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Thomas W Smith MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurological Surgery

    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DivisionAnatomic Pathology

    Collapse Biography 
    Collapse education and training
    Ohio State University Columbus, Columbus, OH, United StatesBSBiological Sciences
    Weill Cornell Graduate School of Medical Sciences, New York, NY, United StatesMDMedicine

    Collapse Overview 
    Collapse overview

    Academic Background:

    1972MD, Weill Medical College of Cornell University
    1972-1973 Resident (PGY1), Anatomic Pathology, New York Hospital-CornellMedical Center, New York, NY
    1973-1976 Resident, Neuropathology, Peter Bent Brigham Hospital, Boston, MA
    1977-1978 Resident, Anatomic Pathology, Peter Bent Brigham Hospital, Boston, MA

    Clinical Activities

    My clinical activities specifically focus on diagnostic neuropathology and neuromuscular pathology. I am responsible for all clinical neuropathology services at UMMHC and its affiliated hospitals. I also serve as a consultant neuropathologist for a number of hospitals in Central, Western and Southeastern Massachusetts and for the Western Massachusetts Office of the Chief Medical Examiner. I am the medical director of diagnostic electron microscopy for UMMHC hospitals.


    I have a strong interest in and major commitment to undergraduate and graduate medical education. My undergraduate educational activities include co-directorships of the Mind, Brain, and Behavior (MBB2) and Biology of Disease (BoD) courses for the 2nd year medical students as well as being the General Pathology block coordinator in the BoD course. I am an active lecturer and laboratory instructor in both of these courses and in the 1st year Histology and MBB1 (Neuroscience) courses. I am an active member of a number of medical school committees and working groups, including Chair of the Second Year Curriculum Committee, and am an active participant in the ongoing curriculum revision effort in the medical school. My graduate medical educational activities primarily involve teaching Neurology and Pathology residents rotating through the neuropathology service.

