Header Logo

Gilles E Martin PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentNeurobiology
AddressBrudnick Neuropsychiatric Research Institute
364 Plantation Street, LRB 721
Worcester MA 01605
Phone774-455-4309
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurobiology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentPsychiatry

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBrudnick Neuropsychiatric Research Institute


    Collapse Biography 
    Collapse education and training
    Pierre and Marie Curie University, Paris, , FranceBANeurobiology
    Pierre and Marie Curie University, Paris, , FranceMANeurobiology
    Pierre and Marie Curie University, Paris, , FrancePHDNeurobiology

    Collapse Overview 
    Collapse overview

    EDUCATION

    1988 Université Pierre et Marie Curie (Paris, France) B.A., Neurophysiology
    1989 Université Pierre et Marie Curie (Paris, France) M.A., Neurobiology
    1993 Université Pierre et Marie Curie (Paris, France) Ph.D., Neurobiology

    PROFESSIONAL APPOINTMENTS

    1993 – 1995Postdoctoral Research Associate
    The Max-Planck Institute, Munich, Germany

    1995 – 2001Postdoctoral Research Associate
    Department of Neuropharmacology
    The Scripps Research Institute, San Diego, CA

    2001-2012 Research Assistant Professor
    Department of Psychiatry
    The Brudnick Neuropsychiatric Research Institute
    University of Massachusetts Medical School, Worcester, MA

    2012-present Assistant Professor
    Department of Neurobiology
    The Brudnick Neuropsychiatric Research Institute
    University of Massachusetts Medical School, Worcester, MA

    RESEARCH

    The hallmark of all drugs of abuse, including alcohol, is their powerful addictive properties that linger for years after the last drug intake. It has been proposed that addiction and relapse may both result from altered mnemonic processes caused by changes in the strength of synaptic communication between nerve cells, the main objective of my research.

    Drugs of abuse and synaptic plasticity

    Our main focus is to understand how early alcohol exposure (i.e. binge alcohol drinking) alters the way neurons and interneurons from the nucleus accumbens, a brain region responsible for alcohol rewarding properties, process information relevant to addiction.

    We currently have two ongoing projects.

    1-The first project focuses on the role played by nucleus accumbens cholinergic interneurons in mediating the effects of binge alcohol drinking on accumbens medium spiny neurons synaptic transmission.

    2- The second project seeks to understand how nucleus accumbens medium spiny neurons, the only output neurons driving alcohol-related behavior, compute simultaneously emotional and cognitive information from the prelimbic cortical and basolateral amygdala regions in alcohol-naïve and binge alcohol drinking mice.

    Techniques employed

    To probe these questions at the cellular and behavioral levels, we combine a variety of techniques ranging from in vitro electrophysiological patch-clamp recording techniques in fresh slices of tissue, in vitro and in vivo optogenetic technique, behavioral assays, and in vivo imaging techniques.

     


    Collapse Rotation Projects

    A rotation project focusing on neuronal processing in alcohol-naive and binge alcohol drinking mice is available 



