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Matthew J Gounis PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentRadiology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1884
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentRadiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesBSMechanical Engineering
    State University of New York, Buffalo, Buffalo, NY, United StatesMSMechanical Engineering
    University of Miami, Coral Gables, FL, United StatesPHDPhilosophy

    Collapse Overview 
    Collapse overview

    Matt received his BS and MS in Mechanical Engineering at SUNY Buffalo in 1997 and 2001, where he was awarded the AHA New York Affiliate pre-doctoral fellowship. He then moved to sunny Miami to work on his PhD in biomedical engineering with advisors Barry Lieber and Keith Webster in the area of new imaging modalities to quantify the functionality of vasculature following pro-angiogenic gene therapy. After obtaining his PhD in 2004 Matt spent a year as Research Assistant Professor in the Biomedical Engineering and Radiology Departments at the University of Miami. Thereafter, he took a short sojourn from academia and joined Cordis Neurovascular (a Johnson and Johnson Company) in 2005 where he was a Principal Engineer responsible for researching new therapies for cerebrovascular aneurysms.

    Matt joined UMMS in 2006 as an Assistant Professor and Director of the newly established New England Center for Stroke Research. He has been the recipient of numerous awards from ASME Bioengineering Division, Sigma Xi, the American Association of Neurological Surgeons, the American Society of Neuroradiology, and Johnson and Johnson. He is an active member of the ASME bioengineering division, having served previously as the Student Paper Competition and Exhibits chairs of the Summer Bioengineering Meeting.

    Matt and the team at NECStR are interested in the design of medical devices for minimally invasive treatment of cerebrovascular pathologies, animal models of cerebral aneurysms, arteriovenous malformations, and acute ischemic stroke; gene and stem cell therapy for arterial occlusive disease; and experimental fluid mechanics for medical device evaluation.

    Examples of on-going research projects:

    Mechanical Obliteration of Clot for the Treatment of Stroke:

    UMMS Team: Matt Gounis, Ajay Wakhloo, Ruby Chueh, Bo Hong, Marc Fisher,

    OmniSonics Medical Technologies Team: Elvira Lang, David Constantine, Anne Kulis, Max Fiore, Rich Ganz

    Stroke carries a severe toll in terms of loss of life and disability for patients and their families. Stroke is the third cause of death in the United States and the leading cause of disability in terms of cost of care and loss of productivity. According to the newest data from the American Stroke Association, each year approximately 700,000 individuals experience a new or recurrent stroke and 160,000 of these events are fatal. This project seeks to find a new treatment to give stroke victims an option other than rehabilitation.

    An ultra-thin thrombectomy wire is being developed that uses transverse ultrasound waves at its tip to selectively and safely disintegrate intracranial blood clot without damage to the adjacent structures. The proposed system challenges the paradigm of current available therapies which rely on either relatively slow pharmacologic action or en block removal of clot. The goal is to provide rapid and immediate perfusion of ischemic tissue as the cornerstone of effective treatment for acute ischemic stroke. There are currently only two FDA-approved therapies: (1) Pharmacologic clot dissolution with tissue plasminogen activator (tPA); and (2) Mechanical thrombectomy with retrieval or aspiration devices. tPA increases the risk of intracranial hemorrhage, and must be started within 3 hours of onset of the ischemic event thus limiting its use to less than 5% of current stroke victims.

    To overcome these limitations we are working with OmniSonics Medical Technologies to develop a low-profile and atraumatic thrombectomy device that uses tailored transmission of ultrasonic energy around an ultra-thin wire that can be advanced through standard neuroangiographic microcatheters. Recanalization is anticipated within seconds or minutes expanding the window of treatment opportunity that so far had to take into account the 2-hours average time tPA infusion requires for flow restoration. To date we have developed a large animal model of acute ischemic stroke and imaging endpoints to evaluate device safety and efficacy (Figure 1). Moreover, we have developed a population based model of the human internal carotid and middle cerebral arteries and use a mock circulation flow loop to evaluate device performance (Figure 2).

    Angiogram Graphics

    Figure 1: (A) 3D rotational angiogram showing the normal canine cerebrovasculature after a left internal carotid artery injection. Angiograms in the ventral plane before (B) and after (C) injection an embolus of autologous clot that leads to diffusion (D) and perfusion lesions (E) under MR. TTC staining four hours after stroke onset shows infarct of the left MCA distribution.

    Human Intercranial Circulation

    Figure 2: Modeling of the human intracranial circulation – from imaging, to computer model to physical model

    Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms

    UMMS Team: Alex Bogdanov, Matt Gounis, Ajay Wakhloo, John Weaver, Mike DeLeo

    Twenty five percent of all deaths associated with cerebrovascular disease in the USA are a result of hemorrhage and stroke caused by rupture of intracranial aneurysms. There is strong evidence suggesting that the progression from stable to unstable aneurysm involves local inflammation. As demonstrated recently, the extent of the inflammation is significantly higher in ruptured versus unruptured aneurysms. We hypothesize that molecular imaging of inflammatory marker presence could provide a strategy for predicting the tendency of aneurysm to develop instability and rupture. This would have a strong positive impact on accuracy of diagnosis and for differential patient management.

