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Matthew J Gounis PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentRadiology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1884
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentRadiology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesBSMechanical Engineering
    State University of New York, Buffalo, Buffalo, NY, United StatesMSMechanical Engineering
    University of Miami, Coral Gables, FL, United StatesPHDPhilosophy

    Collapse Overview 
    Collapse overview

    Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Associate Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. 

    On-going research projects:

    1. 5R44NS076272-03, NIH (PI: A Krtolica)                              8/1/2017-7/31/2020 (NCE) 

    Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

    Role: Subcontract PI

    In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

    2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis)    9/15/2015-7/31/2020 (NCE)

    Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

    Role: MPI

    The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

    3.    2R44NS100163-02, NIH (PI: GJ Ughi)                                                               7/15/2018-4/30/2020

    Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

    Role: Subcontract Co-I

    The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

    4. 2017104, BSF (PIs: N Korin, MJ Gounis)   10/1/2018-9/30/2022

    Hemodynamic transport of drug carriers to cerebral aneurysms

    Role: Co-PI

    Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

    5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool)                                     9/30/2019-8/31/2021

    Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

    Role: Subcontract PI

    Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

    6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves)                      12/1/2018-11/30/2021

    Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

    Role: Co-I

    The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

    7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis)   7/1/2019-06/30/2022

    Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

    Role: PI

    The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Massari F, Dabus G, Cortez GM, Singh J, Kuhn AL, Naragum V, Anagnostakou V, Hanel RA, Gounis MJ, Puri AS. Super large-bore ingestion of clot (SLIC) leads to high first pass effect in thrombectomy for large vessel occlusion. J Neurointerv Surg. 2022 Jun 22. PMID: 35732483.
      Citations:    Fields:    
    2. Mereuta OM, Abbasi M, Arturo Larco JL, Dai D, Liu Y, Arul S, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Savastano L, Cloft HJ, Nimjee SM, McBane Ii RD, Kallmes DF, Brinjikji W. Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study. J Neurointerv Surg. 2022 May 20. PMID: 35595407.
      Citations: 1     Fields:    
    3. Shazeeb MS, King RM, Anagnostakou V, Vardar Z, Kraitem A, Kolstad J, Raskett C, Le Moan N, Winger JA, Kelly L, Krtolica A, Henninger N, Gounis MJ. Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis. Stroke. 2022 04; 53(4):1363-1372. PMID: 35306836.
      Citations:    Fields:    Translation:HumansAnimals
    4. Kühn AL, Singh J, Massari F, de Macedo Rodrigues K, Gounis MJ, Puri AS. Flow Diverter Reconstruction of Internal Carotid Artery (Loop) Dissections with or without Associated Pseudoaneurysms. World Neurosurg. 2022 Jun; 162:e65-e72. PMID: 35217230.
      Citations:    Fields:    Translation:Humans
    5. Brinjikji W, Abbasi M, Mereuta OM, Fitzgerald S, Larco JA, Dai D, Kadirvel R, Nogueira RG, Kvamme P, Layton KF, Delgado JE, Hanel RA, Pereira VM, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel BM, Savastano LE, Cloft HJ, Haussen DC, Al-Bayati A, Mohammaden M, Pisani L, Rodrigues G, Thacker IC, Kayan Y, Copelan AZ, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Doyle KM, Entwistle J, Kallmes DF. Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use. J Stroke Cerebrovasc Dis. 2022 Apr; 31(4):106376. PMID: 35183984.
      Citations:    Fields:    Translation:Humans
    6. Taha A, Bobi J, Dammers R, Dijkhuizen RM, Dreyer AY, van Es ACGM, Ferrara F, Gounis MJ, Nitzsche B, Platt S, Stoffel MH, Volovici V, Del Zoppo GJ, Duncker DJ, Dippel DWJ, Boltze J, van Beusekom HMM. Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use? Stroke. 2022 04; 53(4):1411-1422. PMID: 35164533.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Flotte TR, Cataltepe O, Puri A, Batista AR, Moser R, McKenna-Yasek D, Douthwright C, Gernoux G, Blackwood M, Mueller C, Tai PWL, Jiang X, Bateman S, Spanakis SG, Parzych J, Keeler AM, Abayazeed A, Rohatgi S, Gibson L, Finberg R, Barton BA, Vardar Z, Shazeeb MS, Gounis M, Tifft CJ, Eichler FS, Brown RH, Martin DR, Gray-Edwards HL, Sena-Esteves M. AAV gene therapy for Tay-Sachs disease. Nat Med. 2022 02; 28(2):251-259. PMID: 35145305.
      Citations: 3     Fields:    Translation:HumansCells
    8. Anagnostakou V, Epshtein M, Ughi GJ, King RM, Valavanis A, Puri AS, Gounis MJ. Transvascular in vivo microscopy of the subarachnoid space. J Neurointerv Surg. 2022 May; 14(5). PMID: 35115394.
      Citations:    Fields:    Translation:HumansAnimals
    9. Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021 12 22; 6(24). PMID: 34935646.
      Citations:    Fields:    Translation:Animals
    10. Liu Y, Brinjikji W, Abbasi M, Dai D, Arturo Larco JL, Madhani SI, Shahid AH, Mereuta OM, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Fitzgerald S, Doyle K, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Kadirvel R, Cloft HJ, Kallmes DF, Savastano L. Quantification of clot spatial heterogeneity and its impact on thrombectomy. J Neurointerv Surg. 2021 Dec 15. PMID: 34911736.
      Citations: 2     Fields:    
    11. Anagnostakou V, Epshtein M, Kühn AL, King RM, Puri A, Gounis MJ. Preclinical modeling of mechanical thrombectomy. J Biomech. 2022 01; 130:110894. PMID: 34915309.
      Citations:    Fields:    Translation:HumansAnimals
