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James B Munro PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
368 Plantation Street AS8-1055
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    Collapse Biography 
    Collapse education and training
    Middlebury College, Middlebury, VT, United StatesBAPhysics
    Yale University, New Haven, CTPostdoc07/2014Virology/biophysics
    University of Chicago, Chicago, IL, United StatesMSPhysics
    Cornell University, New York, NYPh.D.05/2010Biophysics
    Cornell University, Ithaca, NY, United StatesPHDBiophysics
    University of Chicago, Chicago, ILM.S.05/2004Physics
    Middlebury College, Middlebury, VTB.A.05/2002Physics/mathematics
    Collapse awards and honors
    2015 - 2020NIH Director's New Innovator Award, NIAID/NIH
    2016 - 2018Gilead Research Scholar in HIV, Gilead Sciences

    Collapse Overview 
    Collapse Summary
    Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.
    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Baron JA, Johnson CS, Schor MA, Olley D, Nickel L, Felix V, Munro JB, Bello SM, Bearer C, Lichenstein R, Bisordi K, Koka R, Greene C, Schriml LM. The DO-KB Knowledgebase: a 20-year journey developing the disease open science ecosystem. Nucleic Acids Res. 2024 Jan 05; 52(D1):D1305-D1314. PMID: 37953304.
      Citations: 1     Fields:    Translation:Humans
    2. Jain A, Govindan R, Berkman AR, Luban J, D?az-Salinas MA, Durham ND, Munro JB. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. PLoS Pathog. 2023 Dec; 19(12):e1011848. PMID: 38055723.
      Citations:    Fields:    Translation:HumansCells
    3. Palmateer NC, Munro JB, Nagaraj S, Crabtree J, Pelle R, Tallon L, Nene V, Bishop R, Silva JC. The Hypervariable Tpr Multigene Family of Theileria Parasites, Defined by a Conserved, Membrane-Associated, C-Terminal Domain, Includes Several Copies with Defined Orthology Between Species. J Mol Evol. 2023 12; 91(6):897-911. PMID: 38017120.
      Citations:    Fields:    Translation:AnimalsCells
    4. Jain A, Govindan R, Berkman A, Luban J, Durham ND, Munro J. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. bioRxiv. 2023 Oct 17. PMID: 36711925.
    5. Mbambo G, Dwivedi A, Ifeonu OO, Munro JB, Shrestha B, Bromley RE, Hodges T, Adkins RS, Kouriba B, Diarra I, Niangaly A, Kone AK, Coulibaly D, Traore K, Dolo A, Thera MA, Laurens MB, Doumbo OK, Plowe CV, Berry AA, Travassos M, Lyke KE, Silva JC. Immunogenomic profile at baseline predicts host susceptibility to clinical malaria. Front Immunol. 2023; 14:1179314. PMID: 37465667.
      Citations:    Fields:    Translation:HumansCells
    6. Chen C, Zhu R, Hodge EA, D?az-Salinas MA, Nguyen A, Munro JB, Lee KK. hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics. ACS Infect Dis. 2023 06 09; 9(6):1180-1189. PMID: 37166130.
      Citations: 4     Fields:    Translation:HumansCells
    7. Egri SB, Wang X, D?az-Salinas MA, Luban J, Dudkina NV, Munro JB, Shen K. Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination. Nat Commun. 2023 05 03; 14(1):2527. PMID: 37137903.
      Citations: 1     Fields:    Translation:HumansCells
    8. Yurkovetskiy L, Egri S, Kurhade C, Diaz-Salinas MA, Jaimes JA, Nyalile T, Xie X, Choudhary MC, Dauphin A, Li JZ, Munro JB, Shi PY, Shen K, Luban J. S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness. bioRxiv. 2023 Apr 24. PMID: 37034621.
    9. Kumar MS, Stallworth KM, Murthy AC, Lim SM, Li N, Jain A, Munro JB, Fawzi NL, Lagier-Tourenne C, Bosco DA. Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies. J Mol Biol. 2023 03 15; 435(6):167972. PMID: 36690069.