    Recent epidemiological evidence suggests that the elevated presence of myeloperoxidase (MPO) in blood is an important risk factor for coronary disease and atherosclerotic plaque rupture. In view of the above, we hypothesize that some of the MPO-specific effects in plaque progression could also contribute to intracranial aneurysm instability. By combining MRI with the use of MPO-specific paramagnetic contrast probe in small animal models we recently demonstrated that in artificial implant systems as well as experimentally induced inflammation there was stable MPO-specific increase of MR signal (Chen, JW et al. Radiology 240:473, 2006). The major objective of the proposed work is to develop and validate the MPO-specific probe which could be used for non-invasive assessment of potential instability of intracranial aneurysms. We propose to explore the above concept by establishing a team lead by PhD PI of molecular imaging probe development who will work closely with PhD bioengineer, an expert in aneurysm models, and PhD MRI scientist who will optimize rabbit aneurysm imaging protocols. The essential element of this proposal is collaboration with two MDs (a neuroradiologist and a neurosurgeon) who will evaluate rabbit data and supply human surgical material under a clinical protocol. The major goal of proposed research is to perform exploratory research directed at the testing of the molecular imaging approach using paramagnetic substrates in rabbit model of aneurysm in a 3T MRI setup with an ultimate goal of dramatically improving the ability to differentiate between likely and unlikely candidates for further interventional or surgical procedures. Two major aims are: Aim 1. Optimize rabbit model of aneurysm and correlate MPO activity in rabbit aneurysm with MPO activity in samples obtained from ruptured/unruptured resected human aneurysms. Aim 2. Perform feasibility MR imaging of MPO activity using MPO-specific paramagnetic susbtrate in experimental inflammatory lesions induced in rabbit aneurysm.

    Current Grants:

    NIH NIBIB 1R21EB007767-01, Funding Period: August 2007 – July 2010, Title: Mechanical Clot Obliteration for the Treatment of Stroke, PI: MJ Gounis

    NIH NINDS, 1R21NS061132, Funding Period: June 2008 – May 2010, Title: Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms, PI: AA Bogdanov Jr, co-PI: MJ Gounis

