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Matthew J Gounis PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentRadiology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1884
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentRadiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesBSMechanical Engineering
    State University of New York, Buffalo, Buffalo, NY, United StatesMSMechanical Engineering
    University of Miami, Coral Gables, FL, United StatesPHDPhilosophy

    Collapse Overview 
    Collapse overview

    Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Associate Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. 

    On-going research projects:

    1. 5R44NS076272-03, NIH (PI: A Krtolica)                              8/1/2017-7/31/2020 (NCE) 

    Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

    Role: Subcontract PI

    In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

    2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis)    9/15/2015-7/31/2020 (NCE)

    Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

    Role: MPI

    The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

    3.    2R44NS100163-02, NIH (PI: GJ Ughi)                                                               7/15/2018-4/30/2020

    Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

    Role: Subcontract Co-I

    The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

    4. 2017104, BSF (PIs: N Korin, MJ Gounis)   10/1/2018-9/30/2022

    Hemodynamic transport of drug carriers to cerebral aneurysms

    Role: Co-PI

    Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

    5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool)                                     9/30/2019-8/31/2021

    Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

    Role: Subcontract PI

    Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

    6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves)                      12/1/2018-11/30/2021

    Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

    Role: Co-I

    The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

    7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis)   7/1/2019-06/30/2022

    Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

    Role: PI

    The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ferguson CM, Godinho BM, Alterman JF, Coles AH, Hassler M, Echeverria D, Gilbert JW, Knox EG, Caiazzi J, Haraszti RA, King RM, Taghian T, Puri A, Moser RP, Gounis MJ, Aronin N, Gray-Edwards H, Khvorova A. Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep. JCI Insight. 2021 Dec 22; 6(24). PMID: 34935646.
      Citations:    
    2. Liu Y, Brinjikji W, Abbasi M, Dai D, Arturo Larco JL, Madhani SI, Shahid AH, Mereuta OM, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Fitzgerald S, Doyle K, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Kadirvel R, Cloft HJ, Kallmes DF, Savastano L. Quantification of clot spatial heterogeneity and its impact on thrombectomy. J Neurointerv Surg. 2021 Dec 15. PMID: 34911736.
      Citations:    
    3. Anagnostakou V, Epshtein M, Kühn AL, King RM, Puri A, Gounis MJ. Preclinical modeling of mechanical thrombectomy. J Biomech. 2021 Dec 08; 130:110894. PMID: 34915309.
      Citations:    
    4. Taghian T, Batista AR, Kamper S, Caldwell M, Lilley L, Li H, Rodriguez P, Mesa K, Zheng S, King RM, Gounis MJ, Todeasa S, Maguire A, Martin DR, Sena-Esteves M, Meade TJ, Gray-Edwards HL. Real-time MR tracking of AAV gene therapy with ßgal-responsive MR probe in a murine model of GM1-gangliosidosis. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:128-134. PMID: 34703836.
      Citations:    
    5. Ospel JM, van der Lugt A, Gounis M, Goyal M, Majoie CBLM. A clinical perspective on endovascular stroke treatment biomechanics. J Biomech. 2021 Aug 14; 127:110694. PMID: 34419825.
      Citations:    
    6. Anagnostakou V, Ughi GJ, Puri AS, Gounis MJ. Optical Coherence Tomography for Neurovascular Disorders. Neuroscience. 2021 Jun 11. PMID: 34126186.
      Citations:    
    7. Gounis MJ, Steinman DA. Up around the bend: progress and promise of intravascular imaging in neurointerventional surgery. J Neurointerv Surg. 2021 Jun; 13(6):495-496. PMID: 33986130.
      Citations:    
    8. Mereuta OM, Abbasi M, Fitzgerald S, Dai D, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Arturo Larco JL, Savastano L, Cloft HJ, Kallmes DF, Doyle KM, Brinjikji W. Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy. J Neurointerv Surg. 2021 May 11. PMID: 33975922.
      Citations:    
    9. Abbasi M, Kvamme P, Layton KF, Hanel RA, Almekhlafi MA, Delgado JE, Pereira VM, Patel BM, Jahromi BS, Yoo AJ, Nogueira RG, Gounis MJ, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Kallmes DF, Doyle KM, Savastano LE, Cloft HJ, Liu Y, Thacker IC, Aghaebrahim A, Sauvageau E, Demchuk AM, Kayan Y, Copelan AZ, Entwistle J, Nazari P, Cantrell DR, Bhuva P, Soomro J, Haussen DC, Al-Bayati A, Mohammaden M, Pisani L, Rodrigues G, Puri AS, Brinjikji W. Per pass analysis of thrombus composition retrieved by mechanical thrombectomy. Interv Neuroradiol. 2021 Apr 07; 15910199211009119. PMID: 33823621.
      Citations:    
