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Arthur M Mercurio PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-8676
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Rutgers University- New Brunswick, New Brunswick, NJ, United StatesBSBiochemistry
    Columbia University, New York, NY, United StatesMABiology
    Columbia University, New York, NY, United StatesMPHILBiology
    Columbia University, New York, NY, United StatesPHDCell Biology

    Collapse Overview 
    Collapse overview

    ACADEMIC BACKGROUND

    Arthur Mercurio received his B.S. in Biochemistry from Rutgers University in 1975 and a Ph.D. in Cell Biology from Columbia University in 1981. He was a Postdoctoral Fellow in the Center for Cancer Research at M.I.T. from 1981-1985. In 1986, he joined the faculty at Harvard Medical School and the Beth Israel Deaconess Medical Center. He was the Director of the Division of Cancer Biology and Angiogenesis at BIDMC until 2005 when he became Vice Chairman of the Department of Cancer Biology at the University of Massachusetts Medical School and Interim Chair in 2010. Dr. Mercurio is a recipient of the American Cancer Society Junior Faculty and Faculty Research Awards, and he was an Honorary Professor at the University of Copenhagen.

    TRANSLATIONAL CANCER CELL BIOLOGY

    We are interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors. Our research projects emphasize molecular cell biology but they derive from the analysis and clinical behavior of carcinomas. Our goal is to identify mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and to exploit these mechanisms to improve prognosis and therapy. Ongoing projects in the lab include studies on:

    Regulation and Function of Integrins

    The lab has a long-standing interest in the a6 integrins (a6ß1 and a6ß4). These integrins have pivotal roles in the biology of carcinomas as demonstrated by our work and that of others. The a6ß1 integrin (CD49f) is an established marker for many populations of tumor stem/initiating cells including those present in breast and prostate carcinomas and it is essential for the function of these cells. Current studies on a6ß1 involve its regulation by Neuropilin-2 and VEGF signaling (see below) and elucidating the mechanism by which it contributes to the function of tumor stem/initiating cells. We are continuing our studies on the integrin a6ß4 (referred to as ‘ß4 integrin’) in this context. The primary function of this integrin, which is expressed on the basal surface of most epithelia, is to anchor the epithelium to laminins in the basement membrane and maintain epithelial integrity. Our lab pioneered studies that established that this integrin also plays a significant role in functions associated with carcinoma progression, including migration, invasion and survival, and that it is often expressed in poorly differentiated carcinomas. What has emerged from these studies is the premise that the ß4 integrin plays a dominant role in progression through its ability to influence other receptors and key signaling pathways. Given these findings and their implications, current projects are assessing mechanisms that regulate ß4 integrin gene expression in human cancers, the role of specific microRNAs in regulating ß4 integrin function and signaling and the contribution of ß4 integrin to epithelial biology and carcinoma progression using mouse models of specific carcinomas.

    VEGF Function and Signaling in Carcinoma Cells

    This project is based on the hypothesis that VEGF receptors expressed on carcinoma cells mediate VEGF signaling and that VEGF signaling in epithelial cells contributes to tumor initiation. This hypothesis challenges the notion that the function of VEGF in cancer is limited to angiogenesis and that therapeutic approaches based on the inhibition of VEGF and its receptors target only angiogenesis. We are most interested in a specific class of VEGF receptors termed the neuropilins (NRPs). NRP1 and NRP2 were identified initially as neuronal receptors for semaphorins, but they also function as VEGF receptors on tumor cells. We are particularly interested in NRP2 because our recent findings indicate that its contribution to breast tumorigenesis is significant. NRP2 expression correlates with progression and poor outcome in women with breast cancer, and its expression is associated with aggressive, triple-negative breast cancers. Moreover, our data indicate that NRP2 expression is induced by oncogenic stimuli that promote mammary tumor formation and they suggest that it has a causal role in tumorigenesis. We also discovered that NRP2 is highly enriched in tumor-initiating cells isolated from triple-negative tumors and that it can regulate the function of the a6ß1 integrin (CD49f), a marker of tumor-initiating cells. An important implication of our findings is that NRP2 is a prime target for therapeutic intervention, a highly feasible possibility because function-blocking antibodies are available for clinical trials. This issue is timely because the FDA has recommended discontinuing the use of Avastin (bevacizumab) for treating breast cancer because it has not been shown to be effective. Bevacizumab, however, does not inhibit the VEGF/NRP2 interaction, strengthening the rationale for targeting NRP2 directly. Based on existing data, we postulate that VEGF/NRP2 signaling cooperates with oncogenic stimuli to drive the formation of breast cancers by promoting the functions of tumor-initiating cells, especially the function and signaling properties of the a6ß1 integrin.

    We are also pursuing the contribution of VEGF/NRP2 to prostate cancer. This project is based on our novel findings that PTEN deletion induces JNK/Jun-dependent NRP2 expression, NRP2 contributes to the growth of PTEN-null prostate carcinoma cells in soft agar and as xenografts, and NRP2 expression correlates with Gleason grade. The role of VEGF/NRP2 signaling in prostate tumorigenesis can be explained by our exciting discovery that NRP2 facilitates the expression of Bmi-1, a transcriptional repressor that has a critical role in the function of prostate stem and tumor initiating cells. We have also shown that NRP2 suppresses the IGF-1 receptor (IGF-1R) by a mechanism that involves transcriptional repression by Bmi-1 and, as a consequence, confers resistance to IGF-1R therapy of prostate carcinoma. In fact, we have found that NRP2 expressing prostate tumors are resistant to IGF-1R therapy. This hypothesis is significant because several IGF-1R inhibitors are in clinical trials but the mechanisms to account for patient response to these inhibitors are largely unknown. Given that clinical trials of the VEGF Ab bevacizumab have been disappointing, we are targeting NRP2 directly on tumor cells in combination with IGF-1R inhibition as a novel and a potentially potent approach for treating prostate carcinoma.


