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Heather Gardner DVM

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
DepartmentPediatrics
AddressCummings School of Veterinary Medicine at Tufts
200 Westboro Road
North Grafton MA 01536
Phone614-867-3653
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics
    DivisionPediatric Research


    Collapse Biography 
    Collapse education and training
    Washington State University, Pullman, WA, United StatesBSZoology
    Tufts University School of Medicine, Boston, MA, United StatesPHDGenetics
    Washington State University, Pullman, WA, United StatesDVM

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Megquier K, Husted C, Rhoades J, White ME, Genereux DP, Chen FL, Xiong K, Kwon E, Swofford R, Painter C, Adalsteinsson VA, London CA, Gardner HL, Karlsson EK. Impact of preanalytical factors on liquid biopsy in the canine cancer model. Commun Med (Lond). 2026 Jun 11. PMID: 42277247.
      Citations:    
    2. Garg A, Mannheimer JD, Gardner H, London CA, Hendricks WPD, Wang G, Day K, Sakthikumar S, Warrier M, Mazcko C, Beck JA, LeBlanc AK. Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma. Clin Cancer Res. 2026 Apr 22. PMID: 42018306.
      Citations:    
    3. Rao K, Rao Z, Huang A, Heston S, Wang M, Yildiz-Altay ?, Qutab F, Kwong DA, Gardner HL, Richmond JM, London CA. Peripheral blood mononuclear cell gene expression signatures predict long-term survivorship in canine DLBCL. Sci Rep. 2026 Mar 17; 16(1). PMID: 41844944.
      Citations:    
    4. Draelos RL, Afreen S, Blasko B, Brazile TL, Chase N, Desai DP, Evert J, Gardner HL, Herrmann L, House AV, Kass S, Kavan M, Khemani K, Koire A, McDonald LM, Rabeeah Z, Shah A. Large language models provide unsafe answers to patient-posed medical questions. NPJ Digit Med. 2026 Feb 13; 9(1). PMID: 41688533.
      Citations:    
    5. Husted C, Seidel K, Karagiannis TT, Peterson C, Megquier K, Genereux D, Richmond J, Karlsson E, Shulman DS, Crompton B, London CA, Gardner HL. Multi-omic Longitudinal Analysis of Canine Osteosarcoma Identifies Inter-Patient Heterogeneity and Immune Enrichment in Metastatic Lesions. bioRxiv. 2026 Jan 15. PMID: 41542617.
      Citations:    
    6. Rao K, Rao Z, Huang A, Heston S, Wang M, Yildiz-Altay ?, Qutab F, Kwong DA, Gardner HL, Richmond JM, London CA. Peripheral Blood Mononuclear Cell Gene Expression Signatures Predict Long-term Survivorship in Canine DLBCL. Res Sq. 2025 Aug 19. PMID: 40894012.
      Citations:    
    7. Husted C, Adrianowycz S, Peterson C, DeWitt SB, Karlsson EK, Eward W, Somarelli JA, Megquier K, Gardner HL. Characterization of the genomic landscape of canine oral osteosarcoma reveals similarities with appendicular osteosarcoma. PLoS One. 2025; 20(6):e0325181. PMID: 40493617.
      Citations:    
    8. van der Heiden AD, Pensch R, Agger S, Gardner HL, Hendricks W, Zismann V, Wong S, Briones N, Turner B, Forsberg-Nilsson K, London C, Lindblad-Toh K, Arendt ML. Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival. Sci Rep. 2025 02 08; 15(1):4724. PMID: 39922874.
      Citations:    
    9. Megquier K, Husted C, Rhoades J, White ME, Genereux DP, Chen FL, Xiong K, Kwon E, Swofford R, Painter C, Adalsteinsson V, London CA, Gardner HL, Karlsson EK. Impact of preanalytical factors on liquid biopsy in the canine cancer model. bioRxiv. 2024 Jul 30. PMID: 39131379.
      Citations:    
    10. McLinden GP, Avery AC, Gardner HL, Hughes K, Rodday AM, Liang K, London CA. Safety and biologic activity of a canine anti-CD20 monoclonal antibody in dogs with diffuse large B-cell lymphoma. J Vet Intern Med. 2024 May-Jun; 38(3):1666-1674. PMID: 38662527.
