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Last Name

Jie Song PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentOrthopedics and Physical Rehabilitation
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentOrthopedics and Physical Rehabilitation

    InstitutionUMMS - School of Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentChemical Biology

    Collapse Biography 
    Collapse education and training
    Fudan University Shanghai, Shanghai, , ChinaBSChemistry
    Michigan State University, East Lansing, MI, United StatesPHDOrganic Chemistry
    Collapse awards and honors
    2017ALSF Innovation Grant award, Alex's Lemonade Stand Foundation
    2017Bassick Family Foundation Award, Worcester Foundation/Hudson Hoagland Society
    2016OTCV Technology Development Fund Award, University of Massachusetts
    2015OTCV Technology Development Fund Award, University of Massachusetts
    2015Faculty Vitality Award, UMASS Medical School
    2015J.R. Neff Award , Musculoskeletal Transplant Foundation
    2014Mel and Sandy Cutler Award, Worcester Foundation/Hudson Hoagland Society
    2013Dean’s Award for Research Mentoring and Commitment to Student Professional Advancement, GSBS/UMMS
    2013Commercial Ventures & Intellectual Property Award, University of Massachusetts
    2011Commercial Ventures & Intellectual Property Award, University of Massachusetts
    2008Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award, National Institutes of Health
    2008Career Enhancement Award, American Society for Bone and Mineral Research
    2007Commercial Ventures & Intellectual Property Award, University of Massachusetts
    2007Technology Investigation Award, Massachusetts Technology Transfer Center
    2007Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research

    Collapse Overview 
    Collapse overview


    B.S. 1995, Fudan University, P.R. China
    Ph.D. 1999, Michigan State University
    Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
    Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

    Research Interests

    With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, cancer and metabolic diseases is rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment and stable fixation), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.

    Additional Info on Dr. Song

    Representative Publications

    Lab Members

     Song Lab 2017 ORS

    San Diego (ORS meeting), March 2017

    Collapse Rotation Projects

    Potential Rotation Projects

    1. Design and evaluation of smart synthetic bone / cartilage tissue grafts

    2. Metallic implant surface modifications for reducing periprosthetic infections

    3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis

    Collapse Post Docs

    Postdoc openings are available in the Song Lab for projects aimed at developing synthetic niches for stem cell therapy and bone/cartilage regeneration. 

    A recent Ph.D. (within 2 years) in stem cell/skeletal biology, chemistry or polymer sciences is required. Hands-on experience in cell / molecular biology or synthetic chemistry is desired; experience with animal work or materials fabrication/characterization preferred but not required.

    Interested candidate should email a copy of CV including a list of publications, names of 3 referees and a brief statement of research interest (1-2 pages) to Dr. Song: Jie.Song@umassmed.edu

    Paid undergraduate research intern position available!

    Preference is given to local college students who are interested in a career in biomedical science/engineering and able to commit >10-12 h/week during regular semesters and full-time during summers. Chemistry, Biology and Biomedical Engineering majors are welcome! Interested candidate should send resume (indicating GPA and contact info of referees) to Dr. Song: Jie.Song@umassmed.edu