      Citations: 1     Fields:    Translation:HumansCells
    10. Charbonneau AL, Brady A, Czajkowski K, Aluvathingal J, Canchi S, Carter R, Chard K, Clarke DJB, Crabtree J, Creasy HH, D'Arcy M, Felix V, Giglio M, Gingrich A, Harris RM, Hodges TK, Ifeonu O, Jeon M, Kropiwnicki E, Lim MCW, Liming RL, Lumian J, Mahurkar AA, Mandal M, Munro JB, Nadendla S, Richter R, Romano C, Rocca-Serra P, Schor M, Schuler RE, Tangmunarunkit H, Waldrop A, Williams C, Word K, Sansone SA, Ma'ayan A, Wagner R, Foster I, Kesselman C, Brown CT, White O. Making Common Fund data more findable: catalyzing a data ecosystem. Gigascience. 2022 11 21; 11. PMID: 36409836.
      Citations: 5     Fields:    
    11. Lai KK, Munro JB, Shi G, Majdoul S, Compton AA, Rein A. Restriction of Influenza A Virus by SERINC5. mBio. 2022 12 20; 13(6):e0292322. PMID: 36409124.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. D?az-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Elife. 2022 03 24; 11. PMID: 35323111.
      Citations: 21     Fields:    Translation:HumansCells
    13. Blakemore RJ, Burnett C, Swanson C, Kharytonchyk S, Telesnitsky A, Munro JB. Stability and conformation of the dimeric HIV-1 genomic RNA 5'UTR. Biophys J. 2021 11 02; 120(21):4874-4890. PMID: 34529947.
      Citations: 7     Fields:    Translation:Cells
    14. Murray LP, Govindan R, Mora AC, Munro JB, Mace CR. Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. Anal Bioanal Chem. 2021 Jun; 413(14):3695-3706. PMID: 33852053.
      Citations:    Fields:    Translation:HumansCells
    15. Gao R, Yu CJ, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES. A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy. Nat Nanotechnol. 2021 06; 16(6):698-707. PMID: 33782587.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    16. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 10 29; 183(3):739-751.e8. PMID: 32991842.
      Citations: 567     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Bulow U, Govindan R, Munro JB. Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP. Viruses. 2020 07 02; 12(7). PMID: 32630688.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 05; 16(5):e1008577. PMID: 32392227.
      Citations: 1     Fields:    Translation:HumansCells
    19. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 02; 18(2):e3000626. PMID: 32040508.
      Citations: 41     Fields:    Translation:HumansCells
    20. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 01 15; 12(1). PMID: 31952255.
      Citations: 10     Fields:    Translation:HumansCells
    21. Howard AR, Munro JB. Developments in single-molecule and single-particle fluorescence-based approaches for studying viral envelope glycoprotein dynamics and membrane fusion. Adv Virus Res. 2019; 104:123-146. PMID: 31439147.
      Citations: 3     Fields:    Translation:Cells
    22. Brigham BS, Kitzrow JP, Reyes JC, Musier-Forsyth K, Munro JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10372-10381. PMID: 31068467.
      Citations: 19     Fields:    Translation:Cells
    23. Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikic-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the?virus observed by smFRET. Nature. 2019 04; 568(7752):415-419. PMID: 30971821.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    24. Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Pr?vost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5. PMID: 30974085.
      Citations: 66     Fields:    Translation:HumansCells
    25. Das DK, Govindan R, Nikic-Spiegel I, Krammer F, Lemke EA, Munro JB. Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers. Cell. 2018 08 09; 174(4):926-937.e12. PMID: 29961575.
      Citations: 73     Fields:    Translation:HumansCells
    26. Munro JB. HIV Env on Lockdown. Cell Host Microbe. 2018 06 13; 23(6):699-701. PMID: 29902434.
      Citations:    Fields:    Translation:HumansCells
    27. Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018 03 21; 7. PMID: 29561264.
