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Last Name

Sumeda Nandadasa PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - School of Medicine

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    Collapse Biography 
    Collapse awards and honors
    2017 - 2019Mark Lauer Pediatric Research Grant Awardee , Cleveland Clinic Children's Hospital
    2016 - 2017Excellence in Postdoctoral Research Award 1st place , Cleveland Clinic Lerner Research Institute
    2012 - 2015David and Lindsey Morgenthalar Endowed Postdoctoral Fellowship , Cleveland Clinic Lerner Research Institute
    2008 - 2010Albert J. Ryan Fellowship, University of Cincinnati College of Medicine
    2009 - 2010Distinguished Dissertation Completion Fellowship, University of Cincinnati College of Medicine

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nandadasa S, Burin des Roziers C, Koch C, Tran-Lundmark K, Dours-Zimmermann MT, Zimmermann DR, Valleix S, Apte SS. A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression. Matrix Biol Plus. 2021 Jun; 10:100064. PMID: 34195596.
      View in: PubMed
    2. Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 Jan 14. PMID: 33454424.
      View in: PubMed
    3. Nandadasa S, Szafron JM, Pathak V, Murtada SI, Kraft CM, O'Donnell A, Norvik C, Hughes C, Caterson B, Domowicz MS, Schwartz NB, Tran-Lundmark K, Veigl M, Sedwick D, Philipson EH, Humphrey JD, Apte SS. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. Elife. 2020 09 10; 9. PMID: 32909945.
      View in: PubMed
    4. Wang LW, Nandadasa S, Annis DS, Dubail J, Mosher DF, Willard BB, Apte SS. A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover. J Biol Chem. 2019 06 21; 294(25):9924-9936. PMID: 31085586.
      View in: PubMed
    5. Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe K, Cox TC, Hildebrandt F, Apte SS. Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 02 27; 10(1):953. PMID: 30814516.
      View in: PubMed
    6. Choi YJ, Halbritter J, Braun DA, Schueler M, Schapiro D, Rim JH, Nandadasa S, Choi WI, Widmeier E, Shril S, K├Ârber F, Sethi SK, Lifton RP, Beck BB, Apte SS, Gee HY, Hildebrandt F. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet. 2019 01 03; 104(1):45-54. PMID: 30609407.
      View in: PubMed
    7. Asano K, Nelson CM, Nandadasa S, Aramaki-Hattori N, Lindner DJ, Alban T, Inagaki J, Ohtsuki T, Oohashi T, Apte SS, Hirohata S. Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis. Sci Rep. 2017 12 08; 7(1):17225. PMID: 29222454.
      View in: PubMed
    8. Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RPT, Apte SS, Haltiwanger RS, Holdener BC. Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016 08 01; 416(1):111-122. PMID: 27297885.
      View in: PubMed
    9. Nandadasa S, Nelson CM, Apte SS. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16; 11(10):1519-28. PMID: 26027930.
      View in: PubMed
    10. Nandadasa S, Foulcer S, Apte SS. The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 2014 Apr; 35:34-41. PMID: 24444773.
      View in: PubMed
    11. Nandadasa S, Tao Q, Shoemaker A, Cha SW, Wylie C. Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. PLoS One. 2012; 7(6):e38756. PMID: 22719936.
      View in: PubMed
    12. Morita H, Nandadasa S, Yamamoto TS, Terasaka-Iioka C, Wylie C, Ueno N. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development. 2010 Apr; 137(8):1315-25. PMID: 20332149.
      View in: PubMed
    13. Nandadasa S, Tao Q, Menon NR, Heasman J, Wylie C. N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. Development. 2009 Apr; 136(8):1327-38. PMID: 19279134.
      View in: PubMed
    14. Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development. 2007 Jul; 134(14):2651-61. PMID: 17567666.
      View in: PubMed
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