    Various Grants from Biomedical Device Industry




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Shazeeb MS, King RM, Brooks OW, Puri AS, Henninger N, Boltze J, Gounis MJ. Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion. Transl Stroke Res. 2019 Sep 03. PMID: 31478129.
      View in: PubMed
    2. Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nat Biotechnol. 2019 Aug; 37(8):884-894. PMID: 31375812.
      View in: PubMed
    3. Caroff J, King RM, Mitchell JE, Marosfoi M, Licwinko JR, Gray-Edwards HL, Puri AS, Merrill TL, Gounis MJ. Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept. J Neurointerv Surg. 2019 Jul 30. PMID: 31363042.
      View in: PubMed
    4. Prestigiacomo CJ, Gounis MJ, Gonzalez LF, Frösen J. Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms. Neurosurg Focus. 2019 Jul 01; 47(1):E1. PMID: 31261113.
      View in: PubMed
    5. Fitzgerald S, Dai D, Wang S, Douglas A, Kadirvel R, Layton KF, Thacker IC, Gounis MJ, Chueh JY, Puri AS, Almekhlafi M, Demchuk AM, Hanel RA, Sauvageau E, Aghaebrahim A, Yoo AJ, Kvamme P, M Pereira V, Kayan Y, Delgado Almandoz JE, Nogueira RG, Rabinstein AA, Kallmes DF, Doyle KM, Brinjikji W. Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source. Stroke. 2019 May 29; STROKEAHA118024543. PMID: 31138084.
      View in: PubMed
    6. Brooks OW, King RM, Nossek E, Marosfoi M, Caroff J, Chueh JY, Puri AS, Gounis MJ. A canine model of mechanical thrombectomy in stroke. J Neurointerv Surg. 2019 May 18. PMID: 31103992.
      View in: PubMed
    7. Kühn AL, Kan P, Henninger N, Srinivasan V, de Macedo Rodrigues K, Wakhloo AK, Gounis MJ, Puri AS. Impact of age on cerebral aneurysm occlusion after flow diversion. J Clin Neurosci. 2019 May 06. PMID: 31072739.
      View in: PubMed
    8. King RM, Marosfoi M, Caroff J, Ughi GJ, Groth DM, Gounis MJ, Puri AS. High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion. J Neurointerv Surg. 2019 Apr 29. PMID: 31036558.
      View in: PubMed
    9. Fitzgerald ST, Wang S, Dai D, Douglas A, Kadirvel R, Gounis MJ, Chueh J, Puri AS, Layton KF, Thacker IC, Hanel RA, Sauvageau E, Aghaebrahim A, Almekhlafi MA, Demchuk AM, Nogueira RG, Pereira VM, Kvamme P, Kayan Y, Delgado Almandoz JE, Yoo AJ, Kallmes DF, Doyle KM, Brinjikji W. Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT. J Neurointerv Surg. 2019 Apr 05. PMID: 30952688.
      View in: PubMed
    10. Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Sci Transl Med. 2019 Feb 13; 11(479). PMID: 30760580.
      View in: PubMed
    11. Herrmann AM, Meckel S, Gounis MJ, Kringe L, Motschall E, Mülling C, Boltze J. Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations. J Cereb Blood Flow Metab. 2019 Feb 07; 271678X19827446. PMID: 30732549.
      View in: PubMed
    12. Arslanian RA, Marosfoi M, Caroff J, King RM, Raskett C, Puri AS, Gounis MJ, Chueh JY. Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization. J Neurointerv Surg. 2019 Feb 04. PMID: 30718384.
      View in: PubMed
    13. Gounis MJ, Ughi GJ, Marosfoi M, Lopes DK, Fiorella D, Bezerra HG, Liang CW, Puri AS. Intravascular Optical Coherence Tomography for Neurointerventional Surgery. Stroke. 2018 Nov 29; STROKEAHA118022315. PMID: 30580737.
      View in: PubMed
    14. Mondo E, Moser R, Gao G, Mueller C, Sena-Esteves M, Sapp E, Pfister E, O'Connell D, Takle K, Erger KE, Liu W, Conlon TJ, DiFiglia M, Gounis MJ, Aronin N. Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration. J Huntingtons Dis. 2018 Sep 29. PMID: 30320596.
      View in: PubMed
    15. Caroff J, King RM, Arslanian R, Marosfoi M, Langan ET, Gounis MJ, Chueh JY. Microcatheter navigation through the clot: does size matter? J Neurointerv Surg. 2018 Sep 03. PMID: 30177546.
      View in: PubMed
    16. Brouwer PA, Yeo LLL, Gounis MJ, Gontu VK. Size matters… but how do I know what size it is? J Neurointerv Surg. 2018 Jul 24. PMID: 30042158.
      View in: PubMed
    17. Gounis MJ. Commentary on 'Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases'. J Neurointerv Surg. 2018 Jul; 10(Suppl 1):i50. PMID: 30037957.
      View in: PubMed
    18. MacDonell J, Patel N, Fischer G, Burdette EC, Qian J, Chumbalkar V, Ghoshal G, Heffter T, Williams E, Gounis M, King R, Thibodeau J, Bogdanov G, Brooks OW, Langan E, Hwang R, Pilitsis JG. Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model. Neurosurgery. 2018 Jun 14. PMID: 29905844.
      View in: PubMed
    19. Wadghiri YZ, Hoang DM, Leporati A, Gounis MJ, Rodríguez-Rodríguez A, Mazzanti ML, Weaver JP, Wakhloo AK, Caravan P, Bogdanov AA. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018 May 16; 8(1):7687. PMID: 29769642.
      View in: PubMed
    20. Aquarius R, de Korte A, Smits D, Gounis M, Verrijp K, Driessen L, Leenders W, de Vries J. The Importance of Wall Apposition in Flow Diverters. Neurosurgery. 2018 Apr 04. PMID: 29659995.
      View in: PubMed
    21. Caroff J, Tamura T, King RM, Lylyk PN, Langan ET, Brooks OW, Clarençon F, Wainwright JM, Spelle L, Marosfoi M, Gounis MJ, Puri AS. Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. J Neurointerv Surg. 2018 Mar 06. PMID: 29511117.
      View in: PubMed
    22. Nitzsche B, Boltze J, Ludewig E, Flegel T, Schmidt MJ, Seeger J, Barthel H, Brooks OW, Gounis MJ, Stoffel MH, Schulze S. A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets. Neuroimage. 2018 Jan 31. PMID: 29407456.
