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Diogo D Magnani PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressMassBiologics
460 Walk Hill Street
Boston MA 02126
Phone617-474-4069
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionMassachusetts Biological Laboratory


    Collapse ORNG Applications 
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    Collapse Biography 
    Collapse education and training
    Federal University of Minas Gerais, Belo Horizonte, MG, BrazilBSBiology
    Federal University of Minas Gerais, Belo Horizonte, MG, BrazilMSBiochemistry & Immunology
    University of Wisconsin, Madison, Madison, WI, United StatesPHDBiomedical Sciences

    Collapse Research 
    Collapse research activities and funding
    R24OD010976     (MAGNANI, DIOGO)Sep 1, 2000 - Nov 30, 2019
    NIH
    Resource fo Nonhuman Primate Cell Depleting Antibodies
    Role: Principal Investigator

    W81XWH-18-1-0094/A     (Diogo Magnani)Nov 1, 2018 - Oct 30, 2021
    Department of Defense
    A Fetus-Targeted Antibody Therapy to Prevent Zika Virus Infection During Pregnancy
    Role Description: The goal of this proposal is to generate bi-specific Zika virus-neutralizing antibodies with asymmetric heavy chain mutations to enhance transplacental antibody transport and prevent infection of the fetus.
    Role: PI

    U24AI126683     (Diogo Magnani)May 31, 2019 - May 31, 2021
    NIH NIAID
    Preclinical evaluation of rhesus ATG as a depletional induction agent in rhesus macaques
    Role Description: Preclinical evaluation of rhesus ATG as a depletional induction agent in rhesus macaques
    Role: PI

    P40OD028116     (MAGNANI, DIOGO)Jan 1, 2020 - Dec 31, 2024
    NIH
    Nonhuman Primate Antibody Resource for Immune Cell Depletion
    Role: Principal Investigator

    U24AI126683-05S1     (Diogo Magnani)Apr 13, 2020 - Apr 12, 2021
    NIH NIAID (PI)
    Nonhuman primate reagent resource – Supplement
    Role Description: Our proposal will also establish large-scale industrial methodologies for producing and purifying viral antigens, shall they become necessary in the future.
    Role: PI

    U24AI126683     (MAGNANI, DIOGO)Jun 1, 2020 - May 31, 2021
    NIH
    Nonhuman Primate Reagent Resource
    Role: Principal Investigator

    P40OD028116     (Diogo Magnani)Jul 1, 2020 - Dec 31, 2020
    NIH / ORIP
    Coronavirus-specific antibodies for nonhuman primate research
    Role Description: Our recombinant standard reagents will support the development of rigorous coronavirus-specific antibody assays for nonhuman primate research and colony management.
    Role: PI

