordon JA, Heath JL, Messier T, Hong D, Boyd JR, Kang M, Imbalzano AN, Lian JB, Stein JL, Stein GS. Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer. Mol Cell Biol. 2017 Dec 01; 37(23). PMID: 28923849.
      View in: PubMed
    5. Harada A, Ohkawa Y, Imbalzano AN. Temporal regulation of chromatin during myoblast differentiation. Semin Cell Dev Biol. 2017 Dec; 72:77-86. PMID: 29079444.
      View in: PubMed
    6. Padilla-Benavides T, Nasipak BT, Paskavitz AL, Haokip DT, Schnabl JM, Nickerson JA, Imbalzano AN. Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition. J Biol Chem. 2017 11 10; 292(45):18592-18607. PMID: 28939766.
      View in: PubMed
    7. Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN. The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017 May 19. PMID: 28521512.
      View in: PubMed
    8. Fritz AJ, Ghule PN, Boyd JR, Tye CE, Page NA, Hong D, Weinheimer AS, Barutcu AR, Gerrard DL, Frietze S, Zaidi SK, Imbalzano A, Lian JB, Stein JL, Stein GS. Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer. J Cell Physiol. 2017 May 15. PMID: 28504305.
      View in: PubMed
    9. Nickerson JA, Wu Q, Imbalzano AN. Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming. Front Oncol. 2017; 7:49. PMID: 28421159.
      View in: PubMed
    10. Barutcu AR, Lian JB, Stein JL, Stein GS, Imbalzano AN. The connection between BRG1, CTCF and topoisomerases at TAD boundaries. Nucleus. 2017 Jan 06; 1-6. PMID: 28060558.
      View in: PubMed
    11. Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS. Identifying Nuclear Matrix-Attached DNA Across the Genome. J Cell Physiol. 2016 Sep 14. PMID: 27627025.
      View in: PubMed
    12. Barutcu AR, Hong D, Lajoie BR, McCord RP, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells. Biochim Biophys Acta. 2016 Nov; 1859(11):1389-1397. PMID: 27514584.
      View in: PubMed
    13. Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN. SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells. Genome Res. 2016 Sep; 26(9):1188-201. PMID: 27435934.
      View in: PubMed
    14. Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA. The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation. Oncotarget. 2016 Jun 21; 7(25):38270-38281. PMID: 27223259.
      View in: PubMed
    15. Wu Q, Sharma S, Cui H, LeBlanc SE, Zhang H, Muthuswami R, Nickerson JA, Imbalzano AN. Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells. Oncotarget. 2016 May 10; 7(19):27158-75. PMID: 27029062.
      View in: PubMed
    16. Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. J Med Chem. 2016 May 26; 59(10):4800-11. PMID: 27115555.
      View in: PubMed
    17. Hu YJ, Imbalzano AN. Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts. Sci Data. 2016 Apr 12; 3:160022. PMID: 27071056.
      View in: PubMed
    18. LeBlanc SE, Wu Q, Lamba P, Sif S, Imbalzano AN. Promoter-enhancer looping at the PPAR?2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res. 2016 Jun 20; 44(11):5133-47. PMID: 26935580.
      View in: PubMed
    19. Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS. Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. J Cell Biochem. 2016 Jan; 117(1):9-19. PMID: 26192137.
      View in: PubMed
    20. Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS. C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization. J Cell Physiol. 2016 Jan; 231(1):31-5. PMID: 26059817.
      View in: PubMed
    21. Padilla-Benavides T, Nasipak BT, Imbalzano AN. Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts. J Cell Physiol. 2015 Dec; 230(12):2990-7. PMID: 26036967.
      View in: PubMed
    22. Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN. The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation. J Cell Physiol. 2015 Nov; 230(11):2683-94. PMID: 25808524.
      View in: PubMed
    23. Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS. Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells. Genome Biol. 2015 Sep 28; 16:214. PMID: 26415882.
      View in: PubMed
    24. Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN. Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Res. 2015 Sep 18; 43(16):7790-804. PMID: 26117538.