    Regulation of Epithelial Fate and Carcinoma Differentiation by Estrogen Receptors
    We are interested in the hypothesis that ligand-dependent activation of estrogen receptors (either ERa or ß) sustains epithelial differentiation and that loss of this activation in carcinomas contributes to a more de-differentiated, aggressive phenotype. This hypothesis is supported by the observation that ERa-negative breast carcinomas are typically less differentiated and more aggressive than ERa-positive tumors. Also, the loss of ERß in high-grade prostate carcinomas is also linked to de-differentiation and highly invasive behavior. We reported that a key function of ERß and its specific ligand 5a-androstane-3ß,17ß-diol (3ß-adiol) is to maintain an epithelial phenotype and repress mesenchymal characteristics in prostate carcinoma. The mechanism involves ERß-mediated destabilization of HIF-1a and transcriptional repression of HIF-1 target genes including VEGF-A. This mechanism is extremely important and relevant because we demonstrated that high Gleason grade tumors exhibit significantly elevated expression of HIF-1a but clinically relevant hypoxia is not seen in localized primary prostate cancer including high-grade tumors. These observations indicate that loss of ERß in prostate cancer mimics hypoxia by stabilizing HIF-1a. The mechanism by which ERß destabilizes HIF-1a is under investigation and we hypothesize that this mechanism is critical for maintaining an epithelial state and preventing a mesenchymal transition. The loss of ERß that characterizes high-grade, aggressive prostate cancer results in increased VEGF expression in tumor cells and consequent autocrine VEGF/NRP2 signaling as described above.


    RNA Binding Proteins in Aggressive Carcinomas
    This project is based on the finding that the expression of IGFII mRNA-binding protein 3 (IMP3) is associated with highly aggressive cancers, including triple-negative breast carcinomas. We are pursuing the hypothesis that IMP3 has an essential role in maintaining a de-differentiated state characteristic of high-grade tumors and that it functions in this capacity by interacting with and facilitating the expression of specific mRNAs whose proteins products promote epithelial de-differentiation.


    Collapse Rotation Projects

    Rotation Projects

    Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include:

    Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer

    • Epigenetic mechanisms that regulate integrin gene expression in human cancers
    • Regulation of integrin expression and function during the EMT
    • Role of specfic microRNAs (miRs) in regulating integrin function and signaling
    • Contribution of integrins to carcinoma progression using mouse models of breast carcinoma

    Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression

    • Function and expression of VEGF receptors in carcinoma cells
    • Regulation of VEGF transcription in response to EMT stimuli
    • Role of miRs in regulating VEGF receptors and signaling
    • Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas

    Nuclear Hormone Receptors and EMT

    • Role of estrogen receptors in regulating the EMT
    • Regulation of VEGF transcription by estrogen receptors


