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Gregory J Pazour PhD

InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 213
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    South Dakota State University, Brookings, SD, United StatesBA
    South Dakota State University, Brookings, SD, United StatesBSChemistry & Biology
    University of Minnesota, Minneapolis, Minneapolis, MN, United StatesPHDBiochemistry
    Collapse awards and honors
    2019Fellow, American Society for Cell Biology
    2015Lilian Jean Kaplan International Prize for Advancement in the Understanding of PKD, International Society for Nephrology
    2009Bensley Award in Cell Biology, American Association of Anatomists
    2004 - 2006Keith R. Porter Fellow, Keith R. Porter Foundation for Cell Biology

    Collapse Overview 
    Collapse overview

    Academic Background

    BS: 1986, South Dakota State University

    PhD: 1991, University of Minnesota

    Post Doctoral Studies: Worcester Foundation for Biomedical Research

    Function of the Mammalian Primary Cilium and Mechanisms of Eukaryotic Ciliary Assembly

    The Pazour lab is interested in understanding the mechanism for assembly of eukaryotic cilia and the function that these organelles play in vertebrate health and development.  Across the eukaryotic kingdom, cilia function to produce force for cell motility and serve as cellular antennae allowing cells to sense the environment.  In vertebrates, cilia play critical roles in development by establishing the left-right pattern of organ development and in organizing hedgehog and other signaling pathways.  Ciliary dysfunction leads to a spectrum of structural birth defects affecting every organ of the body. In addition, our senses of sight and smell utilize ciliary localized receptors and thus ciliary defects can lead to anosmia and blindness.  Post development, cilia play critical roles in tissue homeostasis and ciliary dysfunction causes a number of serious adult onset diseases including polycystic kidney disease, obesity and cancers such as medulloblastoma and basal cell carcinoma.

    In the kidney, the epithelial cells of uriniferous tubule have prominent primary cilia extending from their apical surface into the lumen.  The precise function of the cilia is unknown but they are thought to monitor the tubule diameter. If the cilia are defective, the tubule epithelial cell over proliferate and transform the normally narrow-lumen tubule into a large cyst.  For more information see "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella"

     Tg737 Scanning EM

     IFT20 Deletion Histology

    In the heart, cilia (green in the image below) play critical roles in left-right patterning and hedgehog signaling.  Ciliary dysfunction causes severe structural cardiac malformations and is thought to be a major cause of structural heart disease in the human population.  For more information see "Global genetic analysis in mice unveils central role for cilia in congenital heart disease"



    Collapse Rotation Projects

    Potential Rotation Projects

    Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals.

    Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gupta M, Pazour GJ. Intraflagellar transport: A critical player in photoreceptor development and the pathogenesis of retinal degenerative diseases. Cytoskeleton (Hoboken). 2023 Dec 23. PMID: 38140908.
      Citations:    Fields:    
    2. Francis RJB, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ. Autonomous and non-cell autonomous role of cilia in structural birth defects in mice. PLoS Biol. 2023 Dec; 21(12):e3002425. PMID: 38079449.
      Citations:    Fields:    Translation:AnimalsCells
    3. Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ. The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease. medRxiv. 2023 Dec 04. PMID: 38106222.
    4. Bakey Z, Cabrera OA, Hoefele J, Antony D, Wu K, Stuck MW, Micha D, Eguether T, Smith AO, van der Wel NN, Wagner M, Strittmatter L, Beales PL, Jonassen JA, Thiffault I, Cadieux-Dion M, Boyes L, Sharif S, T?ys?z B, Dunstheimer D, Niessen HWM, Devine W, Lo CW, Mitchison HM, Schmidts M, Pazour GJ. IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. PLoS Genet. 2023 06; 19(6):e1010796. PMID: 37315079.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Francis R, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ. Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defects. bioRxiv. 2023 Jun 07. PMID: 37333142.
    6. Bakey Z, Cabrera OA, Hoefele J, Antony D, Wu K, Stuck MW, Micha D, Eguether T, Smith AO, van der Wel NN, Wagner M, Strittmatter L, Beales PL, Jonassen JA, Thiffault I, Cadieux-Dion M, Boyes L, Sharif S, T?ys?z B, Dunstheimer D, Niessen HWM, Devine W, Lo CW, Mitchison HM, Schmidts M, Pazour GJ. IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. medRxiv. 2023 Feb 26. PMID: 36865301.
    7. Lv B, Zhang XO, Pazour GJ. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. J Cell Sci. 2022 08 15; 135(16). PMID: 35899529.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Hansen JN, Kaiser F, Leyendecker P, St?ven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, H?ndler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D. A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation. EMBO Rep. 2022 08 03; 23(8):e54315. PMID: 35695071.
      Citations: 8     Fields:    Translation:HumansCells
    9. M?nch J, Engesser M, Sch?nauer R, Hamm JA, Hartig C, Hantmann E, Akay G, Pehlivan D, Mitani T, Coban Akdemir Z, T?ys?z B, Shirakawa T, Dateki S, Claus LR, van Eerde AM, Smol T, Devisme L, Franquet H, Atti?-Bitach T, Wagner T, Bergmann C, H?hn AK, Shril S, Pollack A, Wenger T, Scott AA, Paolucci S, Buchan J, Gabriel GC, Posey JE, Lupski JR, Petit F, McCarthy AA, Pazour GJ, Lo CW, Popp B, Halbritter J. Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract. Kidney Int. 2022 05; 101(5):1039-1053. PMID: 35227688.
      Citations: 4     Fields:    Translation:HumansAnimals
    10. Braschi B, Omran H, Witman GB, Pazour GJ, Pfister KK, Bruford EA, King SM. Consensus nomenclature for dyneins and associated assembly factors. J Cell Biol. 2022 02 07; 221(2). PMID: 35006274.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    11. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease. J Cell Signal. 2022; 3(1):62-78. PMID: 35253003.
    12. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711. PMID: 34962918.
      Citations: 4     Fields:    Translation:HumansCells
    13. Cyge B, Voronina V, Hoque M, Kim EN, Hall J, Bailey-Lundberg JM, Pazour GJ, Crawford HC, Moon RT, Li FQ, Takemaru KI. Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis. Sci Rep. 2021 08 26; 11(1):17220. PMID: 34446743.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Lv B, Stuck MW, Desai PB, Cabrera OA, Pazour GJ. E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened. J Cell Biol. 2021 09 06; 220(9). PMID: 34161574.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    15. Paulson D, Harms R, Ward C, Latterell M, Pazour GJ, Fink DM. Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation. Front Cell Dev Biol. 2021; 9:672625. PMID: 34055805.
    16. Stuck MW, Chong WM, Liao JC, Pazour GJ. Rab34 is necessary for early stages of intracellular ciliogenesis. Curr Biol. 2021 07 12; 31(13):2887-2894.e4. PMID: 33989524.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Desai PB, Stuck MW, Lv B, Pazour GJ. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020 07 06; 219(7). PMID: 32435793.
      Citations: 37     Fields:    Translation:AnimalsCells
    18. Struck MW, Pazour GJ, Lambright DG. X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease. Structure. 2020 04 07; 28(4):385-387. PMID: 32268075.
      Citations:    Fields:    Translation:HumansCells
