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Gregory J Pazour PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street, Two Biotech, Suite 213
Worcester MA 01605
Phone508-856-8078
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    South Dakota State University, Brookings, SD, United StatesBSChemistry & Biology
    University of Minnesota, Minneapolis, Minneapolis, MN, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse overview

    Academic Background


    BS: 1986, South Dakota State University


    PhD: 1991, University of Minnesota


    Post Doctoral Studies: Worcester Foundation for Biomedical Research


    Function of the Mammalian Primary Cilium and Mechanisms of Eukaryotic Ciliary Assembly


    The Pazour lab is interested in understanding the mechanism for assembly of eukaryotic cilia and the function that these organelles play in vertebrate health and development.  Across the eukaryotic kingdom, cilia function to produce force for cell motility and serve as cellular antennae allowing cells to sense the environment.  In vertebrates, cilia play critical roles in development by establishing the left-right pattern of organ development and in organizing hedgehog and other signaling pathways.  Ciliary dysfunction leads to a spectrum of structural birth defects affecting every organ of the body. In addition, our senses of sight and smell utilize ciliary localized receptors and thus ciliary defects can lead to anosmia and blindness.  Post development, cilia play critical roles in tissue homeostasis and ciliary dysfunction causes a number of serious adult onset diseases including polycystic kidney disease, obesity and cancers such as medulloblastoma and basal cell carcinoma.


    In the kidney, the epithelial cells of uriniferous tubule have prominent primary cilia extending from their apical surface into the lumen.  The precise function of the cilia is unknown but they are thought to monitor the tubule diameter. If the cilia are defective, the tubule epithelial cell over proliferate and transform the normally narrow-lumen tubule into a large cyst.  For more information see "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella"


     Tg737 Scanning EM


     IFT20 Deletion Histology


    In the heart, cilia (green in the image below) play critical roles in left-right patterning and hedgehog signaling.  Ciliary dysfunction causes severe structural cardiac malformations and is thought to be a major cause of structural heart disease in the human population.  For more information see "Global genetic analysis in mice unveils central role for cilia in congenital heart disease"



    Chlamydomonas Flagellar Proteome



    Collapse Rotation Projects

    Potential Rotation Projects

    Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals.

    Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018; 6:175. PMID: 29963541.
      View in: PubMed
    2. Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 Apr 04. PMID: 29626631.
      View in: PubMed
    3. Eguether T, Cordelieres FP, Pazour GJ. Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell. 2018 Mar 14. PMID: 29540531.
      View in: PubMed
    4. Zhang Y, Liu H, Li W, Zhang Z, Zhang S, Teves ME, Stevens C, Foster JA, Campbell GE, Windle JJ, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice. Cytoskeleton (Hoboken). 2018 Feb; 75(2):70-84. PMID: 29236364.
      View in: PubMed
    5. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct 31; 19(11):1379. PMID: 29087383.
      View in: PubMed
    6. Hartwig C, Monis WJ, Chen X, Dickman DK, Pazour GJ, Faundez V. Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes. Dev Neurobiol. 2017 Oct 07. PMID: 28986965.
      View in: PubMed
    7. Zhang Y, Liu H, Li W, Zhang Z, Shang X, Zhang D, Li Y, Zhang S, Liu J, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Dev Biol. 2017 Sep 28. PMID: 28964737.
      View in: PubMed
    8. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188. PMID: 28846093.
      View in: PubMed
    9. Monis WJ, Faundez V, Pazour GJ. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. J Cell Biol. 2017 Jun 02. PMID: 28576874.
      View in: PubMed
    10. Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 May 01. PMID: 28459465.
      View in: PubMed
    11. Liu H, Li W, Zhang Y, Zhang Z, Shang X, Zhang L, Zhang S, Li Y, Somoza AV, Delpi B, Gerton GL, Foster JA, Hess RA, Pazour GJ, Zhang Z. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Biol Reprod. 2017 Apr 18. PMID: 28430876.
      View in: PubMed
    12. Pearring JN, San Agustin JT, Lobanova ES, Gabriel CJ, Lieu EC, Monis WJ, Stuck MW, Strittmatter L, Jaber SM, Arshavsky VY, Pazour GJ. Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. PLoS Genet. 2017 Apr 14; 13(4):e1006740. PMID: 28410364.
      View in: PubMed
    13. Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C. Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. J Med Genet. 2017 Mar 13. PMID: 28289185.
      View in: PubMed
    14. Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep. 2017 Dec; 7(1):1. PMID: 28127051.
      View in: PubMed
    15. Zhang Z, Li W, Zhang Y, Zhang L, Teves ME, Liu H, Strauss JF, Pazour GJ, Foster JA, Hess RA, Zhang Z. Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice. Mol Biol Cell. 2016 Sep 28. PMID: 27682589.
      View in: PubMed
    16. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Erratum: Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Jun 08; 7:11910. PMID: 27273704.
      View in: PubMed
    17. Thevenon J, Duplomb L, Phadke S, Eguether T, Saunier A, Avila M, Carmignac V, Bruel AL, St-Onge J, Duffourd Y, Pazour GJ, Franco B, Attie-Bitach T, Masurel-Paulet A, Rivière JB, Cormier-Daire V, Philippe C, Faivre L, Thauvin-Robinet C. Autosomal recessive IFT57 hypomorphic mutation cause ciliary transport defect in unclassified oral-facial-digital syndrome with short stature and brachymesophalangia. Clin Genet. 2016 Dec; 90(6):509-517. PMID: 27060890.
      View in: PubMed
    18. Oud MM, Bonnard C, Mans DA, Altunoglu U, Tohari S, Ng AY, Eskin A, Lee H, Rupar CA, de Wagenaar NP, Wu KM, Lahiry P, Pazour GJ, Nelson SF, Hegele RA, Roepman R, Kayserili H, Venkatesh B, Siu VM, Reversade B, Arts HH. A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome. Cilia. 2016; 5:8. PMID: 27069622.
      View in: PubMed
    19. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Mar 22; 7:11103. PMID: 27002738.
      View in: PubMed
    20. Li Y, Yagi H, Onuoha EO, Damerla RR, Francis R, Furutani Y, Tariq M, King SM, Hendricks G, Cui C, Saydmohammed M, Lee DM, Zahid M, Sami I, Leatherbury L, Pazour GJ, Ware SM, Nakanishi T, Goldmuntz E, Tsang M, Lo CW. DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genet. 2016 Feb; 12(2):e1005821. PMID: 26918822.
      View in: PubMed
    21. Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT. IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):386-91. PMID: 26715756.
      View in: PubMed
    22. San Agustin JT, Pazour GJ, Witman GB. Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm. Mol Biol Cell. 2015 Dec 01; 26(24):4358-72. PMID: 26424803.
      View in: PubMed
    23. Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015 Aug 15; 142(16):2860. PMID: 26286943.
      View in: PubMed
    24. Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT. The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse. J Cell Sci. 2015 Jul 15; 128(14):2541-52. PMID: 26034069.
