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Christopher M Sassetti PhD

InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North AS8-2051
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology

    Collapse Biography 
    Collapse education and training
    Santa Clara University, Santa Clara, CA, United StatesBSBiology
    University of California, San Francisco, San Francisco, CA, United StatesPHDImmunology

    Collapse Overview 
    Collapse Summary
    Focus: Pathogenesis of tuberculosis
    Collapse overview

    Academic Background:

    Ph.D. University of California, San Francisco, CA. 2000
    Damon Runyon Foundation Scholar (www.damonrunyon.org)


    Howard Hughes Medical Institute Investigator (www.hhmi.org)

    Pathogenesis of tuberculosis

    Christopher Sassetti, Ph.D.

    Mycobacterium tuberculosis is often called the world's most successful pathogen. It is estimated that one third of the human population has been exposed to this organism, and tuberculosis (TB) kills millions every year. Unlike many other bacterial pathogens that cause acute disease and replicate only in a specific host niche, M. tuberculosis can maintain a chronic infection by adapting to many distinctly different host microenvironments. Our lab is focused on defining the survival strategies used by this pathogen in each of these environments.

    To this end, we have developed a variety of new methodologies, which take advantage of both classical genetic tools and genome sequence information. Using these methods, we have identified hundreds of mycobacterial genes that are specifically required for the bacterium to survive under a variety of conditions including acute and chronic infection models. Current work is focused on the characterizing the functional roles played by these virulence systems.

    Specific projects include:

    1)Understanding how nutrients are acquired in vivo. M. tuberculosis resides largely within a membrane bound compartment during infection, and it remains unclear how the bacterium acquires nutrients in this apparently isolated niche. We have identified a series of lipid and carbohydrate import systems that are critical for growth during specific phases of disease. One of these functions as a sterol uptake system, which has lead to the discovery that host cholesterol is an essential carbon source during chronic infection (see figure). We are currently focused on defining the mechanisms by which the bacterium extracts and degrades nutrients, such as cholesterol, from the host cell and understanding why the nutritional habits of the bacterium change so dramatically as disease progresses.


    RFP-labeledM. tuberculosis resides in
    cholesterol rich regions of the cell (green).

    2)Understanding the unique physiology of the mycobacterial cell wall. The cell envelope of M. tuberculosis forms a unique barrier to environmental insults and is essential for the viability of the pathogen. Using a combination of high-throughput genetic, biochemical and structural approaches, we are investigating how phosphosignaling cascades regulate the synthesis of this complex structure.

    Cell Wall Systhesis

    Cell wall synthesis (green) is dysregulated in mycobacterial mutants compared to wild type cells (red).

    3)Metabolic regulation of cell growth and antibiotic sensitivity. The immune system of the host exerts a variety of stresses on the bacterium, which cause it to stop replicating and become refractory to antibiotic treatment. Using a combination of genetic and metabolomic approaches, we are defining the mechanisms by which M. tuberculosis senses these stresses and responds by reducing its growth and metabolic rate.

    To see information on the Sassetti Lab .

    For more information, visit hisHoward Hughes Medical Institute web page.

    Collapse Rotation Projects

    Rotation Projects

    We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in:

    1. Phosphosignaling systems that regulate cell wall synthesis
    2. Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection.