      View in: PubMed
    25. Nasipak BT, Padilla-Benavides T, Green KM, Leszyk JD, Mao W, Konda S, Sif S, Shaffer SA, Ohkawa Y, Imbalzano AN. Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme. Nat Commun. 2015 Jun 17; 6:7441. PMID: 26081415.
      View in: PubMed
    26. Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN. Spatial re-organization of myogenic regulatory sequences temporally controls gene expression. Nucleic Acids Res. 2015 Feb 27; 43(4):2008-21. PMID: 25653159.
      View in: PubMed
    27. Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. J Cell Sci. 2015 Feb 15; 128(4):728-40. PMID: 25609707.
      View in: PubMed
    28. Cho OH, Mallappa C, Hernández-Hernández JM, Rivera-Pérez JA, Imbalzano AN. Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015 Jan; 244(1):43-55. PMID: 25329411.
      View in: PubMed
    29. Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter. Nucleic Acids Res. 2014; 42(16):10360-72. PMID: 25120271.
      View in: PubMed
    30. LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN. The PPAR? locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner. PLoS One. 2014; 9(1):e86140. PMID: 24465921.
      View in: PubMed
    31. Hu YJ, Sif S, Imbalzano AN. Prmt7 is dispensable in tissue culture models for adipogenic differentiation. F1000Res. 2013; 2:279. PMID: 24715966.
      View in: PubMed
    32. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 8; 33(19):2441-53. PMID: 23770848.
      View in: PubMed
    33. Imbalzano AN, Imbalzano KM, Nickerson JA. BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity. Commun Integr Biol. 2013 Sep 1; 6(5):e25153. PMID: 24228137.
      View in: PubMed
    34. Hernández-Hernández JM, Mallappa C, Nasipak BT, Oesterreich S, Imbalzano AN. The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state. Nucleic Acids Res. 2013 Jun; 41(11):5704-16. PMID: 23609547.
      View in: PubMed
    35. Imbalzano KM, Cohet N, Wu Q, Underwood JM, Imbalzano AN, Nickerson JA. Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. PLoS One. 2013; 8(2):e55628. PMID: 23405182.
      View in: PubMed
    36. Tortelote GG, Hernández-Hernández JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Pérez JA. Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 1; 374(1):164-73. PMID: 23085236.
      View in: PubMed
    37. Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase d catalytic subunit gene, POLD1. J Biol Chem. 2012 Aug 24; 287(35):29801-14. PMID: 22761421.
      View in: PubMed
    38. Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y. Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J. 2012 Jun 29; 31(13):2994-3007. PMID: 22569126.
      View in: PubMed
    39. LeBlanc SE, Konda S, Wu Q, Hu YJ, Oslowski CM, Sif S, Imbalzano AN. Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor ?2 (PPAR?2) and its target genes during adipogenesis. Mol Endocrinol. 2012 Apr; 26(4):583-97. PMID: 22361822.
      View in: PubMed
    40. Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN. An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number. Methods Mol Biol. 2012; 798:531-42. PMID: 22130859.
      View in: PubMed
    41. Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN. Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays. Methods Mol Biol. 2012; 798:517-30. PMID: 22130858.
      View in: PubMed
    42. Karkhanis V, Hu YJ, Baiocchi RA, Imbalzano AN, Sif S. Versatility of PRMT5-induced methylation in growth control and development. Trends Biochem Sci. 2011 Dec; 36(12):633-41. PMID: 21975038.
      View in: PubMed
    43. Mudhasani R, Puri V, Hoover K, Czech MP, Imbalzano AN, Jones SN. Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol. 2011 May; 226(5):1399-406. PMID: 20945399.
      View in: PubMed
    44. Pockwinse SM, Kota KP, Quaresma AJ, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Nickerson JA. Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression. J Cell Physiol. 2011 May; 226(5):1383-9. PMID: 20945391.
      View in: PubMed
    45. Cho OH, Rivera-Pérez JA, Imbalzano AN. Chromatin immunoprecipitation assay for tissue-specific genes using early-stage mouse embryos. J Vis Exp. 2011 Apr 29; (50). PMID: 21559006.
