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Sumeda Nandadasa PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North, S7-741
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    Collapse Biography 
    Collapse education and training
    Moorhead State University, Moorhead, MN, United StatesBABiotechnology & Biochemistry
    University of Cincinnati College of Medicine, Cincinnati, OH, United StatesPHDMolecular & Develop Biology
    Collapse awards and honors
    2017 - 2019Mark Lauer Pediatric Research Grant Awardee , Cleveland Clinic Children's Hospital
    2016 - 2017Excellence in Postdoctoral Research Award 1st place , Cleveland Clinic Lerner Research Institute
    2012 - 2015David and Lindsey Morgenthalar Endowed Postdoctoral Fellowship , Cleveland Clinic Lerner Research Institute
    2008 - 2010Albert J. Ryan Fellowship, University of Cincinnati College of Medicine
    2009 - 2010Distinguished Dissertation Completion Fellowship, University of Cincinnati College of Medicine

    Collapse Overview 

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    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nandadasa S, Martin D, Deshpande G, Robert KL, Stack MS, Itoh Y, Apte SS. Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate. Mol Cell Proteomics. 2023 Jun; 22(6):100566. PMID: 37169079.
      Citations:    Fields:    Translation:HumansCells
    2. Nandadasa S, Burin des Roziers C, Koch C, Tran-Lundmark K, Dours-Zimmermann MT, Zimmermann DR, Valleix S, Apte SS. A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression. Matrix Biol Plus. 2021 Jun; 10:100064. PMID: 34195596.
    3. Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 03; 97:40-57. PMID: 33454424.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Nandadasa S, Szafron JM, Pathak V, Murtada SI, Kraft CM, O'Donnell A, Norvik C, Hughes C, Caterson B, Domowicz MS, Schwartz NB, Tran-Lundmark K, Veigl M, Sedwick D, Philipson EH, Humphrey JD, Apte SS. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. Elife. 2020 09 10; 9. PMID: 32909945.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    5. Wang LW, Nandadasa S, Annis DS, Dubail J, Mosher DF, Willard BB, Apte SS. A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover. J Biol Chem. 2019 06 21; 294(25):9924-9936. PMID: 31085586.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe K, Cox TC, Hildebrandt F, Apte SS. Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 02 27; 10(1):953. PMID: 30814516.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    7. Choi YJ, Halbritter J, Braun DA, Schueler M, Schapiro D, Rim JH, Nandadasa S, Choi WI, Widmeier E, Shril S, K?rber F, Sethi SK, Lifton RP, Beck BB, Apte SS, Gee HY, Hildebrandt F. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet. 2019 01 03; 104(1):45-54. PMID: 30609407.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    8. Asano K, Nelson CM, Nandadasa S, Aramaki-Hattori N, Lindner DJ, Alban T, Inagaki J, Ohtsuki T, Oohashi T, Apte SS, Hirohata S. Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis. Sci Rep. 2017 12 08; 7(1):17225. PMID: 29222454.
      Citations: 44     Fields:    Translation:AnimalsCells
    9. Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RPT, Apte SS, Haltiwanger RS, Holdener BC. Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016 08 01; 416(1):111-122. PMID: 27297885.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    10. Nandadasa S, Nelson CM, Apte SS. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16; 11(10):1519-28. PMID: 26027930.
      Citations: 35     Fields:    Translation:AnimalsCells
    11. Nandadasa S, Foulcer S, Apte SS. The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 2014 Apr; 35:34-41. PMID: 24444773.
      Citations: 82     Fields:    Translation:AnimalsCells
    12. Nandadasa S, Tao Q, Shoemaker A, Cha SW, Wylie C. Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. PLoS One. 2012; 7(6):e38756. PMID: 22719936.
      Citations: 4     Fields:    Translation:Animals
    13. Morita H, Nandadasa S, Yamamoto TS, Terasaka-Iioka C, Wylie C, Ueno N. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development. 2010 Apr; 137(8):1315-25. PMID: 20332149.
      Citations: 35     Fields:    Translation:AnimalsCells
    14. Nandadasa S, Tao Q, Menon NR, Heasman J, Wylie C. N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. Development. 2009 Apr; 136(8):1327-38. PMID: 19279134.
      Citations: 63     Fields:    Translation:AnimalsCells
    15. Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development. 2007 Jul; 134(14):2651-61. PMID: 17567666.
      Citations: 21     Fields:    Translation:AnimalsCells
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