    A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cuthbert BJ, Mendoza J, de Miranda R, Papavinasasundaram K, Sassetti CM, Goulding CW. The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics. 2024 Mar 12; 16(3). PMID: 38425033.
    2. Kurtz SL, Baker RE, Boehm FJ, Lehman CC, Mittereder LR, Khan H, Rossi AP, Gatti DM, Beamer G, Sassetti CM, Elkins KL. Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice. PLoS Pathog. 2024 Mar; 20(3):e1012069. PMID: 38452145.
    3. Blanchard MW, Sigmon JS, Brennan J, Ahulamibe C, Allen ME, Baric RS, Bell TA, Farrington J, Ciavatta D, Cruz Cisneros M, Drushal M, Ferris MT, Fry R, Gaines C, Gu B, Heise MT, Hodges RA, Kafri T, Lynch R, Magnuson T, Miller D, Murphy CEY, Nguyen DT, Noll KE, Proulx M, Sassetti C, Shaw GD, Simon JM, Smith C, Styblo M, Tarantino L, Woo J, Pardo Manuel de Villena F. The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice. bioRxiv. 2024 Mar 03. PMID: 38464063.
    4. de Miranda R, Cuthbert BJ, Klevorn T, Chao A, Mendoza J, Arbing M, Sieminski PJ, Papavinasasundaram K, Abdul-Hafiz S, Chan S, Sassetti CM, Ehrt S, Goulding CW. Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake. PLoS Pathog. 2023 09; 19(9):e1011650. PMID: 37747938.
      Citations:    Fields:    Translation:HumansCells
    5. Martinez N, Smulan LJ, Jameson ML, Smith CM, Cavallo K, Bellerose M, Williams J, West K, Sassetti CM, Singhal A, Kornfeld H. Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes. Nat Commun. 2023 09 20; 14(1):5840. PMID: 37730757.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Meade RK, Long JE, Jinich A, Rhee KY, Ashbrook DG, Williams RW, Sassetti CM, Smith CM. Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent mice. G3 (Bethesda). 2023 08 30; 13(9). PMID: 37405387.
      Citations:    Fields:    Translation:AnimalsCells
    7. Vargas R, Luna MJ, Freschi L, Marin M, Froom R, Murphy KC, Campbell EA, Ioerger TR, Sassetti CM, Farhat MR. Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex. Proc Natl Acad Sci U S A. 2023 07 11; 120(28):e2301394120. PMID: 37399390.
      Citations:    Fields:    Translation:Cells
    8. Lai R, Gong DN, Williams T, Ogunsola AF, Cavallo K, Lindestam Arlehamn CS, Acolatse S, Beamer GL, Ferris MT, Sassetti CM, Lauffenburger DA, Behar SM. Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis. J Clin Invest. 2023 07 03; 133(13). PMID: 37200108.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Nelson SJ, Williams JT, Buglino JA, Nambi S, Lojek LJ, Glickman MS, Ioerger TR, Sassetti CM. The Rip1 intramembrane protease contributes to iron and zinc homeostasis in Mycobacterium tuberculosis. mSphere. 2023 08 24; 8(4):e0038922. PMID: 37318217.
      Citations:    Fields:    Translation:AnimalsCells
    10. Mott D, Yang J, Baer C, Papavinasasundaram K, Sassetti CM, Behar SM. High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis-Infected Macrophages to CD8 T Cells. J Immunol. 2023 05 15; 210(10):1531-1542. PMID: 37000471.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Meade RK, Long JE, Jinich A, Rhee KY, Ashbrook DG, Williams RW, Sassetti CM, Smith CM. Genome-wide screen identifies host loci that modulate M. tuberculosis fitness in immunodivergent mice. bioRxiv. 2023 Mar 06. PMID: 36945430.
    12. Olive AJ, Smith CM, Baer CE, Coers J, Sassetti CM. Mycobacterium tuberculosis Evasion of Guanylate Binding Protein-Mediated Host Defense in Mice Requires the ESX1 Secretion System. Int J Mol Sci. 2023 Feb 02; 24(3). PMID: 36769182.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Wilburn KM, Meade RK, Heckenberg EM, Dockterman J, Coers J, Sassetti CM, Olive AJ, Smith CM. Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice. Infect Immun. 2023 02 16; 91(2):e0051022. PMID: 36629440.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Melzer ES, Kado T, Garc?a-Heredia A, Gupta KR, Meniche X, Morita YS, Sassetti CM, Rego EH, Siegrist MS. Cell Wall Damage Reveals Spatial Flexibility in Peptidoglycan Synthesis and a Nonredundant Role for RodA in Mycobacteria. J Bacteriol. 2022 06 21; 204(6):e0054021. PMID: 35543537.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Koh EI, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A, Zimmerman MD, Aslebagh R, Baker RE, Shaffer SA, Guinn KM, Fitzgerald M, Dartois V, Ehrt S, Hung DT, Ioerger TR, Rubin EJ, Rhee KY, Schnappinger D, Sassetti CM. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2201632119. PMID: 35380903.
