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David Ayers MD

TitleDistinguished Professor and Chair Emeritus
Endowed TitleArthur M. Pappas, MD, Chair in Orthopedics
InstitutionUMass Chan Medical School
DepartmentOrthopedics and Physical Rehabilitation
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-334-9750
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentOrthopedics and Physical Rehabilitation
    DivisionJoint Replacement

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences


    Collapse Biography 
    Collapse education and training
    Tufts University, Medford, MA, United StatesBSChemistry
    University of Rochester School of Medicine, Rochester, NY, United StatesMDMedicine

    Collapse Overview 
    Collapse overview
    TitlesArthur M. Pappas, Chair, Orthopedics and Physical Rehabilitation, UMass Memorial Medical Center
    Professor of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School
    Clinical InterestsArthritis of the hip and knee, avascular necrosis of the hip, hip and knee replacement
    Practice LocationUMass Memorial Medical Center - Memorial Campus
    119 Belmont Street
    Worcester, MA 01605
    Appointments: 508-334-1955 Fax: 508-334-9762
    Primary HospitalUMass Memorial Medical Center
    Board CertifiedOrthopedic Surgery
    Medical SchoolUniversity of Rochester School of Medicine 1982
    ResidencyStrong Memorial Hospital University of Rochester
    FellowshipNuffield Orthopedic Center, University of Oxford (Joint Replacement)
    Research Interests
    • Radiostereometric (RSA) Imaging of Hip Prostheses and Spine Fusion
    • Total Knee Replacement (TKR) (in collaboration with Prof. P. Franklin)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McClennen T, Carvalho B, Yousef M, Ayers DC. Evaluating Robotic-Assisted Total Knee Arthroplasty Compared to Conventional Methods: A Systematic Review of the Literature in the United States. Int J Med Robot. 2025 Apr; 21(2):e70067. PMID: 40252242.
      Citations:    
    2. Ayers DC, Zheng H, Yang W, Yousef M. The Chitranjan S. Ranawat Award: Factors That Predict Outcome Five Years Following Total Knee Arthroplasty. J Arthroplasty. 2025 Jul; 40(7S1):S12-S19. PMID: 40068725.
      Citations:    
    3. Ayers DC, Zheng H, Yang W, Yousef M. Gender Differences in Pain, Function, and Quality of Life Five Years Following Primary Total Knee Arthroplasty. J Arthroplasty. 2024 Aug; 39(8S1):S100-S107. PMID: 38640963.
      Citations:    
    4. Yousef M, Zheng H, Yang W, Ayers DC. Predictive Factors of Pain and Functional Outcome 5 Years Following Total Hip Arthroplasty: A Prospective Function and Outcomes Research for Comparative Effectiveness in Total Joint Replacement Cohort Study. J Arthroplasty. 2024 Sep; 39(9S1):S105-S111. PMID: 38412901.
      Citations:    
    5. Zheng H, Ash AS, Yang W, Liu SH, Allison J, Ayers DC. Strengthening Quality Measurement to Predict Success for Total Knee Arthroplasty: Results from a Nationally Representative Total Knee Arthroplasty Cohort. J Bone Joint Surg Am. 2024 Apr 17; 106(8):708-715. PMID: 38271493.
      Citations:    Fields:    
    6. Skelly JD, Chen F, Chang SY, Ujjwal RR, Ghimire A, Ayers DC, Song J. Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker. ACS Appl Mater Interfaces. 2023 Aug 09; 15(31):37174-37183. PMID: 37525332.
      Citations:    Fields:    Translation:AnimalsCells
    7. Ayers DC, Yousef M, Yang W, Zheng H. Age-Related Differences in Pain, Function, and Quality of Life Following Primary Total Knee Arthroplasty: Results From a FORCE-TJR (Function and Outcomes Research for Comparative Effectiveness in Total Joint Replacement) Cohort. J Arthroplasty. 2023 07; 38(7 Suppl 2):S169-S176. PMID: 37121490.
      Citations: 1     Fields:    Translation:Humans
    8. Ayers DC, Zheng H, Yang W, Yousef M. How Back Pain Affects Patient Satisfaction After Primary Total Knee Arthroplasty. J Arthroplasty. 2023 06; 38(6S):S103-S108. PMID: 37001625.