    19. Pazour GJ, Quarmby L, Smith AO, Desai PB, Schmidts M. Cilia in cystic kidney and other diseases. Cell Signal. 2020 05; 69:109519. PMID: 31881326.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    20. Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK. WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data. Genetics. 2020 02; 214(2):279-294. PMID: 31810987.
      Citations: 59     Fields:    Translation:AnimalsCells
    21. Pazour GJ, King SM. Ciliary Doublet Microtubules at Near-Atomic Resolution. Cell. 2019 10 31; 179(4):805-807. PMID: 31675493.
      Citations: 1     Fields:    Translation:Cells
    22. Wang Z, Shi Y, Ma S, Huang Q, Yap YT, Shi L, Zhang S, Zhou T, Li W, Hu B, Zhang L, Krawetz SA, Pazour GJ, Hess RA, Zhang Z. Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice. Am J Physiol Cell Physiol. 2020 01 01; 318(1):C174-C190. PMID: 31577511.
      Citations: 5     Fields:    Translation:AnimalsCells
    23. Shientag LJ, Cabrera OA, Pazour GJ. Allelic Diversity in the Serum Amyloid A2 Gene and Amyloid A Amyloidosis in a Breeding Colony of Zebra Finches (Taeniopygia guttata). Comp Med. 2019 10 01; 69(5):425-431. PMID: 31462347.
      Citations: 1     Fields:    Translation:Animals
    24. Shi L, Zhou T, Huang Q, Zhang S, Li W, Zhang L, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in mice?. Biol Reprod. 2019 07 01; 101(1):188-199. PMID: 31004481.
      Citations: 18     Fields:    Translation:Animals
    25. Zucchetti AE, Bataille L, Carpier JM, Dogniaux S, San Roman-Jouve M, Maurin M, Stuck MW, Rios RM, Baldari CT, Pazour GJ, Hivroz C. Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse. Nat Commun. 2019 06 28; 10(1):2864. PMID: 31253807.
      Citations: 15     Fields:    Translation:HumansCells
    26. Picariello T, Brown JM, Hou Y, Swank G, Cochran DA, King OD, Lechtreck K, Pazour GJ, Witman GB. A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia. J Cell Sci. 2019 02 11; 132(3). PMID: 30659111.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Wehrle A, Witkos TM, Unger S, Schneider J, Follit JA, Hermann J, Welting T, Fano V, Hietala M, Vatanavicharn N, Schoner K, Spranger J, Schmidts M, Zabel B, Pazour GJ, Bloch-Zupan A, Nishimura G, Superti-Furga A, Lowe M, Lausch E. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728324.
      Citations: 17     Fields:    
    28. Gabriel GC, Pazour GJ, Lo CW. Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes. Front Pediatr. 2018; 6:175. PMID: 29963541.
    29. Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 06; 151:10-17. PMID: 29626631.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. Eguether T, Cordelieres FP, Pazour GJ. Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell. 2018 05 15; 29(10):1178-1189. PMID: 29540531.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    31. Zhang Y, Liu H, Li W, Zhang Z, Zhang S, Teves ME, Stevens C, Foster JA, Campbell GE, Windle JJ, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice. Cytoskeleton (Hoboken). 2018 02; 75(2):70-84. PMID: 29236364.
      Citations: 23     Fields:    Translation:AnimalsCells
    32. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 10 31; 19(11):1379. PMID: 29087383.
      Citations: 5     Fields:    
    33. Hartwig C, Monis WJ, Chen X, Dickman DK, Pazour GJ, Faundez V. Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes. Dev Neurobiol. 2018 03; 78(3):311-330. PMID: 28986965.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Zhang Y, Liu H, Li W, Zhang Z, Shang X, Zhang D, Li Y, Zhang S, Liu J, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Dev Biol. 2017 12 01; 432(1):125-139. PMID: 28964737.
      Citations: 34     Fields:    Translation:AnimalsCells
    35. Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert?syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188. PMID: 28846093.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    36. Monis WJ, Faundez V, Pazour GJ. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. J Cell Biol. 2017 07 03; 216(7):2131-2150. PMID: 28576874.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    37. Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 08 31; 36(35):4997-5005. PMID: 28459465.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    38. Liu H, Li W, Zhang Y, Zhang Z, Shang X, Zhang L, Zhang S, Li Y, Somoza AV, Delpi B, Gerton GL, Foster JA, Hess RA, Pazour GJ, Zhang Z. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Biol Reprod. 2017 May 01; 96(5):993-1006. PMID: 28430876.
      Citations: 33     Fields:    Translation:AnimalsCells