      Citations: 10     Fields:    Translation:HumansCells
    16. Shah JA, Warr AJ, Graustein AD, Saha A, Dunstan SJ, Thuong NTT, Thwaites GE, Caws M, Thai PVK, Bang ND, Chau TTH, Khor CC, Li Z, Hibberd M, Chang X, Nguyen FK, Hernandez CA, Jones MA, Sassetti CM, Fitzgerald KA, Musvosvi M, Gela A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk. J Immunol. 2022 03 15; 208(6):1352-1361. PMID: 35217585.
      Citations: 4     Fields:    Translation:HumansCells
    17. Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SW, Lee HN, Kiritsy MC, Bellerose MM, Olive AJ, Murphy KC, Papavinasasundaram K, Boehm FJ, Reames CJ, Meade RK, Hampton BK, Linnertz CL, Shaw GD, Hock P, Bell TA, Ehrt S, Schnappinger D, Pardo-Manuel de Villena F, Ferris MT, Ioerger TR, Sassetti CM. Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. Elife. 2022 02 03; 11. PMID: 35112666.
      Citations: 24     Fields:    Translation:AnimalsCells
    18. Kiritsy MC, McCann K, Mott D, Holland SM, Behar SM, Sassetti CM, Olive AJ. Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells. Elife. 2021 11 02; 10. PMID: 34726598.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    19. Choudhery S, Brown AJ, Akusobi C, Rubin EJ, Sassetti CM, Ioerger TR. Modeling Site-Specific Nucleotide Biases Affecting Himar1 Transposon Insertion Frequencies in TnSeq Data Sets. mSystems. 2021 Oct 26; 6(5):e0087621. PMID: 34665010.
      Citations: 4     Fields:    
    20. Dutta E, DeJesus MA, Ruecker N, Zaveri A, Koh EI, Sassetti CM, Schnappinger D, Ioerger TR. An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence. PLoS One. 2021; 16(10):e0257911. PMID: 34597304.
      Citations:    Fields:    Translation:Cells
    21. Cai Y, Jaecklein E, Mackenzie JS, Papavinasasundaram K, Olive AJ, Chen X, Steyn AJC, Sassetti CM. Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase. PLoS Pathog. 2021 07; 17(7):e1008911. PMID: 34320028.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    22. Mesman AW, Baek SH, Huang CC, Kim YM, Cho SN, Ioerger TR, Barreda NN, Calderon R, Sassetti CM, Murray MB. Characterization of Drug-Resistant Lipid-Dependent Differentially Detectable Mycobacterium tuberculosis. J Clin Med. 2021 Jul 23; 10(15). PMID: 34362035.
    23. Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1). PMID: 33531400.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Shamma F, Papavinasasundaram K, Quintanilla SY, Bandekar A, Sassetti C, Boutte CC. Phosphorylation on PstP Regulates Cell Wall Metabolism and Antibiotic Tolerance in Mycobacterium smegmatis. J Bacteriol. 2021 01 25; 203(4). PMID: 33257524.
      Citations: 4     Fields:    Translation:Cells
    25. Grover S, Engelhart CA, P?rez-Herr?n E, Li W, Abrahams KA, Papavinasasundaram K, Bean JM, Sassetti CM, Mendoza-Losana A, Besra GS, Jackson M, Schnappinger D. Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis. ACS Infect Dis. 2021 01 08; 7(1):141-152. PMID: 33319550.
      Citations: 8     Fields:    Translation:Cells
    26. Khan N, Downey J, Sanz J, Kaufmann E, Blankenhaus B, Pacis A, Pernet E, Ahmed E, Cardoso S, Nijnik A, Mazer B, Sassetti C, Behr MA, Soares MP, Barreiro LB, Divangahi M. M.?tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity. Cell. 2020 10 29; 183(3):752-770.e22. PMID: 33125891.
      Citations: 82     Fields:    Translation:AnimalsCells