      Citations:    Fields:    Translation:Humans
    9. Iovanel G, Ayers D, Zheng H. The Role of Wearable Technology in Measuring and Supporting Patient Outcomes Following Total Joint Replacement: Review of the Literature. JMIR Perioper Med. 2023 Jan 12; 6:e39396. PMID: 36633891.
      Citations:    
    10. Ayers DC, Yousef M, Zheng H, Yang W, Franklin PD. Do Patient Outcomes Vary by Patient Age Following Primary Total Hip Arthroplasty? J Arthroplasty. 2022 07; 37(7S):S510-S516. PMID: 35292339.
      Citations: 3     Fields:    Translation:Humans
    11. Ayers DC, Yousef M, Zheng H, Yang W, Franklin PD. The Prevalence and Predictors of Patient Dissatisfaction 5-years Following Primary Total Knee Arthroplasty. J Arthroplasty. 2022 06; 37(6S):S121-S128. PMID: 35227816.
      Citations: 9     Fields:    Translation:Humans
    12. Yousef MA, Ayers DC. Challenging Diagnosis of Stickler Syndrome in a Patient with Premature Osteoarthritis: A Case Report. JBJS Case Connect. 2021 03 23; 11(1). PMID: 33755637.
      Citations: 1     Fields:    Translation:Humans
    13. Yousef MA, Ayers DC. Multiple Joint Osteonecrosis in a Patient on Long-term Intranasal Corticosteroids. J Am Acad Orthop Surg Glob Res Rev. 2020 11 12; 4(11):e20.00095. PMID: 33986210.
      Citations:    Fields:    Translation:Humans
    14. Zhang B, Skelly JD, Braun BM, Ayers DC, Song J. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing S. aureus periprosthetic infections. ACS Appl Bio Mater. 2020 Sep 21; 3(9):5896-5904. PMID: 34368642.
      Citations: 2     Fields:    
    15. Zhang B, Braun BM, Skelly JD, Ayers DC, Song J. Significant Suppression of Staphylococcus aureus Colonization on Intramedullary Ti6Al4V Implants Surface-Grafted with Vancomycin-Bearing Polymer Brushes. ACS Appl Mater Interfaces. 2019 Aug 14; 11(32):28641-28647. PMID: 31313901.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Zhang B, Skelly JD, Maalouf JR, Ayers DC, Song J. Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents. Sci Transl Med. 2019 07 24; 11(502). PMID: 31341064.
      Citations: 16     Fields:    Translation:HumansAnimals
    17. Makhni EC, Baumhauer JF, Ayers D, Bozic KJ. Patient-Reported Outcome Measures: How and Why They Are Collected. Instr Course Lect. 2019; 68:675-680. PMID: 32032076.
      Citations: 3     Fields:    Translation:Humans
    18. Ayers DC. Tranexamic Acid: Both Efficacious and Safe When Used in Total Hip Arthroplasty to Reduce Blood Transfusions: Commentary on an article by Alexander Dastrup, MD, et al.: "Perioperative Tranexamic Acid Treatment and Risk of Cardiovascular Events or Death After Total Hip Arthroplasty. A Population-Based Cohort Study from National Danish Databases". J Bone Joint Surg Am. 2018 10 17; 100(20):e135. PMID: 30334896.
      Citations:    Fields:    Translation:Humans
    19. Swart E, Kates S, McGee S, Ayers DC. The Case for Comanagement and Care Pathways for Osteoporotic Patients with a Hip Fracture. J Bone Joint Surg Am. 2018 Aug 01; 100(15):1343-1350. PMID: 30063599.
      Citations: 3     Fields:    Translation:Humans
    20. Tan Y, Huang H, Ayers DC, Song J. Modulating Viscoelasticity, Stiffness, and Degradation of Synthetic Cellular Niches via Stoichiometric Tuning of Covalent versus Dynamic Noncovalent Cross-Linking. ACS Cent Sci. 2018 Aug 22; 4(8):971-981. PMID: 30159394.