      Citations: 81     Fields:    Translation:HumansCells
    28. Munro JB, Lee KK. Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein. Curr HIV Res. 2018; 16(1):5-12. PMID: 29268688.
      Citations: 7     Fields:    Translation:HumansCells
    29. Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. mBio. 2016 10 25; 7(5). PMID: 27795397.
      Citations: 92     Fields:    Translation:HumansCells
    30. Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Sch?n A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat Struct Mol Biol. 2015 Jul; 22(7):522-31. PMID: 26098315.
      Citations: 242     Fields:    Translation:HumansCells
    31. Munro JB, Mothes W. Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 89(11):5752-5. PMID: 25762739.
      Citations: 47     Fields:    Translation:HumansCells
    32. Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 07; 346(6210):759-63. PMID: 25298114.
      Citations: 309     Fields:    Translation:HumansCells
    33. Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-61. PMID: 25296255.
      Citations: 497     Fields:    Translation:HumansCells
    34. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15; 127(Pt 18):3928-42. PMID: 25015296.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    35. Munro JB, Mothes W. The HIV-1 Env trimer in HD. Structure. 2014 Jul 08; 22(7):935-6. PMID: 25007222.
      Citations: 3     Fields:    Translation:HumansCells
    36. Agosto LM, Zhong P, Munro J, Mothes W. Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb; 10(2):e1003982. PMID: 24586176.
      Citations: 61     Fields:    Translation:HumansCells
    37. Munro JB, Nath A, F?rber M, Datta SA, Rein A, Rhoades E, Mothes W. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 88(6):3577-85. PMID: 24403576.
      Citations: 35     Fields:    Translation:HumansCells
    38. Zhong P, Agosto LM, Munro JB, Mothes W. Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb; 3(1):44-50. PMID: 23219376.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    39. Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell. 2011 Oct 21; 44(2):214-24. PMID: 22017870.
      Citations: 69     Fields:    Translation:AnimalsCells
    40. Fu J, Munro JB, Blanchard SC, Frank J. Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4817-21. PMID: 21383139.
      Citations: 20     Fields:    Translation:Cells
    41. Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation. Nat Struct Mol Biol. 2010 Dec; 17(12):1470-7. PMID: 21057527.
      Citations: 65     Fields:    Translation:Cells
    42. Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. J Mol Biol. 2010 Jun 18; 399(4):576-95. PMID: 20434456.
      Citations: 81     Fields:    Translation:Cells
    43. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome. EMBO J. 2010 Feb 17; 29(4):770-81. PMID: 20033061.
      Citations: 53     Fields:    Translation:Cells
    44. Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):709-14. PMID: 20018653.
      Citations: 75     Fields:    Translation:Cells
    45. Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome's metastable energy landscape. Trends Biochem Sci. 2009 Aug; 34(8):390-400. PMID: 19647434.
      Citations: 78     Fields:    Translation:Cells
    46. Dave R, Terry DS, Munro JB, Blanchard SC. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J. 2009 Mar 18; 96(6):2371-81. PMID: 19289062.
      Citations: 103     Fields:    Translation:Cells
    47. Munro JB, Vaiana A, Sanbonmatsu KY, Blanchard SC. A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers. 2008 Jul; 89(7):565-77. PMID: 18286627.
      Citations: 28     Fields:    Translation:Cells
    48. Munro JB, Altman RB, O'Connor N, Blanchard SC. Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell. 2007 Feb 23; 25(4):505-17. PMID: 17317624.
      Citations: 168     Fields:    Translation:Cells
    49. Bleuit JS, Ma Y, Munro J, Morrical SW. Mutations in a conserved motif inhibit single-stranded DNA binding and recombination mediator activities of bacteriophage T4 UvsY protein. J Biol Chem. 2004 Feb 13; 279(7):6077-86. PMID: 14634008.
      Citations: 11     Fields:    Translation:Cells
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