    27. Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog. 2020 10; 16(10):e1009000. PMID: 33075106.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    28. Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy CEY, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka MJ, Ferris MT, McMillan L, Manuel de Villena FP. Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics. 2020 12; 216(4):905-930. PMID: 33067325.
      Citations: 32     Fields:    Translation:Animals
    29. Bandekar AC, Subedi S, Ioerger TR, Sassetti CM. Cell-Cycle-Associated Expression Patterns Predict Gene Function in Mycobacteria. Curr Biol. 2020 10 19; 30(20):3961-3971.e6. PMID: 32916109.
      Citations: 5     Fields:    Translation:Cells
    30. Bellerose MM, Proulx MK, Smith CM, Baker RE, Ioerger TR, Sassetti CM. Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis. mSystems. 2020 Aug 04; 5(4). PMID: 32753506.
      Citations: 24     Fields:    
    31. Lee J, Boyce S, Powers J, Baer C, Sassetti CM, Behar SM. CD11cHi?monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis. PLoS Pathog. 2020 06; 16(6):e1008621. PMID: 32544188.
      Citations: 17     Fields:    Translation:AnimalsCells
    32. Lovewell RR, Baer CE, Mishra BB, Smith CM, Sassetti CM. Granulocytes act as a niche for Mycobacterium tuberculosis growth. Mucosal Immunol. 2021 01; 14(1):229-241. PMID: 32483198.
      Citations: 27     Fields:    Translation:AnimalsCells
    33. Winchell CG, Mishra BB, Phuah JY, Saqib M, Nelson SJ, Maiello P, Causgrove CM, Ameel CL, Stein B, Borish HJ, White AG, Klein EC, Zimmerman MD, Dartois V, Lin PL, Sassetti CM, Flynn JL. Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques. Front Immunol. 2020; 11:891. PMID: 32477361.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Behar SM, Sassetti C. Tuberculosis vaccine finds an improved route. Nature. 2020 01; 577(7788):31-32. PMID: 31894152.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    35. Poweleit N, Czudnochowski N, Nakagawa R, Trinidad DD, Murphy KC, Sassetti CM, Rosenberg OS. The structure of the endogenous ESX-3 secretion system. Elife. 2019 12 30; 8. PMID: 31886769.
      Citations: 28     Fields:    Translation:Cells
    36. Smith CM, Proulx MK, Lai R, Kiritsy MC, Bell TA, Hock P, Pardo-Manuel de Villena F, Ferris MT, Baker RE, Behar SM, Sassetti CM. Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice. mBio. 2019 11 26; 10(6). PMID: 31772048.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    37. Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR. Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression. BMC Bioinformatics. 2019 Nov 21; 20(1):603. PMID: 31752678.
      Citations: 10     Fields:    Translation:AnimalsCells
    38. Bellerose MM, Baek SH, Huang CC, Moss CE, Koh EI, Proulx MK, Smith CM, Baker RE, Lee JS, Eum S, Shin SJ, Cho SN, Murray M, Sassetti CM. Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy. mBio. 2019 07 30; 10(4). PMID: 31363023.
      Citations: 57     Fields:    Translation:Cells
    39. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78. PMID: 31217586.
      Citations: 63     Fields:    Translation:Cells
    40. Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM. Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research. Am J Respir Crit Care Med. 2019 04 15; 199(8):947-951. PMID: 30428263.
      Citations: 40     Fields:    Translation:HumansCells
    41. Murphy KC, Nelson SJ, Nambi S, Papavinasasundaram K, Baer CE, Sassetti CM. ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes. mBio. 2018 12 11; 9(6). PMID: 30538179.
      Citations: 54     Fields:    Translation:Cells
    42. Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150. PMID: 30442645.
      Citations: 20     Fields:    Translation:AnimalsCells
