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Sunil K Malonia PhD

InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street, LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    Collapse Biography 
    Collapse education and training
    Dr. Bhimrao Ambedkar University, Agra, UP, IndiaBSBiology
    Savitribai Phule Pune University, Pune, MH, IndiaMSBiotechnology
    Savitribai Phule Pune University, Pune, MH, IndiaPHDBiotechnology
    Collapse awards and honors
    2005 - 2007Junior Research fellowship, Indian Council of Medical Research, India
    2007 - 2010Senior Research fellowship, Indian Council of Medical Research, India

    Collapse Overview 
    Collapse overview

    My research program focuses on identifying novel genes and regulatory pathways involved in the initiation, progression, and metastasis of various cancers. These investigations aim to deepen our understanding of cancer at the molecular level and uncover promising targets for therapeutic intervention. We utilize a variety of functional genomics techniques, such as genome-wide loss-of-function RNAi- and CRISPR-based screens, to discover new genes and regulatory pathways implicated in cancer development.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ye T, Mishra AK, Banday S, Li R, Hu K, Coleman MM, Shan Y, Chowdhury SR, Zhou L, Pak ML, Simone TM, Malonia SK, Zhu LJ, Kelliher MA, Green MR. Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma. Cell Rep. 2024 May 28; 43(5):114211. PMID: 38722741.
    2. Satam H, Joshi K, Mangrolia U, Waghoo S, Zaidi G, Rawool S, Thakare RP, Banday S, Mishra AK, Das G, Malonia SK. Correction: Satam et al. Next-Generation Sequencing Technology: Current Trends and Advancements. Biology 2023, 12, 997. Biology (Basel). 2024 Apr 24; 13(5). PMID: 38785841.
    3. Mishra AK, Ye T, Banday S, Thakare RP, Su CT, Pham NNH, Ali A, Kulshreshtha A, Chowdhury SR, Simone TM, Hu K, Zhu LJ, Eisenhaber B, Deibler SK, Simin K, Thompson PR, Kelliher MA, Eisenhaber F, Malonia SK, Green MR. Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer. Cell Rep. 2024 Apr 23; 43(4):114041. PMID: 38573857.
    4. Satam H, Joshi K, Mangrolia U, Waghoo S, Zaidi G, Rawool S, Thakare RP, Banday S, Mishra AK, Das G, Malonia SK. Next-Generation Sequencing Technology: Current Trends and Advancements. Biology (Basel). 2023 Jul 13; 12(7). PMID: 37508427.
    5. Mishra AK, Malonia SK. Advancing cellular immunotherapy with macrophages. Life Sci. 2023 Sep 01; 328:121857. PMID: 37307965.
      Citations: 3     Fields:    Translation:HumansCells
    6. Mishra AK, Banday S, Bharadwaj R, Ali A, Rashid R, Kulshreshtha A, Malonia SK. Macrophages as a Potential Immunotherapeutic Target in Solid Cancers. Vaccines (Basel). 2022 Dec 26; 11(1). PMID: 36679900.
    7. Mishra AK, Ali A, Dutta S, Banday S, Malonia SK. Emerging Trends in Immunotherapy for Cancer. Diseases. 2022 Sep 06; 10(3). PMID: 36135216.
    8. Manne RK, Agrawal Y, Malonia SK, Banday S, Edachery S, Patel A, Kumar A, Shetty P, Santra MK. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. J Biol Chem. 2021 10; 297(4):101253. PMID: 34587475.
      Citations: 2     Fields:    Translation:HumansCells
    9. Paul D, Islam S, Manne RK, Dinesh US, Malonia SK, Maity B, Boppana R, Rapole S, Shetty PK, Santra MK. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear ?-catenin function. J Pathol. 2019 07; 248(3):266-279. PMID: 30714168.
      Citations: 11     Fields:    Translation:HumansCells
    10. Choppara S, Malonia SK, Sankaran G, Green MR, Santra MK. Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):998-1003. PMID: 29343641.
      Citations: 9     Fields:    Translation:HumansCells
    11. Mou H, Moore J, Malonia SK, Li Y, Ozata DM, Hough S, Song CQ, Smith JL, Fischer A, Weng Z, Green MR, Xue W. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):3648-3653. PMID: 28320962.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Yadav B, Malonia SK, Majumdar SS, Gupta P, Wadhwa N, Badhwar A, Gupta UD, Katoch VM, Chattopadhyay S. Constitutive expression of SMAR1 confers susceptibility to Mycobacterium tuberculosis infection in a transgenic mouse model. Indian J Med Res. 2015 Dec; 142(6):732-41. PMID: 26831422.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Malonia SK, Dutta P, Santra MK, Green MR. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8632-7. PMID: 26124108.
      Citations: 30     Fields:    Translation:HumansCells
    14. Chemmannur SV, Badhwar AJ, Mirlekar B, Malonia SK, Gupta M, Wadhwa N, Bopanna R, Mabalirajan U, Majumdar S, Ghosh B, Chattopadhyay S. Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease. Mucosal Immunol. 2015 Nov; 8(6):1201-11. PMID: 25736456.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Malonia SK, Yadav B, Sinha S, Lazennec G, Chattopadhyay S. Chromatin remodeling protein SMAR1 regulates NF-?B dependent Interleukin-8 transcription in breast cancer. Int J Biochem Cell Biol. 2014 Oct; 55:220-6. PMID: 25239884.
      Citations: 5     Fields:    Translation:HumansCells
    16. Wajapeyee N, Malonia SK, Palakurthy RK, Green MR. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15; 27(20):2221-6. PMID: 24105743.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. Sinha S, Malonia SK, Mittal SP, Mathai J, Pal JK, Chattopadhyay S. Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300. Int J Biochem Cell Biol. 2012 Jan; 44(1):46-52. PMID: 22074660.
      Citations: 7     Fields:    Translation:HumansCells
    18. Malonia SK, Sinha S, Lakshminarasimhan P, Singh K, Jalota-Badhwar A, Rampalli S, Kaul-Ghanekar R, Chattopadhyay S. Gene regulation by SMAR1: Role in cellular homeostasis and cancer. Biochim Biophys Acta. 2011 Jan; 1815(1):1-12. PMID: 20709157.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    19. Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. EMBO J. 2010 Feb 17; 29(4):830-42. PMID: 20075864.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    20. Singh K, Sinha S, Malonia SK, Chattopadhyay S. Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation. Biochem Biophys Res Commun. 2010 Jan 08; 391(2):1255-61. PMID: 20006573.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Singh K, Sinha S, Malonia SK, Bist P, Tergaonkar V, Chattopadhyay S. Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. J Biol Chem. 2009 Jan 09; 284(2):1267-78. PMID: 18981184.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Singh P, Wesley C, Jadaun GP, Malonia SK, Das R, Upadhyay P, Faujdar J, Sharma P, Gupta P, Mishra AK, Singh K, Chauhan DS, Sharma VD, Gupta UD, Venkatesan K, Katoch VM. Comparative evaluation of L?wenstein-Jensen proportion method, BacT/ALERT 3D system, and enzymatic pyrazinamidase assay for pyrazinamide susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol. 2007 Jan; 45(1):76-80. PMID: 17093022.
      Citations: 22     Fields:    Translation:HumansCells
    23. Singh P, Mishra AK, Malonia SK, Chauhan DS, Sharma VD, Venkatesan K, Katoch VM. The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria. J Commun Dis. 2006 Mar; 38(3):288-98. PMID: 17373362.
      Citations: 25     Fields:    Translation:HumansCells
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