    10. Brinjikji W, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Abbasi M, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Doyle K, Savastano L, Cloft HJ, Haussen DC, Al-Bayati AR, Mohammaden MH, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Kallmes DF. Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Mar 15. PMID: 33722963.
      Citations:    
    11. El-Bouri WK, MacGowan A, Józsa TI, Gounis MJ, Payne SJ. Modelling the impact of clot fragmentation on the microcirculation after thrombectomy. PLoS Comput Biol. 2021 Mar; 17(3):e1008515. PMID: 33711015.
      Citations:    
    12. Nikoubashman O, Kraitem A, Arslanian R, Gounis MJ, Sichtermann T, Wiesmann M. Preventing Inadvertent Foreign Body Injection in Angiography. Radiology. 2021 May; 299(2):460-467. PMID: 33687288.
      Citations:    
    13. Kühn AL, Satti SR, Eden T, de Macedo Rodrigues K, Singh J, Massari F, Gounis MJ, Puri AS. Anatomic Snuffbox (Distal Radial Artery) and Radial Artery Access for Treatment of Intracranial Aneurysms with FDA-Approved Flow Diverters. AJNR Am J Neuroradiol. 2021 Jan 14. PMID: 33446501.
      Citations:    
    14. Chueh JY, Marosfoi MG, Anagnostakou V, Arslanian RA, Marks MP, Gounis MJ. Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device. Cardiovasc Intervent Radiol. 2020 Nov 11. PMID: 33179161.
      Citations:    
    15. Kühn AL, Singh J, de Macedo Rodrigues K, Massari F, Moholkar VM, Marwah SK, Unar D, Gounis MJ, Puri AS. Distal radial artery (Snuffbox) access for intracranial aneurysm treatment using the Woven EndoBridge (WEB) device. J Clin Neurosci. 2020 Nov; 81:310-315. PMID: 33222936.
      Citations:    
    16. Vargas J, Blalock J, Venkatraman A, Anagnostakou V, King RM, Ewing JA, Gounis MJ, Turner RD, Chaudry I, Turk A. Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke. J Neurointerv Surg. 2020 Oct 06. PMID: 33024028.
      Citations:    
    17. King RM, Caroff J, Langan ET, Leporati A, Rodriguez-Rodriguez A, Raskett CM, Gupta S, Puri AS, Caravan P, Gounis MJ, Bogdanov AA. In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling. J Neurointerv Surg. 2020 Oct 05. PMID: 33020207.
      Citations:    
    18. Vardar Z, King RM, Kraitem A, Langan ET, Peterson LM, Duncan BH, Raskett CM, Anagnostakou V, Gounis MJ, Puri AS, Ughi GJ. High-resolution image-guided WEB aneurysm embolization by high-frequency optical coherence tomography. J Neurointerv Surg. 2020 Sep 28. PMID: 32989033.
      Citations:    
    19. Kühn AL, Singh J, Moholkar VM, Satti SR, Rodrigues KM, Massari F, Gounis MJ, McGowen A, Puri AS. Distal radial artery (snuffbox) access for carotid artery stenting - Technical pearls and procedural set-up. Interv Neuroradiol. 2020 Sep 13; 1591019920959537. PMID: 32924692.
      Citations:    
    20. Ughi GJ, Marosfoi MG, King RM, Caroff J, Peterson LM, Duncan BH, Langan ET, Collins A, Leporati A, Rousselle S, Lopes DK, Gounis MJ, Puri AS. A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy. Nat Commun. 2020 Jul 31; 11(1):3851. PMID: 32737314.
      Citations:    
    21. Caroff J, King RM, Ughi GJ, Marosfoi M, Langan ET, Raskett C, Puri AS, Gounis MJ. Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography. Neurosurgery. 2020 May 28. PMID: 32463884.
      Citations:    
    22. Kühn AL, Vardar Z, Kraitem A, King RM, Anagnostakou V, Puri AS, Gounis MJ. Biomechanics and hemodynamics of stent-retrievers. J Cereb Blood Flow Metab. 2020 May 19; 271678X20916002. PMID: 32428424.
      Citations:    
    23. King RM, Langan ET, Ughi GJ, Raskett CM, Puri AS, Henkes H, Gounis MJ. Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography. Cardiovasc Intervent Radiol. 2020 May 08. PMID: 32385610.
      Citations:    
    24. Taghian T, Horn E, Shazeeb MS, Bierfeldt LJ, Tuominen SM, Koehler J, Fernau D, Bertrand S, Frey S, Cataltepe OI, Gounis MJ, Abayazeed AH, Flotte TR, Sena-Esteves M, Gray-Edwards H. Volume and Infusion Rate Dynamics of Intraparenchymal CNS Infusion in a Large Animal Model. Hum Gene Ther. 2020 May 02. PMID: 32363942.
      Citations:    
    25. Kühn AL, Gounis MJ, Puri AS. Introduction: History and Development of Flow Diverter Technology and Evolution. Neurosurgery. 2020 Jan 01; 86(Supplement_1):S3-S10. PMID: 31838534.
      Citations:    
    26. Fitzgerald S, Wang S, Dai D, Murphree DH, Pandit A, Douglas A, Rizvi A, Kadirvel R, Gilvarry M, McCarthy R, Stritt M, Gounis MJ, Brinjikji W, Kallmes DF, Doyle KM. Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots. PLoS One. 2019; 14(12):e0225841. PMID: 31805096.
      Citations:    
    27. Johnson S, Chueh J, Gounis MJ, McCarthy R, McGarry JP, McHugh PE, Gilvarry M. Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment. J Neurointerv Surg. 2019 Nov 28. PMID: 31780453.
      Citations:    
    28. Taghian T, Marosfoi MG, Puri AS, Cataltepe OI, King RM, Diffie EB, Maguire AS, Martin DR, Fernau D, Batista AR, Kuchel T, Christou C, Perumal R, Chandra S, Gamlin PD, Bertrand SG, Flotte TR, McKenna-Yasek D, Tai PWL, Aronin N, Gounis MJ, Sena-Esteves M, Gray-Edwards HL. A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna. Mol Ther. 2019 Nov 16. PMID: 31813800.
      Citations:    
    29. Staessens S, Fitzgerald S, Andersson T, Clarençon F, Denorme F, Gounis MJ, Hacke W, Liebeskind DS, Szikora I, van Es A, Brinjikji W, Doyle KM, De Meyer SF. Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations. Int J Stroke. 2019 Nov 03; 1747493019884527. PMID: 31679478.
      Citations:    