      View in: PubMed
    25. Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015 Jun 15; 142(12):2194-202. PMID: 26023097.
      View in: PubMed
    26. Damerla RR, Cui C, Gabriel GC, Liu X, Craige B, Gibbs BC, Francis R, Li Y, Chatterjee B, San Agustin JT, Eguether T, Subramanian R, Witman GB, Michaud JL, Pazour GJ, Lo CW. Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies. Hum Mol Genet. 2015 Jul 15; 24(14):3994-4005. PMID: 25877302.
      View in: PubMed
    27. Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28; 521(7553):520-4. PMID: 25807483.
      View in: PubMed
    28. May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW. Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. Development. 2015 Feb 1; 142(3):555-66. PMID: 25605782.
      View in: PubMed
    29. Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV. ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Nat Commun. 2015 Jan 20; 6:6023. PMID: 25599650.
      View in: PubMed
    30. Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell. 2014 Nov 10; 31(3):279-90. PMID: 25446516.
      View in: PubMed
    31. Awata J, Takada S, Standley C, Lechtreck KF, Bellvé KD, Pazour GJ, Fogarty KE, Witman GB. NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone. J Cell Sci. 2014 Nov 1; 127(Pt 21):4714-27. PMID: 25150219.
      View in: PubMed
    32. Rao Damerla R, Gabriel GC, Li Y, Klena NT, Liu X, Chen Y, Cui C, Pazour GJ, Lo CW. Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models. Birth Defects Res C Embryo Today. 2014 Jun; 102(2):115-25. PMID: 24975753.
      View in: PubMed
    33. Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ. Distinct functions for IFT140 and IFT20 in opsin transport. Cytoskeleton (Hoboken). 2014 May; 71(5):302-10. PMID: 24619649.
      View in: PubMed
    34. Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS. Casein kinase 1d functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell. 2014 May; 25(10):1629-40. PMID: 24648492.
      View in: PubMed
    35. Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014 Feb; 10(2):e1004170. PMID: 24586199.
      View in: PubMed
    36. Finetti F, Patrussi L, Masi G, Onnis A, Galgano D, Lucherini OM, Pazour GJ, Baldari CT. Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system. J Cell Sci. 2014 May 1; 127(Pt 9):1924-37. PMID: 24554435.
      View in: PubMed
    37. Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov; 11(11):e1001720. PMID: 24302887.
      View in: PubMed
    38. Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet. 2013 Sep; 45(9):1004-12. PMID: 23892607.
      View in: PubMed
    39. Schmidts M, Frank V, Eisenberger T, Al Turki S, Bizet AA, Antony D, Rix S, Decker C, Bachmann N, Bald M, Vinke T, Toenshoff B, Di Donato N, Neuhann T, Hartley JL, Maher ER, Bogdanovic R, Peco-Antic A, Mache C, Hurles ME, Joksic I, Guc-Šcekic M, Dobricic J, Brankovic-Magic M, Bolz HJ, Pazour GJ, Beales PL, Scambler PJ, Saunier S, Mitchison HM, Bergmann C. Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat. 2013 May; 34(5):714-24. PMID: 23418020.
      View in: PubMed
    40. Follit JA, Pazour GJ. Analysis of ciliary membrane protein dynamics using SNAP technology. Methods Enzymol. 2013; 524:195-204. PMID: 23498741.
      View in: PubMed
    41. Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D, Mello CC. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell. 2012 Dec 21; 151(7):1488-500. PMID: 23260138.
      View in: PubMed
    42. Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF. The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function. J Cell Biol. 2012 Oct 1; 199(1):151-67. PMID: 23027906.
      View in: PubMed
    43. Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell. 2012 May 15; 22(5):940-51. PMID: 22595669.
      View in: PubMed
    44. Jonassen JA, SanAgustin J, Baker SP, Pazour GJ. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr; 23(4):641-51. PMID: 22282595.
      View in: PubMed
    45. Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM. A unified taxonomy for ciliary dyneins. Cytoskeleton (Hoboken). 2011 Oct; 68(10):555-65. PMID: 21953912.
      View in: PubMed
    46. Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci. 2011 Jul 6; 31(27):9933-44. PMID: 21734285.
      View in: PubMed
    47. Keady BT, Le YZ, Pazour GJ. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell. 2011 Apr; 22(7):921-30. PMID: 21307337.
      View in: PubMed
    48. Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW. Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech. 2011 Jan; 4(1):43-56. PMID: 21045211.