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang M, Xiong C, Mercurio AM. PD-LI promotes rear retraction during persistent cell migration by altering integrin ?4 dynamics. J Cell Biol. 2022 May 02; 221(5). PMID: 35344032.
      Citations:    Fields:    Translation:Cells
    2. Walker MR, Goel HL, Mukhopadhyay D, Chhoy P, Karner ER, Clark JL, Liu H, Li R, Zhu JL, Chen S, Mahal LK, Bensing BA, Mercurio AM. O-linked ?2,3 sialylation defines stem cell populations in breast cancer. Sci Adv. 2022 Jan 07; 8(1):eabj9513. PMID: 34995107.
      Citations:    Fields:    
    3. Brown CW, Chhoy P, Mukhopadhyay D, Karner ER, Mercurio AM. Targeting prominin2 transcription to overcome ferroptosis resistance in cancer. EMBO Mol Med. 2021 08 09; 13(8):e13792. PMID: 34223704.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Chhoy P, Brown CW, Amante JJ, Mercurio AM. Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models. STAR Protoc. 2021 03 19; 2(1):100303. PMID: 33554138.
      Citations: 2     Fields:    Translation:HumansCells
    5. Geng Y, Amante JJ, Goel HL, Zhang X, Walker MR, Luther DC, Mercurio AM, Rotello VM. Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering. ACS Nano. 2020 11 24; 14(11):15276-15285. PMID: 33164505.
      Citations: 4     Fields:    Translation:HumansCells
    6. Mancarella C, Caldoni G, Ribolsi I, Parra A, Manara MC, Mercurio AM, Morrione A, Scotlandi K. Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis. Front Oncol. 2020; 10:994. PMID: 32719743.
      Citations:    
    7. Brown CW, Mercurio AM. Ferroptosis resistance mediated by exosomal release of iron. Mol Cell Oncol. 2020; 7(3):1730144. PMID: 32391424.
      Citations:    
    8. Barney LE, Hall CL, Schwartz AD, Parks AN, Sparages C, Galarza S, Platt MO, Mercurio AM, Peyton SR. Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. Sci Adv. 2020 03; 6(11):eaaz4157. PMID: 32195352.
      Citations: 27     Fields:    Translation:HumansCells
    9. Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, Baer CE, Dixon SJ, Mercurio AM. Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019 12 02; 51(5):575-586.e4. PMID: 31735663.
      Citations: 80     Fields:    Translation:HumansCells
    10. Walker MR, Amante JJ, Li J, Liu H, Zhu LJ, Feltri ML, Goel HL, Mercurio AM. Alveolar progenitor cells in the mammary gland are dependent on the ?4 integrin. Dev Biol. 2020 01 01; 457(1):13-19. PMID: 31586558.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 07 31; 132(15). PMID: 31262785.
      Citations: 5     Fields:    Translation:Humans
    12. Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM. The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14174-14180. PMID: 31235595.
      Citations: 10     Fields:    Translation:HumansCells
    13. Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 02 01; 33(3-4):166-179. PMID: 30692202.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    14. Mercurio AM. VEGF/Neuropilin Signaling in Cancer Stem Cells. Int J Mol Sci. 2019 Jan 23; 20(3). PMID: 30678134.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    15. Elaimy AL, Mercurio AM. Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology. Sci Signal. 2018 10 16; 11(552). PMID: 30327408.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    16. Brown CW, Amante JJ, Mercurio AM. Cell clustering mediated by the adhesion protein PVRL4 is necessary for ?6?4 integrin-promoted ferroptosis resistance in matrix-detached cells. J Biol Chem. 2018 08 17; 293(33):12741-12748. PMID: 29934307.
      Citations: 15     Fields:    Translation:HumansCells
    17. Samanta S, Guru S, Elaimy AL, Amante JJ, Ou J, Yu J, Zhu LJ, Mercurio AM. IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer. Cell Rep. 2018 05 29; 23(9):2559-2567. PMID: 29847788.
      Citations: 17     Fields:    Translation:HumansCells
    18. Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM. Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays. Nanomedicine. 2018 08; 14(6):1931-1939. PMID: 29778888.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    19. Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM. VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin. Sci Signal. 2018 05 01; 11(528). PMID: 29717062.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    20. Brown CW, Amante JJ, Goel HL, Mercurio AM. The ?6?4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017 12 04; 216(12):4287-4297. PMID: 28972104.
      Citations: 36     Fields:    Translation:HumansCells
    21. Yoshii T, Geng Y, Peyton S, Mercurio AM, Rotello VM. Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine. Drug Discov Today. 2016 09; 21(9):1489-1494. PMID: 27238384.
      Citations: 6     Fields:    Translation:Humans
    22. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-2208. PMID: 26923603.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    23. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180. PMID: 26832411.
      Citations: 90     Fields:    Translation:HumansCells
    24. Yoshii T, Geng Y, Le ND, Goel HL, Mercurio AM, Rotello VM. Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells. Nanomedicine (Lond). 2015; 10(23):3427-9. PMID: 26606862.
      Citations: 1     Fields:    
    25. Mak P, Li J, Samanta S, Mercurio AM. ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1. Oncotarget. 2015 Nov 24; 6(37):40247-54. PMID: 26450901.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    26. Li J, Sun H, Feltri ML, Mercurio AM. Integrin ?4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15; 407(2):313-20. PMID: 26432258.
      Citations: 6     Fields:    Translation:Animals
    27. Samanta S, Sun H, Goel HL, Pursell B, Chang C, Khan A, Greiner DL, Cao S, Lim E, Shultz LD, Mercurio AM. IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. Oncogene. 2016 Mar 03; 35(9):1111-21. PMID: 25982283.
      Citations: 26     Fields:    Translation:HumansCells