      Citations:    
    21. Ayers DC. How Common Is Revision for Adverse Reaction to Metal Debris After Total Hip Replacement with a Metal-on-Polyethylene Bearing Surface?: Commentary on an article by Anders Persson, MD, et al.: "Revision for Symptomatic Pseudotumor Following Primary Total Hip Arthroplasty with a Standard Femoral Stem". J Bone Joint Surg Am. 2018 06 06; 100(11):e82. PMID: 29870456.
      Citations:    Fields:    
    22. Zheng H, Rosal MC, Li W, Borg A, Yang W, Ayers DC, Franklin PD. A Web-Based Treatment Decision Support Tool for Patients With Advanced Knee Arthritis: Evaluation of User Interface and Content Design. JMIR Hum Factors. 2018 Apr 30; 5(2):e17. PMID: 29712620.
      Citations:    
    23. Huang H, Tan Y, Ayers DC, Song J. Anionic and Zwitterionic Residues Modulate Stiffness of Photo-Cross-Linked Hydrogels and Cellular Behavior of Encapsulated Chondrocytes. ACS Biomater Sci Eng. 2018 May 14; 4(5):1843-1851. PMID: 33445339.
      Citations: 3     Fields:    
    24. Li W, Ayers DC, Lewis CG, Bowen TR, Allison JJ, Franklin PD. Functional Gain and Pain Relief After Total Joint Replacement According to Obesity Status. J Bone Joint Surg Am. 2017 Jul 19; 99(14):1183-1189. PMID: 28719557.
      Citations: 26     Fields:    Translation:Humans
    25. Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther. 2017 03 11; 8(1):65. PMID: 28283030.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Huang H, Skelly JD, Ayers DC, Song J. Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus. Sci Rep. 2017 02 09; 7:42294. PMID: 28181577.
      Citations: 41     Fields:    Translation:Animals
    27. Ayers DC. Implementation of Patient-reported Outcome Measures in Total Knee Arthroplasty. J Am Acad Orthop Surg. 2017 Feb; 25 Suppl 1:S48-S50. PMID: 27941415.
      Citations: 18     Fields:    Translation:Humans
    28. Franklin PD, Miozzari H, Christofilopoulos P, Hoffmeyer P, Ayers DC, L?bbeke A. Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States. BMC Musculoskelet Disord. 2017 01 11; 18(1):14. PMID: 28077124.
      Citations: 15     Fields:    Translation:Humans
    29. Rolfson O, Wissig S, van Maasakkers L, Stowell C, Ackerman I, Ayers D, Barber T, Benzakour T, Bozic K, Budhiparama N, Caillouette J, Conaghan PG, Dahlberg L, Dunn J, Grady-Benson J, Ibrahim SA, Lewis S, Malchau H, Manzary M, March L, Nassif N, Nelissen R, Smith N, Franklin PD. Defining an International Standard Set of Outcome Measures for Patients With Hip or Knee Osteoarthritis: Consensus of the International Consortium for Health Outcomes Measurement Hip and Knee Osteoarthritis Working Group. Arthritis Care Res (Hoboken). 2016 11; 68(11):1631-1639. PMID: 26881821.
      Citations: 43     Fields:    Translation:Humans
    30. Nguyen UD, Ayers DC, Li W, Harrold LR, Franklin PD. Preoperative Pain and Function: Profiles of Patients Selected for Total Knee Arthroplasty. J Arthroplasty. 2016 11; 31(11):2402-2407.e2. PMID: 27259392.
      Citations: 5     Fields:    Translation:Humans
    31. Huang H, Veien ES, Zhang H, Ayers DC, Song J. Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes. PLoS One. 2016; 11(1):e0148088. PMID: 26815610.
      Citations: 12     Fields:    Translation:AnimalsCells
    32. Ring D, Ayers DC. Editorial Comment: Symposium: Psychosocial Aspects of Musculoskeletal Illness. Clin Orthop Relat Res. 2015 Nov; 473(11):3468-9. PMID: 26338520.