      View in: PubMed
    23. Kallmes DF, Rabinstein AA, Gounis MJ. To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI. J Neurointerv Surg. 2018 Apr; 10(4):323-324. PMID: 29352058.
      View in: PubMed
    24. King RM, Brooks OW, Langan ET, Caroff J, Clarençon F, Tamura T, Wainwright JM, Gounis MJ, Marosfoi M, Puri AS. Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion. J Neurointerv Surg. 2018 Jul; 10(7):693-697. PMID: 29127197.
      View in: PubMed
    25. Chueh JY, Marosfoi MG, Brooks OW, King RM, Puri AS, Gounis MJ. Novel Distal Emboli Protection Technology: The EmboTrap. Interv Neurol. 2017 Oct; 6(3-4):268-276. PMID: 29118805.
      View in: PubMed
    26. Gounis MJ. Neurointervention: a call to science. J Neurointerv Surg. 2017 09; 9(9):813-814. PMID: 28819057.
      View in: PubMed
    27. Marosfoi M, Clarencon F, Langan ET, King RM, Brooks OW, Tamura T, Wainwright JM, Gounis MJ, Vedantham S, Puri AS. Acute thrombus formation on phosphorilcholine surface modified flow diverters. J Neurointerv Surg. 2018 Apr; 10(4):406-411. PMID: 28689183.
      View in: PubMed
    28. Gounis MJ, Chapot R. Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention? Stroke. 2017 Jun 16. PMID: 28626053.
      View in: PubMed
    29. De Macedo Rodrigues K, Kühn AL, Tamura T, Dabus G, Kan P, Marosfoi MG, Lozano JD, Perras M, Brooks C, Howk MC, Hou SY, Rex DE, Massari F, Gounis MJ, Wakhloo AK, Puri AS. Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study. Oper Neurosurg (Hagerstown). 2017 May 17. PMID: 28521024.
      View in: PubMed
    30. Chueh JY, van der Marel K, Gounis MJ, LeMatty T, Brown TR, Ansari SA, Carroll TJ, Buck AK, Zhou XJ, Chatterjee AR, King RM, Mao H, Zheng S, Brooks OW, Rappleye JW, Swartz RH, Feldmann E, Turan TN. Development of a high resolution MRI intracranial atherosclerosis imaging phantom. J Neurointerv Surg. 2017 Mar 09. PMID: 28280114.
      View in: PubMed
    31. Aquarius R, Smits D, Gounis MJ, Leenders WP, de Vries J. Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study. J Neurointerv Surg. 2017 Feb 08. PMID: 28179543.
      View in: PubMed
    32. Golebiowski D, van der Bom IM, Kwon CS, Miller AD, Petrosky K, Bradbury AM, Maitland S, Kühn AL, Bishop N, Curran E, Silva N, GuhaSarkar D, Westmoreland SV, Martin DR, Gounis MJ, Asaad WF, Sena-Esteves M. Direct intracranial injection of AAVrh8 encoding monkey ß-N-acetylhexosaminidase causes neurotoxicity in primate brain. Hum Gene Ther. 2017 Jan 28. PMID: 28132521.
      View in: PubMed
    33. van der Marel K, Vedantham S, van der Bom IM, Howk M, Narain T, Ty K, Karellas A, Gounis MJ, Puri AS, Wakhloo AK. Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform. AJNR Am J Neuroradiol. 2017 Jan 19. PMID: 28104643.
      View in: PubMed
    34. De Meyer SF, Andersson T, Baxter B, Bendszus M, Brouwer P, Brinjikji W, Campbell BC, Costalat V, Dávalos A, Demchuk A, Dippel D, Fiehler J, Fischer U, Gilvarry M, Gounis MJ, Gralla J, Jansen O, Jovin T, Kallmes D, Khatri P, Lees KR, López-Cancio E, Majoie C, Marquering H, Narata AP, Nogueira R, Ringleb P, Siddiqui A, Szikora I, Vale D, von Kummer R, Yoo AJ, Hacke W, Liebeskind DS. Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions. Int J Stroke. 2017 Jan 01; 1747493017709671. PMID: 28534706.
      View in: PubMed
    35. Taschner CA, Vedantham S, de Vries J, Biondi A, Boogaarts J, Sakai N, Lylyk P, Szikora I, Meckel S, Urbach H, Kan P, Siekmann R, Bernardy J, Gounis MJ, Wakhloo AK. Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms. AJNR Am J Neuroradiol. 2016 Dec 22. PMID: 28007769.
      View in: PubMed
    36. Kühn AL, Wakhloo AK, Gounis MJ, Kan P, de Macedo Rodrigues K, Lozano JD, Marosfoi MG, Perras M, Brooks C, Howk MC, Rex DE, Massari F, Puri AS. Use of self-expanding stents for better intracranial flow diverter wall apposition. Interv Neuroradiol. 2016 Dec 12. PMID: 27956518.
      View in: PubMed
    37. Kühn AL, de Macedo Rodrigues K, Lozano JD, Rex DE, Massari F, Tamura T, Howk M, Brooks C, L'Heureux J, Gounis MJ, Wakhloo AK, Puri AS. Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up. J Neurointerv Surg. 2016 Nov 25. PMID: 27888225.
      View in: PubMed
    38. Ansari SA, Kühn AL, Honarmand AR, Khan M, Hurley MC, Potts MB, Jahromi BS, Shaibani A, Gounis MJ, Wakhloo AK, Puri AS. Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents. AJNR Am J Neuroradiol. 2017 Jan; 38(1):97-104. PMID: 28059705.
      View in: PubMed
    39. Marosfoi M, Langan ET, Strittmatter L, van der Marel K, Vedantham S, Arends J, Lylyk IR, Loganathan S, Hendricks GM, Szikora I, Puri AS, Wakhloo AK, Gounis MJ. In situ tissue engineering: endothelial growth patterns as a function of flow diverter design. J Neurointerv Surg. 2016 Oct 5. PMID: 27707872.
      View in: PubMed
    40. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. J Neurointerv Surg. 2017 Mar; 9(3):e10. PMID: 27417184.
      View in: PubMed
    41. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. BMJ Case Rep. 2016 Jul 05; 2016. PMID: 27382015.
      View in: PubMed
    42. Boltze J, Wagner DC, Barthel H, Gounis MJ. Academic-industry Collaborations in Translational Stroke Research. Transl Stroke Res. 2016 Aug; 7(4):343-53. PMID: 27301976.
      View in: PubMed
    43. Kühn AL, Wakhloo AK, Lozano JD, Massari F, De Macedo Rodrigues K, Marosfoi MG, Perras M, Brooks C, Howk M, Rex DE, Gounis MJ, Puri AS. Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke. J Neurointerv Surg. 2016 Jun 9. PMID: 27286991.