    39. Pearring JN, San Agustin JT, Lobanova ES, Gabriel CJ, Lieu EC, Monis WJ, Stuck MW, Strittmatter L, Jaber SM, Arshavsky VY, Pazour GJ. Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. PLoS Genet. 2017 04; 13(4):e1006740. PMID: 28410364.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    40. Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-P?rez V, Goldstein JS, Pasquier L, Loget P, Saunier S, M?garban? A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivi?re JB, Faivre L, Thauvin-Robinet C. Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. J Med Genet. 2017 06; 54(6):371-380. PMID: 28289185.
      Citations: 49     Fields:    Translation:Humans
    41. Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep. 2017 01 26; 7(1):1. PMID: 28127051.
      Citations: 168     Fields:    Translation:HumansCells
    42. Zhang Z, Li W, Zhang Y, Zhang L, Teves ME, Liu H, Strauss JF, Pazour GJ, Foster JA, Hess RA, Zhang Z. Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice. Mol Biol Cell. 2016 Sep 28. PMID: 27682589.
      Citations: 47     Fields:    
    43. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Erratum: Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 06 08; 7:11910. PMID: 27273704.
      Citations: 1     Fields:    
    44. Thevenon J, Duplomb L, Phadke S, Eguether T, Saunier A, Avila M, Carmignac V, Bruel AL, St-Onge J, Duffourd Y, Pazour GJ, Franco B, Attie-Bitach T, Masurel-Paulet A, Rivi?re JB, Cormier-Daire V, Philippe C, Faivre L, Thauvin-Robinet C. Autosomal recessive IFT57 hypomorphic mutation cause ciliary transport defect in unclassified oral-facial-digital syndrome with short stature and brachymesophalangia. Clin Genet. 2016 12; 90(6):509-517. PMID: 27060890.
      Citations: 11     Fields:    Translation:Humans
    45. Oud MM, Bonnard C, Mans DA, Altunoglu U, Tohari S, Ng AYJ, Eskin A, Lee H, Rupar CA, de Wagenaar NP, Wu KM, Lahiry P, Pazour GJ, Nelson SF, Hegele RA, Roepman R, Kayserili H, Venkatesh B, Siu VM, Reversade B, Arts HH. A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome. Cilia. 2016; 5:8. PMID: 27069622.
    46. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Mar 22; 7:11103. PMID: 27002738.
      Citations: 29     Fields:    Translation:HumansAnimals
    47. Li Y, Yagi H, Onuoha EO, Damerla RR, Francis R, Furutani Y, Tariq M, King SM, Hendricks G, Cui C, Saydmohammed M, Lee DM, Zahid M, Sami I, Leatherbury L, Pazour GJ, Ware SM, Nakanishi T, Goldmuntz E, Tsang M, Lo CW. DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genet. 2016 Feb; 12(2):e1005821. PMID: 26918822.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    48. Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT. IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):386-91. PMID: 26715756.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    49. San Agustin JT, Pazour GJ, Witman GB. Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm. Mol Biol Cell. 2015 Dec 01; 26(24):4358-72. PMID: 26424803.
      Citations: 49     Fields:    Translation:AnimalsCells
    50. Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015 Aug 15; 142(16):2860. PMID: 26286943.
      Citations: 5     Fields:    
    51. Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT. The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse. J Cell Sci. 2015 Jul 15; 128(14):2541-52. PMID: 26034069.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    52. Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015 Jun 15; 142(12):2194-202. PMID: 26023097.
      Citations: 20     Fields:    Translation:AnimalsCells
    53. Damerla RR, Cui C, Gabriel GC, Liu X, Craige B, Gibbs BC, Francis R, Li Y, Chatterjee B, San Agustin JT, Eguether T, Subramanian R, Witman GB, Michaud JL, Pazour GJ, Lo CW. Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies. Hum Mol Genet. 2015 Jul 15; 24(14):3994-4005. PMID: 25877302.
      Citations: 27     Fields:    Translation:AnimalsCells
    54. Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28; 521(7553):520-4. PMID: 25807483.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    55. May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW. Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. Development. 2015 Feb 01; 142(3):555-66. PMID: 25605782.
      Citations: 41     Fields:    Translation:AnimalsCells
    56. Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV. ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Nat Commun. 2015 Jan 20; 6:6023. PMID: 25599650.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    57. Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell. 2014 Nov 10; 31(3):279-290. PMID: 25446516.
      Citations: 140     Fields:    Translation:AnimalsCells
    58. Awata J, Takada S, Standley C, Lechtreck KF, Bellv? KD, Pazour GJ, Fogarty KE, Witman GB. NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone. J Cell Sci. 2014 Nov 01; 127(Pt 21):4714-27. PMID: 25150219.
