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Christopher Corey Thomson Hemond MD

TitleAssistant Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MA, United StatesBSBrain & Cognitive Science
    Stanford University, Palo Alto, CA, United StatesMD
    Collapse awards and honors
    2022 - 2023High-throughput antibody profiling of cerebrospinal fluid from Multiple Sclerosis, Riccio Foundation Award
    2020 - 2022EBV-specific CD8 T cell responses in multiple sclerosis, UMass PACE award
    2020 - 2024Immunological and MRI correlates of mindfulness-based stress reduction in MS, Consortium of MS Centers
    2020 - 2022The assessment and prediction of neurodegeneration in multiple sclerosis using advanced MRI and mult, National Center for Advancing Translational Sciences, National Institutes of Health (KL2TR001454)
    2018 - 2024Mindfulness Based Stress Reduction in multiple sclerosis, MS Foundation
    2018 - 2020The role of memory B-cells in multiple sclerosis pathology and disease monitoring, National MS Society Pilot Project Award

    Collapse Overview 
    Collapse Summary
    Dr. Hemond is a board-certified neurologist with clinical subspecialty training in neuroimmunology and multiple sclerosis. His research focuses on the development and validation of MRI-based biomarkers to improve (1) early identification and (2) pathophysiological understanding of the neurodegenerative processes underlying MS.
    Collapse overview

    Dr. Hemond's research capitalizes on the use of high-resolution MRI sequences, in particular structural, susceptibility-sensitive (iron), and diffusion imaging to characterize microstructural MS lesion features.

    Through these detailed MRI assessments we aim to discover new biomarkers that can be used to improve medical decision-making at the bedside. Iron rim lesions, for example, are seen almost exclusively in MS but not other disease mimics; these markers will help improve the diagnostic process. Microstructural features of the MS lesion likely give insight into the current and future disease severity. Identifying patients who are at high risk for a more severe disease course will allow a more personalized approach to treatment, reducing harms and maximizing benefits of the increasing number of options available in MS care.  Microstructural lesion characteristics may also yield insight into the pathophysiology of MS itself. 

    Dr. Hemond's research additionally aims to capture how these microstrucrual aspects of MS lesions evolve over time, based on the use of different MS disease therapies. We anticipate these features can be used as outcome markers in clinical trials, in ongoing work with Dr. Sathish Dundammadappa (UMass neuroradiology) and Dr. Daniel Reich's lab at the NIH. Moreover, in collaboration with immunologists and MS colleagues here at UMass, Dr. Hemond is co-leading projects to leverage this MRI data as a sensitive outcome marker to assist in the development and validation of blood and cerebrospinal fluid biomarker development. Ongoing collaborations include the assessment of Epstein-Barr infection and the dysregulated T-cell response to this virus (with Prof. Liisa Selin and Anna Gil), proteomic biomarker development in cerebrospinal fluid (with Dr. Carolina Ionete and immunologist Jillian Richmond), and deep, molecular immunoprofiling of the infectious "landscape" in MS with faculty neuroscientist Rigel Chan. 

    Dr. Hemond also leads projects focused on the psycho-neuro-immuonlogical aspects of MS, in particular how behavioral interventions such as mindfulness based stress reduce reduce the "silent symptoms of MS" (such as anxiety, fatigue, depression) and mechanistically act through top-down modulation of the immune system.

    Collapse Rotation Projects

    There is a current project opening for using deep learning to train and ultimately perform automatic segmentation for multiple brain structures of interest in Multiple Sclerosis. Helpful background would include some proficiency in shell and Python.  Please email me if interested.