      View in: PubMed
    44. Brinjikji W, Duffy S, Burrows A, Hacke W, Liebeskind D, Majoie CB, Dippel DW, Siddiqui AH, Khatri P, Baxter B, Nogeuira R, Gounis M, Jovin T, Kallmes DF. Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review. J Neurointerv Surg. 2016 May 10. PMID: 27166383.
      View in: PubMed
    45. Vedantham S, Shrestha S, Karellas A, Shi L, Gounis MJ, Bellazzini R, Spandre G, Brez A, Minuti M. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. Med Phys. 2016 May; 43(5):2118. PMID: 27147324.
      View in: PubMed
    46. Chueh JY, Puri AS, Gounis MJ. An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy. J Neurointerv Surg. 2017 Feb; 9(2):183-187. PMID: 26919972.
      View in: PubMed
    47. Massari F, Henninger N, Lozano JD, Patel A, Kuhn AL, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK, Puri AS. ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience. Interv Neuroradiol. 2016 Jun; 22(3):325-32. PMID: 26908591.
      View in: PubMed
    48. van der Marel K, Chueh JY, Brooks OW, King RM, Marosfoi MG, Langan ET, Carniato SL, Gounis MJ, Nogueira RG, Puri AS. Quantitative assessment of device-clot interaction for stent retriever thrombectomy. J Neurointerv Surg. 2016 Feb 01. PMID: 26833539.
      View in: PubMed
    49. Puri AS, Massari F, Asai T, Marosfoi M, Kan P, Hou SY, Howk M, Perras M, Brooks C, Clarencon F, Gounis MJ, Wakhloo AK. Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (<2.5 mm) cerebral vessels for aneurysm treatment: single institution experience. Neuroradiology. 2016 Mar; 58(3):267-75. PMID: 26700827.
      View in: PubMed
    50. Iannaccone F, De Beule M, De Bock S, Van der Bom IM, Gounis MJ, Wakhloo AK, Boone M, Verhegghe B, Segers P. A Finite Element Method to Predict Adverse Events in Intracranial Stenting Using Microstents: In Vitro Verification and Patient Specific Case Study. Ann Biomed Eng. 2016 Feb; 44(2):442-52. PMID: 26620777.
      View in: PubMed
    51. Shen ZT, Zheng S, Gounis MJ, Sigalov AB. Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles. PLoS One. 2015; 10(11):e0143453. PMID: 26569115.
      View in: PubMed
    52. Kühn AL, Kan P, Massari F, Lozano JD, Hou SY, Howk M, Gounis MJ, Wakhloo AK, Puri AS. Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device. J Neurointerv Surg. 2016 Oct; 8(10):1048-51. PMID: 26546600.
      View in: PubMed
    53. Marosfoi MG, Korin N, Gounis MJ, Uzun O, Vedantham S, Langan ET, Papa AL, Brooks OW, Johnson C, Puri AS, Bhatta D, Kanapathipillai M, Bronstein BR, Chueh JY, Ingber DE, Wakhloo AK. Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion. Stroke. 2015 Dec; 46(12):3507-13. PMID: 26493676.
      View in: PubMed
    54. Gounis MJ, van der Marel K, Marosfoi M, Mazzanti ML, Clarençon F, Chueh JY, Puri AS, Bogdanov AA. Imaging Inflammation in Cerebrovascular Disease. Stroke. 2015 Oct; 46(10):2991-7. PMID: 26351362.
      View in: PubMed
    55. van der Marel K, Gounis MJ, Weaver JP, de Korte AM, King RM, Arends JM, Brooks OW, Wakhloo AK, Puri AS. Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT. J Neurointerv Surg. 2016 Aug; 8(8):847-52. PMID: 26220411.
      View in: PubMed
    56. Walvick RP, Roche JP, Reno AL, Gounis MJ, Albert MS. Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia. Magn Reson Med. 2016 May; 75(5):2050-4. PMID: 26079271.
      View in: PubMed
    57. Kühn AL, Hou SY, Puri AS, Silva CF, Gounis MJ, Wakhloo AK. Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis. J Neurointerv Surg. 2016 Jun; 8(6):581-5. PMID: 26041097.
      View in: PubMed
    58. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. J Neurointerv Surg. 2016 Apr; 8(4):e13. PMID: 25854687.
      View in: PubMed
    59. Puri AS, Massari F, Hou SY, Lozano JD, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK. Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms. J Neurointerv Surg. 2016 May; 8(5):501-6. PMID: 25838199.
      View in: PubMed
    60. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. BMJ Case Rep. 2015 Apr 01; 2015. PMID: 25833904.
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    61. Korin N, Gounis MJ, Wakhloo AK, Ingber DE. Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics. JAMA Neurol. 2015 Jan; 72(1):119-22. PMID: 25365638.
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    62. Chueh JY, Puri AS, Wakhloo AK, Gounis MJ. Risk of distal embolization with stent retriever thrombectomy and ADAPT. J Neurointerv Surg. 2016 Feb; 8(2):197-202. PMID: 25540180.
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    63. Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35. PMID: 25344064.
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    64. Gounis MJ, van der Bom IM, Wakhloo AK, Zheng S, Chueh JY, Kühn AL, Bogdanov AA. MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall. AJNR Am J Neuroradiol. 2015 Jan; 36(1):146-52. PMID: 25273534.
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    65. Wakhloo AK, Lylyk P, de Vries J, Taschner C, Lundquist J, Biondi A, Hartmann M, Szikora I, Pierot L, Sakai N, Imamura H, Sourour N, Rennie I, Skalej M, Beuing O, Bonafé A, Mery F, Turjman F, Brouwer P, Boccardi E, Valvassori L, Derakhshani S, Litzenberg MW, Gounis MJ. Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study. AJNR Am J Neuroradiol. 2015 Jan; 36(1):98-107. PMID: 25125666.
