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Natasha D Durham PhD

TitleInstructor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
368 Plantation Street AS8-1005
Worcester MA 01605
Phone744-455-6584
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    University of Toronto, Toronto, ON, CanadaBSHuman Biology
    Imperial College, London, , United KingdomMSMolecular Biology & Pathology
    Mount Sinai School of Medicine, New York, NY, United StatesPHDBiomedical Sciences

    Collapse Overview 
    Collapse Summary
    Focus: Viral entry, antibodies & vaccines, single molecule techniques

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soare AY, Malik HS, Durham ND, Freeman TL, Alvarez R, Patel F, Satija N, Upadhyay C, Hioe CE, Chen BK, Swartz TH. P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion. J Virol. 2020 02 28; 94(6). PMID: 31852781.
      Citations: 6     Fields:    Translation:HumansCells
    2. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 02; 18(2):e3000626. PMID: 32040508.
      Citations: 26     Fields:    Translation:HumansCells
    3. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 01 15; 12(1). PMID: 31952255.
      Citations: 7     Fields:    Translation:HumansCells
    4. Durham ND, Agrawal A, Waltari E, Croote D, Zanini F, Fouch M, Davidson E, Smith O, Carabajal E, Pak JE, Doranz BJ, Robinson M, Sanz AM, Albornoz LL, Rosso F, Einav S, Quake SR, McCutcheon KM, Goo L. Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics. Elife. 2019 12 10; 8. PMID: 31820734.
      Citations: 10     Fields:    Translation:HumansCells
    5. Soare AY, Durham ND, Gopal R, Tweel B, Hoffman KW, Brown JA, O'Brien M, Bhardwaj N, Lim JK, Chen BK, Swartz TH. P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1? in a Human Tonsil Explant Model. J Virol. 2019 01 01; 93(1). PMID: 30305360.
      Citations: 12     Fields:    Translation:HumansCells
    6. Alvarez RA, Maestre AM, Law K, Durham ND, Barria MI, Ishii-Watabe A, Tada M, Kapoor M, Hotta MT, Rodriguez-Caprio G, Fierer DS, Fernandez-Sesma A, Simon V, Chen BK. Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG. JCI Insight. 2017 02 23; 2(4):e88226. PMID: 28239647.
      Citations: 7     Fields:    Translation:HumansCells
    7. Watanabe SM, Simon V, Durham ND, Kemp BR, Machihara S, Kemal KS, Shi B, Foley B, Li H, Chen BK, Weiser B, Burger H, Anastos K, Chen C, Carter CA. The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility. Retrovirology. 2016 09 06; 13(1):64. PMID: 27600154.
      Citations: 4     Fields:    Translation:HumansCells
    8. Esposito AM, Cheung P, Swartz TH, Li H, Tsibane T, Durham ND, Basler CF, Felsenfeld DP, Chen BK. A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry. Virology. 2016 Mar; 490:6-16. PMID: 26803470.
      Citations: 10     Fields:    Translation:HumansCells
    9. Durham ND, Chen BK. Measuring T Cell-to-T Cell HIV-1 Transfer, Viral Fusion, and Infection Using Flow Cytometry. Methods Mol Biol. 2016; 1354:21-38. PMID: 26714702.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Durham ND, Chen BK. HIV-1 Cell-Free and Cell-to-Cell Infections Are Differentially Regulated by Distinct Determinants in the Env gp41 Cytoplasmic Tail. J Virol. 2015 Sep; 89(18):9324-37. PMID: 26136566.
      Citations: 14     Fields:    Translation:HumansCells
    11. Swartz TH, Esposito AM, Durham ND, Hartmann BM, Chen BK. P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection. J Virol. 2014 Oct; 88(19):11504-15. PMID: 25031337.
      Citations: 25     Fields:    Translation:HumansCells
    12. Micsenyi AM, Zony C, Alvarez RA, Durham ND, Chen BK, Klotman ME. Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. J Infect Dis. 2013 Dec 01; 208(11):1756-67. PMID: 23908485.
      Citations: 15     Fields:    Translation:HumansCells
    13. Durham ND, Yewdall AW, Chen P, Lee R, Zony C, Robinson JE, Chen BK. Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail. J Virol. 2012 Jul; 86(14):7484-95. PMID: 22553332.
      Citations: 46     Fields:    Translation:HumansCells
    14. Ramos I, Bernal-Rubio D, Durham N, Belicha-Villanueva A, Lowen AC, Steel J, Fernandez-Sesma A. Effects of receptor binding specificity of avian influenza virus on the human innate immune response. J Virol. 2011 May; 85(9):4421-31. PMID: 21345953.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
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