      View in: PubMed
    46. Xiao H, Leblanc SE, Wu Q, Konda S, Salma N, Marfella CG, Ohkawa Y, Imbalzano AN. Chromatin accessibility and transcription factor binding at the PPAR?2 promoter during adipogenesis is protein kinase A-dependent. J Cell Physiol. 2011 Jan; 226(1):86-93. PMID: 20625991.
      View in: PubMed
    47. Bakshi R, Hassan MQ, Pratap J, Lian JB, Montecino MA, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010 Nov; 225(2):569-76. PMID: 20506188.
      View in: PubMed
    48. Mallappa C, Hu YJ, Shamulailatpam P, Tae S, Sif S, Imbalzano AN. The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4. Nucleic Acids Res. 2011 Mar; 39(4):1243-55. PMID: 20947566.
      View in: PubMed
    49. Mudhasani R, Imbalzano AN, Jones SN. An essential role for Dicer in adipocyte differentiation. J Cell Biochem. 2010 Jul 1; 110(4):812-6. PMID: 20564208.
      View in: PubMed
    50. Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010 Jun; 223(3):667-78. PMID: 20333683.
      View in: PubMed
    51. Mallappa C, Nasipak BT, Etheridge L, Androphy EJ, Jones SN, Sagerström CG, Ohkawa Y, Imbalzano AN. Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Mol Cell Biol. 2010 Jul; 30(13):3176-86. PMID: 20421421.
      View in: PubMed
    52. Stein GS, van Wijnen AJ, Imbalzano AN, Montecino M, Zaidi SK, Lian JB, Nickerson JA, Stein JL. Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments. Crit Rev Eukaryot Gene Expr. 2010; 20(2):149-55. PMID: 21133844.
      View in: PubMed
    53. Pratap J, Imbalzano KM, Underwood JM, Cohet N, Gokul K, Akech J, van Wijnen AJ, Stein JL, Imbalzano AN, Nickerson JA, Lian JB, Stein GS. Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. Cancer Res. 2009 Sep 1; 69(17):6807-14. PMID: 19690135.
      View in: PubMed
    54. Cruzat F, Henriquez B, Villagra A, Hepp M, Lian JB, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS, Montecino M. SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2. Biochemistry. 2009 Aug 4; 48(30):7287-95. PMID: 19545172.
      View in: PubMed
    55. Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ. The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene. 2009 Jul 9; 28(27):2492-501. PMID: 19448667.
      View in: PubMed
    56. Zhou J, Zhang M, Fang H, El-Mounayri O, Rodenberg JM, Imbalzano AN, Herring BP. The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):921-8. PMID: 19342595.
      View in: PubMed
    57. Imbalzano KM, Tatarkova I, Imbalzano AN, Nickerson JA. Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int. 2009 Mar 16; 9:7. PMID: 19291318.
      View in: PubMed
    58. Dacwag CS, Bedford MT, Sif S, Imbalzano AN. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009 Apr; 29(7):1909-21. PMID: 19188441.
      View in: PubMed
    59. Lai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundström T, Imbalzano AN, Chi T. Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1169-74. PMID: 19164553.
      View in: PubMed
    60. Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype. Kidney Blood Press Res. 2008; 31(6):421-32. PMID: 19142019.
      View in: PubMed
    61. Coles AH, Marfella CG, Imbalzano AN, Steinman HA, Garlick DS, Gerstein RM, Jones SN. p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis. Cancer Res. 2008 Nov 01; 68(21):8705-14. PMID: 18974112.
      View in: PubMed
    62. Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30; 181(7):1055-63. PMID: 18591425.
      View in: PubMed
    63. Ounzain S, Dacwag CS, Samani NJ, Imbalzano AN, Chong NW. Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter. BMC Mol Biol. 2008 May 19; 9:50. PMID: 18489770.
      View in: PubMed
    64. Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL. Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6632-7. PMID: 18445650.