    43. Rittershaus ESC, Baek SH, Krieger IV, Nelson SJ, Cheng YS, Nambi S, Baker RE, Leszyk JD, Shaffer SA, Sacchettini JC, Sassetti CM. A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis. Cell Chem Biol. 2018 12 20; 25(12):1495-1505.e3. PMID: 30318462.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    44. Olive AJ, Sassetti CM. Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis. Front Immunol. 2018; 9:2094. PMID: 30258448.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    45. Smith CM, Sassetti CM. Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery? Trends Microbiol. 2018 11; 26(11):892-895. PMID: 30166218.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    46. Olive AJ, Smith CM, Kiritsy MC, Sassetti CM. The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection. J Immunol. 2018 09 15; 201(6):1705-1716. PMID: 30061198.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    47. K?ster S, Klevorn T, Papavinasasundaram K, Sassetti CM, Portal-Celhay C, Philips JA. Consequence of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine. 2018 02 08; 36(7):939-944. PMID: 29343411.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB. A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization. Curr Biol. 2017 Nov 06; 27(21):3367-3374.e7. PMID: 29107550.
      Citations: 31     Fields:    Translation:Cells
    49. Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. mBio. 2017 10 24; 8(5). PMID: 29066547.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    50. K?ster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby SJ, Mittal E, Park HS, Jones V, Hsu FF, Jackson M, Sassetti CM, Philips JA. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8711-E8720. PMID: 28973896.
      Citations: 93     Fields:    Translation:AnimalsCells
    51. Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Molecular and functional analysis of the mce4 operon in Mycobacterium smegmatis. Environ Microbiol. 2017 09; 19(9):3689-3699. PMID: 28752922.
      Citations: 12     Fields:    Translation:Cells
    52. DeJesus MA, Nambi S, Smith CM, Baker RE, Sassetti CM, Ioerger TR. Statistical analysis of genetic interactions in Tn-Seq data. Nucleic Acids Res. 2017 Jun 20; 45(11):e93. PMID: 28334803.
      Citations: 17     Fields:    Translation:Cells
    53. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15; 2:17072. PMID: 28504669.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    54. Garc?a-Fern?ndez J, Papavinasasundaram K, Gal?n B, Sassetti CM, Garc?a JL. Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis. Environ Microbiol. 2017 07; 19(7):2564-2576. PMID: 28447386.
      Citations: 6     Fields:    Translation:Cells
    55. Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol. 2017 Feb 06; 2:16274. PMID: 28165460.
      Citations: 191     Fields:    Translation:Cells
    56. DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. mBio. 2017 01 17; 8(1). PMID: 28096490.
      Citations: 278     Fields:    Translation:Cells
    57. Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM. Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. mBio. 2016 09 20; 7(5). PMID: 27651361.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    58. Prigozhin DM, Papavinasasundaram KG, Baer CE, Murphy KC, Moskaleva A, Chen TY, Alber T, Sassetti CM. Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site. J Biol Chem. 2016 10 28; 291(44):22961-22969. PMID: 27601474.
      Citations: 12     Fields:    Translation:HumansCells
    59. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 2016 06 15; 5. PMID: 27304077.
      Citations: 45     Fields:    Translation:Cells
    60. Cai Y, Yang Q, Liao M, Wang H, Zhang C, Nambi S, Wang W, Zhang M, Wu J, Deng G, Deng Q, Liu H, Zhou B, Jin Q, Feng CG, Sassetti CM, Wang F, Chen X. xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation. Oncotarget. 2016 May 24; 7(21):31001-13. PMID: 27129162.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    61. Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS. Spatially distinct and metabolically active membrane domain in mycobacteria. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5400-5. PMID: 27114527.
      Citations: 37     Fields:    Translation:Cells
    62. Patel SJ, Lewis BE, Long JE, Nambi S, Sassetti CM, Stemmler TL, Arg?ello JM. Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases. J Biol Chem. 2016 May 27; 291(22):11529-39. PMID: 27022029.