    28. Mak P, Li J, Samanta S, Chang C, Jerry DJ, Davis RJ, Leav I, Mercurio AM. Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression. Cell Rep. 2015 Mar 31; 10(12):1982-91. PMID: 25818291.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    29. Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW. Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure. 2015 Apr 07; 23(4):677-87. PMID: 25752543.
      Citations: 22     Fields:    Translation:HumansCells
    30. Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. A cell-ECM screening method to predict breast cancer metastasis. Integr Biol (Camb). 2015 Feb; 7(2):198-212. PMID: 25537447.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    31. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the ?6B?1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      Citations: 54     Fields:    Translation:HumansCells
    32. Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ?4. FASEB J. 2015 Jan; 29(1):131-40. PMID: 25326539.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    33. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the ?6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 08; 7(3):747-61. PMID: 24767994.
      Citations: 55     Fields:    Translation:HumansCells
    34. Gao Y, Yang M, Jiang Z, Woda BA, Mercurio AM, Qin J, Huang X, Zhang F. IMP3 expression is associated with poor outcome and epigenetic deregulation in intrahepatic cholangiocarcinoma. Hum Pathol. 2014 Jun; 45(6):1184-91. PMID: 24745619.
      Citations: 9     Fields:    Translation:HumansCells
    35. Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013 Dec; 13(12):871-82. PMID: 24263190.
      Citations: 426     Fields:    Translation:HumansAnimalsCells
    36. Chang C, Yang X, Pursell B, Mercurio AM. Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4. Mol Cell Biol. 2013 Oct; 33(19):3795-804. PMID: 23878399.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    37. Samanta S, Pursell B, Mercurio AM. IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression. J Biol Chem. 2013 May 03; 288(18):12569-73. PMID: 23539627.
      Citations: 29     Fields:    Translation:HumansCells
    38. Mak P, Chang C, Pursell B, Mercurio AM. Estrogen receptor ? sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4708-13. PMID: 23487784.
      Citations: 25     Fields:    Translation:HumansCells
    39. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/?6?1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    40. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr. 2012 Nov-Dec; 6(6):554-60. PMID: 23076131.
      Citations: 19     Fields:    Translation:HumansCells
    41. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21. PMID: 22777769.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    42. Gerson KD, Maddula VS, Seligmann BE, Shearstone JR, Khan A, Mercurio AM. Effects of ?4 integrin expression on microRNA patterns in breast cancer. Biol Open. 2012 Jul 15; 1(7):658-66. PMID: 23213459.
      Citations: 11     Fields:    
    43. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 2012 Apr 27; 149(3):630-41. PMID: 22541433.
      Citations: 19     Fields:    Translation:Animals
    44. Gerson KD, Shearstone JR, Maddula VSRK, Seligmann BE, Mercurio AM. Integrin ?4 regulates SPARC protein to promote invasion. J Biol Chem. 2012 Mar 23; 287(13):9835-9844. PMID: 22308039.
      Citations: 18     Fields:    Translation:HumansCells
    45. Samanta S, Sharma VM, Khan A, Mercurio AM. Regulation of IMP3 by EGFR signaling and repression by ER?: implications for triple-negative breast cancer. Oncogene. 2012 Nov 01; 31(44):4689-97. PMID: 22266872.
      Citations: 46     Fields:    Translation:HumansCells
    46. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates ?6?1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Jan 15; 125(Pt 2):497-506. PMID: 22302985.
      Citations: 33     Fields:    Translation:HumansCells
    47. Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Res. 2012 Jan 15; 72(2):472-81. PMID: 22127926.
      Citations: 44     Fields:    Translation:AnimalsCells
    48. Lu D, Yang X, Jiang NY, Woda BA, Liu Q, Dresser K, Mercurio AM, Rock KL, Jiang Z. IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. Am J Surg Pathol. 2011 Nov; 35(11):1638-45. PMID: 21997684.
      Citations: 28     Fields:    Translation:HumansCells
    49. Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res. 2011 Nov; 9(11):1449-61. PMID: 21875931.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    50. Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011 Jul; 138(14):2969-76. PMID: 21693513.
      Citations: 10     Fields:    Translation:AnimalsCells
    51. Moriarty CH, Pursell B, Mercurio AM. miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem. 2010 Jul 02; 285(27):20541-6. PMID: 20444703.
      Citations: 47     Fields:    Translation:HumansCells
    52. Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM, Mercurio AM. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 2010 Apr 13; 17(4):319-32. PMID: 20385358.
      Citations: 188     Fields:    Translation:HumansCells
    53. Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One. 2010 Mar 08; 5(3):e9575. PMID: 20221394.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    54. Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, Altieri DC. IAP regulation of metastasis. Cancer Cell. 2010 Jan 19; 17(1):53-64. PMID: 20129247.
      Citations: 155     Fields:    Translation:HumansAnimalsCells
    55. Yang X, Pursell B, Lu S, Chang TK, Mercurio AM. Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci. 2009 Jul 15; 122(Pt 14):2473-80. PMID: 19549682.
      Citations: 42     Fields:    Translation:AnimalsCells
    56. Pankratz SL, Tan EY, Fine Y, Mercurio AM, Shaw LM. Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1. J Biol Chem. 2009 Jan 23; 284(4):2031-7. PMID: 19056742.
      Citations: 20     Fields:    Translation:AnimalsCells
    57. Bae D, Lu S, Taglienti CA, Mercurio AM. Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem. 2008 Oct 17; 283(42):28074-80. PMID: 18708346.