      View in: PubMed
    65. Das AV, James J, Bhattacharya S, Imbalzano AN, Antony ML, Hegde G, Zhao X, Mallya K, Ahmad F, Knudsen E, Ahmad I. SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. J Biol Chem. 2007 Nov 30; 282(48):35187-201. PMID: 17855369.
      View in: PubMed
    66. Coles AH, Liang H, Zhu Z, Marfella CG, Kang J, Imbalzano AN, Jones SN. Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis. Cancer Res. 2007 Mar 1; 67(5):2054-61. PMID: 17332334.
      View in: PubMed
    67. Gutiérrez J, Paredes R, Cruzat F, Hill DA, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter. J Biol Chem. 2007 Mar 30; 282(13):9445-57. PMID: 17272279.
      View in: PubMed
    68. Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007 Jan 25; 445(7126):442-6. PMID: 17251981.
      View in: PubMed
    69. Marfella CG, Imbalzano AN. The Chd family of chromatin remodelers. Mutat Res. 2007 May 1; 618(1-2):30-40. PMID: 17350655.
      View in: PubMed
    70. Ohkawa Y, Yoshimura S, Higashi C, Marfella CG, Dacwag CS, Tachibana T, Imbalzano AN. Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis. J Biol Chem. 2007 Mar 2; 282(9):6564-70. PMID: 17194702.
      View in: PubMed
    71. Kumar RA, Naidu SR, Wang X, Imbalzano AN, Androphy EJ. Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation. J Virol. 2007 Mar; 81(5):2213-20. PMID: 17151122.
      View in: PubMed
    72. Dacwag CS, Ohkawa Y, Pal S, Sif S, Imbalzano AN. The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Mol Cell Biol. 2007 Jan; 27(1):384-94. PMID: 17043109.
      View in: PubMed
    73. Marfella CG, Ohkawa Y, Coles AH, Garlick DS, Jones SN, Imbalzano AN. Mutation of the SNF2 family member Chd2 affects mouse development and survival. J Cell Physiol. 2006 Oct; 209(1):162-71. PMID: 16810678.
      View in: PubMed
    74. Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, Imbalzano AN, Kwon J. Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J. 2006 Sep 6; 25(17):3986-97. PMID: 16932743.
      View in: PubMed
    75. Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN, Jones SN. Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis. Cancer Res. 2006 Aug 15; 66(16):8076-82. PMID: 16912184.
      View in: PubMed
    76. Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006 Jul; 208(1):141-8. PMID: 16607610.
      View in: PubMed
    77. Villagra A, Cruzat F, Carvallo L, Paredes R, Olate J, van Wijnen AJ, Stein GS, Lian JB, Stein JL, Imbalzano AN, Montecino M. Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity. J Biol Chem. 2006 Aug 11; 281(32):22695-706. PMID: 16772287.
      View in: PubMed
    78. de la Serna IL, Ohkawa Y, Imbalzano AN. Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers. Nat Rev Genet. 2006 Jun; 7(6):461-73. PMID: 16708073.
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    79. de la Serna IL, Ohkawa Y, Higashi C, Dutta C, Osias J, Kommajosyula N, Tachibana T, Imbalzano AN. The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. J Biol Chem. 2006 Jul 21; 281(29):20233-41. PMID: 16648630.
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    80. Salma N, Xiao H, Imbalzano AN. Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo. J Mol Endocrinol. 2006 Feb; 36(1):139-51. PMID: 16461934.
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    81. Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev. 2006 Feb 1; 20(3):282-96. PMID: 16452502.
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    82. Hill DA, Imbalzano AN. HMGN1 is dispensable for myogenesis and adipogenesis. Gene. 2006 Apr 12; 371(1):59-67. PMID: 16451822.
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    83. Ohkawa Y, Marfella CG, Imbalzano AN. Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006 Feb 8; 25(3):490-501. PMID: 16424906.
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    84. Vradii D, Wagner S, Doan DN, Nickerson JA, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Imbalzano AN, Stein GS. Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes. J Cell Physiol. 2006 Jan; 206(1):112-8. PMID: 15965950.
