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Thomas W Smith MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-2331
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurological Surgery

    InstitutionUMMS - School of Medicine
    DepartmentNeurology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentPathology
    DivisionAnatomic Pathology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    Ohio State University Columbus, Columbus, OH, United StatesBSBiological Sciences
    Weill Cornell Graduate School of Medical Sciences, New York, NY, United StatesMDMedicine

    Collapse Overview 
    Collapse overview

    Academic Background:

    1972MD, Weill Medical College of Cornell University
    1972-1973 Resident (PGY1), Anatomic Pathology, New York Hospital-CornellMedical Center, New York, NY
    1973-1976 Resident, Neuropathology, Peter Bent Brigham Hospital, Boston, MA
    1977-1978 Resident, Anatomic Pathology, Peter Bent Brigham Hospital, Boston, MA

    Clinical Activities

    My clinical activities specifically focus on diagnostic neuropathology and neuromuscular pathology. I am responsible for all clinical neuropathology services at UMMHC and its affiliated hospitals. I also serve as a consultant neuropathologist for a number of hospitals in Central, Western and Southeastern Massachusetts and for the Western Massachusetts Office of the Chief Medical Examiner. I am the medical director of diagnostic electron microscopy for UMMHC hospitals.

    Teaching

    I have a strong interest in and major commitment to undergraduate and graduate medical education. My undergraduate educational activities include co-directorships of the Mind, Brain, and Behavior (MBB2) and Biology of Disease (BoD) courses for the 2nd year medical students as well as being the General Pathology block coordinator in the BoD course. I am an active lecturer and laboratory instructor in both of these courses and in the 1st year Histology and MBB1 (Neuroscience) courses. I am an active member of a number of medical school committees and working groups, including Chair of the Second Year Curriculum Committee, and am an active participant in the ongoing curriculum revision effort in the medical school. My graduate medical educational activities primarily involve teaching Neurology and Pathology residents rotating through the neuropathology service.

