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Kuang Shen PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    University of Science Technology of China, Hefei, , ChinaBSChemistry
    California Institute of Technology, Pasadena, CA, United StatesPHDChemistry

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    K22CA241362     (SHEN, KUANG)Jan 1, 2020 - Dec 31, 2022
    NIH
    A Molecular Study of Rag GTPase-Dependent Amino Acid Sensing
    Role: Principal Investigator
    R35GM146824     (SHEN, KUANG)Aug 1, 2022 - May 31, 2027
    NIH
    Spatial and temporal regulation of nutrient sensing
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. de Fatima Silva F, Boucher AR, Li H, Chen Q, Gaughan M, Korobkina ED, Isidor MS, Smith AO, Shen K, Allison DB, Tran PV, Pazour GJ, Guertin DA. Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1. bioRxiv. 2025 Jul 31. PMID: 40766400.
      Citations:    
    2. Liu JP, Shen KY, Cheng WC, Chang WC, Hsieh CY, Lo CC, Kuo TT, Lin CC, Liu SJ, Huang WC, Sher YP. ADAM9 drives the immunosuppressive microenvironment by cholesterol biosynthesis-mediated activation of IL6-STAT3 signaling for lung tumor progression. Am J Cancer Res. 2024; 14(4):1850-1865. PMID: 38726266.
      Citations:    
    3. Ivanova I, Shen K. Structures and Functions of the Human GATOR1 Complex. Subcell Biochem. 2024; 104:269-294. PMID: 38963491.
      Citations:    
    4. Tettoni SD, Egri SB, Doxsey DD, Veinotte K, Ouch C, Chang JY, Song K, Xu C, Shen K. Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure. 2023 09 07; 31(9):1065-1076.e5. PMID: 37453417.
      Citations:    Fields:    Translation:HumansAnimals
    5. Doxsey DD, Tettoni SD, Egri SB, Shen K. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells. J Biol Chem. 2023 07; 299(7):104880. PMID: 37269949.
      Citations: 1     Fields:    Translation:HumansCells
    6. Egri SB, Wang X, D?az-Salinas MA, Luban J, Dudkina NV, Munro JB, Shen K. Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination. Nat Commun. 2023 05 03; 14(1):2527. PMID: 37137903.
      Citations: 1     Fields:    Translation:HumansCells
    7. Yurkovetskiy L, Egri S, Kurhade C, Diaz-Salinas MA, Jaimes JA, Nyalile T, Xie X, Choudhary MC, Dauphin A, Li JZ, Munro JB, Shi PY, Shen K, Luban J. S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness. bioRxiv. 2023 Apr 24. PMID: 37034621.
      Citations:    
    8. Doxsey DD, Shen K. Purification and biochemical characterization of the Rag GTPase heterodimer. Methods Enzymol. 2022; 675:131-158. PMID: 36220268.
      Citations: 2     Fields:    Translation:Cells
    9. Egri SB, Ouch C, Chou HT, Yu Z, Song K, Xu C, Shen K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol Cell. 2022 05 19; 82(10):1836-1849.e5. PMID: 35338845.
      Citations: 11     Fields:    Translation:HumansCells
    10. D?az-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Elife. 2022 03 24; 11. PMID: 35323111.
      Citations: 21     Fields:    Translation:HumansCells
    11. Doxsey DD, Veinotte K, Shen K. A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae. Small GTPases. 2022 01; 13(1):327-334. PMID: 36328771.
      Citations: 1     Fields:    Translation:HumansAnimals
    12. van 't Spijker HM, Stackpole EE, Almeida S, Katsara O, Liu B, Shen K, Schneider RJ, Gao FB, Richter JD. Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation. RNA. 2022 02; 28(2):123-138. PMID: 34848561.
      Citations: 9     Fields:    Translation:HumansCells
    13. Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleiner?schkamp F, Oh J, Godefroid N, Eltan M, G?ran T, Burtey S, Parotte MC, K?nig J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altm?ller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF. mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. J Am Soc Nephrol. 2021 11; 32(11):2885-2899. PMID: 34607910.
      Citations: 12     Fields:    Translation:HumansCells
    14. Yan WL, Wu CC, Shen KY, Liu SJ. Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment. J Immunother Cancer. 2021 10; 9(10). PMID: 34599024.
      Citations:    
    15. Egri SB, Shen K. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids. J Biol Chem. 2021 07; 297(1):100861. PMID: 34116056.
      Citations: 1     Fields:    Translation:HumansCells
    16. Sher YP, Chai KM, Chen WC, Shen KY, Chen IH, Lee MH, Chiu FF, Liu SJ. A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity. Vaccines (Basel). 2020 Oct 21; 8(4). PMID: 33096846.
      Citations:    
    17. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 10 29; 183(3):739-751.e8. PMID: 32991842.
      Citations: 567     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Shen KY, Liu HY, Yan WL, Wu CC, Lee MH, Leng CH, Liu SJ. Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells. Cancers (Basel). 2020 Mar 28; 12(4). PMID: 32231003.