      Citations: 63     Fields:    Translation:AnimalsCells
    59. Rao Damerla R, Gabriel GC, Li Y, Klena NT, Liu X, Chen Y, Cui C, Pazour GJ, Lo CW. Role of cilia in structural birth defects: insights from ciliopathy mutant mouse models. Birth Defects Res C Embryo Today. 2014 Jun; 102(2):115-25. PMID: 24975753.
      Citations: 18     Fields:    Translation:AnimalsCells
    60. Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ. Distinct functions for IFT140 and IFT20 in opsin transport. Cytoskeleton (Hoboken). 2014 May; 71(5):302-10. PMID: 24619649.
      Citations: 32     Fields:    Translation:AnimalsCells
    61. Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS. Casein kinase 1d functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell. 2014 May; 25(10):1629-40. PMID: 24648492.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    62. Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014 Feb; 10(2):e1004170. PMID: 24586199.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    63. Finetti F, Patrussi L, Masi G, Onnis A, Galgano D, Lucherini OM, Pazour GJ, Baldari CT. Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system. J Cell Sci. 2014 May 01; 127(Pt 9):1924-37. PMID: 24554435.
      Citations: 67     Fields:    Translation:HumansCells
    64. Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov; 11(11):e1001720. PMID: 24302887.
      Citations: 53     Fields:    Translation:AnimalsCells
    65. Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet. 2013 Sep; 45(9):1004-12. PMID: 23892607.
      Citations: 184     Fields:    Translation:AnimalsCells
    66. Schmidts M, Frank V, Eisenberger T, Al Turki S, Bizet AA, Antony D, Rix S, Decker C, Bachmann N, Bald M, Vinke T, Toenshoff B, Di Donato N, Neuhann T, Hartley JL, Maher ER, Bogdanovic R, Peco-Antic A, Mache C, Hurles ME, Joksic I, Guc-?cekic M, Dobricic J, Brankovic-Magic M, Bolz HJ, Pazour GJ, Beales PL, Scambler PJ, Saunier S, Mitchison HM, Bergmann C. Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat. 2013 May; 34(5):714-24. PMID: 23418020.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    67. Follit JA, Pazour GJ. Analysis of ciliary membrane protein dynamics using SNAP technology. Methods Enzymol. 2013; 524:195-204. PMID: 23498741.
      Citations: 4     Fields:    Translation:AnimalsCells
    68. Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D, Mello CC. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell. 2012 Dec 21; 151(7):1488-500. PMID: 23260138.
      Citations: 128     Fields:    Translation:AnimalsCells
    69. Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF. The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function. J Cell Biol. 2012 Oct 01; 199(1):151-67. PMID: 23027906.
      Citations: 63     Fields:    Translation:AnimalsCells
    70. Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell. 2012 May 15; 22(5):940-51. PMID: 22595669.
      Citations: 134     Fields:    Translation:AnimalsCells
    71. Jonassen JA, SanAgustin J, Baker SP, Pazour GJ. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr; 23(4):641-51. PMID: 22282595.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    72. Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM. A unified taxonomy for ciliary dyneins. Cytoskeleton (Hoboken). 2011 Oct; 68(10):555-65. PMID: 21953912.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    73. Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour GJ, Enikolopov G, Roberts AJ, Terskikh AV. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci. 2011 Jul 06; 31(27):9933-44. PMID: 21734285.
      Citations: 60     Fields:    Translation:AnimalsCells
    74. Keady BT, Le YZ, Pazour GJ. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell. 2011 Apr; 22(7):921-30. PMID: 21307337.
      Citations: 81     Fields:    Translation:AnimalsCells
    75. Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW. Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech. 2011 Jan; 4(1):43-56. PMID: 21045211.
      Citations: 51     Fields:    Translation:AnimalsCells
    76. McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol. 2010 Apr 27; 20(8):731-7. PMID: 20381354.
      Citations: 51     Fields:    Translation:AnimalsCells
    77. Follit JA, Li L, Vucica Y, Pazour GJ. The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence. J Cell Biol. 2010 Jan 11; 188(1):21-8. PMID: 20048263.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    78. Lechtreck KF, Johnson EC, Sakai T, Cochran D, Ballif BA, Rush J, Pazour GJ, Ikebe M, Witman GB. The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol. 2009 Dec 28; 187(7):1117-32. PMID: 20038682.