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    66. Wakhloo AK, Gounis MJ. Revolution in aneurysm treatment: flow diversion to cure aneurysms: a paradigm shift. Neurosurgery. 2014 Aug; 61 Suppl 1:111-20. PMID: 25032539.
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    67. Kühn AL, Hou SY, Perras M, Brooks C, Gounis MJ, Wakhloo AK, Puri AS. Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up. J Neurointerv Surg. 2015 Sep; 7(9):634-40. PMID: 25051964.
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    68. Chueh JY, Vedantham S, Wakhloo AK, Carniato SL, Puri AS, Bzura C, Coffin S, Bogdanov AA, Gounis MJ. Aneurysm permeability following coil embolization: packing density and coil distribution. J Neurointerv Surg. 2015 Sep; 7(9):676-81. PMID: 25031179.
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    69. Gounis MJ, Vedantham S, Weaver JP, Puri AS, Brooks CS, Wakhloo AK, Bogdanov AA. Myeloperoxidase in human intracranial aneurysms: preliminary evidence. Stroke. 2014 May; 45(5):1474-7. PMID: 24713525.
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    70. Zheng S, van der Bom IM, Zu Z, Lin G, Zhao Y, Gounis MJ. Chemical exchange saturation transfer effect in blood. Magn Reson Med. 2014 Mar; 71(3):1082-92. PMID: 23661508.
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    71. Puri AS, Kühn AL, Kwon HJ, Khan M, Hou SY, Lin E, Chueh J, van der Bom IM, Dabus G, Linfante I, Gounis MJ, Wakhloo AK. Endovascular treatment of tandem vascular occlusions in acute ischemic stroke. J Neurointerv Surg. 2015 Mar; 7(3):158-63. PMID: 24578485.
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    72. Flood TF, van der Bom IM, Strittmatter L, Puri AS, Hendricks GM, Wakhloo AK, Gounis MJ. Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia. J Neurointerv Surg. 2015 Feb; 7(2):118-25. PMID: 24480728.
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    73. Wakhloo AK, Gounis MJ, Chueh JY, Pierot L. Advances in stroke: Advances in interventional radiology 2013. Stroke. 2014 Feb; 45(2):365-7. PMID: 24436230.
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    74. Vogl TJ, Pflugmacher R, Hierholzer J, Stender G, Gounis M, Wakhloo A, Fiebig C, Hammerstingl R. Cement directed kyphoplasty reduces cement leakage as compared with vertebroplasty: results of a controlled, randomized trial. Spine (Phila Pa 1976). 2013 Sep 15; 38(20):1730-6. PMID: 23804157.
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    75. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. J Neurointerv Surg. 2014 Jun; 6(5):e34. PMID: 23997121.
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    76. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. BMJ Case Rep. 2013 Aug 14; 2013. PMID: 23946527.
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    77. Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun; 44(6 Suppl 1):S7-S10. PMID: 23709736.
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    78. van der Bom IM, Hou SY, Puri AS, Spilberg G, Ruijters D, van de Haar P, Carelsen B, Vedantham S, Gounis MJ, Wakhloo AK. Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2163-70. PMID: 23721899.
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    79. Chueh JY, Kühn AL, Puri AS, Wilson SD, Wakhloo AK, Gounis MJ. Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study. Stroke. 2013 May; 44(5):1396-401. PMID: 23493730.
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    80. van der Bom IM, Moser RP, Gao G, Mondo E, O'Connell D, Gounis MJ, McGowan S, Chaurette J, Bishop N, Sena-Esteves MS, Mueller C, Aronin N. Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery. J Huntingtons Dis. 2013; 2(1):41-5. PMID: 25063428.
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    81. Gounis MJ, Nogueira RG, Mehra M, Chueh J, Wakhloo AK. A thromboembolic model for the efficacy and safety evaluation of combined mechanical and pharmacologic revascularization strategies. J Neurointerv Surg. 2013 May; 5 Suppl 1:i85-9. PMID: 22962414.
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    82. Chueh JY, Wakhloo AK, Gounis MJ. Effectiveness of mechanical endovascular thrombectomy in a model system of cerebrovascular occlusion. AJNR Am J Neuroradiol. 2012 Nov; 33(10):1998-2003. PMID: 22555570.
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    83. Zarate B, Gutierrez J, Wakhloo AK, Gounis MJ, Reyes-Sánchez A. Clinical evaluation of a new kyphoplasty technique with directed cement flow. J Spinal Disord Tech. 2012 May; 25(3):E61-6. PMID: 22343281.
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    84. Samaniego EA, Tari-Capone F, Linfante I, Silva CF, Spilberg G, Gounis M, Wakhloo AK, Dabus G. Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure. J Neurointerv Surg. 2013 Jul; 5(4):302-5. PMID: 22544819.
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    85. King RM, Chueh JY, van der Bom IM, Silva CF, Carniato SL, Spilberg G, Wakhloo AK, Gounis MJ. The effect of intracranial stent implantation on the curvature of the cerebrovasculature. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1657-62. PMID: 22538075.
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    86. Wakhloo AK, Linfante I, Silva CF, Samaniego EA, Dabus G, Etezadi V, Spilberg G, Gounis MJ. Closed-cell stent for coil embolization of intracranial aneurysms: clinical and angiographic results. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1651-6. PMID: 22492570.