      Citations: 22     Fields:    Translation:Cells
    63. Olive AJ, Sassetti CM. Metabolic crosstalk between host and pathogen: sensing, adapting and competing. Nat Rev Microbiol. 2016 Apr; 14(4):221-34. PMID: 26949049.
      Citations: 97     Fields:    Translation:HumansCells
    64. Lovewell RR, Sassetti CM, VanderVen BC. Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection. Curr Opin Microbiol. 2016 Feb; 29:30-6. PMID: 26544033.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    65. DeJesus MA, Ambadipudi C, Baker R, Sassetti C, Ioerger TR. TRANSIT--A Software Tool for Himar1 TnSeq Analysis. PLoS Comput Biol. 2015 Oct; 11(10):e1004401. PMID: 26447887.
      Citations: 103     Fields:    Translation:Cells
    66. Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13087-92. PMID: 26438867.
      Citations: 48     Fields:    Translation:Cells
    67. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871.
      Citations: 51     Fields:    Translation:Cells
    68. Nambi S, Long JE, Mishra BB, Baker R, Murphy KC, Olive AJ, Nguyen HP, Shaffer SA, Sassetti CM. The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems. Cell Host Microbe. 2015 Jun 10; 17(6):829-37. PMID: 26067605.
      Citations: 67     Fields:    Translation:AnimalsCells
    69. Feltcher ME, Gunawardena HP, Zulauf KE, Malik S, Griffin JE, Sassetti CM, Chen X, Braunstein M. Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall. Mol Cell Proteomics. 2015 Jun; 14(6):1501-16. PMID: 25813378.
      Citations: 22     Fields:    Translation:Cells
    70. Baer CE, Rubin EJ, Sassetti CM. New insights into TB physiology suggest untapped therapeutic opportunities. Immunol Rev. 2015 Mar; 264(1):327-43. PMID: 25703570.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    71. Olive AJ, Sassetti CM. New TB treatments hiding in plain sight. EMBO Mol Med. 2015 Feb; 7(2):125-6. PMID: 25535253.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    72. Murphy KC, Papavinasasundaram K, Sassetti CM. Mycobacterial recombineering. Methods Mol Biol. 2015; 1285:177-99. PMID: 25779316.
      Citations: 45     Fields:    Translation:Cells
    73. Long JE, DeJesus M, Ward D, Baker RE, Ioerger T, Sassetti CM. Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling. Methods Mol Biol. 2015; 1279:79-95. PMID: 25636614.
      Citations: 47     Fields:    Translation:Cells
    74. Zhang G, Zhou B, Li S, Yue J, Yang H, Wen Y, Zhan S, Wang W, Liao M, Zhang M, Zeng G, Feng CG, Sassetti CM, Chen X. Allele-specific induction of IL-1? expression by C/EBP? and PU.1 contributes to increased tuberculosis susceptibility. PLoS Pathog. 2014 Oct; 10(10):e1004426. PMID: 25329476.
      Citations: 59     Fields:    Translation:HumansCells
    75. Trauner A, Sassetti CM, Rubin EJ. Genetic Strategies for Identifying New Drug Targets. Microbiol Spectr. 2014 Aug; 2(4):MGM2-0030-2013. PMID: 26104208.
      Citations: 2     Fields:    Translation:Cells
    76. Baer CE, Iavarone AT, Alber T, Sassetti CM. Biochemical and spatial coincidence in the provisional Ser/Thr protein kinase interaction network of Mycobacterium tuberculosis. J Biol Chem. 2014 Jul 25; 289(30):20422-33. PMID: 24928517.
      Citations: 32     Fields:    Translation:Cells
    77. Meniche X, Otten R, Siegrist MS, Baer CE, Murphy KC, Bertozzi CR, Sassetti CM. Subpolar addition of new cell wall is directed by DivIVA in mycobacteria. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3243-51. PMID: 25049412.
      Citations: 93     Fields:    Translation:Cells
    78. Behar SM, Sassetti CM. Immunology: Fixing the odds against tuberculosis. Nature. 2014 Jul 03; 511(7507):39-40. PMID: 24990740.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    79. Raimunda D, Long JE, Padilla-Benavides T, Sassetti CM, Arg?ello JM. Differential roles for the Co(2+) /Ni(2+) transporting ATPases, CtpD and CtpJ, in Mycobacterium tuberculosis virulence. Mol Microbiol. 2014 Jan; 91(1):185-97. PMID: 24255990.