      Citations: 24     Fields:    Translation:HumansCells
    58. Lu S, Simin K, Khan A, Mercurio AM. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res. 2008 Feb 15; 14(4):1050-8. PMID: 18281537.
      Citations: 62     Fields:    Translation:Humans
    59. Merdek KD, Yang X, Taglienti CA, Shaw LM, Mercurio AM. Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem. 2007 Oct 12; 282(41):30322-30. PMID: 17711859.
      Citations: 26     Fields:    Translation:HumansCells
    60. Folgiero V, Bachelder RE, Bon G, Sacchi A, Falcioni R, Mercurio AM. The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. Cancer Res. 2007 Feb 15; 67(4):1645-52. PMID: 17308105.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    61. Bates RC, Pursell BM, Mercurio AM. Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs. 2007; 185(1-3):29-39. PMID: 17587805.
      Citations: 22     Fields:    Translation:HumansCells
    62. Yoon SO, Shin S, Mercurio AM. Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res. 2006 Jun 15; 66(12):6288-95. PMID: 16778205.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    63. Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P, Mercurio AM. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene. 2006 Nov 02; 25(52):6959-67. PMID: 16715134.
      Citations: 65     Fields:    Translation:HumansCells
    64. Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res. 2005 Dec 01; 65(23):10938-45. PMID: 16322241.
      Citations: 67     Fields:    Translation:HumansCells
    65. Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS, Mercurio AM. The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res. 2005 Dec 01; 65(23):10970-6. PMID: 16322245.
      Citations: 37     Fields:    Translation:HumansCells
    66. Mercurio AM, Lipscomb EA, Bachelder RE. Non-angiogenic functions of VEGF in breast cancer. J Mammary Gland Biol Neoplasia. 2005 Oct; 10(4):283-90. PMID: 16924371.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    67. Lipscomb EA, Mercurio AM. Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 2005 Sep; 24(3):413-23. PMID: 16258729.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    68. Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, Wewer UM. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res. 2005 Jun 01; 65(11):4754-61. PMID: 15930294.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    69. Bates RC, Mercurio AM. The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther. 2005 Apr; 4(4):365-70. PMID: 15846061.
      Citations: 127     Fields:    Translation:HumansAnimals
    70. Yoon SO, Shin S, Mercurio AM. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Cancer Res. 2005 Apr 01; 65(7):2761-9. PMID: 15805276.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    71. Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem. 2005 Apr 08; 280(14):13936-43. PMID: 15695519.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    72. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47. PMID: 15668738.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    73. Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol. 2005 Jan 03; 168(1):29-33. PMID: 15631989.
      Citations: 166     Fields:    Translation:HumansCells
    74. Simpson KJ, Dugan AS, Mercurio AM. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res. 2004 Dec 01; 64(23):8694-701. PMID: 15574779.
      Citations: 73     Fields:    Translation:HumansCells
    75. Bates RC, DeLeo MJ, Mercurio AM. The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp Cell Res. 2004 Oct 01; 299(2):315-24. PMID: 15350531.
      Citations: 56     Fields:    Translation:HumansCells
    76. Chung J, Yoon S, Datta K, Bachelder RE, Mercurio AM. Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. Cancer Res. 2004 Jul 15; 64(14):4711-6. PMID: 15256436.
      Citations: 12     Fields:    Translation:HumansCells
    77. Chung J, Yoon SO, Lipscomb EA, Mercurio AM. The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J Biol Chem. 2004 Jul 30; 279(31):32287-93. PMID: 15161909.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    78. Rabinovitz I, Tsomo L, Mercurio AM. Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol. 2004 May; 24(10):4351-60. PMID: 15121854.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    79. Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells. 2004 Apr 30; 17(2):203-9. PMID: 15179031.
      Citations: 17     Fields:    Translation:HumansCells
    80. Mercurio AM, Bachelder RE, Bates RC, Chung J. Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Semin Cancer Biol. 2004 Apr; 14(2):115-22. PMID: 15018895.
      Citations: 19     Fields:    Translation:HumansCells
    81. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004 Apr; 164(4):1131-9. PMID: 15039201.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    82. Bates RC, Goldsmith JD, Bachelder RE, Brown C, Shibuya M, Oettgen P, Mercurio AM. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol. 2003 Sep 30; 13(19):1721-7. PMID: 14521839.
      Citations: 43     Fields:    Translation:HumansCells
    83. Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ, Mercurio AM. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res. 2003 Sep 01; 63(17):5230-3. PMID: 14500350.
      Citations: 84     Fields:    Translation:Humans
    84. Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Möller P, Mercurio AM, Albrechtsen R, Wewer UM. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci. 2003 Oct 01; 116(Pt 19):3893-904. PMID: 12915587.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    85. Mercurio AM. Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way. Cancer Cell. 2003 Mar; 3(3):201-2. PMID: 12676577.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    86. Bates RC, Mercurio AM. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell. 2003 May; 14(5):1790-800. PMID: 12802055.
      Citations: 132     Fields:    Translation:Humans
    87. Lipscomb EA, Dugan AS, Rabinovitz I, Mercurio AM. Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis. 2003; 20(6):569-76. PMID: 14598892.