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    85. Im H, Grass JA, Johnson KD, Kim SI, Boyer ME, Imbalzano AN, Bieker JJ, Bresnick EH. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17065-70. PMID: 16286657.
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    86. Hill DA, Peterson CL, Imbalzano AN. Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling. J Biol Chem. 2005 Dec 16; 280(50):41777-83. PMID: 16253989.
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    87. de la Serna IL, Ohkawa Y, Berkes CA, Bergstrom DA, Dacwag CS, Tapscott SJ, Imbalzano AN. MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. Mol Cell Biol. 2005 May; 25(10):3997-4009. PMID: 15870273.
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    88. Imbalzano AN, Jones SN. Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability. Cancer Cell. 2005 Apr; 7(4):294-5. PMID: 15837618.
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    89. Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 1; 94(4):720-30. PMID: 15565649.
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    90. Hill DA, Chiosea S, Jamaluddin S, Roy K, Fischer AH, Boyd DD, Nickerson JA, Imbalzano AN. Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. J Cell Sci. 2004 Nov 15; 117(Pt 24):5847-54. PMID: 15537831.
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    91. Biswas D, Imbalzano AN, Eriksson P, Yu Y, Stillman DJ. Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex. Mol Cell Biol. 2004 Sep; 24(18):8312-21. PMID: 15340090.
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    92. Simone C, Forcales SV, Hill DA, Imbalzano AN, Latella L, Puri PL. p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Nat Genet. 2004 Jul; 36(7):738-43. PMID: 15208625.
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    93. Salma N, Xiao H, Mueller E, Imbalzano AN. Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Mol Cell Biol. 2004 Jun; 24(11):4651-63. PMID: 15143161.
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    94. Doan DN, Veal TM, Yan Z, Wang W, Jones SN, Imbalzano AN. Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes. Oncogene. 2004 Apr 22; 23(19):3462-73. PMID: 14990991.
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    95. Hill DA, de la Serna IL, Veal TM, Imbalzano AN. BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2. J Cell Biochem. 2004 Apr 1; 91(5):987-98. PMID: 15034933.
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    96. Imbalzano AN, Xiao H. Functional properties of ATP-dependent chromatin remodeling enzymes. Adv Protein Chem. 2004; 67:157-79. PMID: 14969727.
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    97. Guidi CJ, Veal TM, Jones SN, Imbalzano AN. Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor. J Biol Chem. 2004 Feb 6; 279(6):4180-5. PMID: 14630919.
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    98. Moen PT, Johnson CV, Byron M, Shopland LS, de la Serna IL, Imbalzano AN, Lawrence JB. Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis. Mol Biol Cell. 2004 Jan; 15(1):197-206. PMID: 14617810.
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    99. de la Serna IL, Imbalzano AN. Unfolding heterochromatin for replication. Nat Genet. 2002 Dec; 32(4):560-2. PMID: 12457187.
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    100. Roy K, de la Serna IL, Imbalzano AN. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. J Biol Chem. 2002 Sep 13; 277(37):33818-24. PMID: 12105204.
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    101. Horn PJ, Carruthers LM, Logie C, Hill DA, Solomon MJ, Wade PA, Imbalzano AN, Hansen JC, Peterson CL. Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes. Nat Struct Biol. 2002 Apr; 9(4):263-7. PMID: 11887184.
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    102. de la Serna IL, Roy K, Carlson KA, Imbalzano AN. MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes. J Biol Chem. 2001 Nov 2; 276(44):41486-91. PMID: 11522799.
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    103. Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol. 2001 May; 21(10):3598-603. PMID: 11313485.
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    104. Sif S, Saurin AJ, Imbalzano AN, Kingston RE. Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Genes Dev. 2001 Mar 1; 15(5):603-18. PMID: 11238380.
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    105. de la Serna IL, Carlson KA, Imbalzano AN. Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation. Nat Genet. 2001 Feb; 27(2):187-90. PMID: 11175787.
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    106. Hill DA, Imbalzano AN. Human SWI/SNF nucleosome remodeling activity is partially inhibited by linker histone H1. Biochemistry. 2000 Sep 26; 39(38):11649-56. PMID: 10995232.
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    107. Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN, Knudsen ES. BRG-1 is required for RB-mediated cell cycle arrest. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):7748-53. PMID: 10884406.
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    108. Boyer LA, Logie C, Bonte E, Becker PB, Wade PA, Wolffe AP, Wu C, Imbalzano AN, Peterson CL. Functional delineation of three groups of the ATP-dependent family of chromatin remodeling enzymes. J Biol Chem. 2000 Jun 23; 275(25):18864-70. PMID: 10779516.
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    109. Muthuswami R, Mesner LD, Wang D, Hill DA, Imbalzano AN, Hockensmith JW. Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains. Biochemistry. 2000 Apr 18; 39(15):4358-65. PMID: 10757984.
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    110. de La Serna IL, Carlson KA, Hill DA, Guidi CJ, Stephenson RO, Sif S, Kingston RE, Imbalzano AN. Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene. Mol Cell Biol. 2000 Apr; 20(8):2839-51. PMID: 10733587.
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    111. Kwon J, Imbalzano AN, Matthews A, Oettinger MA. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol Cell. 1998 Dec; 2(6):829-39. PMID: 9885570.
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    112. Imbalzano AN. SWI/SNF complexes and facilitation of TATA binding protein:nucleosome interactions. Methods. 1998 Aug; 15(4):303-14. PMID: 9740718.
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    113. Imbalzano AN. Energy-dependent chromatin remodelers: complex complexes and their components. Crit Rev Eukaryot Gene Expr. 1998; 8(3-4):225-55. PMID: 9807695.
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    114. Imbalzano AN, Schnitzler GR, Kingston RE. Nucleosome disruption by human SWI/SNF is maintained in the absence of continued ATP hydrolysis. J Biol Chem. 1996 Aug 23; 271(34):20726-33. PMID: 8702824.
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    115. Brown SA, Imbalzano AN, Kingston RE. Activator-dependent regulation of transcriptional pausing on nucleosomal templates. Genes Dev. 1996 Jun 15; 10(12):1479-90. PMID: 8666232.
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    116. Kingston RE, Bunker CA, Imbalzano AN. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 1996 Apr 15; 10(8):905-20. PMID: 8608939.
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    117. Wilson CJ, Chao DM, Imbalzano AN, Schnitzler GR, Kingston RE, Young RA. RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling. Cell. 1996 Jan 26; 84(2):235-44. PMID: 8565069.
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    118. Imbalzano AN, Kwon H, Green MR, Kingston RE. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature. 1994 Aug 11; 370(6489):481-5. PMID: 8047170.
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    119. Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR. Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex. Nature. 1994 Aug 11; 370(6489):477-81. PMID: 8047169.
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    120. Rivera-Gonzalez R, Imbalzano AN, Gu B, Deluca NA. The role of ICP4 repressor activity in temporal expression of the IE-3 and latency-associated transcript promoters during HSV-1 infection. Virology. 1994 Aug 1; 202(2):550-64. PMID: 8030221.
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    121. Imbalzano AN, Zaret KS, Kingston RE. Transcription factor (TF) IIB and TFIIA can independently increase the affinity of the TATA-binding protein for DNA. J Biol Chem. 1994 Mar 18; 269(11):8280-6. PMID: 8132551.
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    122. Imbalzano AN, DeLuca NA. Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression. J Virol. 1992 Sep; 66(9):5453-63. PMID: 1323706.
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    123. Imbalzano AN, Coen DM, DeLuca NA. Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J Virol. 1991 Feb; 65(2):565-74. PMID: 1846184.
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    124. Imbalzano AN, Shepard AA, DeLuca NA. Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene. J Virol. 1990 Jun; 64(6):2620-31. PMID: 2159535.
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    125. Shepard AA, Imbalzano AN, DeLuca NA. Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4. J Virol. 1989 Sep; 63(9):3714-28. PMID: 2760981.
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