         (Jonah Sacha)Aug 1, 2020 - Jun 30, 2025
    NIH
    A long-acting CCR5 monoclonal antibody for HIV prevention
    Role Description: The administration of antibodies blocking viral receptors has the potential to be effective in protecting the host against infection. The proposed studies are aimed at understanding the potential of a half-life extended antibody against the co-receptor of AIDS viruses, CCR5, in prevention of viral acquisition against challenges via different routes.
    Role: Subaward PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pedreño-Lopez N, Dang CM, Rosen BC, Ricciardi MJ, Bailey VK, Gutman MJ, Gonzalez-Nieto L, Pauthner MG, Le K, Song G, Andrabi R, Weisgrau KL, Pomplun N, Martinez-Navio JM, Fuchs SP, Wrammert J, Rakasz EG, Lifson JD, Martins MA, Burton DR, Watkins DI, Magnani DM. Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies. Mol Ther Methods Clin Dev. 2020 Mar 13; 16:225-237. PMID: 32083148.
      View in: PubMed
    2. Magnani DM, Sassi FC, Vana LPM, Andrade CRF. Correlation between scar assessment scales and orofacial myofunctional disorders in patients with head and neck burns. Codas. 2019; 31(5):e20180238. PMID: 31618317.
      View in: PubMed
    3. Gonzalez-Nieto L, Castro IM, Bischof GF, Shin YC, Ricciardi MJ, Bailey VK, Dang CM, Pedreño-Lopez N, Magnani DM, Ejima K, Allison DB, Gil HM, Evans DT, Rakasz EG, Lifson JD, Desrosiers RC, Martins MA. Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques. PLoS Pathog. 2019 09; 15(9):e1008015. PMID: 31568531.
      View in: PubMed
    4. Grubaugh ND, Saraf S, Gangavarapu K, Watts A, Tan AL, Oidtman RJ, Ladner JT, Oliveira G, Matteson NL, Kraemer MUG, Vogels CBF, Hentoff A, Bhatia D, Stanek D, Scott B, Landis V, Stryker I, Cone MR, Kopp EW, Cannons AC, Heberlein-Larson L, White S, Gillis LD, Ricciardi MJ, Kwal J, Lichtenberger PK, Magnani DM, Watkins DI, Palacios G, Hamer DH. Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic. Cell. 2019 08 22; 178(5):1057-1071.e11. PMID: 31442400.
      View in: PubMed
    5. Shim BS, Kwon YC, Ricciardi MJ, Stone M, Otsuka Y, Berri F, Kwal JM, Magnani DM, Jackson CB, Richard AS, Norris P, Busch M, Curry CL, Farzan M, Watkins D, Choe H. Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice. mBio. 2019 07 02; 10(4). PMID: 31266863.
      View in: PubMed
    6. Martins MA, Gonzalez-Nieto L, Shin YC, Domingues A, Gutman MJ, Maxwell HS, Magnani DM, Ricciardi MJ, Pedreño-Lopez N, Bailey VK, Altman JD, Parks CL, Allison DB, Ejima K, Rakasz EG, Capuano S, Desrosiers RC, Lifson JD, Watkins DI. The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. J Virol. 2019 03 01; 93(5). PMID: 30541854.
      View in: PubMed
    7. Martins MA, Tully DC, Pedreño-Lopez N, von Bredow B, Pauthner MG, Shin YC, Yuan M, Lima NS, Bean DJ, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Magnani DM, Ricciardi MJ, Bailey VK, Altman JD, Burton DR, Ejima K, Allison DB, Evans DT, Rakasz EG, Parks CL, Bonaldo MC, Capuano S, Lifson JD, Desrosiers RC, Allen TM, Watkins DI. Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication. J Virol. 2018 08 15; 92(16). PMID: 29875239.
      View in: PubMed
    8. Magnani DM, Rogers TF, Maness NJ, Grubaugh ND, Beutler N, Bailey VK, Gonzalez-Nieto L, Gutman MJ, Pedreño-Lopez N, Kwal JM, Ricciardi MJ, Myers TA, Julander JG, Bohm RP, Gilbert MH, Schiro F, Aye PP, Blair RV, Martins MA, Falkenstein KP, Kaur A, Curry CL, Kallas EG, Desrosiers RC, Goldschmidt-Clermont PJ, Whitehead SS, Andersen KG, Bonaldo MC, Lackner AA, Panganiban AT, Burton DR, Watkins DI. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques. Nat Commun. 2018 04 24; 9(1):1624. PMID: 29691387.
      View in: PubMed
    9. Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O'Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A. Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques. Sci Transl Med. 2018 04 04; 10(435). PMID: 29618564.
      View in: PubMed
    10. Ricciardi MJ, Magnani DM, Grifoni A, Kwon YC, Gutman MJ, Grubaugh ND, Gangavarapu K, Sharkey M, Silveira CGT, Bailey VK, Pedreño-Lopez N, Gonzalez-Nieto L, Maxwell HS, Domingues A, Martins MA, Pham J, Weiskopf D, Altman J, Kallas EG, Andersen KG, Stevenson M, Lichtenberger P, Choe H, Whitehead SS, Sette A, Watkins DI. Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL. PLoS Negl Trop Dis. 2017 12; 11(12):e0006000. PMID: 29267278.
      View in: PubMed