    12. Epshtein M, Levi M, Kraitem AM, Zidan H, King RM, Gawaz M, Gounis MJ, Korin N. Biophysical targeting of high-risk cerebral aneurysms. Bioeng Transl Med. 2022 Jan; 7(1):e10251. PMID: 35079628.
      Citations:    
    13. Taghian T, Batista AR, Kamper S, Caldwell M, Lilley L, Li H, Rodriguez P, Mesa K, Zheng S, King RM, Gounis MJ, Todeasa S, Maguire A, Martin DR, Sena-Esteves M, Meade TJ, Gray-Edwards HL. Real-time MR tracking of AAV gene therapy with ?gal-responsive MR probe in a murine model of GM1-gangliosidosis. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:128-134. PMID: 34703836.
      Citations:    
    14. Ospel JM, van der Lugt A, Gounis M, Goyal M, Majoie CBLM. A clinical perspective on endovascular stroke treatment biomechanics. J Biomech. 2021 10 11; 127:110694. PMID: 34419825.
      Citations:    Fields:    Translation:Humans
    15. Anagnostakou V, Ughi GJ, Puri AS, Gounis MJ. Optical Coherence Tomography for Neurovascular Disorders. Neuroscience. 2021 10 15; 474:134-144. PMID: 34126186.
      Citations:    Fields:    Translation:Humans
    16. Gounis MJ, Steinman DA. Up around the bend: progress and promise of intravascular imaging in neurointerventional surgery. J Neurointerv Surg. 2021 Jun; 13(6):495-496. PMID: 33986130.
      Citations: 1     Fields:    Translation:Humans
    17. Mereuta OM, Abbasi M, Fitzgerald S, Dai D, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Arturo Larco JL, Savastano L, Cloft HJ, Kallmes DF, Doyle KM, Brinjikji W. Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy. J Neurointerv Surg. 2022 Apr; 14(4):356-361. PMID: 33975922.
      Citations: 4     Fields:    Translation:HumansCells
    18. Abbasi M, Kvamme P, Layton KF, Hanel RA, Almekhlafi MA, Delgado JE, Pereira VM, Patel BM, Jahromi BS, Yoo AJ, Nogueira RG, Gounis MJ, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Kallmes DF, Doyle KM, Savastano LE, Cloft HJ, Liu Y, Thacker IC, Aghaebrahim A, Sauvageau E, Demchuk AM, Kayan Y, Copelan AZ, Entwistle J, Nazari P, Cantrell DR, Bhuva P, Soomro J, Haussen DC, Al-Bayati A, Mohammaden M, Pisani L, Rodrigues G, Puri AS, Brinjikji W. Per pass analysis of thrombus composition retrieved by mechanical thrombectomy. Interv Neuroradiol. 2021 Dec; 27(6):815-820. PMID: 33823621.
      Citations: 2     Fields:    Translation:HumansCells
    19. Brinjikji W, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Abbasi M, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Doyle K, Savastano L, Cloft HJ, Haussen DC, Al-Bayati AR, Mohammaden MH, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Kallmes DF. Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Jul; 13(7):594-598. PMID: 33722963.
      Citations: 4     Fields:    Translation:HumansCells
    20. El-Bouri WK, MacGowan A, Józsa TI, Gounis MJ, Payne SJ. Modelling the impact of clot fragmentation on the microcirculation after thrombectomy. PLoS Comput Biol. 2021 03; 17(3):e1008515. PMID: 33711015.
      Citations: 1     Fields:    Translation:Humans
    21. Nikoubashman O, Kraitem A, Arslanian R, Gounis MJ, Sichtermann T, Wiesmann M. Preventing Inadvertent Foreign Body Injection in Angiography. Radiology. 2021 05; 299(2):460-467. PMID: 33687288.
      Citations:    Fields:    Translation:HumansPHPublic Health
    22. Kühn AL, Satti SR, Eden T, de Macedo Rodrigues K, Singh J, Massari F, Gounis MJ, Puri AS. Anatomic Snuffbox (Distal Radial Artery) and Radial Artery Access for Treatment of Intracranial Aneurysms with FDA-Approved Flow Diverters. AJNR Am J Neuroradiol. 2021 03; 42(3):487-492. PMID: 33446501.
      Citations:    Fields:    Translation:Humans
    23. Caroff J, King RM, Ughi GJ, Marosfoi M, Langan ET, Raskett C, Puri AS, Gounis MJ. Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography. Neurosurgery. 2020 11 16; 87(6):1311-1319. PMID: 32463884.
      Citations:    Fields:    Translation:Animals
    24. Chueh JY, Marosfoi MG, Anagnostakou V, Arslanian RA, Marks MP, Gounis MJ. Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device. Cardiovasc Intervent Radiol. 2021 Feb; 44(2):318-324. PMID: 33179161.
      Citations: 1     Fields:    Translation:Humans
    25. Kühn AL, Singh J, de Macedo Rodrigues K, Massari F, Moholkar VM, Marwah SK, Unar D, Gounis MJ, Puri AS. Distal radial artery (Snuffbox) access for intracranial aneurysm treatment using the Woven EndoBridge (WEB) device. J Clin Neurosci. 2020 Nov; 81:310-315. PMID: 33222936.
      Citations: 1     Fields:    Translation:Humans
    26. Vargas J, Blalock J, Venkatraman A, Anagnostakou V, King RM, Ewing JA, Gounis MJ, Turner RD, Chaudry I, Turk A. Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke. J Neurointerv Surg. 2021 Sep; 13(9):823-826. PMID: 33024028.
      Citations:    Fields:    Translation:Humans
    27. King RM, Caroff J, Langan ET, Leporati A, Rodriguez-Rodriguez A, Raskett CM, Gupta S, Puri AS, Caravan P, Gounis MJ, Bogdanov AA. In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling. J Neurointerv Surg. 2021 Mar; 13(3):267-271. PMID: 33020207.
      Citations: 1     Fields:    Translation:Animals
    28. Vardar Z, King RM, Kraitem A, Langan ET, Peterson LM, Duncan BH, Raskett CM, Anagnostakou V, Gounis MJ, Puri AS, Ughi GJ. High-resolution image-guided WEB aneurysm embolization by high-frequency optical coherence tomography. J Neurointerv Surg. 2021 Jul; 13(7):669-673. PMID: 32989033.
      Citations: 4     Fields:    Translation:Animals
    29. Kühn AL, Singh J, Moholkar VM, Satti SR, Rodrigues KM, Massari F, Gounis MJ, McGowan A, Puri AS. Distal radial artery (snuffbox) access for carotid artery stenting - Technical pearls and procedural set-up. Interv Neuroradiol. 2021 Apr; 27(2):241-248. PMID: 32924692.
      Citations: 1     Fields:    Translation:Humans
    30. Ughi GJ, Marosfoi MG, King RM, Caroff J, Peterson LM, Duncan BH, Langan ET, Collins A, Leporati A, Rousselle S, Lopes DK, Gounis MJ, Puri AS. A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy. Nat Commun. 2020 07 31; 11(1):3851. PMID: 32737314.
      Citations: 8     Fields:    Translation:HumansAnimals