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    87. van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 1; 5(1):69-72. PMID: 22193239.
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    88. Spilberg G, Carniato SL, King RM, van der Bom IM, Mehra M, Walvick RP, Wakhloo AK, Gounis MJ. Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study. AJNR Am J Neuroradiol. 2012 Apr; 33(4):655-60. PMID: 22194374.
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    89. van der Bom IM, Mehra M, Walvick RP, Chueh JY, Gounis MJ. Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke. AJNR Am J Neuroradiol. 2012 Feb; 33(2):353-8. PMID: 22173756.
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    90. Carniato S, Mehra M, King RM, Wakhloo AK, Gounis MJ. Porcine brachial artery tortuosity for in vivo evaluation of neuroendovascular devices. AJNR Am J Neuroradiol. 2013 Apr; 34(4):E36-8. PMID: 22081678.
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    91. Grunwald IQ, Kamran M, Corkill RA, Kühn AL, Choi IS, Turnbull S, Dobson D, Fassbender K, Watson D, Gounis MJ. Simple measurement of aneurysm residual after treatment: the SMART scale for evaluation of intracranial aneurysms treated with flow diverters. Acta Neurochir (Wien). 2012 Jan; 154(1):21-6; discussion 26. PMID: 22002552.
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    92. Nogueira RG, Levy EI, Gounis M, Siddiqui AH. The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease. J Neurointerv Surg. 2012 Jul; 4(4):295-300. PMID: 21990512.
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    93. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul; 4(4):307-13. PMID: 21990535.
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    94. Chueh JY, Wakhloo AK, Hendricks GH, Silva CF, Weaver JP, Gounis MJ. Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs. AJNR Am J Neuroradiol. 2011 Aug; 32(7):1237-44. PMID: 21596804.
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    95. Mehra M, Hurley MC, Gounis MJ, King RM, Shaibani A, Dabus G, Labdag FE, Levy EI, Bendok BR. The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study. J Neurointerv Surg. 2011 Jun; 3(2):131-6. PMID: 21990804.
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    96. van der Bom MJ, Pluim JP, Gounis MJ, van de Kraats EB, Sprinkhuizen SM, Timmer J, Homan R, Bartels LW. Registration of 2D x-ray images to 3D MRI by generating pseudo-CT data. Phys Med Biol. 2011 Feb 21; 56(4):1031-43. PMID: 21258138.
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    97. Patel NV, Gounis MJ, Wakhloo AK, Noordhoek N, Blijd J, Babic D, Takhtani D, Lee SK, Norbash A. Contrast-enhanced angiographic cone-beam CT of cerebrovascular stents: experimental optimization and clinical application. AJNR Am J Neuroradiol. 2011 Jan; 32(1):137-44. PMID: 20966059.
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    98. Li JM, Newburger PE, Gounis MJ, Dargon P, Zhang X, Messina LM. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther. 2010 Oct; 17(10):1279-87. PMID: 20485380.
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    99. van der Bom MJ, Bartels LW, Gounis MJ, Homan R, Timmer J, Viergever MA, Pluim JP. Robust initialization of 2D-3D image registration using the projection-slice theorem and phase correlation. Med Phys. 2010 Apr; 37(4):1884-92. PMID: 20443510.
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    100. Gounis MJ, DeLeo MJ, Wakhloo AK. Advances in interventional neuroradiology. Stroke. 2010 Feb; 41(2):e81-7. PMID: 20075339.
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    101. Hong B, Patel NV, Gounis MJ, DeLeo MJ, Linfante I, Wojak JC, Wakhloo AK. Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms. Neurosurgery. 2009 Dec; 65(6):1131-8; discussion 1138-9. PMID: 19934972.
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    102. Linfante I, DeLeo MJ, Gounis MJ, Brooks CS, Wakhloo AK. Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results. AJNR Am J Neuroradiol. 2009 Sep; 30(8):1496-501. PMID: 19696138.
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    103. DeLeo MJ, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov AA. Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study. Radiology. 2009 Sep; 252(3):696-703. PMID: 19546428.
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    104. Chueh JY, Wakhloo AK, Gounis MJ. Neurovascular modeling: small-batch manufacturing of silicone vascular replicas. AJNR Am J Neuroradiol. 2009 Jun; 30(6):1159-64. PMID: 19321626.
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    105. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50. PMID: 19246690.
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    106. Linfante I, Delgado-Mederos R, Andreone V, Gounis M, Hendricks L, Wakhloo AK. Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine in cerebral vasospasm. Neurosurgery. 2008 Dec; 63(6):1080-6; discussion 1086-7. PMID: 19057319.
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    107. Cesar L, Miskolczi L, Lieber BB, Sadasivan C, Gounis MJ, Wakhloo AK. Neurological deficits associated with the elastase-induced aneurysm model in rabbits. Neurol Res. 2009 May; 31(4):414-9. PMID: 18826754.
