RNA-Directed DNA Polymerase

"RNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.

Descriptor ID	D012194
MeSH Number(s)	D08.811.913.696.445.308.300.750 D12.776.964.775.375.750 D12.776.964.970.600.850.375.750
Concept/Terms	RNA-Directed DNA Polymerase RNA-Directed DNA Polymerase RNA Directed DNA Polymerase Reverse Transcriptase RNA Transcriptase DNA Polymerase, RNA-Directed DNA Polymerase, RNA Directed RNA-Dependent DNA Polymerase DNA Polymerase, RNA-Dependent RNA Dependent DNA Polymerase Revertase

Below are MeSH descriptors whose meaning is more general than "RNA-Directed DNA Polymerase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
DNA Nucleotidyltransferases [D08.811.913.696.445.308]
DNA-Directed DNA Polymerase [D08.811.913.696.445.308.300]
RNA-Directed DNA Polymerase [D08.811.913.696.445.308.300.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Retroviridae Proteins [D12.776.964.775]
Gene Products, pol [D12.776.964.775.375]
RNA-Directed DNA Polymerase [D12.776.964.775.375.750]
Viral Structural Proteins [D12.776.964.970]
Nucleocapsid Proteins [D12.776.964.970.600]
Viral Core Proteins [D12.776.964.970.600.850]
Gene Products, pol [D12.776.964.970.600.850.375]
RNA-Directed DNA Polymerase [D12.776.964.970.600.850.375.750]

Below are MeSH descriptors whose meaning is related to "RNA-Directed DNA Polymerase".

Below are MeSH descriptors whose meaning is more specific than "RNA-Directed DNA Polymerase".

RNA-Directed DNA Polymerase
HIV Reverse Transcriptase
Telomerase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA-Directed DNA Polymerase" by people in this website by year, and whether "RNA-Directed DNA Polymerase" was a major or minor topic of these publications.

Bar chart showing 18 publications over 14 distinct years, with a maximum of 2 publications in 1995 and 1997 and 2009 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	0	1	1
1997	0	2	2
2001	1	0	1
2003	0	1	1
2007	0	1	1
2009	1	1	2
2014	0	1	1
2016	1	0	1
2019	0	1	1
2020	1	0	1
2021	0	1	1
2022	0	2	2
2024	1	0	1

Below are the most recent publications written about "RNA-Directed DNA Polymerase" by people in Profiles.

Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt AT, Iyer S, Kelly K, Guo D, Kyawe PP, Vanderleeden E, Redick SD, Huang L, Chen Z, Lee JM, Schiffer CA, Harlan DM, Wang JP, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Increasing intracellular dNTP levels improves prime editing efficiency. Nat Biotechnol. 2025 Apr; 43(4):539-544.

View in: PubMed
Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodr?guez TC, Liang SQ, Xue W, Sontheimer EJ. A split prime editor with untethered reverse transcriptase and circular RNA template. Nat Biotechnol. 2022 09; 40(9):1388-1393.

View in: PubMed
Zheng C, Liang SQ, Liu B, Liu P, Kwan SY, Wolfe SA, Xue W. A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver. Mol Ther. 2022 03 02; 30(3):1343-1351.

View in: PubMed
Boateng JO, Wachman EM, Turcinovic J, Devera J, Jain M, Jean-Sicard S, Woodard E, Cruikshank A, Sinha B, Bartolome R, Barnett ED, Parker MG, Yarrington C, Connor JH, Taglauer E, Sabharwal V. SARS-CoV-2 in infant urine and fecal samples after in utero COVID-19 exposure. Pediatr Res. 2022 08; 92(2):536-540.

View in: PubMed
Pederson T. The 50th anniversary of reverse transcriptase-and its ironic legacy in the time of coronavirus. FASEB J. 2020 06; 34(6):7219-7221.

View in: PubMed
Flotte TR, Gao G. Prime Editing: A Novel Cas9-Reverse Transcriptase Fusion May Revolutionize Genome Editing. Hum Gene Ther. 2019 12; 30(12):1445-1446.

View in: PubMed
Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science. 2016 Feb 26; 351(6276):920-1.

View in: PubMed
Gibson RM, Meyer AM, Winner D, Archer J, Feyertag F, Ruiz-Mateos E, Leal M, Robertson DL, Schmotzer CL, Qui?ones-Mateu ME. Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism. Antimicrob Agents Chemother. 2014; 58(4):2167-85.

View in: PubMed
Pinto FL, Lindblad P. A guide for in-house design of template-switch-based 5' rapid amplification of cDNA ends systems. Anal Biochem. 2010 Feb 15; 397(2):227-32.

View in: PubMed
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D. Exploitation of binding energy for catalysis and design. Nature. 2009 Oct 29; 461(7268):1300-4.

View in: PubMed

People

Explore

Similar Concepts

Top Journals