      Citations: 34     Fields:    Translation:AnimalsCells
    80. Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One. 2013; 8(9):e75245. PMID: 24086479.
      Citations: 112     Fields:    Translation:Cells
    81. Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog. 2013; 9(7):e1003419. PMID: 23853579.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    82. Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12; 13(6):643-51. PMID: 23768489.
      Citations: 140     Fields:    Translation:AnimalsCells
    83. O'Sullivan BP, Sassetti CM. Infection control in cystic fibrosis: share and share alike. Lancet. 2013 May 04; 381(9877):1517-9. PMID: 23541536.
      Citations: 2     Fields:    Translation:HumansCells
    84. Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Arg?ello JM. A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria. J Biol Chem. 2013 Apr 19; 288(16):11334-47. PMID: 23482562.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    85. DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15; 29(6):695-703. PMID: 23361328.
      Citations: 45     Fields:    Translation:Cells
    86. Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?. Nat Immunol. 2013 Jan; 14(1):52-60. PMID: 23160153.
      Citations: 303     Fields:    Translation:HumansAnimalsCells
    87. Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog. 2012 Sep; 8(9):e1002946. PMID: 23028335.
      Citations: 146     Fields:    Translation:Cells
    88. Lee HJ, Lang PT, Fortune SM, Sassetti CM, Alber T. Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Nat Struct Mol Biol. 2012 Aug; 19(8):811-8. PMID: 22773105.
      Citations: 34     Fields:    Translation:Cells
    89. Raimunda D, Long JE, Sassetti CM, Arg?ello JM. Role in metal homeostasis of CtpD, a Co?? transporting P(1B4)-ATPase of Mycobacterium smegmatis. Mol Microbiol. 2012 Jun; 84(6):1139-49. PMID: 22591178.
      Citations: 28     Fields:    Translation:Cells
    90. Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol. 2012 Feb 24; 19(2):218-27. PMID: 22365605.
      Citations: 154     Fields:    Translation:AnimalsCells
    91. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24; 5(208):ra7. PMID: 22275220.
      Citations: 91     Fields:    Translation:Cells
    92. Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011 Sep; 7(9):e1002251. PMID: 21980284.
      Citations: 543     Fields:    Translation:AnimalsCells
    93. Baek SH, Li AH, Sassetti CM. Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol. 2011 May; 9(5):e1001065. PMID: 21629732.
      Citations: 146     Fields:    Translation:AnimalsCells
    94. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. 2011 Mar 31; 6(3):e18367. PMID: 21483832.
      Citations: 73     Fields:    Translation:AnimalsCells
    95. Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4176-81. PMID: 21368134.
      Citations: 90     Fields:    Translation:Cells
    96. Fong SS, Rearden P, Kanchagar C, Sassetti C, Trevejo J, Brereton RG. Automated peak detection and matching algorithm for gas chromatography-differential mobility spectrometry. Anal Chem. 2011 Mar 01; 83(5):1537-46. PMID: 21204557.
      Citations: 8     Fields:    Translation:Cells
    97. Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nat Genet. 2010 Jun; 42(6):476-8. PMID: 20502489.
      Citations: 2     Fields:    Translation:HumansCells
    98. Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol. 2010 Jul; 192(14):3645-53. PMID: 20472797.
      Citations: 126     Fields:    Translation:Cells
    99. Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis. 2009 Sep 01; 200(5):774-82. PMID: 19622047.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    100. Coulombe F, Divangahi M, Veyrier F, de L?s?leuc L, Gleason JL, Yang Y, Kelliher MA, Pandey AK, Sassetti CM, Reed MB, Behr MA. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med. 2009 Aug 03; 206(8):1709-16. PMID: 19581406.
