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Neal C Brown PHD DVM

TitleProfessor Emeritus
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
Address55 Lake Avenue North
S7-121
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology


    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NY, United StatesDVM
    Yale University, New Haven, CT, United StatesPHDPHARMACOLOGY

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Barnes MH, Butler MM, Wright GE, Brown NC. Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE. Infect Disord Drug Targets. 2012 Oct; 12(5):327-31. PMID: 23017159.
      View in: PubMed
    2. Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. A novel agent effective against Clostridium difficile infection. Antimicrob Agents Chemother. 2012 Mar; 56(3):1624-6. PMID: 22203600.
      View in: PubMed
    3. Torti A, Lossani A, Savi L, Focher F, Wright GE, Brown NC, Xu WC. Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct; 7(3):147-153. PMID: 22844265.
      View in: PubMed
    4. Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4197-202. PMID: 21684746.
      View in: PubMed
    5. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL. Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan; 51(1):119-27. PMID: 17074800.
      View in: PubMed
    6. Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem. 2006 Feb 23; 49(4):1455-65. PMID: 16480282.
      View in: PubMed
    7. Zhi C, Long ZY, Manikowski A, Brown NC, Tarantino PM, Holm K, Dix EJ, Wright GE, Foster KA, Butler MM, LaMarr WA, Skow DJ, Motorina I, Lamothe S, Storer R. Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. J Med Chem. 2005 Nov 3; 48(22):7063-74. PMID: 16250666.
      View in: PubMed
    8. Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):729-32. PMID: 15664846.
      View in: PubMed
    9. Zhi C, Long ZY, Gambino J, Xu WC, Brown NC, Barnes M, Butler M, LaMarr W, Wright GE. Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth. J Med Chem. 2003 Jun 19; 46(13):2731-9. PMID: 12801236.
      View in: PubMed
    10. Foster KA, Barnes MH, Stephenson RO, Butler MM, Skow DJ, LaMarr WA, Brown NC. DNA polymerase III of Enterococcus faecalis: expression and characterization of recombinant enzymes encoded by the polC and dnaE genes. Protein Expr Purif. 2003 Jan; 27(1):90-7. PMID: 12509989.
      View in: PubMed
    11. Barnes MH, Miller SD, Brown NC. DNA polymerases of low-GC gram-positive eubacteria: identification of the replication-specific enzyme encoded by dnaE. J Bacteriol. 2002 Jul; 184(14):3834-8. PMID: 12081953.
      View in: PubMed
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