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    108. Wakhloo AK, Mandell J, Gounis MJ, Brooks C, Linfante I, Winer J, Weaver JP. Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up. Stroke. 2008 Dec; 39(12):3288-96. PMID: 18772450.
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    109. Wakhloo AK, Gounis MJ. Retrievable closed cell intracranial stent for foreign body and clot removal. Neurosurgery. 2008 May; 62(5 Suppl 2):ONS390-3; discussion ONS393-4. PMID: 18596519.
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    110. Gounis MJ, Lieber BB, Webster KA, Wakhloo AK. A novel angiographic methodology for the quantification of angiogenesis. IEEE Trans Biomed Eng. 2008 Mar; 55(3):996-1003. PMID: 18334391.
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    111. Bendok BR, Parkinson RJ, Hage ZA, Adel JG, Gounis MJ. The effect of vascular reconstruction device-assisted coiling on packing density, effective neck coverage, and angiographic outcome: an in vitro study. Neurosurgery. 2007 Oct; 61(4):835-40; discussion 840-1. PMID: 17986946.
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    112. Wakhloo AK, Gounis MJ, Sandhu JS, Akkawi N, Schenck AE, Linfante I. Complex-shaped platinum coils for brain aneurysms: higher packing density, improved biomechanical stability, and midterm angiographic outcome. AJNR Am J Neuroradiol. 2007 Aug; 28(7):1395-400. PMID: 17698550.
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    113. Onizuka M, Miskolczi L, Gounis MJ, Seong J, Lieber BB, Wakhloo AK. Elastase-induced aneurysms in rabbits: effect of postconstruction geometry on final size. AJNR Am J Neuroradiol. 2006 May; 27(5):1129-31. PMID: 16687557.
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    114. Miskolczi L, Nemes B, Cesar L, Masanari O, Gounis MJ. Contrast injection via the central artery of the left ear in rabbits: a new technique to simplify follow-up studies. AJNR Am J Neuroradiol. 2005 Sep; 26(8):1964-6. PMID: 16155143.
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    115. Lieber BB, Wakhloo AK, Siekmann R, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: effect of ethiodol and glacial acetic acid on penetration, dispersion, and injection force of N-butyl 2-cyanoacrylate. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1707-14. PMID: 16091519.
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    116. Wakhloo AK, Lieber BB, Siekmann R, Eber DJ, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: hemodynamics and vascular remodeling. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1702-6. PMID: 16091518.
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    117. Gounis MJ, Spiga MG, Graham RM, Wilson A, Haliko S, Lieber BB, Wakhloo AK, Webster KA. Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle. Gene Ther. 2005 May; 12(9):762-71. PMID: 15772688.
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    118. Shellock FG, Gounis M, Wakhloo A. Detachable coil for cerebral aneurysms: in vitro evaluation of magnetic field interactions, heating, and artifacts at 3T. AJNR Am J Neuroradiol. 2005 Feb; 26(2):363-6. PMID: 15709137.
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    119. Seong J, Sadasivan C, Onizuka M, Gounis MJ, Christian F, Miskolczi L, Wakhloo AK, Lieber BB. Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas. Biorheology. 2005; 42(5):345-61. PMID: 16308466.
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    120. Lieber BB, Sadasivan C, Gounis MJ, Seong J, Miskolczi L, Wakhloo AK. Functional angiography. Crit Rev Biomed Eng. 2005; 33(1):1-102. PMID: 15777157.
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    121. Wakhloo AK, Lieber BB, Seong J, Sadasivan C, Gounis MJ, Miskolczi L, Sandhu JS. Hemodynamics of carotid artery atherosclerotic occlusive disease. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 2):S111-21. PMID: 15101520.
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    122. Sadasivan C, Lieber BB, Gounis MJ, Lopes DK, Hopkins LN. Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement. AJNR Am J Neuroradiol. 2002 Aug; 23(7):1214-21. PMID: 12169482.
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    123. Gounis MJ, Lieber BB, Wakhloo AK, Siekmann R, Hopkins LN. Effect of glacial acetic acid and ethiodized oil concentration on embolization with N-butyl 2-cyanoacrylate: an in vivo investigation. AJNR Am J Neuroradiol. 2002 Jun-Jul; 23(6):938-44. PMID: 12063221.
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    124. Lieber BB, Gounis MJ. The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms. Neurol Res. 2002; 24 Suppl 1:S33-42. PMID: 12074435.
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    125. Divani AA, Lieber BB, Wakhloo AK, Gounis MJ, Hopkins LN. Determination of blood flow velocity and transit time in cerebral arteriovenous malformation using microdroplet angiography. Ann Biomed Eng. 2001 Feb; 29(2):135-44. PMID: 11284668.
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    126. Siekmann R, Wakhloo AK, Lieber BB, Gounis MJ, Divani AA, Hopkins LN. Modification of a previously described arteriovenous malformation model in the swine: endovascular and combined surgical/endovascular construction and hemodynamics. AJNR Am J Neuroradiol. 2000 Oct; 21(9):1722-5. PMID: 11039356.
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