      Citations:    
    11. Olayinka JT, Nagarkar A, Ma DJ, Wong NB, Romasco A, Piedra-Mora C, Wrijil L, David CN, Gardner HL, Robinson NA, Hughes KL, Barton B, London CA, Almela RM, Richmond JM. Cathepsin W, T-cell receptor-associated transmembrane adapter 1, lymphotactin and killer cell lectin like receptor K1 are sensitive and specific RNA biomarkers of canine epitheliotropic lymphoma. Front Vet Sci. 2023; 10:1225764. PMID: 38026637.
      Citations:    
    12. London CA, Gardner H, Zhao S, Knapp DW, Utturkar SM, Duval DL, Chambers MR, Ostrander E, Trent JM, Kuffel G. Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology. Vet Comp Oncol. 2023 Dec; 21(4):565-577. PMID: 37778398.
      Citations:    Fields:    Translation:HumansAnimals
    13. Dittrich K, Yildiz-Altay ?, Qutab F, Kwong DA, Rao Z, Nievez-Lozano SA, Gardner HL, Richmond JM, London CA. Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma. PLoS One. 2023; 18(8):e0290428. PMID: 37624862.
      Citations:    Fields:    Translation:HumansAnimalsCells
    14. Megquier K, Turner-Maier J, Morrill K, Li X, Johnson J, Karlsson EK, London CA, Gardner HL. The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations. PLoS One. 2022; 17(9):e0274383. PMID: 36099278.
      Citations:    Fields:    Translation:AnimalsCells
    15. Gardner HL, Fenger JM, Roberts RD, London CA. Characterizing the metabolic role of STAT3 in canine osteosarcoma. Vet Comp Oncol. 2022 Dec; 20(4):817-824. PMID: 35608271.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 02 01; 37(2):320-326. PMID: 31642480.
      Citations:    
    17. Somarelli JA, Boddy AM, Gardner HL, DeWitt SB, Tuohy J, Megquier K, Sheth MU, Hsu SD, Thorne JL, London CA, Eward WC. Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life. Mol Biol Evol. 2020 Jan 01; 37(1):11-17. PMID: 31688937.
      Citations: 13     Fields:    Translation:HumansAnimals
    18. Kwong M, Gardner HL, Dieterle N, Rentko V. Optimization of Electronic Medical Records for Data Mining Using a Common Data Model. Top Companion Anim Med. 2019 Dec; 37:100364. PMID: 31837755.
      Citations:    
    19. Kwong M, Gardner HL, Dieterle N, Rentko V. TRANSLATOR Database-A Vision for a Multi-Institutional Research Network. Top Companion Anim Med. 2019 Dec; 37:100363. PMID: 31837763.
      Citations:    
    20. Barrett LE, Gardner HL, Barber LG, Sadowski A, London CA. Safety and toxicity of combined oclacitinib and carboplatin or doxorubicin in dogs with solid tumors: a pilot study. BMC Vet Res. 2019 Aug 13; 15(1):291. PMID: 31409327.
      Citations: 2     Fields:    Translation:Animals
    21. Gardner HL, Sivaprakasam K, Briones N, Zismann V, Perdigones N, Drenner K, Facista S, Richholt R, Liang W, Aldrich J, Trent JM, Shields PG, Robinson N, Johnson J, Lana S, Houghton P, Fenger J, Lorch G, Janeway KA, London CA, Hendricks WPD. Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2. Commun Biol. 2019; 2:266. PMID: 31341965.
      Citations:    
    22. London CA, Acquaviva J, Smith DL, Sequeira M, Ogawa LS, Gardner HL, Bernabe LF, Bear MD, Bechtel SA, Proia DA. Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors. Clin Cancer Res. 2018 12 15; 24(24):6396-6407. PMID: 30171047.
      Citations: 4     Fields:    Translation:AnimalsCellsCTClinical Trials
    23. Sadowski AR, Gardner HL, Borgatti A, Wilson H, Vail DM, Lachowicz J, Manley C, Turner A, Klein MK, Waite A, Sahora A, London CA. Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma. BMC Vet Res. 2018 Aug 24; 14(1):250. PMID: 30143046.
      Citations: 13     Fields:    Translation:AnimalsCTClinical Trials
    24. Gardner HL, Rippy SB, Bear MD, Cronin KL, Heeb H, Burr H, Cannon CM, Penmetsa KV, Viswanadha S, Vakkalanka S, London CA. Phase I/II evaluation of RV1001, a novel PI3Kd inhibitor, in spontaneous canine lymphoma. PLoS One. 2018; 13(4):e0195357. PMID: 29689086.
      Citations: 9     Fields:    Translation:AnimalsCellsCTClinical Trials
    25. Schuh EM, Portela R, Gardner HL, Schoen C, London CA. Safety and efficacy of targeted hyperthermia treatment utilizing gold nanorod therapy in spontaneous canine neoplasia. BMC Vet Res. 2017 Oct 02; 13(1):294. PMID: 28969639.