      Citations: 17     Fields:    Translation:HumansCells
    88. Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM. ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem. 2003 Mar 14; 278(11):9576-84. PMID: 12509413.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    89. Bachelder RE, Wendt MA, Mercurio AM. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res. 2002 Dec 15; 62(24):7203-6. PMID: 12499259.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    90. Chung J, Bachelder RE, Lipscomb EA, Shaw LM, Mercurio AM. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol. 2002 Jul 08; 158(1):165-74. PMID: 12105188.
      Citations: 72     Fields:    Translation:HumansCells
    91. Morena A, Riccioni S, Marchetti A, Polcini AT, Mercurio AM, Blandino G, Sacchi A, Falcioni R. Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells. Blood. 2002 Jul 01; 100(1):96-106. PMID: 12070014.
      Citations: 2     Fields:    Translation:AnimalsCells
    92. Mercurio AM. Lessons from the alpha2 integrin knockout mouse. Am J Pathol. 2002 Jul; 161(1):3-6. PMID: 12107082.
      Citations: 9     Fields:    Translation:Animals
    93. Rabinovitz I, Gipson IK, Mercurio AM. Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion. Mol Biol Cell. 2001 Dec; 12(12):4030-43. PMID: 11739798.
      Citations: 25     Fields:    Translation:HumansCells
    94. O'Connor KL, Mercurio AM. Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem. 2001 Dec 21; 276(51):47895-900. PMID: 11606581.
      Citations: 61     Fields:    Translation:HumansCells
    95. Mercurio AM, Rabinovitz I, Shaw LM. The alpha 6 beta 4 integrin and epithelial cell migration. Curr Opin Cell Biol. 2001 Oct; 13(5):541-5. PMID: 11544021.
      Citations: 90     Fields:    Translation:AnimalsCells
    96. Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, Mercurio AM. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 2001 Aug 01; 61(15):5736-40. PMID: 11479209.
      Citations: 149     Fields:    Translation:HumansCells
    97. Tani TT, Mercurio AM. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J Biol Chem. 2001 Sep 28; 276(39):36535-42. PMID: 11479315.
      Citations: 24     Fields:    Translation:HumansCells
    98. Bachelder RE, Wendt MA, Fujita N, Tsuruo T, Mercurio AM. The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis. J Biol Chem. 2001 Sep 14; 276(37):34702-7. PMID: 11463786.
      Citations: 20     Fields:    Translation:AnimalsCells
    99. Mercurio AM, Bachelder RE, Chung J, O'Connor KL, Rabinovitz I, Shaw LM, Tani T. Integrin laminin receptors and breast carcinoma progression. J Mammary Gland Biol Neoplasia. 2001 Jul; 6(3):299-309. PMID: 11547899.
      Citations: 30     Fields:    Translation:Humans
    100. Mercurio AM, Rabinovitz I. Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin. Semin Cancer Biol. 2001 Apr; 11(2):129-41. PMID: 11322832.
      Citations: 78     Fields:    Translation:HumansCells
    101. Mercurio AM, Bachelder RE, Rabinovitz I, O'Connor KL, Tani T, Shaw LM. The metastatic odyssey: the integrin connection. Surg Oncol Clin N Am. 2001 Apr; 10(2):313-28, viii-ix. PMID: 11382589.
      Citations: 15     Fields:    Translation:HumansCells
    102. Gambaletta D, Marchetti A, Benedetti L, Mercurio AM, Sacchi A, Falcioni R. Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. J Biol Chem. 2000 Apr 07; 275(14):10604-10. PMID: 10744756.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    103. Lotz MM, Rabinovitz I, Mercurio AM. Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol. 2000 Mar; 156(3):985-96. PMID: 10702414.
      Citations: 33     Fields:    Translation:HumansCells
    104. O'Connor KL, Nguyen BK, Mercurio AM. RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J Cell Biol. 2000 Jan 24; 148(2):253-8. PMID: 10648558.
      Citations: 70     Fields:    Translation:HumansCells
    105. Bachelder RE, Ribick MJ, Marchetti A, Falcioni R, Soddu S, Davis KR, Mercurio AM. p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol. 1999 Nov 29; 147(5):1063-72. PMID: 10579725.
      Citations: 50     Fields:    Translation:HumansCells
    106. Rabinovitz I, Toker A, Mercurio AM. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol. 1999 Sep 06; 146(5):1147-60. PMID: 10477766.
      Citations: 79     Fields:    Translation:HumansCells
    107. Bachelder RE, Marchetti A, Falcioni R, Soddu S, Mercurio AM. Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. J Biol Chem. 1999 Jul 16; 274(29):20733-7. PMID: 10400708.
      Citations: 19     Fields:    Translation:HumansCells
    108. Chen MS, Almeida EA, Huovila AP, Takahashi Y, Shaw LM, Mercurio AM, White JM. Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. J Cell Biol. 1999 Feb 08; 144(3):549-61. PMID: 9971748.
      Citations: 12     Fields:    Translation:AnimalsCells
    109. O'Connor KL, Shaw LM, Mercurio AM. Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells. J Cell Biol. 1998 Dec 14; 143(6):1749-60. PMID: 9852165.
      Citations: 58     Fields:    Translation:HumansCells
    110. Homan SM, Mercurio AM, LaFlamme SE. Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail. J Cell Sci. 1998 Sep; 111 ( Pt 18):2717-28. PMID: 9718365.
      Citations: 21     Fields:    Translation:HumansCells
    111. Carloni V, Romanelli RG, Mercurio AM, Pinzani M, Laffi G, Cotrozzi G, Gentilini P. Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. Gastroenterology. 1998 Aug; 115(2):433-42. PMID: 9679049.
      Citations: 10     Fields:    Translation:HumansCells
    112. Wei J, Shaw LM, Mercurio AM. Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit. J Biol Chem. 1998 Mar 06; 273(10):5903-7. PMID: 9488728.
      Citations: 24     Fields:    Translation:Cells
    113. Rabinovitz I, Mercurio AM. The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol. 1997 Dec 29; 139(7):1873-84. PMID: 9412479.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    114. Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell. 1997 Dec 26; 91(7):949-60. PMID: 9428518.