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Henry Huang, Yu Tan, David C. Ayers and Jie Song. Anionic and zwitterionic residues modulate stiffness of photo-crosslinked hydrogels and cellular behavior of encapsulated chondrocytes. ACS Biomater Sci Eng. 2018; 10.1021/acsbiomaterials8b00124.
    2. Ben Zhang and Jie Song. 3D Printed Biomaterials for Guided Tissue Regeneration. Small Methods. 2018; DOI: 10.1002/smtd.201700306.
    3. Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther. 2017 Mar 11; 8(1):65. PMID: 28283030.
      View in: PubMed
    4. Huang H, Skelly JD, Ayers DC, Song J. Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus. Sci Rep. 2017 Feb 09; 7:42294. PMID: 28181577.
      View in: PubMed
    5. Zhang B, DeBartolo JE, Song J. Shape Recovery with Concomitant Mechanical Strengthening of Amphiphilic Shape Memory Polymers in Warm Water. ACS Appl Mater Interfaces. 2017 Feb 08; 9(5):4450-4456. PMID: 28125208.
      View in: PubMed
    6. Ben Zhang, Tera M. Filion, Artem B. Kutikov and Jie Song. Facile Stem Cell Delivery to Bone Grafts Enabled by Smart Shape Recovery and Stiffening of Degradable Synthetic Periosteal Membranes. Adv. Funct. Mater. 2017; 1604784.
    7. Huang H, Veien ES, Zhang H, Ayers DC, Song J. Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes. PLoS One. 2016; 11(1):e0148088. PMID: 26815610.
      View in: PubMed
    8. Liu P, Song J. Well-controlled ATRP of 2-(2-(2-Azidoethyoxy)ethoxy)ethyl Methacrylate for High-density Click Functionalization of Polymers and Metallic Substrates. J Polym Sci A Polym Chem. 2016 May 01; 54(9):1268-1277. PMID: 27616816.
      View in: PubMed
    9. Youssefian S, Liu P, Askarinejad S, Shalchy F, Song J, Rahbar N. Experimental and numerical measurements of adhesion energies between PHEMA and PGLYMA with hydroxyapatite crystal. Bioinspir Biomim. 2015 Aug; 10(4):046011. PMID: 26179911.
      View in: PubMed
    10. Kutikov AB, Song J. Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications. ACS Biomater Sci Eng. 2015 Jul 13; 1(7):463-480. PMID: 27175443.
      View in: PubMed
    11. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 4; 7(8):4890-901. PMID: 25695310.
      View in: PubMed
    12. Liu P, Emmons E, Song J. A comparative study of zwitterionic ligands-mediated mineralization and the potential of mineralized zwitterionic matrices for bone tissue engineering. J Mater Chem B Mater Biol Med. 2014 Nov 21; 2(43):7524-7533. PMID: 25558374.
      View in: PubMed
    13. Kutikov AB, Reyer KA, Song J. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol Chem Phys. 2014 Dec; 215(24):2482-2490. PMID: 26457046.
      View in: PubMed
    14. Kutikov AB, Gurijala A, Song J. Rapid prototyping amphiphilic polymer/hydroxyapatite composite scaffolds with hydration-induced self-fixation behavior. Tissue Eng Part C Methods. 2015 Mar; 21(3):229-41. PMID: 25025950.
      View in: PubMed
    15. Skelly JD, Lange J, Filion TM, Li X, Ayers DC, Song J. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin Orthop Relat Res. 2014 Dec; 472(12):4015-23. PMID: 25099263.
      View in: PubMed
    16. Liu P, Skelly JD, Song J. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014 Oct; 10(10):4296-303. PMID: 24956565.
      View in: PubMed
    17. Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V substrates with well-defined zwitterionic polysulfobetaine brushes for improved surface mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52. PMID: 24828749.
      View in: PubMed
    18. Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90. PMID: 24631657.
      View in: PubMed
    19. Xu J, Feng E, Song J. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci. 2014 Mar 5; 131(5). PMID: 24994939.
      View in: PubMed
    20. Xu J, Feng E, Song J. Bioorthogonally cross-linked hydrogel network with precisely controlled disintegration time over a broad range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8. PMID: 24597638.
      View in: PubMed
    21. Filion TM, Song J. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomater Tissue Eng. 2013 Aug 1; 3(4):486-493. PMID: 25309819.
      View in: PubMed
    22. Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7. PMID: 23070662.
      View in: PubMed
    23. Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep; 9(9):8354-64. PMID: 23791675.
      View in: PubMed
    24. Zhao L, Kutikov A, Shen J, Duan C, Song J, Han G. Stem cell labeling using polyethylenimine conjugated (a-NaYbF4:Tm3+)/CaF2 upconversion nanoparticles. Theranostics. 2013; 3(4):249-57. PMID: 23606911.
      View in: PubMed
    25. Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54. PMID: 23332320.