      Citations: 2     Fields:    Translation:Humans
    33. Troelsen A, Greene ME, Ayers DC, Bragdon CR, Malchau H. A Novel Method for Assessment of Polyethylene Liner Wear in Radiopaque Tantalum Acetabular Cups: Clinical Validation in Patients Enrolled in a Randomized Controlled Trial. J Arthroplasty. 2015 Dec; 30(12):2354-9. PMID: 26216229.
      Citations: 1     Fields:    Translation:Humans
    34. Ayers DC, Greene M, Snyder B, Aubin M, Drew J, Bragdon C. Radiostereometric analysis study of tantalum compared with titanium acetabular cups and highly cross-linked compared with conventional liners in young patients undergoing total hip replacement. J Bone Joint Surg Am. 2015 Apr 15; 97(8):627-34. PMID: 25878306.
      Citations: 7     Fields:    Translation:Humans
    35. Ayers DC, Fehring TK, Odum SM, Franklin PD. Using joint registry data from FORCE-TJR to improve the accuracy of risk-adjustment prediction models for thirty-day readmission after total hip replacement and total knee replacement. J Bone Joint Surg Am. 2015 Apr 15; 97(8):668-71. PMID: 25878312.
      Citations: 16     Fields:    Translation:Humans
    36. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 04; 7(8):4890-901. PMID: 25695310.
      Citations: 8     Fields:    Translation:AnimalsCells
    37. LeBlanc KT, Walcott ME, Gaur T, O'Connell SL, Basil K, Tadiri CP, Mason-Savas A, Silva JA, van Wijnen AJ, Stein JL, Stein GS, Ayers DC, Lian JB, Fanning PJ. Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading. J Cell Physiol. 2015 Feb; 230(2):440-8. PMID: 25078095.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    38. Franklin P, Nguyen U, Ayers D, Weissman N. Improving the criteria for appropriateness of total joint replacement surgery: comment on the article by Riddle et Al. Arthritis Rheumatol. 2015 Feb; 67(2):585. PMID: 25371025.
      Citations:    Fields:    Translation:Humans
    39. Dickson JK, Davies A, Rahman S, Sethu C, Smith JR, Orlando A, Ayers D. Dissections of regional lymph nodes for treatment of skin cancer: predicting annual caseloads that will optimise outcomes. Ann R Coll Surg Engl. 2015 Jan; 97(1):52-5. PMID: 25519267.
      Citations:    Fields:    Translation:Humans
    40. Ayers DC, Li W, Harrold L, Allison J, Franklin PD. Preoperative pain and function profiles reflect consistent TKA patient selection among US surgeons. Clin Orthop Relat Res. 2015 Jan; 473(1):76-81. PMID: 24957788.
      Citations: 3     Fields:    Translation:Humans
    41. Zheng H, Li W, Harrold L, Ayers DC, Franklin PD. Web-based Comparative Patient-reported Outcome Feedback to Support Quality Improvement and Comparative Effectiveness Research in Total Joint Replacement. EGEMS (Wash DC). 2014; 2(1):1130. PMID: 25848601.
      Citations:    
    42. Franklin PD, Lewallen D, Bozic K, Hallstrom B, Jiranek W, Ayers DC. Implementation of patient-reported outcome measures in U.S. Total joint replacement registries: rationale, status, and plans. J Bone Joint Surg Am. 2014 Dec 17; 96 Suppl 1:104-9. PMID: 25520425.
      Citations: 44     Fields:    Translation:Humans
    43. Ayers DC, Li W, Harrold L, Allison J, Franklin PD. Reply to the letter to the editor: preoperative pain and function profiles reflect consistent TKA patient selection among US surgeons. Clin Orthop Relat Res. 2015 Jan; 473(1):395-6. PMID: 25367113.
      Citations:    Fields:    Translation:Humans
    44. Harrold L, Pascal S, Lewis C, O'Keefe R, Pellegrini V, Allison J, Ayers D, Franklin P. Patient report improves posthospital discharge event capture in total joint replacement: a novel approach to capturing all posthospital event data. EGEMS (Wash DC). 2014; 2(1):1107. PMID: 25848596.
      Citations:    
    45. Ayers DC, Franklin PD. Joint replacement registries in the United States: a new paradigm. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1567-9. PMID: 25232081.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    46. Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23. PMID: 25099263.