      Citations: 95     Fields:    Translation:AnimalsCells
    101. Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM, Kelliher MA. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog. 2009 Jul; 5(7):e1000500. PMID: 19578435.
      Citations: 143     Fields:    Translation:AnimalsCells
    102. Chang JC, Miner MD, Pandey AK, Gill WP, Harik NS, Sassetti CM, Sherman DR. igr Genes and Mycobacterium tuberculosis cholesterol metabolism. J Bacteriol. 2009 Aug; 191(16):5232-9. PMID: 19542286.
      Citations: 81     Fields:    Translation:AnimalsCells
    103. Miner MD, Chang JC, Pandey AK, Sassetti CM, Sherman DR. Role of cholesterol in Mycobacterium tuberculosis infection. Indian J Exp Biol. 2009 Jun; 47(6):407-11. PMID: 19634704.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    104. Sassetti CM. Inducible expression systems for mycobacteria. Methods Mol Biol. 2009; 465:255-64. PMID: 20560072.
      Citations: 2     Fields:    Translation:Cells
    105. Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb). 2009 Jan; 89(1):12-6. PMID: 18801704.
      Citations: 44     Fields:    Translation:AnimalsCells
    106. Pandey AK, Sassetti CM. Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4376-80. PMID: 18334639.
      Citations: 526     Fields:    Translation:Cells
    107. Murry JP, Sassetti CM, Lane JM, Xie Z, Rubin EJ. Transposon site hybridization in Mycobacterium tuberculosis. Methods Mol Biol. 2008; 416:45-59. PMID: 18392960.
      Citations: 24     Fields:    Translation:Cells
    108. Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J Biol Chem. 2007 Dec 14; 282(50):36223-9. PMID: 17947236.
      Citations: 103     Fields:    Translation:AnimalsCells
    109. Sassetti CM, Rubin EJ. The open book of infectious diseases. Nat Med. 2007 Mar; 13(3):279-80. PMID: 17342136.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    110. Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11760-5. PMID: 16868085.
      Citations: 93     Fields:    Translation:AnimalsCells
    111. Murry J, Sassetti CM, Moreira J, Lane J, Rubin EJ. A new site-specific integration system for mycobacteria. Tuberculosis (Edinb). 2005 Sep-Nov; 85(5-6):317-23. PMID: 16256438.
      Citations: 11     Fields:    Translation:Cells
    112. Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10676-81. PMID: 16030141.
      Citations: 193     Fields:    Translation:AnimalsCells
    113. Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul; 53(1):275-82. PMID: 15225321.
      Citations: 57     Fields:    Translation:Cells
    114. Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12989-94. PMID: 14569030.
      Citations: 622     Fields:    Translation:AnimalsCells
    115. Fieger CB, Sassetti CM, Rosen SD. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem. 2003 Jul 25; 278(30):27390-8. PMID: 12889478.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    116. Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 2003 Apr; 48(1):77-84. PMID: 12657046.
      Citations: 1141     Fields:    Translation:Cells
    117. Sassetti CM, Boyd DH, Rubin EJ. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12712-7. PMID: 11606763.
      Citations: 274     Fields:    Translation:Cells
    118. Sassetti C, Van Zante A, Rosen SD. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. J Biol Chem. 2000 Mar 24; 275(12):9001-10. PMID: 10722749.
      Citations: 32     Fields:    Translation:HumansCells
    119. Papadopoulos EJ, Sassetti C, Saeki H, Yamada N, Kawamura T, Fitzhugh DJ, Saraf MA, Schall T, Blauvelt A, Rosen SD, Hwang ST. Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 1999 08; 29(8):2551-9. PMID: 10458770.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    120. Sassetti C, Tangemann K, Singer MS, Kershaw DB, Rosen SD. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exp Med. 1998 Jun 15; 187(12):1965-75. PMID: 9625756.
      Citations: 72     Fields:    Translation:HumansCells
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