    Collapse Research 
    Collapse research activities and funding
    K23NS126718     (HEMOND, CHRISTOPHER C.)Apr 1, 2022 - Mar 31, 2027
    MRI paramagnetic rim lesions as biomarkers and agents of neurodegeneration in multiple sclerosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bagnato F, Sati P, Hemond CC, Elliott C, Gauthier SA, Harrison DM, Mainero C, Oh J, Pitt D, Shinohara RT, Smith SA, Trapp B, Azevedo CJ, Calabresi PA, Henry RG, Laule C, Ontaneda D, Rooney WD, Sicotte NL, Reich DS, Absinta M. Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain. 2024 Jan 16. PMID: 38226694.
      Citations:    Fields:    
    2. Bose A, Khalighinejad F, Hoaglin DC, Hemond CC. Evaluating the Clinical Utility of Epstein-Barr Virus Antibodies as Biomarkers in Multiple Sclerosis: A Systematic Review. Mult Scler Relat Disord. 2024 Apr; 84:105410. PMID: 38401201.
    3. Gandhi S, Zelman S, De Armas RE, Hemond C, Levy AN, Singh S, Korzenik J, Jangi S. Natural History of New-onset Inflammatory Bowel Disease Among Patients With Multiple Sclerosis. Inflamm Bowel Dis. 2022 10 03; 28(10):1614-1617. PMID: 35348692.
      Citations: 1     Fields:    Translation:Humans
    4. Hemond CC, Baek J, Ionete C, Reich DS. Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study. Mult Scler. 2022 Nov; 28(13):2046-2056. PMID: 35748669.
      Citations: 4     Fields:    Translation:Humans
    5. Pimentel Maldonado DA, Eusebio JR, Amezcua L, Vasileiou ES, Mowry EM, Hemond CC, Umeton Pizzolato R, Berrios Morales I, Radu I, Ionete C, Fitzgerald KC. The impact of socioeconomic status on mental health and health-seeking behavior across race and ethnicity in a large multiple sclerosis cohort. Mult Scler Relat Disord. 2022 Feb; 58:103451. PMID: 34953410.
      Citations: 5     Fields:    Translation:Humans
    6. Hemond CC, Reich DS, Dundamadappa SK. Paramagnetic Rim Lesions in Multiple Sclerosis: Comparison of Visualization at 1.5-T and 3-T MRI. AJR Am J Roentgenol. 2022 07; 219(1):120-131. PMID: 34851712.
      Citations: 12     Fields:    Translation:Humans
    7. Cristancho C, Hemond CC. Serum Albumin Modifies the Effect of Peripheral Blood Monocytes on Severity of Diabetic Nephropathy in an Adult Population. Can J Diabetes. 2022 Feb; 46(1):69-74. PMID: 34334308.
      Citations: 1     Fields:    Translation:HumansCells
    8. Hemond CC, Bakshi R, Tauhid S, Sarrosa R, Ryan M, Kamath V, Thomas J, Edwards KR. Exacerbation of Multiple Sclerosis by BRAF/MEK Treatment for Malignant Melanoma: The Central Vein Sign to Distinguish Demyelinating Lesions From Metastases. J Investig Med High Impact Case Rep. 2021 Jan-Dec; 9:23247096211033047. PMID: 34308699.
      Citations: 1     Fields:    Translation:Humans
    9. Herman JA, Khalighinejad F, York K, Radu I, Berrios Morales I, Ionete C, Hemond CC. A real-world cohort analysis of alemtuzumab outcomes in relapsing multiple sclerosis. Mult Scler Relat Disord. 2021 Jan; 47:102619. PMID: 33189019.
      Citations: 5     Fields:    Translation:Humans
    10. Bomprezzi R, Chen AP, Hemond CC. Cervical spondylosis is a risk factor for localized spinal cord lesions in multiple sclerosis. Clin Neurol Neurosurg. 2020 12; 199:106311. PMID: 33091657.
      Citations: 1     Fields:    Translation:Humans
    11. Rozenkrantz L, Bernstein MH, Hemond CC. A paradox of social distancing for SARS-CoV-2: loneliness and heightened immunological risk. Mol Psychiatry. 2020 12; 25(12):3442-3444. PMID: 32778817.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    12. Kaptchuk TJ, Hemond CC, Miller FG. Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice. BMJ. 2020 07 20; 370:m1668. PMID: 32690477.
      Citations: 48     Fields:    Translation:Humans
    13. Eliassen E, Hemond CC, Santoro JD. HHV-6-Associated Neurological Disease in Children: Epidemiologic, Clinical, Diagnostic, and Treatment Considerations. Pediatr Neurol. 2020 04; 105:10-20. PMID: 31932119.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Hemond CC, Healy BC, Tauhid S, Mazzola MA, Quintana FJ, Gandhi R, Weiner HL, Bakshi R. MRI phenotypes in MS: Longitudinal changes and miRNA signatures. Neurol Neuroimmunol Neuroinflamm. 2019 03; 6(2):e530. PMID: 30800720.
      Citations: 20     Fields:    Translation:Humans
    15. Hemond CC, Glanz BI, Bakshi R, Chitnis T, Healy BC. The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis. BMC Neurol. 2019 Feb 12; 19(1):23. PMID: 30755165.
      Citations: 34     Fields:    Translation:HumansCells
    16. Santoro JD, Hemond CC. Human herpesvirus 6 associated post-transplant acute limbic encephalitis: Clinical observations of biomarkers for risk of seizure in a pediatric population. Transpl Infect Dis. 2019 Feb; 21(1):e13003. PMID: 30256500.
      Citations: 2     Fields:    Translation:HumansCells
    17. Hemond CC, Chu R, Tummala S, Tauhid S, Healy BC, Bakshi R. Whole-brain atrophy assessed by proportional- versus registration-based pipelines from 3T MRI in multiple sclerosis. Brain Behav. 2018 08; 8(8):e01068. PMID: 30019857.
      Citations: 4     Fields:    Translation:Humans
    18. Leclaire K, Cecil A, LaRussa A, Stuart F, Hemond CC, Healy BC, Chitnis T, Weiner H, Huffman J, Glanz BI. Short Report: A Pilot Study of a Group Positive Psychology Intervention for Patients with Multiple Sclerosis. Int J MS Care. 2018 May-Jun; 20(3):136-141. PMID: 29896050.
    19. Hemond CC, Bakshi R. Magnetic Resonance Imaging in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2018 05 01; 8(5). PMID: 29358319.
      Citations: 27     Fields:    Translation:Humans
    20. Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivis?kk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ. Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jul; 4(4):e359. PMID: 28642887.
      Citations: 27     Fields:    
    21. Hemond C, Brown RM, Robertson EM. A distraction can impair or enhance motor performance. J Neurosci. 2010 Jan 13; 30(2):650-4. PMID: 20071529.
      Citations: 11     Fields:    Translation:Humans
    22. Hemond CC, Fregni F. Transcranial magnetic stimulation in neurology: what we have learned from randomized controlled studies. Neuromodulation. 2007 Oct; 10(4):333-44. PMID: 22150892.
      Citations: 5     Fields:    
    23. Hemond CC, Kanwisher NG, Op de Beeck HP. A preference for contralateral stimuli in human object- and face-selective cortex. PLoS One. 2007 Jun 27; 2(6):e574. PMID: 17593973.
      Citations: 68     Fields:    Translation:Humans
    24. Amedi A, Stern WM, Camprodon JA, Bermpohl F, Merabet L, Rotman S, Hemond C, Meijer P, Pascual-Leone A. Shape conveyed by visual-to-auditory sensory substitution activates the lateral occipital complex. Nat Neurosci. 2007 Jun; 10(6):687-9. PMID: 17515898.
      Citations: 155     Fields:    Translation:Humans
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