    Research Interests

    My research/scholarly interests have focused on clinically-related topics and include retrospective studies using archival case material and prospective clinico-pathological projects. I have also served as neuropathology consultant for individual investigators and several program projects in other UMMS departments. Recent interests have included forensic neuropathology and CNS neoplasia.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Owusu-Adjei B, Mietus CJ, Lim JC, Lambert W, Daci R, Cachia D, Smith TW, Amenta PS. Diffusely invasive supratentorial rosette-forming glioneuronal tumor: illustrative case. J Neurosurg Case Lessons. 2023 Oct 16; 6(16). PMID: 37870758.
    2. English CW, Rogers JH, Smith TW. Intracardiac Echocardiographic Guidance for Structural Heart Procedures: Current Utility as Compared to Transesophageal Echocardiography. Interv Cardiol Clin. 2024 Jan; 13(1):39-49. PMID: 37980066.
      Citations:    Fields:    Translation:Humans
    3. Benjamin S, Schildkrout B, Smith TW, MacGillivray L, Adams CBL, Lauterbach MD, Rice JF, Smock WS, Tucker DM. Life-long deficits in social adaptation and the frontal lobes: New evidence, seventy-five years after Ackerly and Benton's landmark case report of JP. Cortex. 2023 01; 158:4-23. PMID: 36403380.
      Citations:    Fields:    Translation:Humans
    4. Zuo Y, L?pez JE, Smith TW, Foster CC, Carson RE, Badawi RD, Wang G. Multiparametric cardiac18F-FDG PET in humans: pilot comparison of FDG delivery rate with82Rb myocardial blood flow. Phys Med Biol. 2021 07 30; 66(15). PMID: 34280905.
      Citations: 2     Fields:    Translation:Humans
    5. Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature. Acta Neuropathol Commun. 2021 06 29; 9(1):118. PMID: 34187585.
      Citations: 8     Fields:    Translation:HumansAnimals
    6. Lee V, Smith TW, Arikan M?, Zhang L, ?ataltepe O, ?ataltepe S. Fatty Acid-binding Protein 4 Expression in Tumor Cells as a Potential Marker for Anaplastic Meningiomas. Appl Immunohistochem Mol Morphol. 2021 02 01; 29(2):e10-e16. PMID: 32324631.
      Citations: 2     Fields:    Translation:Humans
    7. Rogers JH, Boyd WD, Smith TW, Bolling SF. Transcatheter Mitral Valve Direct Annuloplasty with the Millipede IRIS Ring. Interv Cardiol Clin. 2019 07; 8(3):261-267. PMID: 31078181.
      Citations: 5     Fields:    Translation:Humans
    8. Drachman DA, Smith TW, Alkamachi B, Kane K. Microvascular changes in Down syndrome with Alzheimer's-type pathology: Insights into a potential vascular mechanism for Down syndrome and Alzheimer's disease. Alzheimers Dement. 2017 Dec; 13(12):1389-1396. PMID: 28627379.
      Citations: 9     Fields:    Translation:Humans
    9. Singh GD, Smith TW, Rogers JH. Targeted Transseptal Access for MitraClip Percutaneous Mitral Valve Repair. Interv Cardiol Clin. 2016 01; 5(1):55-69. PMID: 27852482.
      Citations: 2     Fields:    Translation:Humans
    10. Garg N, Smith TW. An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis. Brain Behav. 2015 Sep; 5(9):e00362. PMID: 26445701.
      Citations: 93     Fields:    Translation:Humans
    11. Cataltepe S, Arikan MC, Liang X, Smith TW, Cataltepe O. Fatty acid binding protein 4 expression in cerebral vascular malformations: implications for vascular remodelling. Neuropathol Appl Neurobiol. 2015 Aug; 41(5):646-56. PMID: 24865546.
      Citations: 9     Fields:    Translation:HumansCells
    12. Wirth D, Smith TW, Moser R, Yaroslavsky AN. Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy. Phys Med Biol. 2015 Apr 07; 60(7):3003-11. PMID: 25790138.
      Citations: 7     Fields:    Translation:Humans
    13. Kuhn BT, Javed U, Armstrong EJ, Singh GD, Smith TW, Whitcomb CJ, Allen RP, Rogers JH. Balloon dilation atrial septostomy for advanced pulmonary hypertension in patients on prostanoid therapy. Catheter Cardiovasc Interv. 2015 May; 85(6):1066-72. PMID: 25413481.
      Citations: 6     Fields:    Translation:Humans
    14. Tisdell J, Smith TW, Muehlschlegel S. Multiple septic brain emboli in infectious endocarditis. Arch Neurol. 2012 Sep; 69(9):1206-7. PMID: 22964915.
      Citations: 1     Fields:    Translation:HumansCells
    15. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma. Arch Pathol Lab Med. 2011 Aug; 135(8):1032-6. PMID: 21809995.
      Citations: 7     Fields:    Translation:Humans
    16. Cataltepe O, Liptzin D, Jolley L, Smith TW. Diffuse villous hyperplasia of the choroid plexus and its surgical management. J Neurosurg Pediatr. 2010 May; 5(5):518-22. PMID: 20433267.
      Citations: 11     Fields:    Translation:Humans
    17. Burrows AM, Smith TW, Hall WR, Pilitsis JG. Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. J Neurol Neurosurg Psychiatry. 2010 Apr; 81(4):449-50. PMID: 20360167.
      Citations: 1     Fields:    Translation:Humans
    18. Cataltepe O, Marshall P, Smith TW. Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. J Neurosurg Pediatr. 2009 Jun; 3(6):456-60. PMID: 19485727.
      Citations: 5     Fields:    Translation:Humans
    19. Jaster JH, Ottaviani G, Zamecnik J, Smith TW. Reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008 Aug; 65(8):1135-6; author reply 1136. PMID: 18695069.
      Citations:    Fields:    Translation:Humans
    20. Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. Am J Alzheimers Dis Other Demen. 2007 Apr-May; 22(2):137-44. PMID: 17545141.
      Citations: 6     Fields:    Translation:Humans
    21. Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, Kream BE, Stein GS, Lian JB, Jones SN. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol. 2006 Mar 13; 172(6):909-21. PMID: 16533949.
      Citations: 141     Fields:    Translation:AnimalsCells
    22. Daou MC, Smith TW, Litofsky NS, Hsieh CC, Ross AH. Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol. 2005 Nov; 110(5):472-80. PMID: 16195916.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    23. Salajegheh M, Rudnicki A, Smith TW. Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms. Appl Immunohistochem Mol Morphol. 2005 Jun; 13(2):184-9. PMID: 15894933.
      Citations: 11     Fields:    Translation:Humans
    24. Jang T, Litofsky NS, Smith TW, Ross AH, Recht LD. Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis. 2004 Apr; 15(3):544-52. PMID: 15056462.
      Citations: 12     Fields:    Translation:Animals
    25. Rosales MY, Smith TW, Safran M. Hemorrhagic Rathke's cleft cyst presenting as diplopia. Endocr Pract. 2004 Mar-Apr; 10(2):129-34. PMID: 15256330.
      Citations: 4     Fields:    Translation:Humans
    26. Moore BE, Somers NP, Smith TW. Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med. 2002 Jan; 126(1):79-81. PMID: 11800653.
      Citations: 3     Fields:    Translation:HumansCells
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