    31. Taghian T, Horn E, Shazeeb MS, Bierfeldt LJ, Tuominen SM, Koehler J, Fernau D, Bertrand S, Frey S, Cataltepe OI, Gounis MJ, Abayazeed AH, Flotte TR, Sena-Esteves M, Gray-Edwards HL. Volume and Infusion Rate Dynamics of Intraparenchymal Central Nervous System Infusion in a Large Animal Model. Hum Gene Ther. 2020 06; 31(11-12):617-625. PMID: 32363942.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    32. Kühn AL, Vardar Z, Kraitem A, King RM, Anagnostakou V, Puri AS, Gounis MJ. Biomechanics and hemodynamics of stent-retrievers. J Cereb Blood Flow Metab. 2020 12; 40(12):2350-2365. PMID: 32428424.
      Citations: 1     Fields:    Translation:Humans
    33. King RM, Langan ET, Ughi GJ, Raskett CM, Puri AS, Henkes H, Gounis MJ. Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography. Cardiovasc Intervent Radiol. 2020 Aug; 43(8):1218-1223. PMID: 32385610.
      Citations: 1     Fields:    Translation:Animals
    34. Kühn AL, Gounis MJ, Puri AS. Introduction: History and Development of Flow Diverter Technology and Evolution. Neurosurgery. 2020 01 01; 86(Suppl 1):S3-S10. PMID: 31838534.
      Citations: 5     Fields:    Translation:Humans
    35. Fitzgerald S, Wang S, Dai D, Murphree DH, Pandit A, Douglas A, Rizvi A, Kadirvel R, Gilvarry M, McCarthy R, Stritt M, Gounis MJ, Brinjikji W, Kallmes DF, Doyle KM. Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots. PLoS One. 2019; 14(12):e0225841. PMID: 31805096.
      Citations: 18     Fields:    Translation:HumansCells
    36. Johnson S, Chueh J, Gounis MJ, McCarthy R, McGarry JP, McHugh PE, Gilvarry M. Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment. J Neurointerv Surg. 2020 Sep; 12(9):853-857. PMID: 31780453.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    37. Taghian T, Marosfoi MG, Puri AS, Cataltepe OI, King RM, Diffie EB, Maguire AS, Martin DR, Fernau D, Batista AR, Kuchel T, Christou C, Perumal R, Chandra S, Gamlin PD, Bertrand SG, Flotte TR, McKenna-Yasek D, Tai PWL, Aronin N, Gounis MJ, Sena-Esteves M, Gray-Edwards HL. A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna. Mol Ther. 2020 02 05; 28(2):411-421. PMID: 31813800.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    38. Staessens S, Fitzgerald S, Andersson T, Clarençon F, Denorme F, Gounis MJ, Hacke W, Liebeskind DS, Szikora I, van Es A, Brinjikji W, Doyle KM, De Meyer SF. Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations. Int J Stroke. 2020 07; 15(5):467-476. PMID: 31679478.
      Citations: 18     Fields:    Translation:Humans
    39. Chueh JY, Kang DH, Kim BM, Gounis MJ. Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy. J Korean Neurosurg Soc. 2020 Jan; 63(1):14-25. PMID: 31591997.
      Citations:    
    40. Shazeeb MS, King RM, Brooks OW, Puri AS, Henninger N, Boltze J, Gounis MJ. Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion. Transl Stroke Res. 2020 06; 11(3):468-480. PMID: 31478129.
      Citations: 6     Fields:    Translation:Animals
    41. Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nat Biotechnol. 2019 08; 37(8):884-894. PMID: 31375812.
      Citations: 41     Fields:    Translation:Animals
    42. Caroff J, King RM, Mitchell JE, Marosfoi M, Licwinko JR, Gray-Edwards HL, Puri AS, Merrill TL, Gounis MJ. Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept. J Neurointerv Surg. 2020 Feb; 12(2):209-213. PMID: 31363042.
      Citations: 12     Fields:    Translation:Animals
    43. Prestigiacomo CJ, Gounis MJ, Gonzalez LF, Frösen J. Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms. Neurosurg Focus. 2019 07 01; 47(1):E1. PMID: 31261113.
      Citations:    Fields:    Translation:Humans
    44. Fitzgerald S, Dai D, Wang S, Douglas A, Kadirvel R, Layton KF, Thacker IC, Gounis MJ, Chueh JY, Puri AS, Almekhlafi M, Demchuk AM, Hanel RA, Sauvageau E, Aghaebrahim A, Yoo AJ, Kvamme P, M Pereira V, Kayan Y, Delgado Almandoz JE, Nogueira RG, Rabinstein AA, Kallmes DF, Doyle KM, Brinjikji W. Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source. Stroke. 2019 07; 50(7):1907-1910. PMID: 31138084.
      Citations: 18     Fields:    Translation:HumansCells
    45. Brooks OW, King RM, Nossek E, Marosfoi M, Caroff J, Chueh JY, Puri AS, Gounis MJ. A canine model of mechanical thrombectomy in stroke. J Neurointerv Surg. 2019 Dec; 11(12):1243-1248. PMID: 31103992.
      Citations: 5     Fields:    Translation:Animals
    46. Kühn AL, Kan P, Henninger N, Srinivasan V, de Macedo Rodrigues K, Wakhloo AK, Gounis MJ, Puri AS. Impact of age on cerebral aneurysm occlusion after flow diversion. J Clin Neurosci. 2019 Jul; 65:23-27. PMID: 31072739.
      Citations: 1     Fields:    Translation:Humans
    47. MacDonell J, Patel N, Fischer G, Burdette EC, Qian J, Chumbalkar V, Ghoshal G, Heffter T, Williams E, Gounis M, King R, Thibodeau J, Bogdanov G, Brooks OW, Langan E, Hwang R, Pilitsis JG. Robotic Assisted MRI-Guided Interventional Interstitial MR-Guided Focused Ultrasound Ablation in a Swine Model. Neurosurgery. 2019 05 01; 84(5):1138-1148. PMID: 29905844.
      Citations: 8     Fields:    Translation:Animals
    48. King RM, Marosfoi M, Caroff J, Ughi GJ, Groth DM, Gounis MJ, Puri AS. High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion. J Neurointerv Surg. 2019 Nov; 11(11):1150-1154. PMID: 31036558.
      Citations: 8     Fields:    Translation:Animals
    49. Fitzgerald ST, Wang S, Dai D, Douglas A, Kadirvel R, Gounis MJ, Chueh J, Puri AS, Layton KF, Thacker IC, Hanel RA, Sauvageau E, Aghaebrahim A, Almekhlafi MA, Demchuk AM, Nogueira RG, Pereira VM, Kvamme P, Kayan Y, Delgado Almandoz JE, Yoo AJ, Kallmes DF, Doyle KM, Brinjikji W. Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT. J Neurointerv Surg. 2019 Nov; 11(11):1145-1149. PMID: 30952688.
      Citations: 21     Fields:    Translation:HumansCells
    50. Aquarius R, de Korte A, Smits D, Gounis M, Verrijp K, Driessen L, Leenders W, de Vries J. The Importance of Wall Apposition in Flow Diverters. Neurosurgery. 2019 03 01; 84(3):804-810. PMID: 29659995.
      Citations: 7     Fields:    Translation:Animals
    51. Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Sci Transl Med. 2019 02 13; 11(479). PMID: 30760580.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    52. Herrmann AM, Meckel S, Gounis MJ, Kringe L, Motschall E, Mülling C, Boltze J. Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations. J Cereb Blood Flow Metab. 2019 03; 39(3):375-394. PMID: 30732549.
