Loading...
Header Logo
Keywords
Last Name
Institution

William R Kobertz PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8861
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentChemical Biology


    Collapse Biography 
    Collapse education and training
    University of California, Berkeley, Berkeley, CA, United StatesB SChemistry
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPH DOrganic Chemistry

    Collapse Overview 
    Collapse overview


    Structure, Function and Modulation of Ion Channels.



    Please visit my laboratory's web page




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bandara HMD, Hua Z, Zhang M, Pauff SM, Miller SC, Davie EAC, Kobertz WR. Palladium-mediated Synthesis of a Near-IR Fluorescent K+ Sensor. J Org Chem. 2017 Jun 30. PMID: 28664732.
      View in: PubMed
    2. Zhang L, Bellve K, Fogarty K, Kobertz WR. Fluorescent Visualization of Cellular Proton Fluxes. Cell Chem Biol. 2016 Dec 22; 23(12):1449-1457. PMID: 27916567.
      View in: PubMed
    3. Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH. Erratum to: Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 2016 Jun; 42(3):371. PMID: 27270492.
      View in: PubMed
    4. Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH. Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 2016 Jun; 42(3):351-70. PMID: 27072680.
      View in: PubMed
    5. Mruk K, Kobertz WR. Bioreactive Tethers. Adv Exp Med Biol. 2015; 869:77-100. PMID: 26381941.
      View in: PubMed
    6. Aromolaran AS, Subramanyam P, Chang DD, Kobertz WR, Colecraft HM. LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms. Cardiovasc Res. 2014 Dec 1; 104(3):501-11. PMID: 25344363.
      View in: PubMed
    7. Malaby HL, Kobertz WR. The middle X residue influences cotranslational N-glycosylation consensus site skipping. Biochemistry. 2014 Aug 5; 53(30):4884-93. PMID: 25029371.
      View in: PubMed
    8. Mruk K, Farley BM, Ritacco AW, Kobertz WR. Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 2014 Jul; 144(1):105-14. PMID: 24935744.
      View in: PubMed
    9. Kobertz WR. Stoichiometry of the cardiac IKs complex. Proc Natl Acad Sci U S A. 2014 Apr 8; 111(14):5065-6. PMID: 24706929.
      View in: PubMed
    10. Malaby HL, Kobertz WR. Molecular determinants of co- and post-translational N-glycosylation of type I transmembrane peptides. Biochem J. 2013 Aug 1; 453(3):427-34. PMID: 23718681.
      View in: PubMed
    11. Hua Z, Kobertz WR. Chemical derivatization and purification of peptide-toxins for probing ion channel complexes. Methods Mol Biol. 2013; 995:19-30. PMID: 23494369.
      View in: PubMed
    12. Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. Structural insights into neuronal K+ channel-calmodulin complexes. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13579-83. PMID: 22869708.
      View in: PubMed
    13. Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3ß-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012 Sep 21; 287(39):32354-66. PMID: 22846993.
      View in: PubMed
    14. O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 2011 Aug; 138(2):271-7. PMID: 21788613.
      View in: PubMed
    15. Bas T, Gao GY, Lvov A, Chandrasekhar KD, Gilmore R, Kobertz WR. Post-translational N-glycosylation of type I transmembrane KCNE1 peptides: implications for membrane protein biogenesis and disease. J Biol Chem. 2011 Aug 12; 286(32):28150-9. PMID: 21676880.
      View in: PubMed
    16. Chandrasekhar KD, Lvov A, Terrenoire C, Gao GY, Kass RS, Kobertz WR. O-glycosylation of the cardiac I(Ks) complex. J Physiol. 2011 Aug 1; 589(Pt 15):3721-30. PMID: 21669976.
      View in: PubMed
    17. Hua Z, Lvov A, Morin TJ, Kobertz WR. Chemical control of metabolically-engineered voltage-gated K+ channels. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5021-4. PMID: 21576020.
      View in: PubMed
    18. Lvov A, Gage SD, Berrios VM, Kobertz WR. Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J Gen Physiol. 2010 Jun; 135(6):607-18. PMID: 20479109.
      View in: PubMed
    19. Ahern CA, Kobertz WR. Chemical tools for K(+) channel biology. Biochemistry. 2009 Jan 27; 48(3):517-26. PMID: 19113860.
      View in: PubMed
    20. Mruk K, Kobertz WR. Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes. PLoS One. 2009; 4(1):e4236. PMID: 19156197.
      View in: PubMed
    21. Morin TJ, Kobertz WR. Tethering chemistry and K+ channels. J Biol Chem. 2008 Sep 12; 283(37):25105-9. PMID: 18541528.
      View in: PubMed
    22. Morin TJ, Kobertz WR. Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1478-82. PMID: 18223154.
      View in: PubMed
    23. Rocheleau JM, Kobertz WR. KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels. J Gen Physiol. 2008 Jan; 131(1):59-68. PMID: 18079560.
      View in: PubMed
    24. Morin TJ, Kobertz WR. A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes. ACS Chem Biol. 2007 Jul 20; 2(7):469-73. PMID: 17602620.
      View in: PubMed
    25. Rocheleau JM, Gage SD, Kobertz WR. Secondary structure of a KCNE cytoplasmic domain. J Gen Physiol. 2006 Dec; 128(6):721-9. PMID: 17130521.
      View in: PubMed
    26. Chandrasekhar KD, Bas T, Kobertz WR. KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem. 2006 Dec 29; 281(52):40015-23. PMID: 17065152.
      View in: PubMed
    27. Gage SD, Kobertz WR. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol. 2004 Dec; 124(6):759-71. PMID: 15572349.
      View in: PubMed
    28. Kobertz WR, Essigmann JM. An Efficient Synthesis of a Furan-Side Furocoumarin Thymidine Monoadduct. J Org Chem. 1997 Apr 18; 62(8):2630-2632. PMID: 11671608.
      View in: PubMed
    29. Kobertz WR, Bertozzi CR, Bednarski MD. C-Glycosyl Aldehydes: Synthons for C-Linked Disaccharides. J Org Chem. 1996 Mar 08; 61(5):1894-1897. PMID: 11667074.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Kobertz's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description