      Citations: 5     Fields:    Translation:Animals
    47. Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52. PMID: 24828749.
      Citations: 8     Fields:    Translation:AnimalsCells
    48. Oatis CA, Li W, DiRusso JM, Hoover MJ, Johnston KK, Butz MK, Phillips AL, Nanovic KM, Cummings EC, Rosal MC, Ayers DC, Franklin PD. Variations in Delivery and Exercise Content of Physical Therapy Rehabilitation Following Total Knee Replacement Surgery: A Cross-Sectional Observation Study. Int J Phys Med Rehabil. 2014; Suppl 5. PMID: 26594649.
      Citations:    
    49. Ayers D, Franklin P. Improve care through outcomes reporting. Mod Healthc. 2013 Dec 02; 43(48):34. PMID: 24450098.
      Citations:    Fields:    Translation:Humans
    50. Ayers DC, Franklin PD, Ring DC. The role of emotional health in functional outcomes after orthopaedic surgery: extending the biopsychosocial model to orthopaedics: AOA critical issues. J Bone Joint Surg Am. 2013 Nov 06; 95(21):e165. PMID: 24196477.
      Citations: 67     Fields:    Translation:Humans
    51. Ayers DC, Zheng H, Franklin PD. Integrating patient-reported outcomes into orthopaedic clinical practice: proof of concept from FORCE-TJR. Clin Orthop Relat Res. 2013 Nov; 471(11):3419-25. PMID: 23925525.
      Citations: 36     Fields:    Translation:Humans
    52. Franklin PD, Harrold L, Ayers DC. Incorporating patient-reported outcomes in total joint arthroplasty registries: challenges and opportunities. Clin Orthop Relat Res. 2013 Nov; 471(11):3482-8. PMID: 23897504.
      Citations: 24     Fields:    Translation:Humans
    53. Ayers DC, Li W, Oatis C, Rosal MC, Franklin PD. Patient-reported outcomes after total knee replacement vary on the basis of preoperative coexisting disease in the lumbar spine and other nonoperatively treated joints: the need for a musculoskeletal comorbidity index. J Bone Joint Surg Am. 2013 Oct 16; 95(20):1833-7. PMID: 24132356.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    54. Ayers DC, Bozic KJ. The importance of outcome measurement in orthopaedics. Clin Orthop Relat Res. 2013 Nov; 471(11):3409-11. PMID: 23934032.
      Citations: 21     Fields:    Translation:Humans
    55. Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7. PMID: 23070662.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    56. Franklin PD, Allison JJ, Ayers DC. Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement. JAMA. 2012 Sep 26; 308(12):1217-8. PMID: 23011710.
      Citations: 45     Fields:    Translation:Humans
    57. Rosal MC, Ayers D, Li W, Oatis C, Borg A, Zheng H, Franklin P. A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement. BMC Musculoskelet Disord. 2011 Oct 07; 12:226. PMID: 21981909.
      Citations: 12     Fields:    Translation:Humans
    58. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95. PMID: 21651998.
      Citations: 6     Fields:    Translation:HumansAnimals
    59. St Pierre CA, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA, Finberg RW. Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles. J Orthop Res. 2010 Nov; 28(11):1418-24. PMID: 20872576.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    60. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11. PMID: 20818999.
      Citations: 15     Fields:    Translation:Animals
    61. Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 2010 Oct 15; 16(20):4978-89. PMID: 20843837.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    62. Franklin PD, Karbassi JA, Li W, Yang W, Ayers DC. Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction. J Arthroplasty. 2010 Sep; 25(6 Suppl):12-6. PMID: 20580191.
      Citations: 49     Fields:    Translation:Humans
    63. Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9. PMID: 19544365.
      Citations: 11     Fields:    Translation:AnimalsCells
    64. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11. PMID: 19350632.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    65. Ayers DC, Hays PL, Drew JM, Eskander MS, Osuch D, Bragdon CR. Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients. J Arthroplasty. 2009 Sep; 24(6 Suppl):9-14. PMID: 19698909.
      Citations: 7     Fields:    Translation:Humans
    66. Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB. Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009 Jul; 220(1):174-81. PMID: 19301255.