    Research Interests

    My research/scholarly interests have focused on clinically-related topics and include retrospective studies using archival case material and prospective clinico-pathological projects. I have also served as neuropathology consultant for individual investigators and several program projects in other UMMS departments. Recent interests have included forensic neuropathology and CNS neoplasia.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rogers JH, Boyd WD, Smith TW, Bolling SF. Transcatheter Mitral Valve Direct Annuloplasty with the Millipede IRIS Ring. Interv Cardiol Clin. 2019 Jul; 8(3):261-267. PMID: 31078181.
      View in: PubMed
    2. Drachman DA, Smith TW, Alkamachi B, Kane K. Microvascular changes in Down syndrome with Alzheimer-type pathology: Insights into a potential vascular mechanism for Down syndrome and Alzheimer's disease. Alzheimers Dement. 2017 Jun 13. PMID: 28627379.
      View in: PubMed
    3. Singh GD, Smith TW, Rogers JH. Targeted Transseptal Access for MitraClip Percutaneous Mitral Valve Repair. Interv Cardiol Clin. 2016 Jan; 5(1):55-69. PMID: 27852482.
      View in: PubMed
    4. Garg N, Smith TW. An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis. Brain Behav. 2015 Sep; 5(9):e00362. PMID: 26445701.
      View in: PubMed
    5. Cataltepe S, Arikan MC, Liang X, Smith TW, Cataltepe O. Fatty acid binding protein 4 expression in cerebral vascular malformations: implications for vascular remodelling. Neuropathol Appl Neurobiol. 2015 Aug; 41(5):646-56. PMID: 24865546.
      View in: PubMed
    6. Wirth D, Smith TW, Moser R, Yaroslavsky AN. Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy. Phys Med Biol. 2015 Apr 7; 60(7):3003-11. PMID: 25790138.
      View in: PubMed
    7. Kuhn BT, Javed U, Armstrong EJ, Singh GD, Smith TW, Whitcomb CJ, Allen RP, Rogers JH. Balloon dilation atrial septostomy for advanced pulmonary hypertension in patients on prostanoid therapy. Catheter Cardiovasc Interv. 2015 May; 85(6):1066-72. PMID: 25413481.
      View in: PubMed
    8. Tisdell J, Smith TW, Muehlschlegel S. Multiple septic brain emboli in infectious endocarditis. Arch Neurol. 2012 Sep; 69(9):1206-7. PMID: 22964915.
      View in: PubMed
    9. Cataltepe O, Arikan MC, Ghelfi E, Karaaslan C, Ozsurekci Y, Dresser K, Li Y, Smith TW, Cataltepe S. Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma. Neuropathol Appl Neurobiol. 2012 Aug; 38(5):400-10. PMID: 22093167.
      View in: PubMed
    10. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma. Arch Pathol Lab Med. 2011 Aug; 135(8):1032-6. PMID: 21809995.
      View in: PubMed
    11. Cataltepe O, Liptzin D, Jolley L, Smith TW. Diffuse villous hyperplasia of the choroid plexus and its surgical management. J Neurosurg Pediatr. 2010 May; 5(5):518-22. PMID: 20433267.
      View in: PubMed
    12. Burrows AM, Smith TW, Hall WR, Pilitsis JG. Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. J Neurol Neurosurg Psychiatry. 2010 Apr; 81(4):449-50. PMID: 20360167.
      View in: PubMed
    13. Cataltepe O, Marshall P, Smith TW. Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. J Neurosurg Pediatr. 2009 Jun; 3(6):456-60. PMID: 19485727.
      View in: PubMed
    14. Jaster JH, Ottaviani G, Zamecnik J, Smith TW. Reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008 Aug; 65(8):1135-6; author reply 1136. PMID: 18695069.
      View in: PubMed
    15. Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. Am J Alzheimers Dis Other Demen. 2007 Apr-May; 22(2):137-44. PMID: 17545141.
      View in: PubMed
    16. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21. PMID: 16533949.
      View in: PubMed
    17. Daou MC, Smith TW, Litofsky NS, Hsieh CC, Ross AH. Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol. 2005 Nov; 110(5):472-80. PMID: 16195916.
      View in: PubMed
    18. Salajegheh M, Rudnicki A, Smith TW. Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms. Appl Immunohistochem Mol Morphol. 2005 Jun; 13(2):184-9. PMID: 15894933.
      View in: PubMed
    19. Jang T, Litofsky NS, Smith TW, Ross AH, Recht LD. Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis. 2004 Apr; 15(3):544-52. PMID: 15056462.
      View in: PubMed
    20. Rosales MY, Smith TW, Safran M. Hemorrhagic Rathke's cleft cyst presenting as diplopia. Endocr Pract. 2004 Mar-Apr; 10(2):129-34. PMID: 15256330.
