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Jennifer Wang MD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8414
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBABiochemical Sciences
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesMDMedicine

    Collapse Overview 
    Collapse overview

    Biographical Information


    Academic background



    • A.B., Harvard College, 1991

    • M.D., University of Michigan Medical School, 1995


    Post-graduate training



    • Internal Medicine Residency, Oregon Health Sciences University. 1995 to 1998.

    • Fellowship, Infectious Disease, University of California, San Diego. 1998 to 2002.


    Board certification



    • Diplomate in Internal Medicine, American Board of Internal Medicine, 1998.

    • Diplomate in Infectious Disease, American Board of Internal Medicine, 2001. Recertified 2011.


    Research interests


    My research focuses on the evolution of influenza A virus under the selective pressure of antiviral drugs and antibodies using high-throughput sequencing. My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas and typically develops in children and teenagers. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA. Synonymous mutations at the beginning of the influenza A virus hemagglutinin gene impact experimental fitness. J Mol Biol. 2018 Feb 18. PMID: 29466705.
      View in: PubMed
    2. Li Y, George A, Arnaout S, Wang JP, Abraham GM. Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis? Open Forum Infect Dis. 2018 Mar; 5(3):ofy041. PMID: 29577060.
      View in: PubMed
    3. Qaisar N, Jurczyk A, Wang JP. Potential role of type I interferon in the pathogenic process leading to type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2018 Jan 24. PMID: 29369915.
      View in: PubMed
    4. Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA. Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope. Cell Rep. 2017 Dec 12; 21(11):3243-3255. PMID: 29241550.
      View in: PubMed
    5. Nyalwidhe JO, Gallagher GR, Glenn LM, Morris MA, Vangala P, Jurczyk A, Bortell R, Harlan DM, Wang JP, Nadler JL. Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes. J Endocr Soc. 2017 Oct 01; 1(10):1272-1286. PMID: 29264452.
      View in: PubMed
    6. Ormond L, Liu P, Matuszewski S, Renzette N, Bank C, Zeldovich K, Bolon DN, Kowalik TF, Finberg RW, Jensen JD, Wang JP. The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution. Genome Biol Evol. 2017 Jul 01; 9(7):1913-1924. PMID: 28854600.
      View in: PubMed
    7. Al Hammadi A, Mitchell M, Abraham GM, Wang JP. Recrudescence of Plasmodium falciparum in a Primigravida after Nearly 3 Years of Latency. Am J Trop Med Hyg. 2017 Jan 02. PMID: 28044045.
      View in: PubMed
    8. Tsyrkunou A, Agarwal S, Koirala B, Finberg RW, Nath R, Barton B, Levitz SM, Wang JP, Ram S. Properdin Levels in Individuals with Chemotherapy-Induced Neutropenia. Open Forum Infect Dis. 2017; 4(1):ofw250. PMID: 28480246.
      View in: PubMed
    9. Prachanronarong KL, Özen A, Thayer KM, Yilmaz LS, Zeldovich KB, Bolon DN, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Kurt-Yilmaz N, Schiffer CA. Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase. J Chem Theory Comput. 2016 Dec 13; 12(12):6098-6108. PMID: 27951676.
      View in: PubMed
    10. Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Diabetes. 2017 Jan; 66(1):145-157. PMID: 27999109.
      View in: PubMed
    11. Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, Bolon DN, Zeldovich KB, Kowalik TF, Finberg RW, Wang JP, Jensen JD. An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy. Evolution. 2016 Nov; 70(11):2470-2484. PMID: 27566611.
      View in: PubMed
    12. Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz LS, Caffrey DR, Zeldovich KB, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Bolon DN. A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance. J Mol Biol. 2016 Feb 13; 428(3):538-53. PMID: 26656922.