      View in: PubMed
    49. McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol. 2010 Apr 27; 20(8):731-7. PMID: 20381354.
      View in: PubMed
    50. Follit JA, Li L, Vucica Y, Pazour GJ. The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence. J Cell Biol. 2010 Jan 11; 188(1):21-8. PMID: 20048263.
      View in: PubMed
    51. Lechtreck KF, Johnson EC, Sakai T, Cochran D, Ballif BA, Rush J, Pazour GJ, Ikebe M, Witman GB. The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol. 2009 Dec 28; 187(7):1117-32. PMID: 20038682.
      View in: PubMed
    52. Pazour GJ. Immunoprecipitation to examine protein complexes. Methods Cell Biol. 2009; 91:135-42. PMID: 20409785.
      View in: PubMed
    53. SanAgustin JT, Follit JA, Hendricks G, Pazour GJ. Scanning electron microscopy to examine cells and organs. Methods Cell Biol. 2009; 91:81-7. PMID: 20409781.
      View in: PubMed
    54. Finetti F, Paccani SR, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum JL, Baldari CT. Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol. 2009 Nov; 11(11):1332-9. PMID: 19855387.
      View in: PubMed
    55. Clement CA, Kristensen SG, Møllgård K, Pazour GJ, Yoder BK, Larsen LA, Christensen ST. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci. 2009 Sep 1; 122(Pt 17):3070-82. PMID: 19654211.
      View in: PubMed
    56. Follit JA, Xu F, Keady BT, Pazour GJ. Characterization of mouse IFT complex B. Cell Motil Cytoskeleton. 2009 Aug; 66(8):457-68. PMID: 19253336.
      View in: PubMed
    57. Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec; 4(12):e1000315. PMID: 19112494.
      View in: PubMed
    58. Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 3; 183(3):377-84. PMID: 18981227.
      View in: PubMed
    59. Tanner CA, Rompolas P, Patel-King RS, Gorbatyuk O, Wakabayashi K, Pazour GJ, King SM. Three members of the LC8/DYNLL family are required for outer arm dynein motor function. Mol Biol Cell. 2008 Sep; 19(9):3724-34. PMID: 18579685.
      View in: PubMed
    60. Pazour GJ, Bloodgood RA. Targeting proteins to the ciliary membrane. Curr Top Dev Biol. 2008; 85:115-49. PMID: 19147004.
      View in: PubMed
    61. Huang K, Diener DR, Mitchell A, Pazour GJ, Witman GB, Rosenbaum JL. Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. J Cell Biol. 2007 Nov 5; 179(3):501-14. PMID: 17984324.
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    62. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12; 318(5848):245-50. PMID: 17932292.
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    63. Luby-Phelps K, Fogerty J, Baker SA, Pazour GJ, Besharse JC. Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors. Vision Res. 2008 Feb; 48(3):413-23. PMID: 17931679.
      View in: PubMed
    64. Palenik B, Grimwood J, Aerts A, Rouzé P, Salamov A, Putnam N, Dupont C, Jorgensen R, Derelle E, Rombauts S, Zhou K, Otillar R, Merchant SS, Podell S, Gaasterland T, Napoli C, Gendler K, Manuell A, Tai V, Vallon O, Piganeau G, Jancek S, Heijde M, Jabbari K, Bowler C, Lohr M, Robbens S, Werner G, Dubchak I, Pazour GJ, Ren Q, Paulsen I, Delwiche C, Schmutz J, Rokhsar D, Van de Peer Y, Moreau H, Grigoriev IV. The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7705-10. PMID: 17460045.
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    65. Hou Y, Qin H, Follit JA, Pazour GJ, Rosenbaum JL, Witman GB. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J Cell Biol. 2007 Feb 26; 176(5):653-65. PMID: 17312020.
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    66. Fliegauf M, Horvath J, von Schnakenburg C, Olbrich H, Müller D, Thumfart J, Schermer B, Pazour GJ, Neumann HP, Zentgraf H, Benzing T, Omran H. Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol. 2006 Sep; 17(9):2424-33. PMID: 16885411.
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    67. Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr. 2006 Aug; 149(2):159-64. PMID: 16887426.
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    68. Follit JA, Tuft RA, Fogarty KE, Pazour GJ. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell. 2006 Sep; 17(9):3781-92. PMID: 16775004.
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    69. Yang P, Diener DR, Yang C, Kohno T, Pazour GJ, Dienes JM, Agrin NS, King SM, Sale WS, Kamiya R, Rosenbaum JL, Witman GB. Radial spoke proteins of Chlamydomonas flagella. J Cell Sci. 2006 Mar 15; 119(Pt 6):1165-74. PMID: 16507594.
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    70. Schneider L, Clement CA, Teilmann SC, Pazour GJ, Hoffmann EK, Satir P, Christensen ST. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol. 2005 Oct 25; 15(20):1861-6. PMID: 16243034.