    11. Grifoni A, Pham J, Sidney J, O'Rourke PH, Paul S, Peters B, Martini SR, de Silva AD, Ricciardi MJ, Magnani DM, Silveira CGT, Maestri A, Costa PR, de-Oliveira-Pinto LM, de Azeredo EL, Damasco PV, Phillips E, Mallal S, de Silva AM, Collins M, Durbin A, Diehl SA, Cerpas C, Balmaseda A, Kuan G, Coloma J, Harris E, Crowe JE, Stone M, Norris PJ, Busch M, Vivanco-Cid H, Cox J, Graham BS, Ledgerwood JE, Turtle L, Solomon T, Kallas EG, Watkins DI, Weiskopf D, Sette A. Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans. J Virol. 2017 12 15; 91(24). PMID: 28978707.
      View in: PubMed
    12. Magnani DM, Silveira CGT, Ricciardi MJ, Gonzalez-Nieto L, Pedreño-Lopez N, Bailey VK, Gutman MJ, Maxwell HS, Domingues A, Costa PR, Ferrari L, Goulart R, Martins MA, Martinez-Navio JM, Fuchs SP, Kalil J, Timenetsky MDC, Wrammert J, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine. J Virol. 2017 11 15; 91(22). PMID: 28878078.
      View in: PubMed
    13. Magnani DM, Rogers TF, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. Sci Transl Med. 2017 Oct 04; 9(410). PMID: 28978754.
      View in: PubMed
    14. Termini JM, Magnani DM, Maxwell HS, Lauer W, Castro I, Pecotte J, Barber GN, Watkins DI, Desrosiers RC. Simian T Lymphotropic Virus 1 Infection of Papio anubis: tax Sequence Heterogeneity and T Cell Recognition. J Virol. 2017 10 15; 91(20). PMID: 28724769.
      View in: PubMed
    15. Bischof GF, Magnani DM, Ricciardi M, Shin YC, Domingues A, Bailey VK, Gonzalez-Nieto L, Rakasz EG, Watkins DI, Desrosiers RC. Use of a Recombinant Gamma-2 Herpesvirus Vaccine Vector against Dengue Virus in Rhesus Monkeys. J Virol. 2017 08 15; 91(16). PMID: 28592531.
      View in: PubMed
    16. Magnani DM, Ricciardi MJ, Bailey VK, Gutman MJ, Pedreño-Lopez N, Silveira CGT, Maxwell HS, Domingues A, Gonzalez-Nieto L, Su Q, Newman RM, Pack M, Martins MA, Martinez-Navio JM, Fuchs SP, Rakasz EG, Allen TM, Whitehead SS, Burton DR, Gao G, Desrosiers RC, Kallas EG, Watkins DI. Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys. Mol Ther. 2017 10 04; 25(10):2323-2331. PMID: 28750738.
      View in: PubMed
    17. Martins MA, Shin YC, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Castro I, Magnani DM, Ricciardi M, Pedreño-Lopez N, Bailey V, Betancourt D, Altman JD, Pauthner M, Burton DR, von Bredow B, Evans DT, Yuan M, Parks CL, Ejima K, Allison DB, Rakasz E, Barber GN, Capuano S, Lifson JD, Desrosiers RC, Watkins DI. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques. PLoS Pathog. 2017 Jul; 13(7):e1006529. PMID: 28732035.
      View in: PubMed
    18. Magnani DM, Silveira CGT, Rosen BC, Ricciardi MJ, Pedreño-Lopez N, Gutman MJ, Bailey VK, Maxwell HS, Domingues A, Gonzalez-Nieto L, Avelino-Silva VI, Trindade M, Nogueira J, Oliveira CS, Maestri A, Felix AC, Levi JE, Nogueira ML, Martins MA, Martinez-Navio JM, Fuchs SP, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus. PLoS Negl Trop Dis. 2017 Jun; 11(6):e0005655. PMID: 28604797.
      View in: PubMed
    19. Aliota MT, Bassit L, Bradrick SS, Cox B, Garcia-Blanco MA, Gavegnano C, Friedrich TC, Golos TG, Griffin DE, Haddow AD, Kallas EG, Kitron U, Lecuit M, Magnani DM, Marrs C, Mercer N, McSweegan E, Ng LFP, O'Connor DH, Osorio JE, Ribeiro GS, Ricciardi M, Rossi SL, Saade G, Schinazi RF, Schott-Lerner GO, Shan C, Shi PY, Watkins DI, Vasilakis N, Weaver SC. Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network. Antiviral Res. 2017 08; 144:223-246. PMID: 28595824.
      View in: PubMed
    20. Grubaugh ND, Ladner JT, Kraemer MUG, Dudas G, Tan AL, Gangavarapu K, Wiley MR, White S, Thézé J, Magnani DM, Prieto K, Reyes D, Bingham AM, Paul LM, Robles-Sikisaka R, Oliveira G, Pronty D, Barcellona CM, Metsky HC, Baniecki ML, Barnes KG, Chak B, Freije CA, Gladden-Young A, Gnirke A, Luo C, MacInnis B, Matranga CB, Park DJ, Qu J, Schaffner SF, Tomkins-Tinch C, West KL, Winnicki SM, Wohl S, Yozwiak NL, Quick J, Fauver JR, Khan K, Brent SE, Reiner RC, Lichtenberger PN, Ricciardi MJ, Bailey VK, Watkins DI, Cone MR, Kopp EW, Hogan KN, Cannons AC, Jean R, Monaghan AJ, Garry RF, Loman NJ, Faria NR, Porcelli MC, Vasquez C, Nagle ER, Cummings DAT, Stanek D, Rambaut A, Sanchez-Lockhart M, Sabeti PC, Gillis LD, Michael SF, Bedford T, Pybus OG, Isern S, Palacios G, Andersen KG. Genomic epidemiology reveals multiple introductions of Zika virus into the United States. Nature. 2017 06 15; 546(7658):401-405. PMID: 28538723.
      View in: PubMed
    21. Smith JA, Khan M, Magnani DD, Harms JS, Durward M, Radhakrishnan GK, Liu YP, Splitter GA. Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. PLoS Pathog. 2013; 9(12):e1003785. PMID: 24339776; PMCID: PMC3855547.
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