      Citations: 34     Fields:    Translation:HumansAnimals
    53. Arslanian RA, Marosfoi M, Caroff J, King RM, Raskett C, Puri AS, Gounis MJ, Chueh JY. Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization. J Neurointerv Surg. 2019 Sep; 11(9):931-936. PMID: 30718384.
      Citations: 14     Fields:    Translation:HumansAnimals
    54. Gounis MJ, Ughi GJ, Marosfoi M, Lopes DK, Fiorella D, Bezerra HG, Liang CW, Puri AS. Intravascular Optical Coherence Tomography for Neurointerventional Surgery. Stroke. 2018 Nov 29; STROKEAHA118022315. PMID: 30580737.
      Citations: 6     Fields:    
    55. Caroff J, King RM, Arslanian R, Marosfoi M, Langan ET, Gounis MJ, Chueh JY. Microcatheter navigation through the clot: does size matter? J Neurointerv Surg. 2019 Mar; 11(3):271-274. PMID: 30177546.
      Citations: 5     Fields:    Translation:Humans
    56. Brouwer PA, Yeo LLL, Gounis MJ, Gontu VK. Size matters… but how do I know what size it is? J Neurointerv Surg. 2019 01; 11(1):3-5. PMID: 30042158.
      Citations:    Fields:    
    57. Gounis MJ. Commentary on 'Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases'. J Neurointerv Surg. 2018 07; 10(Suppl 1):i50. PMID: 30037957.
      Citations:    Fields:    
    58. Wadghiri YZ, Hoang DM, Leporati A, Gounis MJ, Rodríguez-Rodríguez A, Mazzanti ML, Weaver JP, Wakhloo AK, Caravan P, Bogdanov AA. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018 05 16; 8(1):7687. PMID: 29769642.
      Citations: 9     Fields:    Translation:Humans
    59. De Macedo Rodrigues K, Kühn AL, Tamura T, Dabus G, Kan P, Marosfoi MG, Lozano JD, Perras M, Brooks C, Howk MC, Hou SY, Rex DE, Massari F, Gounis MJ, Wakhloo AK, Puri AS. Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study. Oper Neurosurg (Hagerstown). 2018 04 01; 14(4):351-358. PMID: 28521024.
      Citations: 5     Fields:    Translation:Humans
    60. Caroff J, Tamura T, King RM, Lylyk PN, Langan ET, Brooks OW, Clarençon F, Wainwright JM, Spelle L, Marosfoi M, Gounis MJ, Puri AS. Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. J Neurointerv Surg. 2018 Nov; 10(11):1097-1101. PMID: 29511117.
      Citations: 10     Fields:    Translation:Animals
    61. Nitzsche B, Boltze J, Ludewig E, Flegel T, Schmidt MJ, Seeger J, Barthel H, Brooks OW, Gounis MJ, Stoffel MH, Schulze S. A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets. Neuroimage. 2019 02 15; 187:93-103. PMID: 29407456.
      Citations: 13     Fields:    Translation:Animals
    62. Kallmes DF, Rabinstein AA, Gounis MJ. To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI. J Neurointerv Surg. 2018 Apr; 10(4):323-324. PMID: 29352058.
      Citations:    Fields:    
    63. Mondo E, Moser R, Gao G, Mueller C, Sena-Esteves M, Sapp E, Pfister E, O'Connell D, Takle K, Erger KE, Liu W, Conlon TJ, DiFiglia M, Gounis MJ, Aronin N. Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration. J Huntingtons Dis. 2018; 7(4):309-319. PMID: 30320596.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    64. King RM, Brooks OW, Langan ET, Caroff J, Clarençon F, Tamura T, Wainwright JM, Gounis MJ, Marosf?i M, Puri AS. Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion. J Neurointerv Surg. 2018 Jul; 10(7):693-697. PMID: 29127197.
      Citations: 16     Fields:    Translation:Animals
    65. Chueh JY, Marosfoi MG, Brooks OW, King RM, Puri AS, Gounis MJ. Novel Distal Emboli Protection Technology: The EmboTrap. Interv Neurol. 2017 Oct; 6(3-4):268-276. PMID: 29118805.
      Citations:    
    66. Gounis MJ. Neurointervention: a call to science. J Neurointerv Surg. 2017 09; 9(9):813-814. PMID: 28819057.
      Citations:    Fields:    
    67. Marosfoi M, Clarencon F, Langan ET, King RM, Brooks OW, Tamura T, Wainwright JM, Gounis MJ, Vedantham S, Puri AS. Acute thrombus formation on phosphorilcholine surface modified flow diverters. J Neurointerv Surg. 2018 Apr; 10(4):406-411. PMID: 28689183.
      Citations: 21     Fields:    Translation:Animals
    68. Gounis MJ, Chapot R. Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention? Stroke. 2017 08; 48(8):2040-2041. PMID: 28626053.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    69. De Meyer SF, Andersson T, Baxter B, Bendszus M, Brouwer P, Brinjikji W, Campbell BC, Costalat V, Dávalos A, Demchuk A, Dippel D, Fiehler J, Fischer U, Gilvarry M, Gounis MJ, Gralla J, Jansen O, Jovin T, Kallmes D, Khatri P, Lees KR, López-Cancio E, Majoie C, Marquering H, Narata AP, Nogueira R, Ringleb P, Siddiqui A, Szikora I, Vale D, von Kummer R, Yoo AJ, Hacke W, Liebeskind DS. Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions. Int J Stroke. 2017 08; 12(6):606-614. PMID: 28534706.
      Citations: 56     Fields:    Translation:Humans
    70. Chueh JY, van der Marel K, Gounis MJ, LeMatty T, Brown TR, Ansari SA, Carroll TJ, Buck AK, Zhou XJ, Chatterjee AR, King RM, Mao H, Zheng S, Brooks OW, Rappleye JW, Swartz RH, Feldmann E, Turan TN. Development of a high resolution MRI intracranial atherosclerosis imaging phantom. J Neurointerv Surg. 2018 Feb; 10(2):143-149. PMID: 28280114.
      Citations: 5     Fields:    Translation:Humans
    71. Aquarius R, Smits D, Gounis MJ, Leenders WPJ, de Vries J. Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study. J Neurointerv Surg. 2018 Jan; 10(1):88-92. PMID: 28179543.
      Citations: 3     Fields:    Translation:HumansAnimals
    72. Golebiowski D, van der Bom IMJ, Kwon CS, Miller AD, Petrosky K, Bradbury AM, Maitland S, Kühn AL, Bishop N, Curran E, Silva N, GuhaSarkar D, Westmoreland SV, Martin DR, Gounis MJ, Asaad WF, Sena-Esteves M. Direct Intracranial Injection of AAVrh8 Encoding Monkey ?-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain. Hum Gene Ther. 2017 06; 28(6):510-522. PMID: 28132521.
      Citations: 30     Fields:    Translation:AnimalsCells
