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Dohoon Kim PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
55 Lake Avenue North LRB 422
Worcester MA 01655
Phone508-856-5330
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    Korea Advanced Institute of Science, Daejeon, , Korea, Republic ofBSBiological Sciences
    Korea Advanced Institute of Science, Daejeon, , Korea, Republic ofMSBiological Sciences
    Harvard University, Cambridge, MA, United StatesPHDCellular & Dev Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Choi KM, Berard BA, Yoon JH, Kim D. Uridine as a hub in cancer metabolism and RNA biology. Exp Mol Med. 2025 Aug; 57(8):1651-1662. PMID: 40804482.
      Citations:    
    2. Park SJ, Lee N, Wang IH, Jiang HC, Luu T, Uemura T, Futai K, Kim D, Macosko E, Greer P. The neurexin gene family regulates olfactory glomerular formation. Cell Rep. 2025 Aug 26; 44(8):116125. PMID: 40768336.
      Citations:    
    3. Park S, Kim D, Ryoo N. Comparative Assessment of Rapid Identification and Antimicrobial Susceptibility Testing Methods for Bloodstream Infections in a Non-24/7 Clinical Microbiology Laboratory. Microorganisms. 2025 Apr 30; 13(5). PMID: 40431219.
      Citations:    
    4. Lee N, Kim D. Adapt or Perish: Efficient Selenocysteine Insertion Is Critical for Metastasizing Cancer Cells. Cancer Res. 2025 Feb 01; 85(3):410-412. PMID: 39589764.
      Citations:    
    5. Park SJ, Wang IH, Lee N, Jiang HC, Uemura T, Futai K, Kim D, Macosko E, Greer P. Combinatorial expression of neurexin genes regulates glomerular targeting by olfactory sensory neurons. bioRxiv. 2024 Apr 02. PMID: 38617205.
      Citations:    
    6. Lee N, Park SJ, Lange M, Tseyang T, Doshi MB, Kim TY, Song Y, Kim DI, Greer PL, Olzmann JA, Spinelli JB, Kim D. Selenium reduction of ubiquinone via SQOR suppresses ferroptosis. Nat Metab. 2024 Feb; 6(2):343-358. PMID: 38351124.
      Citations:    
    7. Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 11; 623(7987):625-632. PMID: 37880368.
      Citations: 1     Fields:    Translation:HumansCells
    8. Costanzo MC, Paquin-Proulx D, Schuetz A, Akapirat S, Shubin Z, Kim D, Wieczorek L, Polonis VR, Trinh HV, Rao M, Anenia H, Barrera MD, Boeckelman J, Nails B, Thapa P, Zemil M, Sacdalan C, Kroon E, Kaewboon B, Tipsuk S, Jongrakthaitae S, Gurunathan S, Sinangil F, Kim JH, Robb ML, Ake JA, O'Connell RJ, Pitisutthithum P, Nitayaphan S, Chariyalertsak S, Eller MA, Phanuphak N, Vasan S. ALVAC-HIV and AIDSVAX B/E vaccination induce improved immune responses compared with AIDSVAX B/E vaccination alone. JCI Insight. 2023 05 08; 8(9). PMID: 37154156.
      Citations:    
    9. Jang S, Kang YS, Kim D, Park S, Seol C, Lee S, Kim SM, Yoo SJ. Multiscale Architectured Membranes, Electrodes, and Transport Layers for Next-Generation Polymer Electrolyte Membrane Fuel Cells. Adv Mater. 2023 Oct; 35(43):e2204902. PMID: 36222387.
      Citations:    
    10. Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D. De novo sphingolipid biosynthesis necessitates detoxification in cancer cells. Cell Rep. 2022 09 27; 40(13):111415. PMID: 36170811.
      Citations: 2     Fields:    Translation:Cells
    11. Lee N, Kim D. Toxic Metabolites and Inborn Errors of Amino Acid Metabolism: What One Informs about the Other. Metabolites. 2022 Jun 08; 12(6). PMID: 35736461.
      Citations:    
    12. Choi Y, Kim D, Shin YS, Lee W, Orr S, Kim JY, Park J. Highly luminescent red-emitting In(Zn)P quantum dots using zinc oxo cluster: synthesis and application to light-emitting diodes. Nanoscale. 2022 Feb 17; 14(7):2771-2779. PMID: 35119065.
      Citations:    
    13. Park JS, Kim T, Kim D, Jeong YI. The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of N-Methyl-d-aspartate Receptor Subunit 1 in Brain Cancer Cells for Alzheimer's Disease Application. Int J Mol Sci. 2021 Nov 15; 22(22). PMID: 34830191.
      Citations:    
    14. Lee N, Carlisle AE, Kim D. Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells. Methods Enzymol. 2022; 662:1-24. PMID: 35101206.
      Citations:    Fields:    
    15. Yoo H, Lee SH, Arru CD, Doda Khera R, Singh R, Siebert S, Kim D, Lee Y, Park JH, Eom HJ, Digumarthy SR, Kalra MK. AI-based improvement in lung cancer detection on chest radiographs: results of a multi-reader study in NLST dataset. Eur Radiol. 2021 Dec; 31(12):9664-9674. PMID: 34089072.
      Citations:    
    16. Paquin-Proulx D, Gunn BM, Alrubayyi A, Clark DV, Creegan M, Kim D, Kibuuka H, Millard M, Wakabi S, Eller LA, Michael NL, Schoepp RJ, Hepburn MJ, Hensley LE, Robb ML, Alter G, Eller MA. Associations Between Antibody Fc-Mediated Effector Functions and Long-Term Sequelae in Ebola Virus Survivors. Front Immunol. 2021; 12:682120. PMID: 34093585.