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    71. DiBella LM, Gorbatyuk O, Sakato M, Wakabayashi K, Patel-King RS, Pazour GJ, Witman GB, King SM. Differential light chain assembly influences outer arm dynein motor function. Mol Biol Cell. 2005 Dec; 16(12):5661-74. PMID: 16195342.
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    72. Teilmann SC, Byskov AG, Pedersen PA, Wheatley DN, Pazour GJ, Christensen ST. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 2005 Aug; 71(4):444-52. PMID: 15858826.
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    73. Pazour GJ, Agrin N, Leszyk J, Witman GB. Proteomic analysis of a eukaryotic cilium. J Cell Biol. 2005 Jul 4; 170(1):103-13. PMID: 15998802.
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    74. Pazour GJ, Agrin N, Walker BL, Witman GB. Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes. J Med Genet. 2006 Jan; 43(1):62-73. PMID: 15937072.
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    75. Armbrust EV, Berges JA, Bowler C, Green BR, Martinez D, Putnam NH, Zhou S, Allen AE, Apt KE, Bechner M, Brzezinski MA, Chaal BK, Chiovitti A, Davis AK, Demarest MS, Detter JC, Glavina T, Goodstein D, Hadi MZ, Hellsten U, Hildebrand M, Jenkins BD, Jurka J, Kapitonov VV, Kröger N, Lau WW, Lane TW, Larimer FW, Lippmeier JC, Lucas S, Medina M, Montsant A, Obornik M, Parker MS, Palenik B, Pazour GJ, Richardson PM, Rynearson TA, Saito MA, Schwartz DC, Thamatrakoln K, Valentin K, Vardi A, Wilkerson FP, Rokhsar DS. The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Science. 2004 Oct 1; 306(5693):79-86. PMID: 15459382.
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    76. Pazour GJ. Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol. 2004 Oct; 15(10):2528-36. PMID: 15466257.
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    77. Jurczyk A, Gromley A, Redick S, San Agustin J, Witman G, Pazour GJ, Peters DJ, Doxsey S. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol. 2004 Aug 30; 166(5):637-43. PMID: 15337773.
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    78. DiBella LM, Sakato M, Patel-King RS, Pazour GJ, King SM. The LC7 light chains of Chlamydomonas flagellar dyneins interact with components required for both motor assembly and regulation. Mol Biol Cell. 2004 Oct; 15(10):4633-46. PMID: 15304520.
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    79. Pazour GJ. Comparative genomics: prediction of the ciliary and basal body proteome. Curr Biol. 2004 Jul 27; 14(14):R575-7. PMID: 15268880.
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    80. Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development. 2004 Aug; 131(16):4085-93. PMID: 15269167.
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    81. Hou Y, Pazour GJ, Witman GB. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport. Mol Biol Cell. 2004 Oct; 15(10):4382-94. PMID: 15269286.
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    82. Cano DA, Murcia NS, Pazour GJ, Hebrok M. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development. 2004 Jul; 131(14):3457-67. PMID: 15226261.
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    83. Wirschell M, Pazour G, Yoda A, Hirono M, Kamiya R, Witman GB. Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Mol Biol Cell. 2004 Jun; 15(6):2729-41. PMID: 15064350.
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    84. Casey DM, Inaba K, Pazour GJ, Takada S, Wakabayashi K, Wilkerson CG, Kamiya R, Witman GB. DC3, the 21-kDa subunit of the outer dynein arm-docking complex (ODA-DC), is a novel EF-hand protein important for assembly of both the outer arm and the ODA-DC. Mol Biol Cell. 2003 Sep; 14(9):3650-63. PMID: 12972554.
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    85. Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003 Sep 5; 278(36):34211-8. PMID: 12821668.
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    86. Pazour GJ, Witman GB. The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol. 2003 Feb; 15(1):105-10. PMID: 12517711.
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    87. Besharse JC, Baker SA, Luby-Phelps K, Pazour GJ. Photoreceptor intersegmental transport and retinal degeneration: a conserved pathway common to motile and sensory cilia. Adv Exp Med Biol. 2003; 533:157-64. PMID: 15180260.
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    88. Pazour GJ, Rosenbaum JL. Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol. 2002 Dec; 12(12):551-5. PMID: 12495842.