    73. van der Marel K, Vedantham S, van der Bom IM, Howk M, Narain T, Ty K, Karellas A, Gounis MJ, Puri AS, Wakhloo AK. Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform. AJNR Am J Neuroradiol. 2017 Mar; 38(3):442-449. PMID: 28104643.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    74. Taschner CA, Vedantham S, de Vries J, Biondi A, Boogaarts J, Sakai N, Lylyk P, Szikora I, Meckel S, Urbach H, Kan P, Siekmann R, Bernardy J, Gounis MJ, Wakhloo AK. Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms. AJNR Am J Neuroradiol. 2017 Mar; 38(3):582-589. PMID: 28007769.
      Citations: 11     Fields:    Translation:Humans
    75. Kühn AL, Wakhloo AK, Gounis MJ, Kan P, de Macedo Rodrigues K, Lozano JD, Marosfoi MG, Perras M, Brooks C, Howk MC, Rex DE, Massari F, Puri AS. Use of self-expanding stents for better intracranial flow diverter wall apposition. Interv Neuroradiol. 2017 Apr; 23(2):129-136. PMID: 27956518.
      Citations: 6     Fields:    Translation:Humans
    76. Kühn AL, de Macedo Rodrigues K, Lozano JD, Rex DE, Massari F, Tamura T, Howk M, Brooks C, L'Heureux J, Gounis MJ, Wakhloo AK, Puri AS. Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up. J Neurointerv Surg. 2017 Dec; 9(12):1208-1213. PMID: 27888225.
      Citations: 8     Fields:    Translation:Humans
    77. Ansari SA, Kühn AL, Honarmand AR, Khan M, Hurley MC, Potts MB, Jahromi BS, Shaibani A, Gounis MJ, Wakhloo AK, Puri AS. Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents. AJNR Am J Neuroradiol. 2017 Jan; 38(1):97-104. PMID: 28059705.
      Citations: 3     Fields:    Translation:Humans
    78. Marosfoi M, Langan ET, Strittmatter L, van der Marel K, Vedantham S, Arends J, Lylyk IR, Loganathan S, Hendricks GM, Szikora I, Puri AS, Wakhloo AK, Gounis MJ. In situ tissue engineering: endothelial growth patterns as a function of flow diverter design. J Neurointerv Surg. 2017 Oct; 9(10):994-998. PMID: 27707872.
      Citations: 11     Fields:    Translation:Animals
    79. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. J Neurointerv Surg. 2017 Mar; 9(3):e10. PMID: 27417184.
      Citations:    Fields:    Translation:Humans
    80. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. BMJ Case Rep. 2016 Jul 05; 2016. PMID: 27382015.
      Citations: 1     Fields:    Translation:Humans
    81. Boltze J, Wagner DC, Barthel H, Gounis MJ. Academic-industry Collaborations in Translational Stroke Research. Transl Stroke Res. 2016 08; 7(4):343-53. PMID: 27301976.
      Citations: 7     Fields:    Translation:HumansAnimals
    82. Kühn AL, Wakhloo AK, Lozano JD, Massari F, De Macedo Rodrigues K, Marosfoi MG, Perras M, Brooks C, Howk M, Rex DE, Gounis MJ, Puri AS. Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke. J Neurointerv Surg. 2017 Jun; 9(6):541-546. PMID: 27286991.
      Citations: 3     Fields:    Translation:Humans
    83. Brinjikji W, Duffy S, Burrows A, Hacke W, Liebeskind D, Majoie CBLM, Dippel DWJ, Siddiqui AH, Khatri P, Baxter B, Nogeuira R, Gounis M, Jovin T, Kallmes DF. Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review. J Neurointerv Surg. 2017 Jun; 9(6):529-534. PMID: 27166383.
      Citations: 82     Fields:    Translation:Humans
    84. Vedantham S, Shrestha S, Karellas A, Shi L, Gounis MJ, Bellazzini R, Spandre G, Brez A, Minuti M. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. Med Phys. 2016 May; 43(5):2118. PMID: 27147324.
      Citations: 3     Fields:    Translation:Humans
    85. Chueh JY, Puri AS, Gounis MJ. An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy. J Neurointerv Surg. 2017 Feb; 9(2):183-187. PMID: 26919972.
      Citations: 9     Fields:    
    86. Massari F, Henninger N, Lozano JD, Patel A, Kuhn AL, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK, Puri AS. ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience. Interv Neuroradiol. 2016 Jun; 22(3):325-32. PMID: 26908591.
      Citations: 42     Fields:    Translation:Humans
    87. van der Marel K, Chueh JY, Brooks OW, King RM, Marosfoi MG, Langan ET, Carniato SL, Gounis MJ, Nogueira RG, Puri AS. Quantitative assessment of device-clot interaction for stent retriever thrombectomy. J Neurointerv Surg. 2016 Dec; 8(12):1278-1282. PMID: 26833539.
      Citations: 21     Fields:    
    88. Puri AS, Massari F, Asai T, Marosfoi M, Kan P, Hou SY, Howk M, Perras M, Brooks C, Clarencon F, Gounis MJ, Wakhloo AK. Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (<2.5 mm) cerebral vessels for aneurysm treatment: single institution experience. Neuroradiology. 2016 Mar; 58(3):267-75. PMID: 26700827.
      Citations: 21     Fields:    Translation:Humans
    89. Iannaccone F, De Beule M, De Bock S, Van der Bom IM, Gounis MJ, Wakhloo AK, Boone M, Verhegghe B, Segers P. A Finite Element Method to Predict Adverse Events in Intracranial Stenting Using Microstents: In Vitro Verification and Patient Specific Case Study. Ann Biomed Eng. 2016 Feb; 44(2):442-52. PMID: 26620777.
      Citations: 1     Fields:    Translation:Humans
    90. Shen ZT, Zheng S, Gounis MJ, Sigalov AB. Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles. PLoS One. 2015; 10(11):e0143453. PMID: 26569115.
      Citations: 14     Fields:    Translation:AnimalsCells
    91. Kühn AL, Kan P, Massari F, Lozano JD, Hou SY, Howk M, Gounis MJ, Wakhloo AK, Puri AS. Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device. J Neurointerv Surg. 2016 Oct; 8(10):1048-51. PMID: 26546600.
      Citations: 13     Fields:    Translation:Humans
    92. Marosfoi MG, Korin N, Gounis MJ, Uzun O, Vedantham S, Langan ET, Papa AL, Brooks OW, Johnson C, Puri AS, Bhatta D, Kanapathipillai M, Bronstein BR, Chueh JY, Ingber DE, Wakhloo AK. Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion. Stroke. 2015 Dec; 46(12):3507-13. PMID: 26493676.
      Citations: 12     Fields:    Translation:Animals
    93. Gounis MJ, van der Marel K, Marosfoi M, Mazzanti ML, Clarençon F, Chueh JY, Puri AS, Bogdanov AA. Imaging Inflammation in Cerebrovascular Disease. Stroke. 2015 Oct; 46(10):2991-7. PMID: 26351362.
      Citations: 9     Fields:    Translation:Humans
    94. van der Marel K, Gounis MJ, Weaver JP, de Korte AM, King RM, Arends JM, Brooks OW, Wakhloo AK, Puri AS. Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT. J Neurointerv Surg. 2016 Aug; 8(8):847-52. PMID: 26220411.
      Citations: 14     Fields:    Translation:Animals
