Gene Regulatory Networks

"Gene Regulatory Networks" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.

Descriptor ID	D053263
MeSH Number(s)	G05.360.080.689.360
Concept/Terms	Gene Regulatory Networks Gene Regulatory Networks Gene Regulatory Network Network, Gene Regulatory Networks, Gene Regulatory Regulatory Network, Gene Regulatory Networks, Gene Gene Networks Gene Network Network, Gene Networks, Gene Transcriptional Networks Network, Transcriptional Networks, Transcriptional Transcriptional Network Gene Circuits Gene Circuits Circuit, Gene Circuits, Gene Gene Circuit Gene Modules Gene Modules Module, Gene Modules, Gene Gene Module

Below are MeSH descriptors whose meaning is more general than "Gene Regulatory Networks".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Regulatory Sequences, Nucleic Acid [G05.360.080.689]
Gene Regulatory Networks [G05.360.080.689.360]

Below are MeSH descriptors whose meaning is related to "Gene Regulatory Networks".

Below are MeSH descriptors whose meaning is more specific than "Gene Regulatory Networks".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Regulatory Networks" by people in this website by year, and whether "Gene Regulatory Networks" was a major or minor topic of these publications.

Bar chart showing 130 publications over 21 distinct years, with a maximum of 12 publications in 2014 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2007	1	1	2
2008	1	5	6
2009	4	2	6
2010	4	2	6
2011	5	3	8
2012	7	2	9
2013	3	5	8
2014	5	7	12
2015	5	1	6
2016	7	3	10
2017	2	10	12
2018	4	6	10
2019	3	4	7
2020	5	3	8
2021	2	4	6
2022	3	1	4
2023	1	0	1
2024	1	3	4
2025	2	1	3
2026	0	1	1

Below are the most recent publications written about "Gene Regulatory Networks" by people in Profiles.

Xue Y, Su J, Chao Y, Liu L, Lin X, Xiang Y, Ho MK, Su Z, Chen J, Luo Z, Lin C, Luo R, Aurich T, Wu J, Cheung KSC, Huang Y, Ho JWK, Sugimura R. Single-Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids. Adv Sci (Weinh). 2026 Mar; 13(17):e18084.

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Funk MW, Wang Y, Wang L. Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mapping. Nat Commun. 2025 Dec 10; 16(1):11403.

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Liu S, Li L, Zhang F, Garcia-Corral M, Meyer K, Fortuna PRJ, van Sambeek B, Appleton E, Ng AHM, Khoshakhlagh P, Lu YR, Cameron J, Ramirez RN, Chen Y, Wu CT, Huang JY, Tan Y, Chao G, Aach J, Lim ET, Tam JM, Raychaudhuri S, Church GM. Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC. Nat Commun. 2025 Jun 10; 16(1):5136.

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Li X, Zhang H, Hodder T, Wang W, Myers CL, Yilmaz LS, Walhout AJM. Systems-level design principles of metabolic rewiring in an animal. Nature. 2025 04; 640(8057):203-211.

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Deciphering the impact of genomic variation on function. Nature. 2024 09; 633(8028):47-57.

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Gillespie NA, Bell TR, Hearn GC, Hess JL, Tsuang MT, Lyons MJ, Franz CE, Kremen WS, Glatt SJ. A twin analysis to estimate genetic and environmental factors contributing to variation in weighted gene co-expression network module eigengenes. Am J Med Genet B Neuropsychiatr Genet. 2025 Jan; 198(1):e33003.

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Ambros V. MicroRNA-mediated gene regulation and the resilience of multicellular animals. Postepy Biochem. 2024 05 23; 70(1):62-70.

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Johnson JL, Sargsyan D, Neiman EM, Hart A, Stojmirovic A, Kosoy R, Irizar H, Su?rez-Fari?as M, Song WM, Argmann C, Avey S, Shmuel-Galia L, Vierbuchen T, Bongers G, Sun Y, Edelstein L, Perrigoue J, Towne JE, Hall AO, Fitzgerald KA, Hoebe K. Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease. JCI Insight. 2024 02 08; 9(3).

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Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE, Parker SCJ, Powers AC, Brissova M. Genetic risk converges on regulatory networks mediating early type 2 diabetes. Nature. 2023 12; 624(7992):621-629.

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Parisutham V, Chhabra S, Ali MZ, Brewster RC. Tunable transcription factor library for robust quantification of regulatory properties in Escherichia coli. Mol Syst Biol. 2022 06; 18(6):e10843.

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