      Citations: 34     Fields:    Translation:AnimalsCells
    67. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185.
      Citations: 23     Fields:    Translation:AnimalsCells
    68. Franklin PD, Li W, Ayers DC. The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes. Clin Orthop Relat Res. 2008 Nov; 466(11):2597-604. PMID: 18810570.
      Citations: 82     Fields:    Translation:Humans
    69. J?ger M, Fischer J, Dohrn W, Li X, Ayers DC, Czibere A, Prall WC, Lensing-H?hn S, Krauspe R. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res. 2008 Nov; 26(11):1440-8. PMID: 18404732.
      Citations: 29     Fields:    Translation:HumansCells
    70. J?ger M, Urselmann F, Witte F, Zanger K, Li X, Ayers DC, Krauspe R. Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro. J Biomed Mater Res A. 2008 Jul; 86(1):61-75. PMID: 17941017.
      Citations: 10     Fields:    Translation:HumansCells
    71. Franklin PD, McLaughlin J, Boisvert CB, Li W, Ayers DC. Pilot study of methods to document quantity and variation of independent patient exercise and activity after total knee arthroplasty. J Arthroplasty. 2006 Sep; 21(6 Suppl 2):157-63. PMID: 16950079.
      Citations: 6     Fields:    Translation:Humans
    72. Gaur T, Rich L, Lengner CJ, Hussain S, Trevant B, Ayers D, Stein JL, Bodine PV, Komm BS, Stein GS, Lian JB. Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation. J Cell Physiol. 2006 Jul; 208(1):87-96. PMID: 16575902.
      Citations: 35     Fields:    Translation:AnimalsCells
    73. Ayers DC, Franklin PD, Ploutz-Snyder R, Boisvert CB. Total knee replacement outcome and coexisting physical and emotional illness. Clin Orthop Relat Res. 2005 Nov; 440:157-61. PMID: 16239800.
      Citations: 38     Fields:    Translation:Humans
    74. Werner FW, Ayers DC, Maletsky LP, Rullkoetter PJ. The effect of valgus/varus malalignment on load distribution in total knee replacements. J Biomech. 2005 Feb; 38(2):349-55. PMID: 15598463.
      Citations: 91     Fields:    Translation:Humans
    75. Ayers DC, Franklin PD, Trief PM, Ploutz-Snyder R, Freund D. Psychological attributes of preoperative total joint replacement patients: implications for optimal physical outcome. J Arthroplasty. 2004 Oct; 19(7 Suppl 2):125-30. PMID: 15457431.
      Citations: 49     Fields:    Translation:Humans
    76. Mann KA, Gupta S, Race A, Miller MA, Cleary RJ, Ayers DC. Cement microcracks in thin-mantle regions after in vitro fatigue loading. J Arthroplasty. 2004 Aug; 19(5):605-12. PMID: 15284982.
      Citations: 11     Fields:    Translation:Humans
    77. Mann KA, Damron LA, Race A, Ayers DC. Early cementing does not increase debond energy of grit blasted interfaces. J Orthop Res. 2004 Jul; 22(4):822-7. PMID: 15183440.
      Citations: 2     Fields:    Translation:Humans
    78. Ayers D, Mann K. The importance of proximal cement filling of the calcar region: a biomechanical justification. J Arthroplasty. 2003 Oct; 18(7 Suppl 1):103-9. PMID: 14560418.
      Citations: 6     Fields:    Translation:Humans
    79. Race A, Miller MA, Ayers DC, Mann KA. Early cement damage around a femoral stem is concentrated at the cement/bone interface. J Biomech. 2003 Apr; 36(4):489-96. PMID: 12600339.
      Citations: 16     Fields:    Translation:Humans
    80. Race A, Miller MA, Ayers DC, Cleary RJ, Mann KA. The influence of surface roughness on stem-cement gaps. J Bone Joint Surg Br. 2002 Nov; 84(8):1199-204. PMID: 12463671.
      Citations: 7     Fields:    Translation:Humans
    81. Mann KA, Mocarski R, Damron LA, Allen MJ, Ayers DC. Mixed-mode failure response of the cement-bone interface. J Orthop Res. 2001 Nov; 19(6):1153-61. PMID: 11781018.
