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Marian Walhout PhD

TitleChair and Professor
Endowed TitleMaroun Semaan Chair in Biomedical Research
InstitutionUMass Chan Medical School
DepartmentSystems Biology
AddressUMass Chan Medical School
368 Plantation Street AS5-1051
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentSystems Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentSystems Computational and Quantitative Biology

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Utrecht University, Utrecht, , NetherlandsBSBiology
    Utrecht University, Utrecht, , NetherlandsMSBiology
    Utrecht University, Utrecht, , NetherlandsPHDMedicine

    Collapse Overview 
    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Please contact Dr. Walhout for additional details.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang H, Li X, Song D, Yukselen O, Nanda S, Kucukural A, Li JJ, Garber M, Walhout AJM. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq. Nat Commun. 2025 May 23; 16(1):4785. PMID: 40404656.
      Citations:    
    2. Li X, Zhang H, Hodder T, Wang W, Myers CL, Yilmaz LS, Walhout AJM. Systems-level design principles of metabolic rewiring in an animal. Nature. 2025 Apr; 640(8057):203-211. PMID: 40011787.
      Citations:    
    3. Zhang H, Li X, Tseyang LT, Giese GE, Wang H, Yao B, Zhang J, Neve RL, Shank EA, Spinelli JB, Yilmaz LS, Walhout AJM. A systems-level, semi-quantitative landscape of metabolic flux in C. elegans. Nature. 2025 Apr; 640(8057):194-202. PMID: 40011784.
      Citations:    
    4. Li X, Walhout AJM, Yilmaz LS. Enhanced flux potential analysis links changes in enzyme expression to metabolic flux. Mol Syst Biol. 2025 Apr; 21(4):413-445. PMID: 39962320.
      Citations:    
    5. Lee YU, Fox BW, Guo R, Curtis BJ, Yu J, Kim S, Nanda S, Baumann V, Yilmaz LS, Haynes CM, Schroeder FC, Walhout AJM. Publisher Correction: Host-microbe interactions rewire metabolism in a C.?elegans model of leucine breakdown deficiency. Nat Metab. 2024 Sep; 6(9):1837. PMID: 39147935.
      Citations:    
    6. Lee YU, Fox BW, Guo R, Curtis BJ, Yu J, Kim S, Nanda S, Baumann V, Yilmaz LS, Haynes CM, Schroeder FC, Walhout AJM. Host-microbe interactions rewire metabolism in a C.?elegans model of leucine breakdown deficiency. Nat Metab. 2024 Aug; 6(8):1584-1600. PMID: 39117959.
      Citations:    
    7. Ponomarova O, Starbard AN, Belfi A, Anderson AV, Sundaram MV, Walhout AJ. idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans. Life Sci Alliance. 2024 Oct; 7(10). PMID: 39009411.
      Citations:    
    8. Mirza Z, Walhout AJM, Ambros V. A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans. Cell Rep. 2023 10 31; 42(10):113189. PMID: 37801396.
      Citations:    Fields:    Translation:AnimalsCells
    9. Diot C, Garc?a-Gonz?lez AP, Vieira AF, Walker M, Honeywell M, Doyle H, Ponomarova O, Rivera Y, Na H, Zhang H, Lee M, Olsen CP, Walhout AJM. Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism. Nat Commun. 2022 09 23; 13(1):5595. PMID: 36151093.
      Citations:    
    10. Fox BW, Ponomarova O, Lee YU, Zhang G, Giese GE, Walker M, Roberto NM, Na H, Rodrigues PR, Curtis BJ, Kolodziej AR, Crombie TA, Zdraljevic S, Yilmaz LS, Andersen EC, Schroeder FC, Walhout AJM. C. elegans as a model for inter-individual variation in metabolism. Nature. 2022 07; 607(7919):571-577. PMID: 35794472.
      Citations:    
    11. Zhang J, Li X, Olmedo M, Holdorf AD, Shang Y, Artal-Sanz M, Yilmaz LS, Walhout AJM. A Delicate Balance between Bacterial Iron and Reactive Oxygen Species Supports Optimal C.?elegans Development. Cell Host Microbe. 2019 Sep 11; 26(3):400-411.e3. PMID: 31444089.
      Citations:    
    12. Bulcha JT, Giese GE, Ali MZ, Lee YU, Walker MD, Holdorf AD, Yilmaz LS, Brewster RC, Walhout AJM. A Persistence Detector for Metabolic Network Rewiring in an Animal. Cell Rep. 2019 01 08; 26(2):460-468.e4. PMID: 30625328.
      Citations: 23     Fields:    Translation:AnimalsCells
    13. Walhout AJM. If two deletions don't stop growth, try three. Science. 2018 04 20; 360(6386):269-270. PMID: 29674581.
      Citations: 1     Fields:    
    14. Na H, Ponomarova O, Giese GE, Walhout AJM. C.?elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development. Cell Rep. 2018 03 20; 22(12):3126-3133. PMID: 29562169.
      Citations:    
    15. Garc?a-Gonz?lez AP, Ritter AD, Shrestha S, Andersen EC, Yilmaz LS, Walhout AJM. Bacterial Metabolism Affects the C.?elegans Response to Cancer Chemotherapeutics. Cell. 2017 04 20; 169(3):431-441.e8. PMID: 28431244.
      Citations:    
    16. Zhang J, Holdorf AD, Walhout AJ. C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions. Curr Opin Biotechnol. 2017 08; 46:74-80. PMID: 28189107.
      Citations:    
    17. Yilmaz LS, Walhout AJ. Metabolic network modeling with model organisms. Curr Opin Chem Biol. 2017 02; 36:32-39. PMID: 28088694.
      Citations:    
    18. Fuxman Bass JI, Pons C, Kozlowski L, Reece-Hoyes JS, Shrestha S, Holdorf AD, Mori A, Myers CL, Walhout AJ. A gene-centered C.?elegans protein-DNA interaction network provides a framework for functional predictions. Mol Syst Biol. 2016 Oct 24; 12(10):884. PMID: 27777270.
      Citations:    
    19. Yilmaz LS, Walhout AJ. A Caenorhabditis elegans Genome-Scale Metabolic Network Model. Cell Syst. 2016 05 25; 2(5):297-311. PMID: 27211857.
      Citations:    
    20. Fuxman Bass JI, Sahni N, Shrestha S, Garcia-Gonzalez A, Mori A, Bhat N, Yi S, Hill DE, Vidal M, Walhout AJM. Human gene-centered transcription factor networks for enhancers and disease variants. Cell. 2015 Apr 23; 161(3):661-673. PMID: 25910213.
      Citations:    
    21. Watson E, Yilmaz LS, Walhout AJ. Understanding Metabolic Regulation at a Systems Level: Metabolite Sensing, Mathematical Predictions, and Model Organisms. Annu Rev Genet. 2015; 49:553-75. PMID: 26631516.
      Citations: 20     Fields:    Translation:HumansAnimals
    22. Yilmaz LS, Walhout AJ. Worms, bacteria, and micronutrients: an elegant model of our diet. Trends Genet. 2014 Nov; 30(11):496-503. PMID: 25172020.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    23. Watson E, Walhout AJ. Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy. Trends Endocrinol Metab. 2014 Oct; 25(10):502-8. PMID: 24731597.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    24. Watson E, MacNeil LT, Ritter AD, Yilmaz LS, Rosebrock AP, Caudy AA, Walhout AJ. Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Cell. 2014 Feb 13; 156(4):759-70. PMID: 24529378.
      Citations: 96     Fields:    Translation:AnimalsCells
    25. Walhout AJ. Genetic adaptation to diet preserves longevity. Cell Metab. 2014 Feb 04; 19(2):177-8. PMID: 24506862.
      Citations: 1     Fields:    Translation:Animals
    26. Walhout AJ. What does biologically meaningful mean? A perspective on gene regulatory network validation. Genome Biol. 2011; 12(4):109. PMID: 21489330.
      Citations: 30     Fields:    Translation:Humans
    27. Arda HE, Walhout AJ. Gene-centered regulatory networks. Brief Funct Genomics. 2010 Jan; 9(1):4-12. PMID: 20008400.
      Citations: 17     Fields:    Translation:AnimalsCells
    28. Walhout AJ. Unraveling transcription regulatory networks by protein-DNA and protein-protein interaction mapping. Genome Res. 2006 Dec; 16(12):1445-54. PMID: 17053092.
      Citations: 79     Fields:    Translation:AnimalsCells
    29. Walhout AJ. Networking at the second Interactome Meeting. Expert Rev Proteomics. 2006 Oct; 3(5):477-9. PMID: 17078761.
      Citations:    Fields:    Translation:HumansAnimals
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