      View in: PubMed
    21. Jones S, Phillips N, Ali F, Fernandes JA, Flowers MJ, Smith TW. Triplane fractures of the distal tibia requiring open reduction and internal fixation. Pre-operative planning using computed tomography. Injury. 2003 May; 34(4):293-8. PMID: 12667783.
      View in: PubMed
    22. Moore BE, Somers NP, Smith TW. Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med. 2002 Jan; 126(1):79-81. PMID: 11800653.
      View in: PubMed
    23. Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol. 2001 May; 21(10):3598-603. PMID: 11313485.
      View in: PubMed
    24. Gleckman AM, Jiang Z, Liu Y, Smith TW. Neuronal and glial DNA fragmentation in Pick's disease. Acta Neuropathol. 1999 Jul; 98(1):55-61. PMID: 10412801.
      View in: PubMed
    25. Gleckman AM, Bell MD, Evans RJ, Smith TW. Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med. 1999 Feb; 123(2):146-51. PMID: 10050789.
      View in: PubMed
    26. Kotecha N, George MJ, Smith TW, Corvi F, Litofsky NS. Enhancing progressive multifocal leukoencephalopathy: an indicator of improved immune status? Am J Med. 1998 Dec; 105(6):541-3. PMID: 9870842.
      View in: PubMed
    27. Litofsky NS, Pihan G, Corvi F, Smith TW. Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol. 1998 Nov; 40(2):179-83. PMID: 9892100.
      View in: PubMed
    28. Litofsky NS, Smith TW, Megerian CA. Merkel cell carcinoma of the external auditory canal invading the intracranial compartment. Am J Otolaryngol. 1998 Sep-Oct; 19(5):330-4. PMID: 9758183.
      View in: PubMed
    29. O'Sullivan KL, Pap SA, Megerian CA, Li Y, Sheffler LR, Smith TW, Lawrence WT. Improved axon diameter and myelin sheath thickness in facial nerve cable grafts wrapped in temporoparietal fascial flaps. Ann Plast Surg. 1998 May; 40(5):478-85. PMID: 9600431.
      View in: PubMed
    30. Silver B, McAvoy K, Mikesell S, Smith TW. Fulminating encephalopathy with perivenular demyelination and vacuolar myelopathy as the initial presentation of human immunodeficiency virus infection. Arch Neurol. 1997 May; 54(5):647-50. PMID: 9152123.
      View in: PubMed
    31. Lippa CF, Smith TW, Saunders AM, Hulette C, Pulaski-Salo D, Roses AD. Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology. 1997 Feb; 48(2):515-9. PMID: 9040748.
      View in: PubMed
    32. Lippa CF, Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, George-Hyslop SP, Roses AD, Pollen DA. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology. 1996 Feb; 46(2):406-12. PMID: 8614503.
      View in: PubMed
    33. McCann EL, Smith TW, Chad DA, Sargent J. Severe cranial nerve involvement in longstanding demyelinating polyneuropathy: a clinicopathologic correlation. Acta Neuropathol. 1996; 91(3):309-12. PMID: 8834544.
      View in: PubMed
    34. Krishna M, Smith TW, Recht LD. Expression of bcl-2 in reactive and neoplastic astrocytes: lack of correlation with presence or degree of malignancy. J Neurosurg. 1995 Dec; 83(6):1017-22. PMID: 7490615.
      View in: PubMed
    35. Lippa CF, Smith TW, Flanders KC. Transforming growth factor-beta: neuronal and glial expression in CNS degenerative diseases. Neurodegeneration. 1995 Dec; 4(4):425-32. PMID: 8846236.
      View in: PubMed
    36. Lippa CF, Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA. Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor? Dementia. 1995 Jul-Aug; 6(4):191-4. PMID: 7550597.
      View in: PubMed
    37. Smith TW, Lippa CF. Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol. 1995 May; 54(3):297-303. PMID: 7745428.
      View in: PubMed
    38. Lau KY, Ragland RL, Weaver JP, Smith TW, Knorr JR, Weyreuther M. Epidural mass related to calvarial aneurysmal bone cyst: computed tomographic and magnetic resonance demonstration. J Neuroimaging. 1995 Apr; 5(2):128-30. PMID: 7718941.
      View in: PubMed
    39. Tenreiro-Picon OR, Kamath SV, Knorr JR, Ragland RL, Smith TW, Lau KY. Desmoplastic infantile ganglioglioma: CT and MRI features. Pediatr Radiol. 1995; 25(7):540-3. PMID: 8545186.
      View in: PubMed
    40. Gultekin SH, Smith TW. Diffuse axonal injury in craniocerebral trauma. A comparative histologic and immunohistochemical study. Arch Pathol Lab Med. 1994 Feb; 118(2):168-71. PMID: 8311658.
      View in: PubMed
    41. Smith TW, Nikulasson S, De Girolami U, De Gennaro LJ. Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology. Clin Neuropathol. 1993 Nov-Dec; 12(6):335-42. PMID: 8287627.