      Citations: 11     Fields:    Translation:Humans
    82. Ayers DC. Maximizing ultra high molecular weight polyethylene performance in total knee replacement. Instr Course Lect. 2001; 50:421-9. PMID: 11372343.
      Citations:    Fields:    Translation:HumansPHPublic Health
    83. Mann KA, Allen MJ, Ayers DC. Pre-yield and post-yield shear behavior of the cement-bone interface. J Orthop Res. 1998 May; 16(3):370-8. PMID: 9671933.
      Citations: 3     Fields:    Translation:Humans
    84. Francis CW, Pellegrini VD, Totterman S, Boyd AD, Marder VJ, Liebert KM, Stulberg BN, Ayers DC, Rosenberg A, Kessler C, Johanson NA. Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin. J Bone Joint Surg Am. 1997 Sep; 79(9):1365-72. PMID: 9314399.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    85. Mann KA, Bartel DL, Ayers DC. Influence of stem geometry on mechanics of cemented femoral hip components with a proximal bond. J Orthop Res. 1997 Sep; 15(5):700-6. PMID: 9420599.
      Citations: 6     Fields:    Translation:Humans
    86. Ayers DC. Supracondylar fracture of the distal femur proximal to a total knee replacement. Instr Course Lect. 1997; 46:197-203. PMID: 9143963.
      Citations: 5     Fields:    Translation:Humans
    87. Ayers DC. Polyethylene wear and osteolysis following total knee replacement. Instr Course Lect. 1997; 46:205-13. PMID: 9143964.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    88. Mann KA, Ayers DC, Damron TA. Effects of stem length on mechanics of the femoral hip component after cemented revision. J Orthop Res. 1997 Jan; 15(1):62-8. PMID: 9066528.
      Citations: 3     Fields:    Translation:Humans
    89. Riebel GD, Werner FW, Ayers DC, Bromka J, Murray DG. Early failure of the femoral component in unicompartmental knee arthroplasty. J Arthroplasty. 1995 Oct; 10(5):615-21. PMID: 9273372.
      Citations: 5     Fields:    Translation:Humans
    90. Ayers DC, Murray DG, Duerr DM. Blood salvage after total hip arthroplasty. J Bone Joint Surg Am. 1995 Sep; 77(9):1347-51. PMID: 7673284.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    91. Benedict MR, Ayers DC, Calore JD, Richman RA. Differential distribution of insulin-like growth factors and their binding proteins within bone: relationship to bone mineral density. J Bone Miner Res. 1994 Nov; 9(11):1803-11. PMID: 7532348.
      Citations:    Fields:    Translation:HumansAnimals
    92. Benedict MR, Adiyaman S, Ayers DC, Thomas FD, Calore JD, Dhar V, Richman RA. Dissociation of bone mineral density from age-related decreases in insulin-like growth factor-I and its binding proteins in the male rat. J Gerontol. 1994 Sep; 49(5):B224-30. PMID: 8056934.
      Citations: 2     Fields:    Translation:Animals
    93. Ayers DC, Athanasou NA, Woods CG, Duthie RB. Dialysis arthropathy of the hip. Clin Orthop Relat Res. 1993 May; (290):216-24. PMID: 8472452.
      Citations: 8     Fields:    Translation:Humans
    94. Ayers DC, Pellegrini VD, Evarts CM. Prevention of heterotopic ossification in high-risk patients by radiation therapy. Clin Orthop Relat Res. 1991 Feb; (263):87-93. PMID: 1899641.
      Citations: 10     Fields:    Translation:Humans
    95. Evarts CM, Ayers DC, Puzas JE. Prevention of heterotopic bone formation in high-risk patients by postoperative irradiation. Hip. 1987; 70-83. PMID: 3102408.
      Citations: 1     Fields:    Translation:Humans
    96. Ayers DC, Evarts CM, Parkinson JR. The prevention of heterotopic ossification in high-risk patients by low-dose radiation therapy after total hip arthroplasty. J Bone Joint Surg Am. 1986 Dec; 68(9):1423-30. PMID: 3097023.
      Citations: 23     Fields:    Translation:Humans
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