      Citations: 204     Fields:    Translation:AnimalsCells
    79. Pazour GJ. Immunoprecipitation to examine protein complexes. Methods Cell Biol. 2009; 91:135-42. PMID: 20409785.
      Citations: 1     Fields:    Translation:Animals
    80. SanAgustin JT, Follit JA, Hendricks G, Pazour GJ. Scanning electron microscopy to examine cells and organs. Methods Cell Biol. 2009; 91:81-7. PMID: 20409781.
      Citations: 3     Fields:    Translation:AnimalsCells
    81. Finetti F, Paccani SR, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum JL, Baldari CT. Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol. 2009 Nov; 11(11):1332-9. PMID: 19855387.
      Citations: 183     Fields:    Translation:HumansCells
    82. Clement CA, Kristensen SG, M?llg?rd K, Pazour GJ, Yoder BK, Larsen LA, Christensen ST. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci. 2009 Sep 01; 122(Pt 17):3070-82. PMID: 19654211.
      Citations: 54     Fields:    Translation:AnimalsCells
    83. Follit JA, Xu F, Keady BT, Pazour GJ. Characterization of mouse IFT complex B. Cell Motil Cytoskeleton. 2009 Aug; 66(8):457-68. PMID: 19253336.
      Citations: 99     Fields:    Translation:AnimalsCells
    84. Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec; 4(12):e1000315. PMID: 19112494.
      Citations: 105     Fields:    Translation:AnimalsCells
    85. Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 03; 183(3):377-84. PMID: 18981227.
      Citations: 159     Fields:    Translation:AnimalsCells
    86. Tanner CA, Rompolas P, Patel-King RS, Gorbatyuk O, Wakabayashi K, Pazour GJ, King SM. Three members of the LC8/DYNLL family are required for outer arm dynein motor function. Mol Biol Cell. 2008 Sep; 19(9):3724-34. PMID: 18579685.
      Citations: 10     Fields:    Translation:AnimalsCells
    87. Pazour GJ, Bloodgood RA. Targeting proteins to the ciliary membrane. Curr Top Dev Biol. 2008; 85:115-49. PMID: 19147004.
      Citations: 86     Fields:    Translation:AnimalsCells
    88. Huang K, Diener DR, Mitchell A, Pazour GJ, Witman GB, Rosenbaum JL. Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. J Cell Biol. 2007 Nov 05; 179(3):501-14. PMID: 17984324.
      Citations: 106     Fields:    Translation:AnimalsCells
    89. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Mar?chal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fern?ndez E, Fukuzawa H, Gonz?lez-Ballester D, Gonz?lez-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Ria?o-Pach?n DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Mart?nez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12; 318(5848):245-50. PMID: 17932292.
      Citations: 1056     Fields:    Translation:AnimalsCells
    90. Luby-Phelps K, Fogerty J, Baker SA, Pazour GJ, Besharse JC. Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors. Vision Res. 2008 Feb; 48(3):413-23. PMID: 17931679.
      Citations: 23     Fields:    Translation:AnimalsCells
    91. Palenik B, Grimwood J, Aerts A, Rouz? P, Salamov A, Putnam N, Dupont C, Jorgensen R, Derelle E, Rombauts S, Zhou K, Otillar R, Merchant SS, Podell S, Gaasterland T, Napoli C, Gendler K, Manuell A, Tai V, Vallon O, Piganeau G, Jancek S, Heijde M, Jabbari K, Bowler C, Lohr M, Robbens S, Werner G, Dubchak I, Pazour GJ, Ren Q, Paulsen I, Delwiche C, Schmutz J, Rokhsar D, Van de Peer Y, Moreau H, Grigoriev IV. The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7705-10. PMID: 17460045.
      Citations: 253     Fields:    Translation:AnimalsCells
    92. Hou Y, Qin H, Follit JA, Pazour GJ, Rosenbaum JL, Witman GB. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J Cell Biol. 2007 Feb 26; 176(5):653-65. PMID: 17312020.
      Citations: 127     Fields:    Translation:AnimalsCells
    93. Fliegauf M, Horvath J, von Schnakenburg C, Olbrich H, M?ller D, Thumfart J, Schermer B, Pazour GJ, Neumann HP, Zentgraf H, Benzing T, Omran H. Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol. 2006 Sep; 17(9):2424-33. PMID: 16885411.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    94. Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr. 2006 Aug; 149(2):159-64. PMID: 16887426.
      Citations: 35     Fields:    Translation:Humans
    95. Follit JA, Tuft RA, Fogarty KE, Pazour GJ. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell. 2006 Sep; 17(9):3781-92. PMID: 16775004.
      Citations: 288     Fields:    Translation:HumansAnimalsCells
    96. Yang P, Diener DR, Yang C, Kohno T, Pazour GJ, Dienes JM, Agrin NS, King SM, Sale WS, Kamiya R, Rosenbaum JL, Witman GB. Radial spoke proteins of Chlamydomonas flagella. J Cell Sci. 2006 Mar 15; 119(Pt 6):1165-74. PMID: 16507594.
      Citations: 121     Fields:    Translation:AnimalsCells