      View in: PubMed
    13. Gu W, Gallagher GR, Dai W, Liu P, Li R, Trombly MI, Gammon DB, Mello CC, Wang JP, Finberg RW. Influenza A virus preferentially snatches noncoding RNA caps. RNA. 2015 Dec; 21(12):2067-75. PMID: 26428694.
      View in: PubMed
    14. Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW. Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment. Mol Biol Evol. 2015 Jun; 32(6):1519-32. PMID: 25713211.
      View in: PubMed
    15. Loures FV, Röhm M, Lee CK, Santos E, Wang JP, Specht CA, Calich VL, Urban CF, Levitz SM. Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps. PLoS Pathog. 2015 Feb; 11(2):e1004643. PMID: 25659141.
      View in: PubMed
    16. Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses. Antiviral Res. 2015 Apr; 116:34-44. PMID: 25637710.
      View in: PubMed
    17. Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Viral infection of engrafted human islets leads to diabetes. Diabetes. 2015 Apr; 64(4):1358-69. PMID: 25392246.
      View in: PubMed
    18. Narayan K, Waggoner L, Pham ST, Hendricks GL, Waggoner SN, Conlon J, Wang JP, Fitzgerald KA, Kang J. TRIM13 is a negative regulator of MDA5-mediated type I interferon production. J Virol. 2014 Sep; 88(18):10748-57. PMID: 25008915.
      View in: PubMed
    19. Bueter CL, Lee CK, Wang JP, Ostroff GR, Specht CA, Levitz SM. Spectrum and mechanisms of inflammasome activation by chitosan. J Immunol. 2014 Jun 15; 192(12):5943-51. PMID: 24829412.
      View in: PubMed
    20. de Oliveira RB, Wang JP, Ram S, Gazzinelli RT, Finberg RW, Golenbock DT. Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes. MBio. 2014 Mar 18; 5(2):e00949-14. PMID: 24643866.
      View in: PubMed
    21. Foll M, Poh YP, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, Malaspinas AS, Ewing G, Liu P, Wegmann D, Caffrey DR, Zeldovich KB, Bolon DN, Wang JP, Kowalik TF, Schiffer CA, Finberg RW, Jensen JD. Influenza virus drug resistance: a time-sampled population genetics perspective. PLoS Genet. 2014 Feb; 10(2):e1004185. PMID: 24586206.
      View in: PubMed
    22. MacKay CR, Wang JP, Kurt-Jones EA. Dicer's role as an antiviral: still an enigma. Curr Opin Immunol. 2014 Feb; 26:49-55. PMID: 24556400.
      View in: PubMed
    23. Renzette N, Caffrey DR, Zeldovich KB, Liu P, Gallagher GR, Aiello D, Porter AJ, Kurt-Jones EA, Bolon DN, Poh YP, Jensen JD, Schiffer CA, Kowalik TF, Finberg RW, Wang JP. Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro. J Virol. 2014 Jan; 88(1):272-81. PMID: 24155392.
      View in: PubMed
    24. Hendricks GL, Weirich KL, Viswanathan K, Li J, Shriver ZH, Ashour J, Ploegh HL, Kurt-Jones EA, Fygenson DK, Finberg RW, Comolli JC, Wang JP. Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus. J Biol Chem. 2013 Mar 22; 288(12):8061-73. PMID: 23362274.
      View in: PubMed
    25. Wang JP, Zhang L, Madera RF, Woda M, Libraty DH. Plasmacytoid dendritic cell interferon-a production to R-848 stimulation is decreased in male infants. BMC Immunol. 2012 Jul 06; 13:35. PMID: 22769054.
      View in: PubMed
    26. Madera RF, Wang JP, Libraty DH. The combination of early and rapid type I IFN, IL-1a, and IL-1ß production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses. PLoS One. 2011; 6(12):e29412. PMID: 22206014.
      View in: PubMed
    27. Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, Knipe DM, Finberg RW, Kurt-Jones EA. Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol. 2012 Feb; 86(4):2273-81. PMID: 22171256.
      View in: PubMed
    28. Wang JP, Lee CK, Akalin A, Finberg RW, Levitz SM. Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans. PLoS One. 2011; 6(10):e26232. PMID: 22039448.
      View in: PubMed
    29. Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB. LPLUNC1 modulates innate immune responses to Vibrio cholerae. J Infect Dis. 2011 Nov; 204(9):1349-57. PMID: 21900486.
      View in: PubMed