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    89. Purton S, Pazour GJ. Meeting report: Tenth International Conference on the Cell and Molecular Biology of Chlamydomonas. Protist. 2002 Dec; 153(4):325-36. PMID: 12627862.
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    90. Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol. 2002 Jun 4; 12(11):R378-80. PMID: 12062067.
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    91. Pazour GJ, Baker SA, Deane JA, Cole DG, Dickert BL, Rosenbaum JL, Witman GB, Besharse JC. The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. J Cell Biol. 2002 Apr 1; 157(1):103-13. PMID: 11916979.
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    92. Pazour GJ, Witman GB. Forward and reverse genetic analysis of microtubule motors in Chlamydomonas. Methods. 2000 Dec; 22(4):285-98. PMID: 11133235.
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    93. Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30; 151(3):709-18. PMID: 11062270.
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    94. Horst CJ, Fishkind DJ, Pazour GJ, Witman GB. An insertional mutant of Chlamydomonas reinhardtii with defective microtubule positioning. Cell Motil Cytoskeleton. 1999 Oct; 44(2):143-54. PMID: 10506749.
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    95. Pazour GJ, Koutoulis A, Benashski SE, Dickert BL, Sheng H, Patel-King RS, King SM, Witman GB. LC2, the chlamydomonas homologue of the t complex-encoded protein Tctex2, is essential for outer dynein arm assembly. Mol Biol Cell. 1999 Oct; 10(10):3507-20. PMID: 10512883.
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    96. Pazour GJ, Dickert BL, Witman GB. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. J Cell Biol. 1999 Feb 8; 144(3):473-81. PMID: 9971742.
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    97. Pazour GJ, Wilkerson CG, Witman GB. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J Cell Biol. 1998 May 18; 141(4):979-92. PMID: 9585416.
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    98. Koutoulis A, Pazour GJ, Wilkerson CG, Inaba K, Sheng H, Takada S, Witman GB. The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex. J Cell Biol. 1997 Jun 2; 137(5):1069-80. PMID: 9166407.
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    99. Pazour GJ, Sineshchekov OA, Witman GB. Mutational analysis of the phototransduction pathway of Chlamydomonas reinhardtii. J Cell Biol. 1995 Oct; 131(2):427-40. PMID: 7593169.
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    100. Wilkerson CG, King SM, Koutoulis A, Pazour GJ, Witman GB. The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly. J Cell Biol. 1995 Apr; 129(1):169-78. PMID: 7698982.
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    101. Moss AG, Pazour GJ, Witman GB. Assay of Chlamydomonas phototaxis. Methods Cell Biol. 1995; 47:281-7. PMID: 7476500.
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    102. Pazour GJ, Ta CN, Das A. Constitutive mutations of Agrobacterium tumefaciens transcriptional activator virG. J Bacteriol. 1992 Jun; 174(12):4169-74. PMID: 1597431.
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    103. Pazour GJ, Ta CN, Das A. Mutants of Agrobacterium tumefaciens with elevated vir gene expression. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):6941-5. PMID: 1908084.
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    104. Pazour GJ, Das A. Characterization of the VirG binding site of Agrobacterium tumefaciens. Nucleic Acids Res. 1990 Dec 11; 18(23):6909-13. PMID: 2263453.
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    105. Mersereau M, Pazour GJ, Das A. Efficient transformation of Agrobacterium tumefaciens by electroporation. Gene. 1990 May 31; 90(1):149-51. PMID: 2165971.
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    106. Pazour GJ, Das A. virG, an Agrobacterium tumefaciens transcriptional activator, initiates translation at a UUG codon and is a sequence-specific DNA-binding protein. J Bacteriol. 1990 Mar; 172(3):1241-9. PMID: 2307647.
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    107. Das A, Pazour GJ. Delineation of the regulatory region sequences of Agrobacterium tumefaciens virB operon. Nucleic Acids Res. 1989 Jun 26; 17(12):4541-50. PMID: 2748333.
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    108. Sen P, Pazour GJ, Anderson D, Das A. Cooperative binding of Agrobacterium tumefaciens VirE2 protein to single-stranded DNA. J Bacteriol. 1989 May; 171(5):2573-80. PMID: 2708313.
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