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Sudhir Agrawal MSc, DPhil

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases And Immunology

    Collapse Biography 
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    University of Allahabad, Allahabad, UP, IndiaBSChem, Botany, Zoology
    University of Allahabad, Allahabad, UP, IndiaMSScience
    University of Allahabad, Allahabad, UP, IndiaDPHILChemistry
    MRC Laboratory of Molecular Biology, Cambridge, UKPost DoctoralNucleic Acids
    University of Massachusetts Medical School, Worcester, MAFoundation ScholarAntisense

    Collapse Overview 
    Collapse overview

    Over three decades, three drug-discovery platforms have been introduced in my laboratory based on synthetic oligonucleotides. These include: Antisense technology, Toll-Like Receptor Agonism, and Toll-Like Receptor Antagonism. Drug candidates from these technologies have been created and have advanced to clinical proof of concept trials in patients. These technologies have also been licensed to biotechnology and pharmaceutical companies. Several drugs have been approved based on ASO chemistry licensed from Idera.

    Publications available on Google Scholar

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Agrawal S. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey. Biomedicines. 2021 May 03; 9(5). PMID: 34063675.
    2. Agrawal S. RNA Therapeutics Are Stepping Out of the Maze. Trends Mol Med. 2020 12; 26(12):1061-1064. PMID: 32988738.
      Citations: 3     Fields:    Translation:Humans
    3. Agrawal S, Kandimalla ER. Role of Toll-like receptors in antisense and siRNA [corrected]. Nat Biotechnol. 2004 Dec; 22(12):1533-7. PMID: 15583662.
      Citations: 42     Fields:    Translation:Humans
    4. Agrawal S, Kandimalla ER. Medicinal chemistry and therapeutic potential of CpG DNA. Trends Mol Med. 2002 Mar; 8(3):114-21. PMID: 11879771.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
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