    30. Ramirez-Ortiz ZG, Lee CK, Wang JP, Boon L, Specht CA, Levitz SM. A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus. Cell Host Microbe. 2011 May 19; 9(5):415-24. PMID: 21575912.
      View in: PubMed
    31. Li J, Wang JP, Ghiran I, Cerny A, Szalai AJ, Briles DE, Finberg RW. Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence. Infect Immun. 2010 Jul; 78(7):3129-35. PMID: 20439480.
      View in: PubMed
    32. Wang JP, Cerny A, Asher DR, Kurt-Jones EA, Bronson RT, Finberg RW. MDA5 and MAVS mediate type I interferon responses to coxsackie B virus. J Virol. 2010 Jan; 84(1):254-60. PMID: 19846534.
      View in: PubMed
    33. Huang H, Ostroff GR, Lee CK, Wang JP, Specht CA, Levitz SM. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun. 2009 May; 77(5):1774-81. PMID: 19273561.
      View in: PubMed
    34. Finberg RW, Wang JP. Antiviral responses: different roles for different tolls. Immunity. 2009 Feb 20; 30(2):173-5. PMID: 19239899.
      View in: PubMed
    35. Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ. The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009 Jan; 5(1):e1000277. PMID: 19119424.
      View in: PubMed
    36. Wang JP, Bowen GN, Padden C, Cerny A, Finberg RW, Newburger PE, Kurt-Jones EA. Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood. 2008 Sep 1; 112(5):2028-34. PMID: 18544685.
      View in: PubMed
    37. Dan JM, Wang JP, Lee CK, Levitz SM. Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides. PLoS One. 2008 Apr 30; 3(4):e2046. PMID: 18446192.
      View in: PubMed
    38. Ramirez-Ortiz ZG, Specht CA, Wang JP, Lee CK, Bartholomeu DC, Gazzinelli RT, Levitz SM. Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect Immun. 2008 May; 76(5):2123-9. PMID: 18332208.
      View in: PubMed
    39. Wang JP, Kurt-Jones EA, Finberg RW. Innate immunity to respiratory viruses. Cell Microbiol. 2007 Jul; 9(7):1641-6. PMID: 17506818.
      View in: PubMed
    40. Zhou S, Kurt-Jones EA, Fitzgerald KA, Wang JP, Cerny AM, Chan M, Finberg RW. Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection. J Immunol. 2007 Apr 15; 178(8):5173-81. PMID: 17404300.
      View in: PubMed
    41. Wang JP, Asher DR, Chan M, Kurt-Jones EA, Finberg RW. Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA. J Immunol. 2007 Mar 15; 178(6):3363-7. PMID: 17339429.
      View in: PubMed
    42. Finberg RW, Wang JP, Kurt-Jones EA. Toll like receptors and viruses. Rev Med Virol. 2007 Jan-Feb; 17(1):35-43. PMID: 17146842.
      View in: PubMed
    43. Wang JP, Liu P, Latz E, Golenbock DT, Finberg RW, Libraty DH. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J Immunol. 2006 Nov 15; 177(10):7114-21. PMID: 17082628.
      View in: PubMed
    44. Wang JP, Kurt-Jones EA, Shin OS, Manchak MD, Levin MJ, Finberg RW. Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol. 2005 Oct; 79(20):12658-66. PMID: 16188968.
      View in: PubMed
    45. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 1; 45(2):303-10. PMID: 16002269.
      View in: PubMed
    46. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, Chan M, Knipe DM, Finberg RW. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005 Mar 1; 191(5):746-8. PMID: 15688290.
      View in: PubMed
    47. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1315-20. PMID: 14739339.
      View in: PubMed
    48. Wang JP, Rought SE, Corbeil J, Guiney DG. Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection. FEMS Immunol Med Microbiol. 2003 Nov 28; 39(2):163-72. PMID: 14625100.
      View in: PubMed
    49. Wang JP, Granlund KF, Bozzette SA, Botte MJ, Fierer J. Bursal sporotrichosis: case report and review. Clin Infect Dis. 2000 Aug; 31(2):615-6. PMID: 10987734.
      View in: PubMed
    50. Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL, et al. Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. Diabetes. 1995 Jan; 44(1):90-7. PMID: 7813820.
      View in: PubMed
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