    30. Chueh JY, Kang DH, Kim BM, Gounis MJ. Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy. J Korean Neurosurg Soc. 2019 Oct 08. PMID: 31591997.
      Citations:    
    31. Shazeeb MS, King RM, Brooks OW, Puri AS, Henninger N, Boltze J, Gounis MJ. Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion. Transl Stroke Res. 2019 Sep 03. PMID: 31478129.
      Citations:    
    32. Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nat Biotechnol. 2019 Aug; 37(8):884-894. PMID: 31375812.
      Citations:    
    33. Caroff J, King RM, Mitchell JE, Marosfoi M, Licwinko JR, Gray-Edwards HL, Puri AS, Merrill TL, Gounis MJ. Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept. J Neurointerv Surg. 2019 Jul 30. PMID: 31363042.
      Citations:    
    34. Prestigiacomo CJ, Gounis MJ, Gonzalez LF, Frösen J. Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms. Neurosurg Focus. 2019 Jul 01; 47(1):E1. PMID: 31261113.
      Citations:    
    35. Fitzgerald S, Dai D, Wang S, Douglas A, Kadirvel R, Layton KF, Thacker IC, Gounis MJ, Chueh JY, Puri AS, Almekhlafi M, Demchuk AM, Hanel RA, Sauvageau E, Aghaebrahim A, Yoo AJ, Kvamme P, M Pereira V, Kayan Y, Delgado Almandoz JE, Nogueira RG, Rabinstein AA, Kallmes DF, Doyle KM, Brinjikji W. Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source. Stroke. 2019 May 29; STROKEAHA118024543. PMID: 31138084.
      Citations:    
    36. Brooks OW, King RM, Nossek E, Marosfoi M, Caroff J, Chueh JY, Puri AS, Gounis MJ. A canine model of mechanical thrombectomy in stroke. J Neurointerv Surg. 2019 May 18. PMID: 31103992.
      Citations:    
    37. Kühn AL, Kan P, Henninger N, Srinivasan V, de Macedo Rodrigues K, Wakhloo AK, Gounis MJ, Puri AS. Impact of age on cerebral aneurysm occlusion after flow diversion. J Clin Neurosci. 2019 May 06. PMID: 31072739.
      Citations:    
    38. King RM, Marosfoi M, Caroff J, Ughi GJ, Groth DM, Gounis MJ, Puri AS. High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion. J Neurointerv Surg. 2019 Apr 29. PMID: 31036558.
      Citations:    
    39. Fitzgerald ST, Wang S, Dai D, Douglas A, Kadirvel R, Gounis MJ, Chueh J, Puri AS, Layton KF, Thacker IC, Hanel RA, Sauvageau E, Aghaebrahim A, Almekhlafi MA, Demchuk AM, Nogueira RG, Pereira VM, Kvamme P, Kayan Y, Delgado Almandoz JE, Yoo AJ, Kallmes DF, Doyle KM, Brinjikji W. Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT. J Neurointerv Surg. 2019 Apr 05. PMID: 30952688.
      Citations:    
    40. Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Sci Transl Med. 2019 Feb 13; 11(479). PMID: 30760580.
      Citations:    
    41. Herrmann AM, Meckel S, Gounis MJ, Kringe L, Motschall E, Mülling C, Boltze J. Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations. J Cereb Blood Flow Metab. 2019 Feb 07; 271678X19827446. PMID: 30732549.
      Citations:    
    42. Arslanian RA, Marosfoi M, Caroff J, King RM, Raskett C, Puri AS, Gounis MJ, Chueh JY. Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization. J Neurointerv Surg. 2019 Feb 04. PMID: 30718384.
      Citations:    
    43. Gounis MJ, Ughi GJ, Marosfoi M, Lopes DK, Fiorella D, Bezerra HG, Liang CW, Puri AS. Intravascular Optical Coherence Tomography for Neurointerventional Surgery. Stroke. 2018 Nov 29; STROKEAHA118022315. PMID: 30580737.
      Citations:    
    44. Mondo E, Moser R, Gao G, Mueller C, Sena-Esteves M, Sapp E, Pfister E, O'Connell D, Takle K, Erger KE, Liu W, Conlon TJ, DiFiglia M, Gounis MJ, Aronin N. Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration. J Huntingtons Dis. 2018 Sep 29. PMID: 30320596.
      Citations:    
    45. Caroff J, King RM, Arslanian R, Marosfoi M, Langan ET, Gounis MJ, Chueh JY. Microcatheter navigation through the clot: does size matter? J Neurointerv Surg. 2018 Sep 03. PMID: 30177546.
      Citations:    
    46. Brouwer PA, Yeo LLL, Gounis MJ, Gontu VK. Size matters… but how do I know what size it is? J Neurointerv Surg. 2018 Jul 24. PMID: 30042158.
      Citations:    
    47. Gounis MJ. Commentary on 'Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases'. J Neurointerv Surg. 2018 Jul; 10(Suppl 1):i50. PMID: 30037957.
      Citations:    
    48. MacDonell J, Patel N, Fischer G, Burdette EC, Qian J, Chumbalkar V, Ghoshal G, Heffter T, Williams E, Gounis M, King R, Thibodeau J, Bogdanov G, Brooks OW, Langan E, Hwang R, Pilitsis JG. Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model. Neurosurgery. 2018 Jun 14. PMID: 29905844.
      Citations:    
    49. Wadghiri YZ, Hoang DM, Leporati A, Gounis MJ, Rodríguez-Rodríguez A, Mazzanti ML, Weaver JP, Wakhloo AK, Caravan P, Bogdanov AA. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018 May 16; 8(1):7687. PMID: 29769642.
      Citations:    
    50. Aquarius R, de Korte A, Smits D, Gounis M, Verrijp K, Driessen L, Leenders W, de Vries J. The Importance of Wall Apposition in Flow Diverters. Neurosurgery. 2018 Apr 04. PMID: 29659995.
      Citations:    
    51. Caroff J, Tamura T, King RM, Lylyk PN, Langan ET, Brooks OW, Clarençon F, Wainwright JM, Spelle L, Marosfoi M, Gounis MJ, Puri AS. Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. J Neurointerv Surg. 2018 Mar 06. PMID: 29511117.
      Citations:    
    52. Nitzsche B, Boltze J, Ludewig E, Flegel T, Schmidt MJ, Seeger J, Barthel H, Brooks OW, Gounis MJ, Stoffel MH, Schulze S. A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets. Neuroimage. 2018 Jan 31. PMID: 29407456.
      Citations:    