    95. Walvick RP, Roche JP, Reno AL, Gounis MJ, Albert MS. Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia. Magn Reson Med. 2016 May; 75(5):2050-4. PMID: 26079271.
      Citations:    Fields:    Translation:Animals
    96. Kühn AL, Hou SY, Puri AS, Silva CF, Gounis MJ, Wakhloo AK. Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis. J Neurointerv Surg. 2016 Jun; 8(6):581-5. PMID: 26041097.
      Citations: 8     Fields:    Translation:Humans
    97. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. J Neurointerv Surg. 2016 Apr; 8(4):e13. PMID: 25854687.
      Citations: 1     Fields:    Translation:Humans
    98. Puri AS, Massari F, Hou SY, Lozano JD, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK. Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms. J Neurointerv Surg. 2016 May; 8(5):501-6. PMID: 25838199.
      Citations: 3     Fields:    Translation:Humans
    99. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. BMJ Case Rep. 2015 Apr 01; 2015. PMID: 25833904.
      Citations:    Fields:    Translation:Humans
    100. Korin N, Gounis MJ, Wakhloo AK, Ingber DE. Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics. JAMA Neurol. 2015 Jan; 72(1):119-22. PMID: 25365638.
      Citations: 11     Fields:    Translation:Humans
    101. Chueh JY, Puri AS, Wakhloo AK, Gounis MJ. Risk of distal embolization with stent retriever thrombectomy and ADAPT. J Neurointerv Surg. 2016 Feb; 8(2):197-202. PMID: 25540180.
      Citations: 67     Fields:    Translation:Humans
    102. Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35. PMID: 25344064.
      Citations: 6     Fields:    Translation:Humans
    103. Gounis MJ, van der Bom IM, Wakhloo AK, Zheng S, Chueh JY, Kühn AL, Bogdanov AA. MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall. AJNR Am J Neuroradiol. 2015 Jan; 36(1):146-52. PMID: 25273534.
      Citations: 5     Fields:    Translation:Animals
    104. Wakhloo AK, Lylyk P, de Vries J, Taschner C, Lundquist J, Biondi A, Hartmann M, Szikora I, Pierot L, Sakai N, Imamura H, Sourour N, Rennie I, Skalej M, Beuing O, Bonafé A, Mery F, Turjman F, Brouwer P, Boccardi E, Valvassori L, Derakhshani S, Litzenberg MW, Gounis MJ. Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study. AJNR Am J Neuroradiol. 2015 Jan; 36(1):98-107. PMID: 25125666.
      Citations: 49     Fields:    Translation:HumansCTClinical Trials
    105. Wakhloo AK, Gounis MJ. Revolution in aneurysm treatment: flow diversion to cure aneurysms: a paradigm shift. Neurosurgery. 2014 Aug; 61 Suppl 1:111-20. PMID: 25032539.
      Citations: 10     Fields:    Translation:HumansAnimals
    106. Kühn AL, Hou SY, Perras M, Brooks C, Gounis MJ, Wakhloo AK, Puri AS. Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up. J Neurointerv Surg. 2015 Sep; 7(9):634-40. PMID: 25051964.
      Citations: 8     Fields:    Translation:Humans
    107. Chueh JY, Vedantham S, Wakhloo AK, Carniato SL, Puri AS, Bzura C, Coffin S, Bogdanov AA, Gounis MJ. Aneurysm permeability following coil embolization: packing density and coil distribution. J Neurointerv Surg. 2015 Sep; 7(9):676-81. PMID: 25031179.
      Citations: 11     Fields:    Translation:Humans
    108. Gounis MJ, Vedantham S, Weaver JP, Puri AS, Brooks CS, Wakhloo AK, Bogdanov AA. Myeloperoxidase in human intracranial aneurysms: preliminary evidence. Stroke. 2014 May; 45(5):1474-7. PMID: 24713525.
      Citations: 21     Fields:    Translation:Humans
    109. Zheng S, van der Bom IM, Zu Z, Lin G, Zhao Y, Gounis MJ. Chemical exchange saturation transfer effect in blood. Magn Reson Med. 2014 Mar; 71(3):1082-92. PMID: 23661508.
      Citations: 15     Fields:    Translation:HumansAnimals
    110. Puri AS, Kühn AL, Kwon HJ, Khan M, Hou SY, Lin E, Chueh J, van der Bom IM, Dabus G, Linfante I, Gounis MJ, Wakhloo AK. Endovascular treatment of tandem vascular occlusions in acute ischemic stroke. J Neurointerv Surg. 2015 Mar; 7(3):158-63. PMID: 24578485.
      Citations: 19     Fields:    Translation:Humans
    111. Flood TF, van der Bom IM, Strittmatter L, Puri AS, Hendricks GM, Wakhloo AK, Gounis MJ. Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia. J Neurointerv Surg. 2015 Feb; 7(2):118-25. PMID: 24480728.
      Citations: 8     Fields:    Translation:HumansAnimals
    112. Wakhloo AK, Gounis MJ, Chueh JY, Pierot L. Advances in stroke: Advances in interventional radiology 2013. Stroke. 2014 Feb; 45(2):365-7. PMID: 24436230.
      Citations:    Fields:    Translation:Humans
    113. Vogl TJ, Pflugmacher R, Hierholzer J, Stender G, Gounis M, Wakhloo A, Fiebig C, Hammerstingl R. Cement directed kyphoplasty reduces cement leakage as compared with vertebroplasty: results of a controlled, randomized trial. Spine (Phila Pa 1976). 2013 Sep 15; 38(20):1730-6. PMID: 23804157.
      Citations: 18     Fields:    Translation:Humans
    114. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. J Neurointerv Surg. 2014 Jun; 6(5):e34. PMID: 23997121.
      Citations: 3     Fields:    Translation:Humans
    115. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. BMJ Case Rep. 2013 Aug 14; 2013. PMID: 23946527.
      Citations: 1     Fields:    Translation:Humans
    116. Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun; 44(6 Suppl 1):S7-S10. PMID: 23709736.
      Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    117. van der Bom IM, Hou SY, Puri AS, Spilberg G, Ruijters D, van de Haar P, Carelsen B, Vedantham S, Gounis MJ, Wakhloo AK. Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2163-70. PMID: 23721899.
      Citations: 25     Fields:    Translation:Humans
    118. Chueh JY, Kühn AL, Puri AS, Wilson SD, Wakhloo AK, Gounis MJ. Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study. Stroke. 2013 May; 44(5):1396-401. PMID: 23493730.
      Citations: 76     Fields:    Translation:Humans
    119. van der Bom IM, Moser RP, Gao G, Mondo E, O'Connell D, Gounis MJ, McGowan S, Chaurette J, Bishop N, Sena-Esteves MS, Mueller C, Aronin N. Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery. J Huntingtons Dis. 2013; 2(1):41-5. PMID: 25063428.
      Citations: 5     Fields:    Translation:AnimalsCells