    97. Schneider L, Clement CA, Teilmann SC, Pazour GJ, Hoffmann EK, Satir P, Christensen ST. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol. 2005 Oct 25; 15(20):1861-6. PMID: 16243034.
      Citations: 311     Fields:    Translation:AnimalsCells
    98. DiBella LM, Gorbatyuk O, Sakato M, Wakabayashi K, Patel-King RS, Pazour GJ, Witman GB, King SM. Differential light chain assembly influences outer arm dynein motor function. Mol Biol Cell. 2005 Dec; 16(12):5661-74. PMID: 16195342.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    99. Teilmann SC, Byskov AG, Pedersen PA, Wheatley DN, Pazour GJ, Christensen ST. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 2005 Aug; 71(4):444-52. PMID: 15858826.
      Citations: 31     Fields:    Translation:AnimalsCells
    100. Pazour GJ, Agrin N, Leszyk J, Witman GB. Proteomic analysis of a eukaryotic cilium. J Cell Biol. 2005 Jul 04; 170(1):103-13. PMID: 15998802.
      Citations: 497     Fields:    Translation:AnimalsCells
    101. Pazour GJ, Agrin N, Walker BL, Witman GB. Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes. J Med Genet. 2006 Jan; 43(1):62-73. PMID: 15937072.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    102. Pazour GJ. Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol. 2004 Oct; 15(10):2528-36. PMID: 15466257.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    103. Armbrust EV, Berges JA, Bowler C, Green BR, Martinez D, Putnam NH, Zhou S, Allen AE, Apt KE, Bechner M, Brzezinski MA, Chaal BK, Chiovitti A, Davis AK, Demarest MS, Detter JC, Glavina T, Goodstein D, Hadi MZ, Hellsten U, Hildebrand M, Jenkins BD, Jurka J, Kapitonov VV, Kr?ger N, Lau WW, Lane TW, Larimer FW, Lippmeier JC, Lucas S, Medina M, Montsant A, Obornik M, Parker MS, Palenik B, Pazour GJ, Richardson PM, Rynearson TA, Saito MA, Schwartz DC, Thamatrakoln K, Valentin K, Vardi A, Wilkerson FP, Rokhsar DS. The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Science. 2004 Oct 01; 306(5693):79-86. PMID: 15459382.
      Citations: 615     Fields:    Translation:AnimalsCells
    104. Jurczyk A, Gromley A, Redick S, San Agustin J, Witman G, Pazour GJ, Peters DJ, Doxsey S. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol. 2004 Aug 30; 166(5):637-43. PMID: 15337773.
      Citations: 84     Fields:    Translation:AnimalsCells
    105. DiBella LM, Sakato M, Patel-King RS, Pazour GJ, King SM. The LC7 light chains of Chlamydomonas flagellar dyneins interact with components required for both motor assembly and regulation. Mol Biol Cell. 2004 Oct; 15(10):4633-46. PMID: 15304520.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    106. Pazour GJ. Comparative genomics: prediction of the ciliary and basal body proteome. Curr Biol. 2004 Jul 27; 14(14):R575-7. PMID: 15268880.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    107. Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development. 2004 Aug; 131(16):4085-93. PMID: 15269167.
      Citations: 249     Fields:    Translation:AnimalsCells
    108. Hou Y, Pazour GJ, Witman GB. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport. Mol Biol Cell. 2004 Oct; 15(10):4382-94. PMID: 15269286.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    109. Cano DA, Murcia NS, Pazour GJ, Hebrok M. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development. 2004 Jul; 131(14):3457-67. PMID: 15226261.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    110. Wirschell M, Pazour G, Yoda A, Hirono M, Kamiya R, Witman GB. Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase. Mol Biol Cell. 2004 Jun; 15(6):2729-41. PMID: 15064350.
      Citations: 36     Fields:    Translation:AnimalsCells
    111. Casey DM, Inaba K, Pazour GJ, Takada S, Wakabayashi K, Wilkerson CG, Kamiya R, Witman GB. DC3, the 21-kDa subunit of the outer dynein arm-docking complex (ODA-DC), is a novel EF-hand protein important for assembly of both the outer arm and the ODA-DC. Mol Biol Cell. 2003 Sep; 14(9):3650-63. PMID: 12972554.
      Citations: 41     Fields:    Translation:AnimalsCells
    112. Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003 Sep 05; 278(36):34211-8. PMID: 12821668.
      Citations: 73     Fields:    Translation:AnimalsCells
    113. Pazour GJ, Witman GB. The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol. 2003 Feb; 15(1):105-10. PMID: 12517711.
      Citations: 201     Fields:    Translation:HumansAnimalsCells
    114. Besharse JC, Baker SA, Luby-Phelps K, Pazour GJ. Photoreceptor intersegmental transport and retinal degeneration: a conserved pathway common to motile and sensory cilia. Adv Exp Med Biol. 2003; 533:157-64. PMID: 15180260.
      Citations: 30     Fields:    Translation:AnimalsCells
