"DNA Polymerase III" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.
| Descriptor ID |
D004258
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.235
|
| Concept/Terms |
DNA Polymerase III- DNA Polymerase III
- Polymerase III, DNA
- DNA Pol III
- DNA Polymerase delta
- Polymerase delta, DNA
- DNA-Dependent DNA Polymerase III
- DNA Dependent DNA Polymerase III
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase III".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase III".
This graph shows the total number of publications written about "DNA Polymerase III" by people in this website by year, and whether "DNA Polymerase III" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 2 | 3 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase III" by people in Profiles.
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Rivera-Flores IV, Wang EX, Murphy KC. Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5'-3' exonuclease and is independent of homologous recombination and NHEJ. Nucleic Acids Res. 2024 Nov 11; 52(20):12308-12323.
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Tashjian TF, Chien P. Clamp Loader Processing Is Important during DNA Replication Stress. J Bacteriol. 2023 02 22; 205(2):e0043722.
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Wu X, Liu Y, Wang W, Crimmings K, Williams A, Mager J, Cui W. Early embryonic lethality of mice lacking POLD2. Mol Reprod Dev. 2023 02; 90(2):98-108.
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Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding. Elife. 2020 05 19; 9.
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Xu WC, Silverman MH, Yu XY, Wright G, Brown N. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 08 01; 27(15):3209-3217.
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Van C, Williams JS, Kunkel TA, Peterson CL. Deposition of histone H2A.Z by the SWR-C remodeling enzyme prevents genome instability. DNA Repair (Amst). 2015 Jan; 25:9-14.
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Vass RH, Chien P. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18138-43.
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Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH. A structural role for the PHP domain in E. coli DNA polymerase III. BMC Struct Biol. 2013 May 14; 13:8.
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Barnes MH, Butler MM, Wright GE, Brown NC. Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE. Infect Disord Drug Targets. 2012 Oct; 12(5):327-31.
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Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase d catalytic subunit gene, POLD1. J Biol Chem. 2012 Aug 24; 287(35):29801-14.