      Citations: 1     Fields:    Translation:AnimalsCTClinical Trials
    26. Yu PY, Gardner HL, Roberts R, Cam H, Hariharan S, Ren L, LeBlanc AK, Xiao H, Lin J, Guttridge DC, Mo X, Bennett CE, Coss CC, Ling Y, Phelps MA, Houghton P, London CA. Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PLoS One. 2017; 12(7):e0181885. PMID: 28750090.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    27. Rippy SB, Gardner HL, Nguyen SM, Warry EE, Portela RF, Drost WT, Hostnik ET, Green EM, Chew DJ, Peng J, London CA. Erratum to: A pilot study of toceranib/vinblastine therapy for canine transitional cell carcinoma. BMC Vet Res. 2016 Dec 30; 12(1):291. PMID: 28038672.
      Citations:    Fields:    
    28. Rippy SB, Gardner HL, Nguyen SM, Warry EE, Portela RA, Drost WT, Hostnik ET, Green EM, Chew DJ, Peng J, London CA. A pilot study of toceranib/vinblastine therapy for canine transitional cell carcinoma. BMC Vet Res. 2016 Nov 17; 12(1):257. PMID: 27855679.
      Citations: 12     Fields:    Translation:Animals
    29. London CA, Gardner HL, Rippy S, Post G, La Perle K, Crew L, Lopresti-Morrow L, Garton AJ, McMahon G, LaVallee TM, Gedrich R. KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells. Clin Cancer Res. 2017 May 15; 23(10):2565-2574. PMID: 27815356.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    30. Randall VD, Boston SE, Gardner HL, Griffin L, Oblak ML, Kubicek L. Pubectomy and stereotactic radiotherapy for the treatment of a non-resectable sacral osteosarcoma causing pelvic canal obstruction in a dog. Can Vet J. 2016 Sep; 57(9):945-9. PMID: 27587885.
      Citations:    Fields:    Translation:Animals
    31. Cam M, Gardner HL, Roberts RD, Fenger JM, Guttridge DC, London CA, Cam H. ?Np63 mediates cellular survival and metastasis in canine osteosarcoma. Oncotarget. 2016 Jul 26; 7(30):48533-48546. PMID: 27391430.
      Citations: 14     Fields:    Translation:AnimalsCells
    32. Harrington BK, Gardner HL, Izumi R, Hamdy A, Rothbaum W, Coombes KR, Covey T, Kaptein A, Gulrajani M, Van Lith B, Krejsa C, Coss CC, Russell DS, Zhang X, Urie BK, London CA, Byrd JC, Johnson AJ, Kisseberth WC. Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma. PLoS One. 2016; 11(7):e0159607. PMID: 27434128.
      Citations: 22     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    33. Gardner HL, Fenger JM, London CA. Dogs as a Model for Cancer. Annu Rev Anim Biosci. 2016; 4:199-222. PMID: 26566160.
      Citations: 83     Fields:    Translation:HumansAnimals
    34. Karrasch NM, Lerche P, Aarnes TK, Gardner HL, London CA. The effects of preoperative oral administration of carprofen or tramadol on postoperative analgesia in dogs undergoing cutaneous tumor removal. Can Vet J. 2015 Aug; 56(8):817-22. PMID: 26246627.
      Citations: 5     Fields:    Translation:Animals
    35. Gardner HL, London CA, Portela RA, Nguyen S, Rosenberg MP, Klein MK, Clifford C, Thamm DH, Vail DM, Bergman P, Crawford-Jakubiak M, Henry C, Locke J, Garrett LD. Maintenance therapy with toceranib following doxorubicin-based chemotherapy for canine splenic hemangiosarcoma. BMC Vet Res. 2015 Jun 11; 11:131. PMID: 26062540.
      Citations: 14     Fields:    Translation:Animals
    36. London CA, Gardner HL, Mathie T, Stingle N, Portela R, Pennell ML, Clifford CA, Rosenberg MP, Vail DM, Williams LE, Cronin KL, Wilson-Robles H, Borgatti A, Henry CJ, Bailey DB, Locke J, Northrup NC, Crawford-Jakubiak M, Gill VL, Klein MK, Ruslander DM, Thamm DH, Phillips B, Post G. Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study. PLoS One. 2015; 10(4):e0124889. PMID: 25923466.
      Citations: 23     Fields:    Translation:AnimalsCTClinical Trials
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