    115. Pazour GJ, Rosenbaum JL. Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol. 2002 Dec; 12(12):551-5. PMID: 12495842.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    116. Purton S, Pazour GJ. Meeting report: Tenth International Conference on the Cell and Molecular Biology of Chlamydomonas. Protist. 2002 Dec; 153(4):325-36. PMID: 12627862.
      Citations:    Fields:    Translation:AnimalsCells
    117. Pazour GJ, Baker SA, Deane JA, Cole DG, Dickert BL, Rosenbaum JL, Witman GB, Besharse JC. The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. J Cell Biol. 2002 Apr 01; 157(1):103-13. PMID: 11916979.
      Citations: 248     Fields:    Translation:AnimalsCells
    118. Pazour GJ, Witman GB. Forward and reverse genetic analysis of microtubule motors in Chlamydomonas. Methods. 2000 Dec; 22(4):285-98. PMID: 11133235.
      Citations: 28     Fields:    Translation:AnimalsCells
    119. Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30; 151(3):709-18. PMID: 11062270.
      Citations: 510     Fields:    Translation:HumansAnimalsCells
    120. Pazour GJ, Koutoulis A, Benashski SE, Dickert BL, Sheng H, Patel-King RS, King SM, Witman GB. LC2, the chlamydomonas homologue of the t complex-encoded protein Tctex2, is essential for outer dynein arm assembly. Mol Biol Cell. 1999 Oct; 10(10):3507-20. PMID: 10512883.
      Citations: 19     Fields:    Translation:AnimalsCells
    121. Horst CJ, Fishkind DJ, Pazour GJ, Witman GB. An insertional mutant of Chlamydomonas reinhardtii with defective microtubule positioning. Cell Motil Cytoskeleton. 1999 Oct; 44(2):143-54. PMID: 10506749.
      Citations: 8     Fields:    Translation:AnimalsCells
    122. Pazour GJ, Dickert BL, Witman GB. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. J Cell Biol. 1999 Feb 08; 144(3):473-81. PMID: 9971742.
      Citations: 214     Fields:    Translation:AnimalsCells
    123. Pazour GJ, Wilkerson CG, Witman GB. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J Cell Biol. 1998 May 18; 141(4):979-92. PMID: 9585416.
      Citations: 193     Fields:    Translation:AnimalsCells
    124. Koutoulis A, Pazour GJ, Wilkerson CG, Inaba K, Sheng H, Takada S, Witman GB. The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex. J Cell Biol. 1997 Jun 02; 137(5):1069-80. PMID: 9166407.
      Citations: 53     Fields:    Translation:AnimalsCells
    125. Pazour GJ, Sineshchekov OA, Witman GB. Mutational analysis of the phototransduction pathway of Chlamydomonas reinhardtii. J Cell Biol. 1995 Oct; 131(2):427-40. PMID: 7593169.
      Citations: 51     Fields:    Translation:AnimalsCells
    126. Wilkerson CG, King SM, Koutoulis A, Pazour GJ, Witman GB. The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly. J Cell Biol. 1995 Apr; 129(1):169-78. PMID: 7698982.
      Citations: 67     Fields:    Translation:AnimalsCells
    127. Moss AG, Pazour GJ, Witman GB. Assay of Chlamydomonas phototaxis. Methods Cell Biol. 1995; 47:281-7. PMID: 7476500.
      Citations: 10     Fields:    Translation:Animals
    128. Pazour GJ, Ta CN, Das A. Constitutive mutations of Agrobacterium tumefaciens transcriptional activator virG. J Bacteriol. 1992 Jun; 174(12):4169-74. PMID: 1597431.
      Citations: 36     Fields:    Translation:Cells
    129. Pazour GJ, Ta CN, Das A. Mutants of Agrobacterium tumefaciens with elevated vir gene expression. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):6941-5. PMID: 1908084.
      Citations: 21     Fields:    Translation:Cells
    130. Pazour GJ, Das A. Characterization of the VirG binding site of Agrobacterium tumefaciens. Nucleic Acids Res. 1990 Dec 11; 18(23):6909-13. PMID: 2263453.
      Citations: 24     Fields:    Translation:Cells
    131. Mersereau M, Pazour GJ, Das A. Efficient transformation of Agrobacterium tumefaciens by electroporation. Gene. 1990 May 31; 90(1):149-51. PMID: 2165971.
      Citations: 77     Fields:    Translation:Cells
    132. Pazour GJ, Das A. virG, an Agrobacterium tumefaciens transcriptional activator, initiates translation at a UUG codon and is a sequence-specific DNA-binding protein. J Bacteriol. 1990 Mar; 172(3):1241-9. PMID: 2307647.
      Citations: 21     Fields:    Translation:Cells
    133. Das A, Pazour GJ. Delineation of the regulatory region sequences of Agrobacterium tumefaciens virB operon. Nucleic Acids Res. 1989 Jun 26; 17(12):4541-50. PMID: 2748333.
      Citations: 21     Fields:    Translation:Cells
    134. Sen P, Pazour GJ, Anderson D, Das A. Cooperative binding of Agrobacterium tumefaciens VirE2 protein to single-stranded DNA. J Bacteriol. 1989 May; 171(5):2573-80. PMID: 2708313.
      Citations: 40     Fields:    Translation:Cells
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