      Citations:    
    19. Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell. 2019 11 27; 179(6):1319-1329.e8. PMID: 31704029.
      Citations: 61     Fields:    Translation:HumansCells
    20. Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. FEBS Open Bio. 2019 09; 9(9):1589-1602. PMID: 31314152.
      Citations: 3     Fields:    Translation:HumansCells
    21. Lin MH, Shen KY, Liu BS, Chen IH, Sher YP, Tseng GC, Liu SJ, Sung WC. Immunological evaluation of a novel HLA-A2 restricted phosphopeptide of tumor associated Antigen, TRAP1, on cancer therapy. Vaccine X. 2019 Apr 11; 1:100017. PMID: 31384738.
      Citations:    
    22. Shen K, Valenstein ML, Gu X, Sabatini DM. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. J Biol Chem. 2019 02 22; 294(8):2970-2975. PMID: 30651352.
      Citations: 29     Fields:    Translation:HumansCells
    23. Shen K, Sabatini DM. Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9545-9550. PMID: 30181260.
      Citations: 69     Fields:    Translation:HumansCells
    24. Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature. 2018 04 05; 556(7699):64-69. PMID: 29590090.
      Citations: 74     Fields:    Translation:HumansCells
    25. Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Mol Cell. 2017 Nov 02; 68(3):552-565.e8. PMID: 29056322.
      Citations: 47     Fields:    Translation:HumansCells
    26. Hwang Fu YH, Huang WYC, Shen K, Groves JT, Miller T, Shan SO. Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting. Elife. 2017 07 28; 6. PMID: 28753124.
      Citations: 3     Fields:    Translation:Cells
    27. Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 03 16; 543(7645):438-442. PMID: 28199306.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    28. Chen Y, Shen K, Shan SO, Kou SC. Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models. J Am Stat Assoc. 2016; 111(515):951-966. PMID: 28943680.
      Citations:    
    29. Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24; 165(1):153-164. PMID: 26972053.
      Citations: 361     Fields:    Translation:HumansCells
    30. Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 01; 351(6268):43-8. PMID: 26449471.
      Citations: 518     Fields:    Translation:HumansCells
    31. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94. PMID: 25567906.
      Citations: 430     Fields:    Translation:HumansCells
    32. Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May; 4(5):554-63. PMID: 24631838.
      Citations: 224     Fields:    Translation:HumansAnimalsCells
    33. Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, Ban N. The structural basis of FtsY recruitment and GTPase activation by SRP RNA. Mol Cell. 2013 Dec 12; 52(5):643-54. PMID: 24211265.
      Citations: 25     Fields:    Translation:Cells
    34. Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO. Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end. J Biol Chem. 2013 Dec 20; 288(51):36385-97. PMID: 24151069.
      Citations: 14     Fields:    Translation:Cells
    35. Jaru-Ampornpan P, Liang FC, Nisthal A, Nguyen TX, Wang P, Shen K, Mayo SL, Shan SO. Mechanism of an ATP-independent protein disaggregase: II. distinct molecular interactions drive multiple steps during aggregate disassembly. J Biol Chem. 2013 May 10; 288(19):13431-45. PMID: 23519468.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Akopian D, Shen K, Zhang X, Shan SO. Signal recognition particle: an essential protein-targeting machine. Annu Rev Biochem. 2013; 82:693-721. PMID: 23414305.
      Citations: 220     Fields:    Translation:HumansAnimalsCells
    37. Akopian D, Dalal K, Shen K, Duong F, Shan SO. SecYEG activates GTPases to drive the completion of cotranslational protein targeting. J Cell Biol. 2013 Feb 18; 200(4):397-405. PMID: 23401005.
      Citations: 29     Fields:    Translation:Cells
    38. Shen K, Arslan S, Akopian D, Ha T, Shan SO. Activated GTPase movement on an RNA scaffold drives co-translational protein targeting. Nature. 2012 Dec 13; 492(7428):271-5. PMID: 23235881.
      Citations: 45     Fields:    Translation:Cells
    39. Shen K, Zhang X, Shan SO. Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting. RNA. 2011 May; 17(5):892-902. PMID: 21460239.
      Citations: 20     Fields:    Translation:Cells
    40. Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science. 2011 Feb 18; 331(6019):881-6. PMID: 21330537.
      Citations: 76     Fields:    Translation:Cells
    41. Jaru-Ampornpan P, Shen K, Lam VQ, Ali M, Doniach S, Jia TZ, Shan SO. ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit. Nat Struct Mol Biol. 2010 Jun; 17(6):696-702. PMID: 20424608.
      Citations: 43     Fields:    Translation:Cells
    42. Shen K, Shan SO. Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7698-703. PMID: 20385832.
      Citations: 30     Fields:    Translation:Cells
    43. Fu Y, Shen K, Liu L, Guo QX. First-principle calculation of equilibrium cesium ion-pair acidities in tetrahydrofuran. J Am Chem Soc. 2007 Nov 07; 129(44):13510-9. PMID: 17935326.
      Citations:    Fields:    Translation:Cells
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