      View in: PubMed
    42. Lippa CF, Hamos JE, Smith TW, Pulaski-Salo D, Drachman DA. Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles. Arch Neurol. 1993 Oct; 50(10):1088-92. PMID: 8215968.
      View in: PubMed
    43. Lippa CF, Pearson D, Smith TW. Cortical tubers demonstrate reduced immunoreactivity for synapsin I. Acta Neuropathol. 1993; 85(4):449-51. PMID: 8480517.
      View in: PubMed
    44. Lippa CF, Smith TW. The indusium griseum in Alzheimer's disease: an immunocytochemical study. J Neurol Sci. 1992 Aug; 111(1):39-45. PMID: 1328542.
      View in: PubMed
    45. Smith TW, De Girolami U, Hickey WF. Neuropathology of immunosuppression. Brain Pathol. 1992 Jul; 2(3):183-94. PMID: 1343833.
      View in: PubMed
    46. Recht LD, Lew R, Smith TW. Suspected low-grade glioma: is deferring treatment safe? Ann Neurol. 1992 Apr; 31(4):431-6. PMID: 1586143.
      View in: PubMed
    47. Smith TW, Lippa CF, de Girolami U. Immunocytochemical study of ballooned neurons in cortical degeneration with neuronal achromasia. Clin Neuropathol. 1992 Jan-Feb; 11(1):28-35. PMID: 1312403.
      View in: PubMed
    48. Lacomis D, Smith TW, Long RR. Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome. Clin Neurol Neurosurg. 1992; 94(4):311-5. PMID: 1335859.
      View in: PubMed
    49. Lippa CF, Cohen R, Smith TW, Drachman DA. Primary progressive aphasia with focal neuronal achromasia. Neurology. 1991 Jun; 41(6):882-6. PMID: 2046934.
      View in: PubMed
    50. Strongwater SL, Woda BA, Yood RA, Rybak ME, Sargent J, DeGirolami U, Smith TW, Varnis C, Allen S, Murphy K, et al. Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis. Arch Intern Med. 1990 Oct; 150(10):2178-86. PMID: 2222105.
      View in: PubMed
    51. Lippa CF, Smith TW, Degirolami U, Drachman DA. The indusium griseum: is it involved in Alzheimer's disease? Neurobiol Aging. 1990 Sep-Oct; 11(5):551-4. PMID: 2234286.
      View in: PubMed
    52. Smith TW, DeGirolami U, Hénin D, Bolgert F, Hauw JJ. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J Neuropathol Exp Neurol. 1990 Jul; 49(4):357-70. PMID: 2362185.
      View in: PubMed
    53. De Girolami U, Smith TW, Hénin D, Hauw JJ. Neuropathology of the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1990 Jul; 114(7):643-55. PMID: 2194443.
      View in: PubMed
    54. Recht L, Torres CO, Smith TW, Raso V, Griffin TW. Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy. J Neurosurg. 1990 Jun; 72(6):941-5. PMID: 2159987.
      View in: PubMed
    55. Anwer UE, Smith TW, DeGirolami U, Wilkinson HA. Medulloblastoma with cartilaginous differentiation. Arch Pathol Lab Med. 1989 Jan; 113(1):84-8. PMID: 2910231.
      View in: PubMed
    56. Deymeer F, Smith TW, DeGirolami U, Drachman DA. Thalamic dementia and motor neuron disease. Neurology. 1989 Jan; 39(1):58-61. PMID: 2909915.
      View in: PubMed
    57. Lippa CF, Smith TW. Chromatolytic neurons in Werdnig-Hoffmann disease contain phosphorylated neurofilaments. Acta Neuropathol. 1988; 77(1):91-4. PMID: 3149123.
      View in: PubMed
    58. Smith TW, Anwer U, DeGirolami U, Drachman DA. Vacuolar change in Alzheimer's disease. Arch Neurol. 1987 Dec; 44(12):1225-8. PMID: 3314815.
      View in: PubMed
    59. Rudnicki S, Chad DA, Drachman DA, Smith TW, Anwer UE, Levitan N. Motor neuron disease and paraproteinemia. Neurology. 1987 Feb; 37(2):335-7. PMID: 3808319.
      View in: PubMed
    60. Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC, Davidson RI. Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. Neurosurgery. 1986 Aug; 19(2):278-81. PMID: 3748360.
      View in: PubMed
    61. Pinto-Lord MC, Abroms IF, Smith TW. Hyperdense cerebral lesion in childhood tuberous sclerosis: computed tomographic demonstration and neuropathologic analysis. Pediatr Neurol. 1986 Jul-Aug; 2(4):245-8. PMID: 3508697.
      View in: PubMed
    62. Griffin TW, Smith TW, Levy BS, Recht LD. Synchronous occurrence of glioblastoma multiforme in a husband and wife. J Neurooncol. 1986; 4(1):75-8. PMID: 3018184.
      View in: PubMed
    63. Badon SJ, Ansell J, Smith TW, Coslovsky R, Gill L, Woda BA. Diabetes insipidus caused by extramedullary hematopoiesis. Am J Clin Pathol. 1985 Apr; 83(4):509-12. PMID: 3984946.
      View in: PubMed
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