      Citations: 197     Fields:    Translation:AnimalsCells
    115. Wewer UM, Shaw LM, Albrechtsen R, Mercurio AM. The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol. 1997 Nov; 151(5):1191-8. PMID: 9358743.
      Citations: 41     Fields:    Translation:HumansAnimals
    116. Wei J, Shaw LM, Mercurio AM. Integrin signaling in leukocytes: lessons from the alpha6beta1 integrin. J Leukoc Biol. 1997 Apr; 61(4):397-407. PMID: 9103225.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    117. Lise M, Loda M, Fiorentino M, Mercurio AM, Summerhayes IC, Lavin PT, Jessup JM. Association between sucrase-isomaltase and p53 expression in colorectal cancer. Ann Surg Oncol. 1997 Mar; 4(2):176-83. PMID: 9084856.
      Citations:    Fields:    Translation:Humans
    118. Lotz MM, Nusrat A, Madara JL, Ezzell R, Wewer UM, Mercurio AM. Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium. Am J Pathol. 1997 Feb; 150(2):747-60. PMID: 9033287.
      Citations: 38     Fields:    Translation:HumansCells
    119. Chao C, Lotz MM, Clarke AC, Mercurio AM. A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 1996 Oct 15; 56(20):4811-9. PMID: 8841003.
      Citations: 47     Fields:    Translation:HumansCells
    120. Shaw LM, Chao C, Wewer UM, Mercurio AM. Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor. Cancer Res. 1996 Mar 01; 56(5):959-63. PMID: 8640785.
      Citations: 31     Fields:    Translation:HumansCells
    121. Rabinovitz I, Mercurio AM. The integrin alpha 6 beta 4 and the biology of carcinoma. Biochem Cell Biol. 1996; 74(6):811-21. PMID: 9164650.
      Citations: 37     Fields:    Translation:HumansCells
    122. Jessup JM, Lavin PT, Andrews CW, Loda M, Mercurio A, Minsky BD, Mies C, Cukor B, Bleday R, Steele G. Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma. Dis Colon Rectum. 1995 Dec; 38(12):1257-64. PMID: 7497836.
      Citations: 4     Fields:    Translation:Humans
    123. Mercurio AM. Laminin receptors: achieving specificity through cooperation. Trends Cell Biol. 1995 Nov; 5(11):419-23. PMID: 14732046.
      Citations: 57     Fields:    
    124. Shaw LM, Turner CE, Mercurio AM. The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. J Biol Chem. 1995 Oct 06; 270(40):23648-52. PMID: 7559532.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    125. Clarke AS, Lotz MM, Chao C, Mercurio AM. Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain. J Biol Chem. 1995 Sep 29; 270(39):22673-6. PMID: 7559386.
      Citations: 27     Fields:    Translation:HumansCells
    126. Breen E, Steele G, Mercurio AM. Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. Ann Surg Oncol. 1995 Sep; 2(5):378-85. PMID: 7496831.
      Citations: 13     Fields:    Translation:HumansCells
    127. Almeida EA, Huovila AP, Sutherland AE, Stephens LE, Calarco PG, Shaw LM, Mercurio AM, Sonnenberg A, Primakoff P, Myles DG, White JM. Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell. 1995 Jun 30; 81(7):1095-104. PMID: 7600577.
      Citations: 81     Fields:    Translation:AnimalsCells
    128. Byers SW, Sommers CL, Hoxter B, Mercurio AM, Tozeren A. Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength. J Cell Sci. 1995 May; 108 ( Pt 5):2053-64. PMID: 7657723.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    129. Tözeren A, Kleinman HK, Grant DS, Morales D, Mercurio AM, Byers SW. E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers. Int J Cancer. 1995 Jan 27; 60(3):426-31. PMID: 7530236.
      Citations: 48     Fields:    Translation:HumansCells
    130. Shaw LM, Mercurio AM. Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages. Agents Actions Suppl. 1995; 47:101-6. PMID: 7785489.
      Citations: 3     Fields:    Translation:HumansCells
    131. Tözeren A, Kleinman HK, Wu S, Mercurio AM, Byers SW. Integrin alpha 6 beta 4 mediates dynamic interactions with laminin. J Cell Sci. 1994 Nov; 107 ( Pt 11):3153-63. PMID: 7699012.
      Citations: 16     Fields:    Translation:HumansCells
    132. Shaw LM, Mercurio AM. Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages. Mol Biol Cell. 1994 Jun; 5(6):679-90. PMID: 7949424.
      Citations: 13     Fields:    Translation:AnimalsCells
    133. Clarke AS, Lotz MM, Mercurio AM. A novel structural variant of the human beta 4 integrin cDNA. Cell Adhes Commun. 1994 Apr; 2(1):1-6. PMID: 7982032.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    134. Rossen K, Dahlstrøm KK, Mercurio AM, Wewer UM. Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? Acta Derm Venereol. 1994 Mar; 74(2):101-5. PMID: 7911612.
      Citations: 9     Fields:    Translation:Humans
    135. Breen E, Clarke A, Steele G, Mercurio AM. Poorly differentiated colon carcinoma cell lines deficient in alpha-catenin expression express high levels of surface E-cadherin but lack Ca(2+)-dependent cell-cell adhesion. Cell Adhes Commun. 1993 Dec; 1(3):239-50. PMID: 8081881.
      Citations: 17     Fields:    Translation:HumansCells
    136. Shaw LM, Mercurio AM. Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit. J Cell Biol. 1993 Nov; 123(4):1017-25. PMID: 8227138.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    137. Shaw LM, Lotz MM, Mercurio AM. Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line. J Biol Chem. 1993 May 25; 268(15):11401-8. PMID: 8496190.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    138. Lotz MM, Andrews CW, Korzelius CA, Lee EC, Steele GD, Clarke A, Mercurio AM. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3466-70. PMID: 7682704.
      Citations: 61     Fields:    Translation:HumansCells
    139. Messier JM, Shaw LM, Chafel M, Matsudaira P, Mercurio AM. Fimbrin localized to an insoluble cytoskeletal fraction is constitutively phosphorylated on its headpiece domain in adherent macrophages. Cell Motil Cytoskeleton. 1993; 25(3):223-33. PMID: 8221900.
      Citations: 31     Fields:    Translation:AnimalsCells
    140. Andrews CW, O'Hara CJ, Goldman H, Mercurio AM, Silverman ML, Steele GD. Sucrase-isomaltase expression in chronic ulcerative colitis and dysplasia. Hum Pathol. 1992 Jul; 23(7):774-9. PMID: 1612577.
