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William R Kobertz PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-8861
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentChemical Biology


    Collapse Biography 
    Collapse education and training
    University of California, Berkeley, Berkeley, CA, United StatesB SChemistry
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPH DOrganic Chemistry

    Collapse Overview 
    Collapse overview


    Structure, Function and Modulation of Ion Channels.



    Please visit my laboratory's web page



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kobertz WR. Want to hear ClC-6 sing? Push your amp to eleven. J Physiol. 2022 05; 600(9):2019-2020. PMID: 35286714.
      Citations:    Fields:    
    2. Zhang L, Zhang M, Bellve K, Fogarty KE, Castro MA, Brauchi S, Kobertz WR. Wheat germ agglutinin-conjugated fluorescent pH sensors for visualizing proton fluxes. J Gen Physiol. 2020 06 01; 152(6). PMID: 31978216.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Kobertz WR. Oddballs in the Shaker family: Kv2-related regulatory subunits. J Gen Physiol. 2018 12 03; 150(12):1599-1601. PMID: 30446508.
      Citations: 1     Fields:    
    4. Velentzas PD, Zhang L, Das G, Chang TK, Nelson C, Kobertz WR, Baehrecke EH. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Dev Cell. 2018 11 05; 47(3):281-293.e4. PMID: 30318245.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Bandara HMD, Hua Z, Zhang M, Pauff SM, Miller SC, Davie EAC, Kobertz WR. Palladium-Mediated Synthesis of a Near-Infrared Fluorescent K+ Sensor. J Org Chem. 2017 08 04; 82(15):8199-8205. PMID: 28664732.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Zhang L, Bellve K, Fogarty K, Kobertz WR. Fluorescent Visualization of Cellular Proton Fluxes. Cell Chem Biol. 2016 Dec 22; 23(12):1449-1457. PMID: 27916567.
      Citations: 6     Fields:    
    7. Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH. Erratum to: Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 2016 06; 42(3):371. PMID: 27270492.
      Citations:    Fields:    
    8. Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH. Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 2016 06; 42(3):351-70. PMID: 27072680.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Mruk K, Kobertz WR. Bioreactive Tethers. Adv Exp Med Biol. 2015; 869:77-100. PMID: 26381941.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Aromolaran AS, Subramanyam P, Chang DD, Kobertz WR, Colecraft HM. LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms. Cardiovasc Res. 2014 Dec 01; 104(3):501-11. PMID: 25344363.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    11. Malaby HL, Kobertz WR. The middle X residue influences cotranslational N-glycosylation consensus site skipping. Biochemistry. 2014 Aug 05; 53(30):4884-93. PMID: 25029371.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    12. Mruk K, Farley BM, Ritacco AW, Kobertz WR. Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 2014 Jul; 144(1):105-14. PMID: 24935744.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    13. Kobertz WR. Stoichiometry of the cardiac IKs complex. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5065-6. PMID: 24706929.
      Citations: 4     Fields:    Translation:HumansAnimals
    14. Malaby HL, Kobertz WR. Molecular determinants of co- and post-translational N-glycosylation of type I transmembrane peptides. Biochem J. 2013 Aug 01; 453(3):427-34. PMID: 23718681.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Hua Z, Kobertz WR. Chemical derivatization and purification of peptide-toxins for probing ion channel complexes. Methods Mol Biol. 2013; 995:19-30. PMID: 23494369.
      Citations:    Fields:    Translation:AnimalsCells
    16. Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. Structural insights into neuronal K+ channel-calmodulin complexes. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13579-83. PMID: 22869708.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012 Sep 21; 287(39):32354-66. PMID: 22846993.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 2011 Aug; 138(2):271-7. PMID: 21788613.
      Citations: 11     Fields:    Translation:AnimalsCells
    19. Bas T, Gao GY, Lvov A, Chandrasekhar KD, Gilmore R, Kobertz WR. Post-translational N-glycosylation of type I transmembrane KCNE1 peptides: implications for membrane protein biogenesis and disease. J Biol Chem. 2011 Aug 12; 286(32):28150-9. PMID: 21676880.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    20. Chandrasekhar KD, Lvov A, Terrenoire C, Gao GY, Kass RS, Kobertz WR. O-glycosylation of the cardiac I(Ks) complex. J Physiol. 2011 Aug 01; 589(Pt 15):3721-30. PMID: 21669976.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Hua Z, Lvov A, Morin TJ, Kobertz WR. Chemical control of metabolically-engineered voltage-gated K+ channels. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5021-4. PMID: 21576020.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Lvov A, Gage SD, Berrios VM, Kobertz WR. Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J Gen Physiol. 2010 Jun; 135(6):607-18. PMID: 20479109.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    23. Ahern CA, Kobertz WR. Chemical tools for K(+) channel biology. Biochemistry. 2009 Jan 27; 48(3):517-26. PMID: 19113860.
      Citations: 5     Fields:    Translation:Humans
    24. Mruk K, Kobertz WR. Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes. PLoS One. 2009; 4(1):e4236. PMID: 19156197.
      Citations: 17     Fields:    Translation:AnimalsCells
    25. Morin TJ, Kobertz WR. Tethering chemistry and K+ channels. J Biol Chem. 2008 Sep 12; 283(37):25105-25109. PMID: 18541528.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    26. Morin TJ, Kobertz WR. Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1478-82. PMID: 18223154.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    27. Rocheleau JM, Kobertz WR. KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels. J Gen Physiol. 2008 Jan; 131(1):59-68. PMID: 18079560.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    28. Morin TJ, Kobertz WR. A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes. ACS Chem Biol. 2007 Jul 20; 2(7):469-73. PMID: 17602620.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Rocheleau JM, Gage SD, Kobertz WR. Secondary structure of a KCNE cytoplasmic domain. J Gen Physiol. 2006 Dec; 128(6):721-9. PMID: 17130521.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Chandrasekhar KD, Bas T, Kobertz WR. KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem. 2006 Dec 29; 281(52):40015-23. PMID: 17065152.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    31. Gage SD, Kobertz WR. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol. 2004 Dec; 124(6):759-71. PMID: 15572349.
      Citations: 28     Fields:    Translation:AnimalsCells
    32. Kobertz WR, Essigmann JM. An Efficient Synthesis of a Furan-Side Furocoumarin Thymidine Monoadduct. J Org Chem. 1997 Apr 18; 62(8):2630-2632. PMID: 11671608.
      Citations:    Fields:    
    33. Kobertz WR, Bertozzi CR, Bednarski MD. C-Glycosyl Aldehydes: Synthons for C-Linked Disaccharides. J Org Chem. 1996 Mar 08; 61(5):1894-1897. PMID: 11667074.
      Citations: 3     Fields:    
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