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Michela Frascoli PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine

    Collapse Biography 
    Collapse education and training
    University of Insubria, Varese, VA, ItalyBSBiology
    University of Insubria, Varese, VA, ItalyMSMolecular & Cellular Biology
    Institute for Research in Biomedicine, Bellinzona, , SwitzerlandPHDBiomedicine
    University of California San Francisco, San FranciscoPostdocImmunology

    Collapse Research 
    Collapse research activities and funding
         (Michela Frascoli)Jul 1, 2018 - Jun 30, 2020
    Charles H. Hood Foundation Child Health Research Awards Program
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frascoli M, Ferraj E, Miu B, Malin J, Spidale NA, Cowan J, Shissler SC, Brink R, Xu Y, Cyster JG, Bhandoola A, Kang J, Reboldi A. Skin ?d T?cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity. 2023 03 14; 56(3):562-575.e6. PMID: 36842431.
      Citations:    Fields:    Translation:HumansAnimals
    2. Frascoli M, Reboldi A, Kang J. Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell Development and Function. J Immunol. 2022 08 15; 209(4):645-653. PMID: 35961669.
      Citations: 3     Fields:    Translation:Humans
    3. Witt RG, Blair L, Frascoli M, Rosen MJ, Nguyen QH, Bercovici S, Zompi S, Romero R, Mackenzie TC. Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing. PLoS One. 2020; 15(4):e0231239. PMID: 32294121.
      Citations: 7     Fields:    Translation:HumansCells
    4. Spidale NA, Malhotra N, Frascoli M, Sylvia K, Miu B, Freeman C, Stadinski BD, Huseby E, Kang J. Neonatal-derived IL-17 producing dermal ?d T cells are required to prevent spontaneous atopic dermatitis. Elife. 2020 02 17; 9. PMID: 32065580.
      Citations: 9     Fields:    Translation:AnimalsCells
    5. Spidale NA, Frascoli M, Kang J. ?dTCR-independent origin of neonatal ?d T cells prewired for IL-17 production. Curr Opin Immunol. 2019 06; 58:60-67. PMID: 31128446.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    6. Spidale NA, Sylvia K, Narayan K, Miu B, Frascoli M, Melichar HJ, Zhihao W, Kisielow J, Palin A, Serwold T, Love P, Kobayashi M, Yoshimoto M, Jain N, Kang J. Interleukin-17-Producing ?d T Cells Originate from SOX13+ Progenitors that Are Independent of ?dTCR Signaling. Immunity. 2018 11 20; 49(5):857-872.e5. PMID: 30413363.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    7. Malhotra N, Qi Y, Spidale NA, Frascoli M, Miu B, Cho O, Sylvia K, Kang J. SOX4 controls invariant NKT cell differentiation by tuning TCR signaling. J Exp Med. 2018 11 05; 215(11):2887-2900. PMID: 30287480.
      Citations: 15     Fields:    Translation:AnimalsCells
    8. Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-? and TNF-a. Sci Transl Med. 2018 04 25; 10(438). PMID: 29695455.
      Citations: 59     Fields:    Translation:AnimalsCells
    9. Falanga YT, Frascoli M, Kaymaz Y, Forconi C, Ong'echa JM, Bailey JA, Berg LJ, Moormann AM. High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells. JCI Insight. 2017 Aug 03; 2(15). PMID: 28768916.
      Citations: 12     Fields:    
    10. Gomez-Lopez N, Romero R, Xu Y, Miller D, Unkel R, C MacKenzie T, Frascoli M, Hassan SS. Umbilical cord CD71+ erythroid cells are reduced in neonates born to women in spontaneous preterm labor. Am J Reprod Immunol. 2016 10; 76(4):280-4. PMID: 27625200.
      Citations: 12     Fields:    Translation:HumansCells
    11. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66. PMID: 27183609.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Frascoli M, Proietti M, Grassi F. Phenotypic analysis and isolation of murine hematopoietic stem cells and lineage-committed progenitors. J Vis Exp. 2012 Jul 08; (65). PMID: 22805770.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Frascoli M, Marcandalli J, Schenk U, Grassi F. Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral ?d cells. J Immunol. 2012 Jul 01; 189(1):174-80. PMID: 22649196.
      Citations: 24     Fields:    Translation:AnimalsCells
    14. Schenk U, Frascoli M, Proietti M, Geffers R, Traggiai E, Buer J, Ricordi C, Westendorf AM, Grassi F. ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors. Sci Signal. 2011 Mar 01; 4(162):ra12. PMID: 21364186.
      Citations: 142     Fields:    Translation:HumansCells
    15. Casati A, Frascoli M, Traggiai E, Proietti M, Schenk U, Grassi F. Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ. 2011 Mar; 18(3):396-404. PMID: 20798687.
      Citations: 26     Fields:    Translation:AnimalsCells
    16. Traggiai E, Casati A, Frascoli M, Porcellini S, Ponzoni M, Sanvito F, Leng L, Bucala R, Moretta L, Grassi F. Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation. PLoS One. 2010 Jun 22; 5(6):e11262. PMID: 20582316.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Badi I, Cinquetti R, Frascoli M, Parolini C, Chiesa G, Taramelli R, Acquati F. Intracellular ANKRD1 protein levels are regulated by 26S proteasome-mediated degradation. FEBS Lett. 2009 Aug 06; 583(15):2486-92. PMID: 19589340.
      Citations: 11     Fields:    Translation:HumansCells
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