    120. Gounis MJ, Nogueira RG, Mehra M, Chueh J, Wakhloo AK. A thromboembolic model for the efficacy and safety evaluation of combined mechanical and pharmacologic revascularization strategies. J Neurointerv Surg. 2013 May; 5 Suppl 1:i85-9. PMID: 22962414.
      Citations: 7     Fields:    Translation:Animals
    121. Chueh JY, Wakhloo AK, Gounis MJ. Effectiveness of mechanical endovascular thrombectomy in a model system of cerebrovascular occlusion. AJNR Am J Neuroradiol. 2012 Nov; 33(10):1998-2003. PMID: 22555570.
      Citations: 27     Fields:    Translation:Humans
    122. Zarate B, Gutierrez J, Wakhloo AK, Gounis MJ, Reyes-Sánchez A. Clinical evaluation of a new kyphoplasty technique with directed cement flow. J Spinal Disord Tech. 2012 May; 25(3):E61-6. PMID: 22343281.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    123. Samaniego EA, Tari-Capone F, Linfante I, Silva CF, Spilberg G, Gounis M, Wakhloo AK, Dabus G. Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure. J Neurointerv Surg. 2013 Jul; 5(4):302-5. PMID: 22544819.
      Citations: 7     Fields:    Translation:Humans
    124. King RM, Chueh JY, van der Bom IM, Silva CF, Carniato SL, Spilberg G, Wakhloo AK, Gounis MJ. The effect of intracranial stent implantation on the curvature of the cerebrovasculature. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1657-62. PMID: 22538075.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    125. Wakhloo AK, Linfante I, Silva CF, Samaniego EA, Dabus G, Etezadi V, Spilberg G, Gounis MJ. Closed-cell stent for coil embolization of intracranial aneurysms: clinical and angiographic results. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1651-6. PMID: 22492570.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    126. van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 01; 5(1):69-72. PMID: 22193239.
      Citations: 6     Fields:    Translation:AnimalsCells
    127. Spilberg G, Carniato SL, King RM, van der Bom IM, Mehra M, Walvick RP, Wakhloo AK, Gounis MJ. Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study. AJNR Am J Neuroradiol. 2012 Apr; 33(4):655-60. PMID: 22194374.
      Citations: 2     Fields:    Translation:HumansAnimals
    128. van der Bom IM, Mehra M, Walvick RP, Chueh JY, Gounis MJ. Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke. AJNR Am J Neuroradiol. 2012 Feb; 33(2):353-8. PMID: 22173756.
      Citations: 14     Fields:    Translation:Animals
    129. Carniato S, Mehra M, King RM, Wakhloo AK, Gounis MJ. Porcine brachial artery tortuosity for in vivo evaluation of neuroendovascular devices. AJNR Am J Neuroradiol. 2013 Apr; 34(4):E36-8. PMID: 22081678.
      Citations: 5     Fields:    Translation:HumansAnimals
    130. Grunwald IQ, Kamran M, Corkill RA, Kühn AL, Choi IS, Turnbull S, Dobson D, Fassbender K, Watson D, Gounis MJ. Simple measurement of aneurysm residual after treatment: the SMART scale for evaluation of intracranial aneurysms treated with flow diverters. Acta Neurochir (Wien). 2012 Jan; 154(1):21-6; discussion 26. PMID: 22002552.
      Citations: 9     Fields:    Translation:Humans
    131. Nogueira RG, Levy EI, Gounis M, Siddiqui AH. The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease. J Neurointerv Surg. 2012 Jul; 4(4):295-300. PMID: 21990512.
      Citations: 35     Fields:    Translation:Animals
    132. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul; 4(4):307-13. PMID: 21990535.
      Citations: 18     Fields:    Translation:HumansAnimals
    133. Chueh JY, Wakhloo AK, Hendricks GH, Silva CF, Weaver JP, Gounis MJ. Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs. AJNR Am J Neuroradiol. 2011 Aug; 32(7):1237-44. PMID: 21596804.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    134. Mehra M, Hurley MC, Gounis MJ, King RM, Shaibani A, Dabus G, Labdag FE, Levy EI, Bendok BR. The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study. J Neurointerv Surg. 2011 Jun; 3(2):131-6. PMID: 21990804.
      Citations: 10     Fields:    Translation:Humans
    135. van der Bom MJ, Pluim JP, Gounis MJ, van de Kraats EB, Sprinkhuizen SM, Timmer J, Homan R, Bartels LW. Registration of 2D x-ray images to 3D MRI by generating pseudo-CT data. Phys Med Biol. 2011 Feb 21; 56(4):1031-43. PMID: 21258138.
      Citations: 4     Fields:    Translation:HumansAnimals
    136. Patel NV, Gounis MJ, Wakhloo AK, Noordhoek N, Blijd J, Babic D, Takhtani D, Lee SK, Norbash A. Contrast-enhanced angiographic cone-beam CT of cerebrovascular stents: experimental optimization and clinical application. AJNR Am J Neuroradiol. 2011 Jan; 32(1):137-44. PMID: 20966059.
      Citations: 31     Fields:    Translation:HumansAnimals
    137. Li JM, Newburger PE, Gounis MJ, Dargon P, Zhang X, Messina LM. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther. 2010 Oct; 17(10):1279-87. PMID: 20485380.
      Citations: 22     Fields:    Translation:Animals
    138. van der Bom MJ, Bartels LW, Gounis MJ, Homan R, Timmer J, Viergever MA, Pluim JP. Robust initialization of 2D-3D image registration using the projection-slice theorem and phase correlation. Med Phys. 2010 Apr; 37(4):1884-92. PMID: 20443510.
      Citations: 4     Fields:    Translation:HumansAnimals
    139. Gounis MJ, DeLeo MJ, Wakhloo AK. Advances in interventional neuroradiology. Stroke. 2010 Feb; 41(2):e81-7. PMID: 20075339.
      Citations: 3     Fields:    Translation:Humans
    140. Hong B, Patel NV, Gounis MJ, DeLeo MJ, Linfante I, Wojak JC, Wakhloo AK. Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms. Neurosurgery. 2009 Dec; 65(6):1131-8; discussion 1138-9. PMID: 19934972.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    141. Linfante I, DeLeo MJ, Gounis MJ, Brooks CS, Wakhloo AK. Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results. AJNR Am J Neuroradiol. 2009 Sep; 30(8):1496-501. PMID: 19696138.
      Citations: 12     Fields:    Translation:Humans
    142. DeLeo MJ, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov AA. Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study. Radiology. 2009 Sep; 252(3):696-703. PMID: 19546428.
      Citations: 15     Fields:    Translation:Animals
    143. Chueh JY, Wakhloo AK, Gounis MJ. Neurovascular modeling: small-batch manufacturing of silicone vascular replicas. AJNR Am J Neuroradiol. 2009 Jun; 30(6):1159-64. PMID: 19321626.
      Citations: 30     Fields:    Translation:Humans
    144. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50. PMID: 19246690.
      Citations: 564     Fields:    Translation:HumansAnimals
    145. Linfante I, Delgado-Mederos R, Andreone V, Gounis M, Hendricks L, Wakhloo AK. Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine in cerebral vasospasm. Neurosurgery. 2008 Dec; 63(6):1080-6; discussion 1086-7. PMID: 19057319.
      Citations: 13     Fields:    Translation:Humans
    146. Cesar L, Miskolczi L, Lieber BB, Sadasivan C, Gounis MJ, Wakhloo AK. Neurological deficits associated with the elastase-induced aneurysm model in rabbits. Neurol Res. 2009 May; 31(4):414-9. PMID: 18826754.
      Citations: 4     Fields:    Translation:Animals
    147. Wakhloo AK, Mandell J, Gounis MJ, Brooks C, Linfante I, Winer J, Weaver JP. Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up. Stroke. 2008 Dec; 39(12):3288-96. PMID: 18772450.
      Citations: 51     Fields:    Translation:Humans
    148. Wakhloo AK, Gounis MJ. Retrievable closed cell intracranial stent for foreign body and clot removal. Neurosurgery. 2008 May; 62(5 Suppl 2):ONS390-3; discussion ONS393-4. PMID: 18596519.
      Citations: 8     Fields:    Translation:Animals
    149. Gounis MJ, Lieber BB, Webster KA, Wakhloo AK. A novel angiographic methodology for the quantification of angiogenesis. IEEE Trans Biomed Eng. 2008 Mar; 55(3):996-1003. PMID: 18334391.
      Citations: 1     Fields:    Translation:Animals
    150. Bendok BR, Parkinson RJ, Hage ZA, Adel JG, Gounis MJ. The effect of vascular reconstruction device-assisted coiling on packing density, effective neck coverage, and angiographic outcome: an in vitro study. Neurosurgery. 2007 Oct; 61(4):835-40; discussion 840-1. PMID: 17986946.
      Citations: 29     Fields:    
    151. Wakhloo AK, Gounis MJ, Sandhu JS, Akkawi N, Schenck AE, Linfante I. Complex-shaped platinum coils for brain aneurysms: higher packing density, improved biomechanical stability, and midterm angiographic outcome. AJNR Am J Neuroradiol. 2007 Aug; 28(7):1395-400. PMID: 17698550.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    152. Onizuka M, Miskolczi L, Gounis MJ, Seong J, Lieber BB, Wakhloo AK. Elastase-induced aneurysms in rabbits: effect of postconstruction geometry on final size. AJNR Am J Neuroradiol. 2006 May; 27(5):1129-31. PMID: 16687557.
      Citations: 6     Fields:    Translation:Animals
    153. Miskolczi L, Nemes B, Cesar L, Masanari O, Gounis MJ. Contrast injection via the central artery of the left ear in rabbits: a new technique to simplify follow-up studies. AJNR Am J Neuroradiol. 2005 Sep; 26(8):1964-6. PMID: 16155143.
      Citations: 4     Fields:    Translation:Animals
    154. Lieber BB, Wakhloo AK, Siekmann R, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: effect of ethiodol and glacial acetic acid on penetration, dispersion, and injection force of N-butyl 2-cyanoacrylate. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1707-14. PMID: 16091519.
      Citations: 4     Fields:    Translation:Animals
    155. Wakhloo AK, Lieber BB, Siekmann R, Eber DJ, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: hemodynamics and vascular remodeling. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1702-6. PMID: 16091518.
      Citations: 6     Fields:    Translation:Animals
    156. Gounis MJ, Spiga MG, Graham RM, Wilson A, Haliko S, Lieber BB, Wakhloo AK, Webster KA. Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle. Gene Ther. 2005 May; 12(9):762-71. PMID: 15772688.
      Citations: 20     Fields:    Translation:AnimalsCells
    157. Shellock FG, Gounis M, Wakhloo A. Detachable coil for cerebral aneurysms: in vitro evaluation of magnetic field interactions, heating, and artifacts at 3T. AJNR Am J Neuroradiol. 2005 Feb; 26(2):363-6. PMID: 15709137.
      Citations: 9     Fields:    Translation:Humans
    158. Seong J, Sadasivan C, Onizuka M, Gounis MJ, Christian F, Miskolczi L, Wakhloo AK, Lieber BB. Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas. Biorheology. 2005; 42(5):345-61. PMID: 16308466.
      Citations: 15     Fields:    Translation:Animals
    159. Lieber BB, Sadasivan C, Gounis MJ, Seong J, Miskolczi L, Wakhloo AK. Functional angiography. Crit Rev Biomed Eng. 2005; 33(1):1-102. PMID: 15777157.
      Citations: 9     Fields:    Translation:Humans
    160. Wakhloo AK, Lieber BB, Seong J, Sadasivan C, Gounis MJ, Miskolczi L, Sandhu JS. Hemodynamics of carotid artery atherosclerotic occlusive disease. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 2):S111-21. PMID: 15101520.
      Citations: 8     Fields:    Translation:Humans
    161. Sadasivan C, Lieber BB, Gounis MJ, Lopes DK, Hopkins LN. Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement. AJNR Am J Neuroradiol. 2002 Aug; 23(7):1214-21. PMID: 12169482.
      Citations: 22     Fields:    Translation:Humans
    162. Gounis MJ, Lieber BB, Wakhloo AK, Siekmann R, Hopkins LN. Effect of glacial acetic acid and ethiodized oil concentration on embolization with N-butyl 2-cyanoacrylate: an in vivo investigation. AJNR Am J Neuroradiol. 2002 Jun-Jul; 23(6):938-44. PMID: 12063221.
      Citations: 14     Fields:    Translation:Animals
    163. Lieber BB, Gounis MJ. The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms. Neurol Res. 2002; 24 Suppl 1:S33-42. PMID: 12074435.
      Citations: 32     Fields:    
    164. Divani AA, Lieber BB, Wakhloo AK, Gounis MJ, Hopkins LN. Determination of blood flow velocity and transit time in cerebral arteriovenous malformation using microdroplet angiography. Ann Biomed Eng. 2001 Feb; 29(2):135-44. PMID: 11284668.
      Citations: 1     Fields:    Translation:Humans
    165. Siekmann R, Wakhloo AK, Lieber BB, Gounis MJ, Divani AA, Hopkins LN. Modification of a previously described arteriovenous malformation model in the swine: endovascular and combined surgical/endovascular construction and hemodynamics. AJNR Am J Neuroradiol. 2000 Oct; 21(9):1722-5. PMID: 11039356.
      Citations: 8     Fields:    Translation:Animals
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