      View in: PubMed
    26. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7. PMID: 22928629.
      View in: PubMed
    27. Jianwen Xu and Jie Song. Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications, Chapter 11. Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed.Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed. 2012.
    28. Xu J, Filion TM, Prifti F, Song J. Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry. Chem Asian J. 2011 Oct 4; 6(10):2730-7. PMID: 21954076.
      View in: PubMed
    29. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95. PMID: 21651998.
      View in: PubMed
    30. Xu J, Prifti F, Song J. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules. 2011 Apr 26; 44(8):2660-2667. PMID: 21686053.
      View in: PubMed
    31. Filion TM, Kutikov A, Song J. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg Med Chem Lett. 2011 Sep 1; 21(17):5067-70. PMID: 21536439.
      View in: PubMed
    32. Chung WJ, Kwon KY, Song J, Lee SW. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir. 2011 Jun 21; 27(12):7620-8. PMID: 21291244.
      View in: PubMed
    33. Jianwen Xu and Jie Song. Thermal responsive shape memory polymers for biomedical applications, Chapter 6. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 125-142.
    34. Tera M. Filion and Jie Song. Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials, Chapter 12. Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed. 2011; 233-248.
    35. Filion TM, Xu J, Prasad ML, Song J. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials. 2011 Feb; 32(4):985-91. PMID: 21040968.
      View in: PubMed
    36. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11. PMID: 20818999.
      View in: PubMed
    37. Xu J, Song J. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7652-7. PMID: 20375285.
      View in: PubMed
    38. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11. PMID: 19350632.
      View in: PubMed
    39. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185.
      View in: PubMed
    40. Su J, Iomdina E, Tarutta E, Ward B, Song J, Wildsoet CF. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. Exp Eye Res. 2009 Mar; 88(3):445-57. PMID: 19109950.
      View in: PubMed
    41. Song J. A chemical and engineering approach towards "smart" synthetic bone grafts. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):325. PMID: 18094494.
      View in: PubMed
    42. Kaufman JD, Song J, Klapperich CM. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res A. 2007 Jun 1; 81(3):611-23. PMID: 17187400.
      View in: PubMed
    43. Song J, Malathong V, Bertozzi CR. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72. PMID: 15755154.
      View in: PubMed
    44. Jie Song and Carolyn R. Bertozzi. Functional polymers for bone tissue engineering applications. Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed. 2005; 2:371-392.
    45. Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005; 7(11):999-1004.
    46. Jie Song and , Carolyn R. Bertozzi. Functional Hydrogel-Biomineral Composites Inspired by Natural Bone, Chapter 7. Polymer Biocatalysis and Biomaterials. 2005; 900:96-106.
    47. Song J, Cisar JS, Bertozzi CR. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65. PMID: 15238003.
      View in: PubMed
    48. Cheng Q, Zhu S, Song J, Zhang N. Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin. Analyst. 2004 Apr; 129(4):309-14. PMID: 15042161.
      View in: PubMed
    49. Jie Song, Raymond C. Stevens and Quan Cheng. Functional Amphiphilic and Bolaamphiphilic Poly(diacetylene) Assemblies with Controlled Optical and Morphological Properties, Chapter 7. Chromogenic Phenomena in Polymers. 2004; 888:96-109.
    50. Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands. J. Mater. Chem. 2004; 14:2643-2648.
    51. Song J, Saiz E, Bertozzi CR. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 5; 125(5):1236-43. PMID: 12553825.
      View in: PubMed
    52. Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003; 23(15):2905-2919.
    53. Jie Song, Quan Cheng and Raymond C. Stevens. Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem. Phys. Lipids. 2002; 114:203-214.
    54. Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices. 2002; 4(3):213-221.
    55. Song J, Cheng Q, Kopta S, Stevens RC. Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers. J Am Chem Soc. 2001 Apr 11; 123(14):3205-13. PMID: 11457054.
      View in: PubMed
    56. Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry. 2001; 12:387-391.
    57. Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999; 121:1851-1861.
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