    53. Kallmes DF, Rabinstein AA, Gounis MJ. To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI. J Neurointerv Surg. 2018 Apr; 10(4):323-324. PMID: 29352058.
      Citations:    
    54. King RM, Brooks OW, Langan ET, Caroff J, Clarençon F, Tamura T, Wainwright JM, Gounis MJ, Marosfoi M, Puri AS. Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion. J Neurointerv Surg. 2018 Jul; 10(7):693-697. PMID: 29127197.
      Citations:    
    55. Chueh JY, Marosfoi MG, Brooks OW, King RM, Puri AS, Gounis MJ. Novel Distal Emboli Protection Technology: The EmboTrap. Interv Neurol. 2017 Oct; 6(3-4):268-276. PMID: 29118805.
      Citations:    
    56. Gounis MJ. Neurointervention: a call to science. J Neurointerv Surg. 2017 09; 9(9):813-814. PMID: 28819057.
      Citations:    
    57. Marosfoi M, Clarencon F, Langan ET, King RM, Brooks OW, Tamura T, Wainwright JM, Gounis MJ, Vedantham S, Puri AS. Acute thrombus formation on phosphorilcholine surface modified flow diverters. J Neurointerv Surg. 2018 Apr; 10(4):406-411. PMID: 28689183.
      Citations:    
    58. Gounis MJ, Chapot R. Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention? Stroke. 2017 Jun 16. PMID: 28626053.
      Citations:    
    59. De Macedo Rodrigues K, Kühn AL, Tamura T, Dabus G, Kan P, Marosfoi MG, Lozano JD, Perras M, Brooks C, Howk MC, Hou SY, Rex DE, Massari F, Gounis MJ, Wakhloo AK, Puri AS. Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study. Oper Neurosurg (Hagerstown). 2017 May 17. PMID: 28521024.
      Citations:    
    60. Chueh JY, van der Marel K, Gounis MJ, LeMatty T, Brown TR, Ansari SA, Carroll TJ, Buck AK, Zhou XJ, Chatterjee AR, King RM, Mao H, Zheng S, Brooks OW, Rappleye JW, Swartz RH, Feldmann E, Turan TN. Development of a high resolution MRI intracranial atherosclerosis imaging phantom. J Neurointerv Surg. 2017 Mar 09. PMID: 28280114.
      Citations:    
    61. Aquarius R, Smits D, Gounis MJ, Leenders WP, de Vries J. Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study. J Neurointerv Surg. 2017 Feb 08. PMID: 28179543.
      Citations:    
    62. Golebiowski D, van der Bom IM, Kwon CS, Miller AD, Petrosky K, Bradbury AM, Maitland S, Kühn AL, Bishop N, Curran E, Silva N, GuhaSarkar D, Westmoreland SV, Martin DR, Gounis MJ, Asaad WF, Sena-Esteves M. Direct intracranial injection of AAVrh8 encoding monkey ß-N-acetylhexosaminidase causes neurotoxicity in primate brain. Hum Gene Ther. 2017 Jan 28. PMID: 28132521.
      Citations:    
    63. van der Marel K, Vedantham S, van der Bom IM, Howk M, Narain T, Ty K, Karellas A, Gounis MJ, Puri AS, Wakhloo AK. Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform. AJNR Am J Neuroradiol. 2017 Jan 19. PMID: 28104643.
      Citations:    
    64. De Meyer SF, Andersson T, Baxter B, Bendszus M, Brouwer P, Brinjikji W, Campbell BC, Costalat V, Dávalos A, Demchuk A, Dippel D, Fiehler J, Fischer U, Gilvarry M, Gounis MJ, Gralla J, Jansen O, Jovin T, Kallmes D, Khatri P, Lees KR, López-Cancio E, Majoie C, Marquering H, Narata AP, Nogueira R, Ringleb P, Siddiqui A, Szikora I, Vale D, von Kummer R, Yoo AJ, Hacke W, Liebeskind DS. Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions. Int J Stroke. 2017 Jan 01; 1747493017709671. PMID: 28534706.
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    65. Taschner CA, Vedantham S, de Vries J, Biondi A, Boogaarts J, Sakai N, Lylyk P, Szikora I, Meckel S, Urbach H, Kan P, Siekmann R, Bernardy J, Gounis MJ, Wakhloo AK. Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms. AJNR Am J Neuroradiol. 2016 Dec 22. PMID: 28007769.
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    66. Kühn AL, Wakhloo AK, Gounis MJ, Kan P, de Macedo Rodrigues K, Lozano JD, Marosfoi MG, Perras M, Brooks C, Howk MC, Rex DE, Massari F, Puri AS. Use of self-expanding stents for better intracranial flow diverter wall apposition. Interv Neuroradiol. 2016 Dec 12. PMID: 27956518.
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    67. Kühn AL, de Macedo Rodrigues K, Lozano JD, Rex DE, Massari F, Tamura T, Howk M, Brooks C, L'Heureux J, Gounis MJ, Wakhloo AK, Puri AS. Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up. J Neurointerv Surg. 2016 Nov 25. PMID: 27888225.
      Citations:    
    68. Ansari SA, Kühn AL, Honarmand AR, Khan M, Hurley MC, Potts MB, Jahromi BS, Shaibani A, Gounis MJ, Wakhloo AK, Puri AS. Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents. AJNR Am J Neuroradiol. 2017 Jan; 38(1):97-104. PMID: 28059705.
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    69. Marosfoi M, Langan ET, Strittmatter L, van der Marel K, Vedantham S, Arends J, Lylyk IR, Loganathan S, Hendricks GM, Szikora I, Puri AS, Wakhloo AK, Gounis MJ. In situ tissue engineering: endothelial growth patterns as a function of flow diverter design. J Neurointerv Surg. 2016 Oct 5. PMID: 27707872.
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    70. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. J Neurointerv Surg. 2017 Mar; 9(3):e10. PMID: 27417184.
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    71. Tamura T, Rex DE, Marosfoi MG, Puri AS, Gounis MJ, Wakhloo AK. Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery. BMJ Case Rep. 2016 Jul 05; 2016. PMID: 27382015.
      Citations:    
    72. Boltze J, Wagner DC, Barthel H, Gounis MJ. Academic-industry Collaborations in Translational Stroke Research. Transl Stroke Res. 2016 Aug; 7(4):343-53. PMID: 27301976.
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    73. Kühn AL, Wakhloo AK, Lozano JD, Massari F, De Macedo Rodrigues K, Marosfoi MG, Perras M, Brooks C, Howk M, Rex DE, Gounis MJ, Puri AS. Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke. J Neurointerv Surg. 2016 Jun 9. PMID: 27286991.
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    74. Brinjikji W, Duffy S, Burrows A, Hacke W, Liebeskind D, Majoie CB, Dippel DW, Siddiqui AH, Khatri P, Baxter B, Nogeuira R, Gounis M, Jovin T, Kallmes DF. Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review. J Neurointerv Surg. 2016 May 10. PMID: 27166383.
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    75. Vedantham S, Shrestha S, Karellas A, Shi L, Gounis MJ, Bellazzini R, Spandre G, Brez A, Minuti M. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. Med Phys. 2016 May; 43(5):2118. PMID: 27147324.
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    76. Chueh JY, Puri AS, Gounis MJ. An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy. J Neurointerv Surg. 2017 Feb; 9(2):183-187. PMID: 26919972.
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    77. Massari F, Henninger N, Lozano JD, Patel A, Kuhn AL, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK, Puri AS. ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience. Interv Neuroradiol. 2016 Jun; 22(3):325-32. PMID: 26908591.
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    78. van der Marel K, Chueh JY, Brooks OW, King RM, Marosfoi MG, Langan ET, Carniato SL, Gounis MJ, Nogueira RG, Puri AS. Quantitative assessment of device-clot interaction for stent retriever thrombectomy. J Neurointerv Surg. 2016 Feb 01. PMID: 26833539.
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    79. Puri AS, Massari F, Asai T, Marosfoi M, Kan P, Hou SY, Howk M, Perras M, Brooks C, Clarencon F, Gounis MJ, Wakhloo AK. Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (<2.5 mm) cerebral vessels for aneurysm treatment: single institution experience. Neuroradiology. 2016 Mar; 58(3):267-75. PMID: 26700827.
      Citations:    
    80. Iannaccone F, De Beule M, De Bock S, Van der Bom IM, Gounis MJ, Wakhloo AK, Boone M, Verhegghe B, Segers P. A Finite Element Method to Predict Adverse Events in Intracranial Stenting Using Microstents: In Vitro Verification and Patient Specific Case Study. Ann Biomed Eng. 2016 Feb; 44(2):442-52. PMID: 26620777.
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    81. Shen ZT, Zheng S, Gounis MJ, Sigalov AB. Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles. PLoS One. 2015; 10(11):e0143453. PMID: 26569115.
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    82. Kühn AL, Kan P, Massari F, Lozano JD, Hou SY, Howk M, Gounis MJ, Wakhloo AK, Puri AS. Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device. J Neurointerv Surg. 2016 Oct; 8(10):1048-51. PMID: 26546600.
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    83. Marosfoi MG, Korin N, Gounis MJ, Uzun O, Vedantham S, Langan ET, Papa AL, Brooks OW, Johnson C, Puri AS, Bhatta D, Kanapathipillai M, Bronstein BR, Chueh JY, Ingber DE, Wakhloo AK. Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion. Stroke. 2015 Dec; 46(12):3507-13. PMID: 26493676.
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    84. Gounis MJ, van der Marel K, Marosfoi M, Mazzanti ML, Clarençon F, Chueh JY, Puri AS, Bogdanov AA. Imaging Inflammation in Cerebrovascular Disease. Stroke. 2015 Oct; 46(10):2991-7. PMID: 26351362.
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    85. van der Marel K, Gounis MJ, Weaver JP, de Korte AM, King RM, Arends JM, Brooks OW, Wakhloo AK, Puri AS. Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT. J Neurointerv Surg. 2016 Aug; 8(8):847-52. PMID: 26220411.
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    86. Walvick RP, Roche JP, Reno AL, Gounis MJ, Albert MS. Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia. Magn Reson Med. 2016 May; 75(5):2050-4. PMID: 26079271.
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    87. Kühn AL, Hou SY, Puri AS, Silva CF, Gounis MJ, Wakhloo AK. Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis. J Neurointerv Surg. 2016 Jun; 8(6):581-5. PMID: 26041097.
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    88. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. J Neurointerv Surg. 2016 Apr; 8(4):e13. PMID: 25854687.
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    89. Puri AS, Massari F, Hou SY, Lozano JD, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK. Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms. J Neurointerv Surg. 2016 May; 8(5):501-6. PMID: 25838199.
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    90. Puri AS, Gounis MJ, Massari F, Howk M, Weaver J, Wakhloo AK. Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection. BMJ Case Rep. 2015 Apr 01; 2015. PMID: 25833904.
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    91. Korin N, Gounis MJ, Wakhloo AK, Ingber DE. Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics. JAMA Neurol. 2015 Jan; 72(1):119-22. PMID: 25365638.
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    92. Chueh JY, Puri AS, Wakhloo AK, Gounis MJ. Risk of distal embolization with stent retriever thrombectomy and ADAPT. J Neurointerv Surg. 2016 Feb; 8(2):197-202. PMID: 25540180.
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    93. Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35. PMID: 25344064.
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    94. Gounis MJ, van der Bom IM, Wakhloo AK, Zheng S, Chueh JY, Kühn AL, Bogdanov AA. MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall. AJNR Am J Neuroradiol. 2015 Jan; 36(1):146-52. PMID: 25273534.
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    95. Wakhloo AK, Lylyk P, de Vries J, Taschner C, Lundquist J, Biondi A, Hartmann M, Szikora I, Pierot L, Sakai N, Imamura H, Sourour N, Rennie I, Skalej M, Beuing O, Bonafé A, Mery F, Turjman F, Brouwer P, Boccardi E, Valvassori L, Derakhshani S, Litzenberg MW, Gounis MJ. Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study. AJNR Am J Neuroradiol. 2015 Jan; 36(1):98-107. PMID: 25125666.
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    96. Wakhloo AK, Gounis MJ. Revolution in aneurysm treatment: flow diversion to cure aneurysms: a paradigm shift. Neurosurgery. 2014 Aug; 61 Suppl 1:111-20. PMID: 25032539.
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    97. Kühn AL, Hou SY, Perras M, Brooks C, Gounis MJ, Wakhloo AK, Puri AS. Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up. J Neurointerv Surg. 2015 Sep; 7(9):634-40. PMID: 25051964.
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    98. Chueh JY, Vedantham S, Wakhloo AK, Carniato SL, Puri AS, Bzura C, Coffin S, Bogdanov AA, Gounis MJ. Aneurysm permeability following coil embolization: packing density and coil distribution. J Neurointerv Surg. 2015 Sep; 7(9):676-81. PMID: 25031179.
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    99. Gounis MJ, Vedantham S, Weaver JP, Puri AS, Brooks CS, Wakhloo AK, Bogdanov AA. Myeloperoxidase in human intracranial aneurysms: preliminary evidence. Stroke. 2014 May; 45(5):1474-7. PMID: 24713525.
      Citations:    
    100. Zheng S, van der Bom IM, Zu Z, Lin G, Zhao Y, Gounis MJ. Chemical exchange saturation transfer effect in blood. Magn Reson Med. 2014 Mar; 71(3):1082-92. PMID: 23661508.
      Citations:    
    101. Puri AS, Kühn AL, Kwon HJ, Khan M, Hou SY, Lin E, Chueh J, van der Bom IM, Dabus G, Linfante I, Gounis MJ, Wakhloo AK. Endovascular treatment of tandem vascular occlusions in acute ischemic stroke. J Neurointerv Surg. 2015 Mar; 7(3):158-63. PMID: 24578485.
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    102. Flood TF, van der Bom IM, Strittmatter L, Puri AS, Hendricks GM, Wakhloo AK, Gounis MJ. Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia. J Neurointerv Surg. 2015 Feb; 7(2):118-25. PMID: 24480728.
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    103. Wakhloo AK, Gounis MJ, Chueh JY, Pierot L. Advances in stroke: Advances in interventional radiology 2013. Stroke. 2014 Feb; 45(2):365-7. PMID: 24436230.
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    104. Vogl TJ, Pflugmacher R, Hierholzer J, Stender G, Gounis M, Wakhloo A, Fiebig C, Hammerstingl R. Cement directed kyphoplasty reduces cement leakage as compared with vertebroplasty: results of a controlled, randomized trial. Spine (Phila Pa 1976). 2013 Sep 15; 38(20):1730-6. PMID: 23804157.
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    105. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. J Neurointerv Surg. 2014 Jun; 6(5):e34. PMID: 23997121.
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    106. van der Bom IM, Gounis MJ, Ding L, Kühn AL, Goff D, Puri AS, Wakhloo AK. Target delineation for radiosurgery of a small brain arteriovenous malformation using high-resolution contrast-enhanced cone beam CT. BMJ Case Rep. 2013 Aug 14; 2013. PMID: 23946527.
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    107. Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun; 44(6 Suppl 1):S7-S10. PMID: 23709736.
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    108. van der Bom IM, Hou SY, Puri AS, Spilberg G, Ruijters D, van de Haar P, Carelsen B, Vedantham S, Gounis MJ, Wakhloo AK. Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2163-70. PMID: 23721899.
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    109. Chueh JY, Kühn AL, Puri AS, Wilson SD, Wakhloo AK, Gounis MJ. Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study. Stroke. 2013 May; 44(5):1396-401. PMID: 23493730.
      Citations:    
    110. van der Bom IM, Moser RP, Gao G, Mondo E, O'Connell D, Gounis MJ, McGowan S, Chaurette J, Bishop N, Sena-Esteves MS, Mueller C, Aronin N. Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery. J Huntingtons Dis. 2013; 2(1):41-5. PMID: 25063428.
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    111. Gounis MJ, Nogueira RG, Mehra M, Chueh J, Wakhloo AK. A thromboembolic model for the efficacy and safety evaluation of combined mechanical and pharmacologic revascularization strategies. J Neurointerv Surg. 2013 May; 5 Suppl 1:i85-9. PMID: 22962414.
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    112. Chueh JY, Wakhloo AK, Gounis MJ. Effectiveness of mechanical endovascular thrombectomy in a model system of cerebrovascular occlusion. AJNR Am J Neuroradiol. 2012 Nov; 33(10):1998-2003. PMID: 22555570.
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    113. Zarate B, Gutierrez J, Wakhloo AK, Gounis MJ, Reyes-Sánchez A. Clinical evaluation of a new kyphoplasty technique with directed cement flow. J Spinal Disord Tech. 2012 May; 25(3):E61-6. PMID: 22343281.
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    114. Samaniego EA, Tari-Capone F, Linfante I, Silva CF, Spilberg G, Gounis M, Wakhloo AK, Dabus G. Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure. J Neurointerv Surg. 2013 Jul; 5(4):302-5. PMID: 22544819.
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    115. King RM, Chueh JY, van der Bom IM, Silva CF, Carniato SL, Spilberg G, Wakhloo AK, Gounis MJ. The effect of intracranial stent implantation on the curvature of the cerebrovasculature. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1657-62. PMID: 22538075.
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    116. Wakhloo AK, Linfante I, Silva CF, Samaniego EA, Dabus G, Etezadi V, Spilberg G, Gounis MJ. Closed-cell stent for coil embolization of intracranial aneurysms: clinical and angiographic results. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1651-6. PMID: 22492570.
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    117. van der Bom IM, Moser RP, Gao G, Sena-Esteves M, Aronin N, Gounis MJ. Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain. J Neurointerv Surg. 2013 Jan 1; 5(1):69-72. PMID: 22193239.
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    118. Spilberg G, Carniato SL, King RM, van der Bom IM, Mehra M, Walvick RP, Wakhloo AK, Gounis MJ. Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study. AJNR Am J Neuroradiol. 2012 Apr; 33(4):655-60. PMID: 22194374.
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    119. van der Bom IM, Mehra M, Walvick RP, Chueh JY, Gounis MJ. Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke. AJNR Am J Neuroradiol. 2012 Feb; 33(2):353-8. PMID: 22173756.
      Citations:    
    120. Carniato S, Mehra M, King RM, Wakhloo AK, Gounis MJ. Porcine brachial artery tortuosity for in vivo evaluation of neuroendovascular devices. AJNR Am J Neuroradiol. 2013 Apr; 34(4):E36-8. PMID: 22081678.
      Citations:    
    121. Grunwald IQ, Kamran M, Corkill RA, Kühn AL, Choi IS, Turnbull S, Dobson D, Fassbender K, Watson D, Gounis MJ. Simple measurement of aneurysm residual after treatment: the SMART scale for evaluation of intracranial aneurysms treated with flow diverters. Acta Neurochir (Wien). 2012 Jan; 154(1):21-6; discussion 26. PMID: 22002552.
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    122. Nogueira RG, Levy EI, Gounis M, Siddiqui AH. The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease. J Neurointerv Surg. 2012 Jul; 4(4):295-300. PMID: 21990512.
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    123. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul; 4(4):307-13. PMID: 21990535.
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    124. Chueh JY, Wakhloo AK, Hendricks GH, Silva CF, Weaver JP, Gounis MJ. Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs. AJNR Am J Neuroradiol. 2011 Aug; 32(7):1237-44. PMID: 21596804.
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    125. Mehra M, Hurley MC, Gounis MJ, King RM, Shaibani A, Dabus G, Labdag FE, Levy EI, Bendok BR. The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study. J Neurointerv Surg. 2011 Jun; 3(2):131-6. PMID: 21990804.
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    126. van der Bom MJ, Pluim JP, Gounis MJ, van de Kraats EB, Sprinkhuizen SM, Timmer J, Homan R, Bartels LW. Registration of 2D x-ray images to 3D MRI by generating pseudo-CT data. Phys Med Biol. 2011 Feb 21; 56(4):1031-43. PMID: 21258138.
      Citations:    
    127. Patel NV, Gounis MJ, Wakhloo AK, Noordhoek N, Blijd J, Babic D, Takhtani D, Lee SK, Norbash A. Contrast-enhanced angiographic cone-beam CT of cerebrovascular stents: experimental optimization and clinical application. AJNR Am J Neuroradiol. 2011 Jan; 32(1):137-44. PMID: 20966059.
      Citations:    
    128. Li JM, Newburger PE, Gounis MJ, Dargon P, Zhang X, Messina LM. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther. 2010 Oct; 17(10):1279-87. PMID: 20485380.
      Citations:    
    129. van der Bom MJ, Bartels LW, Gounis MJ, Homan R, Timmer J, Viergever MA, Pluim JP. Robust initialization of 2D-3D image registration using the projection-slice theorem and phase correlation. Med Phys. 2010 Apr; 37(4):1884-92. PMID: 20443510.
      Citations:    
    130. Gounis MJ, DeLeo MJ, Wakhloo AK. Advances in interventional neuroradiology. Stroke. 2010 Feb; 41(2):e81-7. PMID: 20075339.
      Citations:    
    131. Hong B, Patel NV, Gounis MJ, DeLeo MJ, Linfante I, Wojak JC, Wakhloo AK. Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms. Neurosurgery. 2009 Dec; 65(6):1131-8; discussion 1138-9. PMID: 19934972.
      Citations:    
    132. Linfante I, DeLeo MJ, Gounis MJ, Brooks CS, Wakhloo AK. Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results. AJNR Am J Neuroradiol. 2009 Sep; 30(8):1496-501. PMID: 19696138.
      Citations:    
    133. DeLeo MJ, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov AA. Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study. Radiology. 2009 Sep; 252(3):696-703. PMID: 19546428.
      Citations:    
    134. Chueh JY, Wakhloo AK, Gounis MJ. Neurovascular modeling: small-batch manufacturing of silicone vascular replicas. AJNR Am J Neuroradiol. 2009 Jun; 30(6):1159-64. PMID: 19321626.
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    135. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50. PMID: 19246690.
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    136. Linfante I, Delgado-Mederos R, Andreone V, Gounis M, Hendricks L, Wakhloo AK. Angiographic and hemodynamic effect of high concentration of intra-arterial nicardipine in cerebral vasospasm. Neurosurgery. 2008 Dec; 63(6):1080-6; discussion 1086-7. PMID: 19057319.
      Citations:    
    137. Cesar L, Miskolczi L, Lieber BB, Sadasivan C, Gounis MJ, Wakhloo AK. Neurological deficits associated with the elastase-induced aneurysm model in rabbits. Neurol Res. 2009 May; 31(4):414-9. PMID: 18826754.
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    138. Wakhloo AK, Mandell J, Gounis MJ, Brooks C, Linfante I, Winer J, Weaver JP. Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up. Stroke. 2008 Dec; 39(12):3288-96. PMID: 18772450.
      Citations:    
    139. Wakhloo AK, Gounis MJ. Retrievable closed cell intracranial stent for foreign body and clot removal. Neurosurgery. 2008 May; 62(5 Suppl 2):ONS390-3; discussion ONS393-4. PMID: 18596519.
      Citations:    
    140. Gounis MJ, Lieber BB, Webster KA, Wakhloo AK. A novel angiographic methodology for the quantification of angiogenesis. IEEE Trans Biomed Eng. 2008 Mar; 55(3):996-1003. PMID: 18334391.
      Citations:    
    141. Bendok BR, Parkinson RJ, Hage ZA, Adel JG, Gounis MJ. The effect of vascular reconstruction device-assisted coiling on packing density, effective neck coverage, and angiographic outcome: an in vitro study. Neurosurgery. 2007 Oct; 61(4):835-40; discussion 840-1. PMID: 17986946.
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    142. Wakhloo AK, Gounis MJ, Sandhu JS, Akkawi N, Schenck AE, Linfante I. Complex-shaped platinum coils for brain aneurysms: higher packing density, improved biomechanical stability, and midterm angiographic outcome. AJNR Am J Neuroradiol. 2007 Aug; 28(7):1395-400. PMID: 17698550.
      Citations:    
    143. Onizuka M, Miskolczi L, Gounis MJ, Seong J, Lieber BB, Wakhloo AK. Elastase-induced aneurysms in rabbits: effect of postconstruction geometry on final size. AJNR Am J Neuroradiol. 2006 May; 27(5):1129-31. PMID: 16687557.
      Citations:    
    144. Miskolczi L, Nemes B, Cesar L, Masanari O, Gounis MJ. Contrast injection via the central artery of the left ear in rabbits: a new technique to simplify follow-up studies. AJNR Am J Neuroradiol. 2005 Sep; 26(8):1964-6. PMID: 16155143.
      Citations:    
    145. Lieber BB, Wakhloo AK, Siekmann R, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: effect of ethiodol and glacial acetic acid on penetration, dispersion, and injection force of N-butyl 2-cyanoacrylate. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1707-14. PMID: 16091519.
      Citations:    
    146. Wakhloo AK, Lieber BB, Siekmann R, Eber DJ, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: hemodynamics and vascular remodeling. AJNR Am J Neuroradiol. 2005 Aug; 26(7):1702-6. PMID: 16091518.
      Citations:    
    147. Gounis MJ, Spiga MG, Graham RM, Wilson A, Haliko S, Lieber BB, Wakhloo AK, Webster KA. Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle. Gene Ther. 2005 May; 12(9):762-71. PMID: 15772688.
      Citations:    
    148. Shellock FG, Gounis M, Wakhloo A. Detachable coil for cerebral aneurysms: in vitro evaluation of magnetic field interactions, heating, and artifacts at 3T. AJNR Am J Neuroradiol. 2005 Feb; 26(2):363-6. PMID: 15709137.
      Citations:    
    149. Seong J, Sadasivan C, Onizuka M, Gounis MJ, Christian F, Miskolczi L, Wakhloo AK, Lieber BB. Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas. Biorheology. 2005; 42(5):345-61. PMID: 16308466.
      Citations:    
    150. Lieber BB, Sadasivan C, Gounis MJ, Seong J, Miskolczi L, Wakhloo AK. Functional angiography. Crit Rev Biomed Eng. 2005; 33(1):1-102. PMID: 15777157.
      Citations:    
    151. Wakhloo AK, Lieber BB, Seong J, Sadasivan C, Gounis MJ, Miskolczi L, Sandhu JS. Hemodynamics of carotid artery atherosclerotic occlusive disease. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 2):S111-21. PMID: 15101520.
      Citations:    
    152. Sadasivan C, Lieber BB, Gounis MJ, Lopes DK, Hopkins LN. Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement. AJNR Am J Neuroradiol. 2002 Aug; 23(7):1214-21. PMID: 12169482.
      Citations:    
    153. Gounis MJ, Lieber BB, Wakhloo AK, Siekmann R, Hopkins LN. Effect of glacial acetic acid and ethiodized oil concentration on embolization with N-butyl 2-cyanoacrylate: an in vivo investigation. AJNR Am J Neuroradiol. 2002 Jun-Jul; 23(6):938-44. PMID: 12063221.
      Citations:    
    154. Lieber BB, Gounis MJ. The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms. Neurol Res. 2002; 24 Suppl 1:S33-42. PMID: 12074435.
      Citations:    
    155. Divani AA, Lieber BB, Wakhloo AK, Gounis MJ, Hopkins LN. Determination of blood flow velocity and transit time in cerebral arteriovenous malformation using microdroplet angiography. Ann Biomed Eng. 2001 Feb; 29(2):135-44. PMID: 11284668.
      Citations:    
    156. Siekmann R, Wakhloo AK, Lieber BB, Gounis MJ, Divani AA, Hopkins LN. Modification of a previously described arteriovenous malformation model in the swine: endovascular and combined surgical/endovascular construction and hemodynamics. AJNR Am J Neuroradiol. 2000 Oct; 21(9):1722-5. PMID: 11039356.
      Citations:    
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