      Citations:    
    17. Ryu WI, Bormann MK, Shen M, Kim D, Forester B, Park Y, So J, Seo H, Sonntag KC, Cohen BM. Brain cells derived from Alzheimer's disease patients have multiple specific innate abnormalities in energy metabolism. Mol Psychiatry. 2021 10; 26(10):5702-5714. PMID: 33863993.
      Citations:    
    18. Lee N, Carlisle AE, Peppers A, Park SJ, Doshi MB, Spears ME, Kim D. xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers. Antioxidants (Basel). 2021 Feb 20; 10(2). PMID: 33672555.
      Citations:    
    19. Lee N, Spears ME, Carlisle AE, Kim D. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 08; 39(35):5709-5720. PMID: 32709924.
      Citations: 10     Fields:    Translation:Humans
    20. Carlisle AE, Lee N, Matthew-Onabanjo AN, Spears ME, Park SJ, Youkana D, Doshi MB, Peppers A, Li R, Joseph AB, Smith M, Simin K, Zhu LJ, Greer PL, Shaw LM, Kim D. Selenium detoxification is required for cancer-cell survival. Nat Metab. 2020 07; 2(7):603-611. PMID: 32694795.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    21. Colby DJ, Sarnecki M, Barouch DH, Tipsuk S, Stieh DJ, Kroon E, Schuetz A, Intasan J, Sacdalan C, Pinyakorn S, Grandin P, Song H, Tovanabutra S, Shubin Z, Kim D, Paquin-Proulx D, Eller MA, Thomas R, de Souza M, Wieczorek L, Polonis VR, Pagliuzza A, Chomont N, Peter L, Nkolola JP, Vingerhoets J, Truyers C, Pau MG, Schuitemaker H, Phanuphak N, Michael N, Robb ML, Tomaka FL, Ananworanich J. Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption. Nat Med. 2020 04; 26(4):498-501. PMID: 32235883.
      Citations:    
    22. Pitisuttithum P, Nitayaphan S, Chariyalertsak S, Kaewkungwal J, Dawson P, Dhitavat J, Phonrat B, Akapirat S, Karasavvas N, Wieczorek L, Polonis V, Eller MA, Pegu P, Kim D, Schuetz A, Jongrakthaitae S, Zhou Y, Sinangil F, Phogat S, Diazgranados CA, Tartaglia J, Heger E, Smith K, Michael NL, Excler JL, Robb ML, Kim JH, O'Connell RJ, Vasan S. Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial. Lancet HIV. 2020 04; 7(4):e238-e248. PMID: 32035516.
      Citations:    
    23. Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM. Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation. Cancer Res. 2020 01 15; 80(2):249-262. PMID: 31744816.
      Citations: 10     Fields:    Translation:HumansCells
    24. Wang C, Choi HJ, Kim SJ, Desai A, Lee N, Kim D, Bae Y, Lee K. Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging. Nat Commun. 2018 04 27; 9(1):1688. PMID: 29703977.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    25. Kim W, Yang Y, Kim D, Jeong S, Yoo JW, Yoon JH, Jung Y. Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes. Drug Des Devel Ther. 2017; 11:419-429. PMID: 28243064.
      Citations:    
    26. Lee N, Kim D. Cancer Metabolism: Fueling More than Just Growth. Mol Cells. 2016 Dec; 39(12):847-854. PMID: 28030896.
      Citations: 43     Fields:    Translation:HumansAnimals
    27. Lee S, Jeong S, Kim W, Kim D, Yang Y, Yoon JH, Kim BJ, Min DS, Jung Y. Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase. Biochem Biophys Res Commun. 2017 01 29; 483(1):449-455. PMID: 28011266.
      Citations:    
    28. Oh J, Hlatky L, Jeong YS, Kim D. Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells. Toxins (Basel). 2016 06 30; 8(7). PMID: 27376325.
      Citations:    
    29. Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16; 520(7547):363-7. PMID: 25855294.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    30. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28; 158(5):1094-1109. PMID: 25171410.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    31. Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep. 2014 Jan 30; 6(2):313-24. PMID: 24440720.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    32. Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci. 2013 Aug; 16(8):1008-15. PMID: 23852118.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    33. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011 Aug 18; 476(7360):346-50. PMID: 21760589.
      Citations: 851     Fields:    Translation:HumansAnimalsCells
    34. Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 2011 May 17; 19(5):613-28. PMID: 21575862.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    35. Gr?ff J, Kim D, Dobbin MM, Tsai LH. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev. 2011 Apr; 91(2):603-49. PMID: 21527733.
      Citations: 159     Fields:    Translation:HumansAnimals
    36. Gao J, Wang WY, Mao YW, Gr?ff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010 Aug 26; 466(7310):1105-9. PMID: 20622856.
      Citations: 461     Fields:    Translation:AnimalsCells
    37. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28; 38(4):500-11. PMID: 20513426.
      Citations: 88     Fields:    Translation:HumansCells
    38. Kim D, Tsai LH. Linking cell cycle reentry and DNA damage in neurodegeneration. Ann N Y Acad Sci. 2009 Jul; 1170:674-9. PMID: 19686210.
      Citations: 15     Fields:    Translation:Humans
    39. Kim D, Tsai LH. Bridging physiology and pathology in AD. Cell. 2009 Jun 12; 137(6):997-1000. PMID: 19524503.
      Citations: 39     Fields:    Translation:HumansAnimals
    40. Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 2008 Dec 10; 60(5):803-17. PMID: 19081376.
      Citations: 146     Fields:    Translation:HumansAnimalsCells
    41. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. PMID: 17581637.
      Citations: 487     Fields:    Translation:HumansAnimalsCells
    42. Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci. 2006 Oct 11; 26(41):10536-41. PMID: 17035538.
      Citations: 102     Fields:    Translation:AnimalsCells
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