      Citations: 4     Fields:    Translation:Humans
    141. Lee EC, Lotz MM, Steele GD, Mercurio AM. The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol. 1992 May; 117(3):671-8. PMID: 1533398.
      Citations: 82     Fields:    Translation:HumansCells
    142. Lee EC, Woo HJ, Korzelius CA, Steele GD, Mercurio AM. Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma. Arch Surg. 1991 Dec; 126(12):1498-502. PMID: 1842179.
      Citations: 8     Fields:    Translation:HumansCells
    143. Woo HJ, Lotz MM, Jung JU, Mercurio AM. Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186. J Biol Chem. 1991 Oct 05; 266(28):18419-22. PMID: 1917966.
      Citations: 17     Fields:    Translation:AnimalsCells
    144. Mercurio AM, Shaw LM. Laminin binding proteins. Bioessays. 1991 Sep; 13(9):469-73. PMID: 1839124.
      Citations: 15     Fields:    Translation:AnimalsCells
    145. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Expression of enzymatically active sucrase-isomaltase is a ubiquitous property of colon adenocarcinomas. Gastroenterology. 1991 May; 100(5 Pt 1):1266-78. PMID: 1707385.
      Citations: 5     Fields:    Translation:HumansCells
    146. Wewer UM, Mercurio AM, Chung SY, Albrechtsen R. Deoxyribonucleic-binding homeobox proteins are augmented in human cancer. Lab Invest. 1990 Oct; 63(4):447-54. PMID: 1977958.
      Citations: 2     Fields:    Translation:HumansAnimals
    147. Mercurio AM. Laminin: multiple forms, multiple receptors. Curr Opin Cell Biol. 1990 Oct; 2(5):845-9. PMID: 2150589.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    148. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Sucrase-isomaltase: a marker associated with the progression of adenomatous polyps to adenocarcinomas. Surgery. 1990 Aug; 108(2):269-75; discussion 275-6. PMID: 1696400.
      Citations: 4     Fields:    Translation:Humans
    149. Shaw LM, Messier JM, Mercurio AM. The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin. J Cell Biol. 1990 Jun; 110(6):2167-74. PMID: 2141029.
      Citations: 75     Fields:    Translation:AnimalsCells
    150. Woo HJ, Shaw LM, Messier JM, Mercurio AM. The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2). J Biol Chem. 1990 May 05; 265(13):7097-9. PMID: 2332426.
      Citations: 57     Fields:    Translation:AnimalsCells
    151. Lotz MM, Korzelius CA, Mercurio AM. Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins. Cell Regul. 1990 Feb; 1(3):249-57. PMID: 2100200.
      Citations: 35     Fields:    Translation:HumansCells
    152. Daneker GW, Piazza AJ, Steele GD, Mercurio AM. Interactions of human colorectal carcinoma cells with basement membranes. Analysis and correlation with differentiation. Arch Surg. 1989 Feb; 124(2):183-7. PMID: 2916940.
      Citations: 3     Fields:    Translation:HumansCells
    153. Daneker GW, Piazza AJ, Steele GD, Mercurio AM. Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines. Cancer Res. 1989 Feb 01; 49(3):681-6. PMID: 2910488.
      Citations: 23     Fields:    Translation:HumansCells
    154. Shaw LM, Mercurio AM. Interferon gamma and lipopolysaccharide promote macrophage adherence to basement membrane glycoproteins. J Exp Med. 1989 Jan 01; 169(1):303-8. PMID: 2491881.
      Citations: 18     Fields:    Translation:AnimalsCells
    155. Mercurio AM, Shaw LM. Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum. J Cell Biol. 1988 Nov; 107(5):1873-80. PMID: 2972733.
      Citations: 29     Fields:    Translation:AnimalsCells
    156. Daneker GW, Mercurio AM, Guerra L, Wolf B, Salem RR, Bagli DJ, Steele GD. Laminin expression in colorectal carcinomas varying in degree of differentiation. Arch Surg. 1987 Dec; 122(12):1470-4. PMID: 3318759.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    157. Sheares BT, Mercurio AM. Modulation of two distinct galactosyltransferase activities in populations of mouse peritoneal macrophages. J Immunol. 1987 Dec 01; 139(11):3748-52. PMID: 3119716.
      Citations: 4     Fields:    Translation:AnimalsCells
    158. Mercurio AM. Disruption of oligosaccharide processing in murine tumor cells inhibits their susceptibility to lysis by activated mouse macrophages. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2609-13. PMID: 2939455.
      Citations: 8     Fields:    Translation:AnimalsCells
    159. Mercurio AM, Robbins PW. Activation of mouse peritoneal macrophages alters the structure and surface expression of protein-bound lactosaminoglycans. J Immunol. 1985 Aug; 135(2):1305-12. PMID: 3925007.
      Citations: 4     Fields:    Translation:AnimalsCells
    160. Mercurio AM, Schwarting GA, Robbins PW. Glycolipids of the mouse peritoneal macrophage. Alterations in amount and surface exposure of specific glycolipid species occur in response to inflammation and tumoricidal activation. J Exp Med. 1984 Oct 01; 160(4):1114-25. PMID: 6481302.
      Citations: 26     Fields:    Translation:AnimalsCells
    161. Mercurio AM, Holtzman E. Ultrastructural localization of glycerolipid synthesis in rod cells of the isolated frog retina. J Neurocytol. 1982 Apr; 11(2):295-322. PMID: 6175734.
      Citations: 6     Fields:    Translation:AnimalsCells
    162. Mercurio AM, Holtzman E. Smooth endoplasmic reticulum and other agranular reticulum in frog retinal photoreceptors. J Neurocytol. 1982 Apr; 11(2):263-93. PMID: 6978386.
      Citations: 30     Fields:    Translation:AnimalsCells
    163. Holtzman E, Mercurio AM. Membrane circulation in neurons and photoreceptors: some unresolved issues. Int Rev Cytol. 1980; 67:1-67. PMID: 6161097.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    164. Holtzman E, Gronowicz G, Mercurio A. Notes on the heterogeneity, circulation, and modification of membranes, with emphasis on secretory cells, photoreceptors, and the toad bladder. Biomembranes. 1979; 10:77-139. PMID: 387104.
      Citations: 2     Fields:    Translation:AnimalsCells
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