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kolpakova J, van der Vinne V, Giménez-Gómez P, Le T, You IJ, Zhao-Shea R, Velazquez-Marrero C, Tapper AR, Martin GE. Binge Alcohol Drinking Alters Synaptic Processing of Executive and Emotional Information in Core Nucleus Accumbens Medium Spiny Neurons. Front Cell Neurosci. 2021; 15:742207. PMID: 34867199.
      Citations:    
    2. Sweeney CG, Kearney PJ, Fagan RR, Smith LA, Bolden NC, Zhao-Shea R, Rivera IV, Kolpakova J, Xie J, Gao G, Tapper AR, Martin GE, Melikian HE. Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function. Neuropsychopharmacology. 2020 01; 45(2):384-393. PMID: 31277075.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    3. Hasegawa Y, Mao W, Saha S, Gunner G, Kolpakova J, Martin GE, Futai K. Luciferase shRNA Presents off-Target Effects on Voltage-Gated Ion Channels in Mouse Hippocampal Pyramidal Neurons. eNeuro. 2017 Sep-Oct; 4(5). PMID: 29034317.
      Citations: 6     Fields:    Translation:AnimalsCells
    4. Ji X, Saha S, Kolpakova J, Guildford M, Tapper AR, Martin GE. Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways. J Neurosci. 2017 05 31; 37(22):5463-5474. PMID: 28473645.
      Citations: 13     Fields:    Translation:AnimalsCells
    5. Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE. The Sodium Channel ?4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons. Front Cell Neurosci. 2017; 11:17. PMID: 28243192.
      Citations:    
    6. Ji X, Saha S, Martin GE. The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens. Front Synaptic Neurosci. 2015; 7:12. PMID: 26257641.
      Citations:    
    7. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Jul 02; 6:7625. PMID: 26133887.
      Citations: 2     Fields:    
    8. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770. PMID: 25898242.
      Citations: 66     Fields:    Translation:AnimalsCells
    9. Dopico AM, Bukiya AN, Martin GE. Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior. Front Physiol. 2014; 5:466. PMID: 25538625.
      Citations:    
    10. Ji X, Martin GE. BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons. Brain Res. 2014 Nov 07; 1588:1-16. PMID: 25219484.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Velázquez-Marrero C, Seale GE, Treistman SN, Martin GE. Large conductance voltage- and Ca2+-gated potassium (BK) channel ?4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases. J Biol Chem. 2014 Oct 17; 289(42):29261-72. PMID: 25190810.
      Citations: 12     Fields:    Translation:HumansCells
    12. Ji X, Martin GE. New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons. Eur J Neurosci. 2012 Dec; 36(12):3615-27. PMID: 23013293.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Jiang Y, Jakovcevski M, Bharadwaj R, Connor C, Schroeder FA, Lin CL, Straubhaar J, Martin G, Akbarian S. Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci. 2010 May 26; 30(21):7152-67. PMID: 20505083.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    14. Treistman SN, Martin GE. BK Channels: mediators and models for alcohol tolerance. Trends Neurosci. 2009 Dec; 32(12):629-37. PMID: 19781792.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    15. Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul; 33(7):1125-35. PMID: 19389201.
      Citations: 38     Fields:    Translation:HumansAnimals
    16. Martin GE, Hendrickson LM, Penta KL, Friesen RM, Pietrzykowski AZ, Tapper AR, Treistman SN. Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17543-8. PMID: 18981408.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    17. Pietrzykowski AZ, Friesen RM, Martin GE, Puig SI, Nowak CL, Wynne PM, Siegelmann HT, Treistman SN. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron. 2008 Jul 31; 59(2):274-87. PMID: 18667155.
      Citations: 193     Fields:    Translation:HumansAnimalsCells
    18. Martin G, O'Connell RJ, Pietrzykowski AZ, Treistman SN, Ethier MF, Madison JM. Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol. 2008 Jul; 93(7):908-18. PMID: 18403443.
      Citations: 6     Fields:    Translation:HumansCells
    19. Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007 Sep 15; 21(18):2336-46. PMID: 17875667.
      Citations: 23     Fields:    Translation:AnimalsCells
    20. Levine JB, Morrow EM, Berdichevsky Y, Martin GE. BKca channel in autism and mental retardation. Am J Psychiatry. 2007 Jun; 164(6):977-8; author reply 978-9. PMID: 17541064.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Pietrzykowski AZ, Martin GE, Puig SI, Knott TK, Lemos JR, Treistman SN. Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density. J Neurosci. 2004 Sep 22; 24(38):8322-32. PMID: 15385615.
      Citations: 41     Fields:    Translation:AnimalsCells
    22. Martin G, Puig S, Pietrzykowski A, Zadek P, Emery P, Treistman S. Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. J Neurosci. 2004 Jul 21; 24(29):6563-72. PMID: 15269268.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    23. Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. J Pharmacol Exp Ther. 2004 Oct; 311(1):265-73. PMID: 15263066.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Levine JB, Martin G, Wilson A, Treistman SN. Clozapine inhibits isolated N-methyl-D-aspartate receptors expressed in xenopus oocytes in a subunit specific manner. Neurosci Lett. 2003 Aug 07; 346(3):125-8. PMID: 12853100.
      Citations: 2     Fields:    Translation:AnimalsCells
    25. Martin G, Siggins GR. Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens. J Pharmacol Exp Ther. 2002 Sep; 302(3):1135-45. PMID: 12183673.
      Citations: 14     Fields:    Translation:AnimalsCells
    Martin's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (175)
    Explore
    _
    Co-Authors (13)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _