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Matthew J Gounis PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentRadiology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1884
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentRadiology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesBSMechanical Engineering
    State University of New York, Buffalo, Buffalo, NY, United StatesMSMechanical Engineering
    University of Miami, Coral Gables, FL, United StatesPHDPhilosophy

    Collapse Overview 
    Collapse overview

    Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. 

    On-going research projects:

    1. 5R44NS076272-03, NIH (PI: A Krtolica)                              8/1/2017-7/31/2020 (NCE) 

    Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

    Role: Subcontract PI

    In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

    2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis)    9/15/2015-7/31/2020 (NCE)

    Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

    Role: MPI

    The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

    3.    2R44NS100163-02, NIH (PI: GJ Ughi)                                                               7/15/2018-4/30/2020

    Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

    Role: Subcontract Co-I

    The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

    4. 2017104, BSF (PIs: N Korin, MJ Gounis)   10/1/2018-9/30/2022

    Hemodynamic transport of drug carriers to cerebral aneurysms

    Role: Co-PI

    Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

    5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool)                                     9/30/2019-8/31/2021

    Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

    Role: Subcontract PI

    Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

    6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves)                      12/1/2018-11/30/2021

    Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

    Role: Co-I

    The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

    7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis)   7/1/2019-06/30/2022

    Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

    Role: PI

    The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MacDonell J, Patel N, Fischer G, Burdette EC, Qian J, Chumbalkar V, Ghoshal G, Heffter T, Williams E, Gounis M, King R, Thibodeau J, Bogdanov G, Brooks OW, Langan E, Hwang R, Pilitsis JG. Robotic Assisted MRI-Guided Interventional Interstitial MR-Guided Focused Ultrasound Ablation in a Swine Model. Neurosurgery. 2019 05 01; 84(5):1138-1148. PMID: 29905844.
      Citations: 9     Fields:    Translation:Animals
    2. Aquarius R, de Korte A, Smits D, Gounis M, Verrijp K, Driessen L, Leenders W, de Vries J. The Importance of Wall Apposition in Flow Diverters. Neurosurgery. 2019 03 01; 84(3):804-810. PMID: 29659995.
      Citations: 14     Fields:    Translation:Animals
    3. Caroff J, King RM, Arslanian R, Marosfoi M, Langan ET, Gounis MJ, Chueh JY. Microcatheter navigation through the clot: does size matter? J Neurointerv Surg. 2019 Mar; 11(3):271-274. PMID: 30177546.
      Citations: 6     Fields:    Translation:Humans
    4. Brouwer PA, Yeo LLL, Gounis MJ, Gontu VK. Size matters? but how do I know what size it is? J Neurointerv Surg. 2019 01; 11(1):3-5. PMID: 30042158.
      Citations:    Fields:    
    5. Gounis MJ. Commentary on 'Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases'. J Neurointerv Surg. 2018 07; 10(Suppl 1):i50. PMID: 30037957.
      Citations:    Fields:    
    6. Wadghiri YZ, Hoang DM, Leporati A, Gounis MJ, Rodr?guez-Rodr?guez A, Mazzanti ML, Weaver JP, Wakhloo AK, Caravan P, Bogdanov AA. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018 05 16; 8(1):7687. PMID: 29769642.
      Citations: 12     Fields:    Translation:Humans
    7. Caroff J, Tamura T, King RM, Lylyk PN, Langan ET, Brooks OW, Claren?on F, Wainwright JM, Spelle L, Marosfoi M, Gounis MJ, Puri AS. Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. J Neurointerv Surg. 2018 Nov; 10(11):1097-1101. PMID: 29511117.
      Citations: 18     Fields:    Translation:Animals
    8. Nitzsche B, Boltze J, Ludewig E, Flegel T, Schmidt MJ, Seeger J, Barthel H, Brooks OW, Gounis MJ, Stoffel MH, Schulze S. A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets. Neuroimage. 2019 02 15; 187:93-103. PMID: 29407456.
      Citations: 25     Fields:    Translation:Animals
    9. Kallmes DF, Rabinstein AA, Gounis MJ. To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI. J Neurointerv Surg. 2018 Apr; 10(4):323-324. PMID: 29352058.
      Citations:    Fields:    
    10. King RM, Brooks OW, Langan ET, Caroff J, Claren?on F, Tamura T, Wainwright JM, Gounis MJ, Marosfoi M, Puri AS. Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion. J Neurointerv Surg. 2018 Jul; 10(7):693-697. PMID: 29127197.
      Citations: 17     Fields:    Translation:Animals
    11. Chueh JY, Marosfoi MG, Brooks OW, King RM, Puri AS, Gounis MJ. Novel Distal Emboli Protection Technology: The EmboTrap. Interv Neurol. 2017 Oct; 6(3-4):268-276. PMID: 29118805.
      Citations:    
    12. Gounis MJ. Neurointervention: a call to science. J Neurointerv Surg. 2017 09; 9(9):813-814. PMID: 28819057.
      Citations:    Fields:    
    13. Marosfoi M, Clarencon F, Langan ET, King RM, Brooks OW, Tamura T, Wainwright JM, Gounis MJ, Vedantham S, Puri AS. Acute thrombus formation on phosphorilcholine surface modified flow diverters. J Neurointerv Surg. 2018 Apr; 10(4):406-411. PMID: 28689183.
      Citations: 26     Fields:    Translation:Animals
    14. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50. PMID: 19246690.
      Citations: 625     Fields:    Translation:HumansAnimals
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